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nature portfolio research development award permissions reprints privacy policy inhibit cancer-driving pathways author information authors editing mmtv-polyoma middle advertising nature 448 nature 419 nature language improvement social media phosphatidylinositol 3-kinase/akt-dependent pathway scientific publication china medical university akt-ps473 status combined prolyl isomerase pin1 serine/threonine protein kinase phosphorylated thr-pro motifs epigallocatechin-3-gallate induces apoptosis personal data springerlink instant access d3 phosphoinositide-regulated kinases dr lu kp data protection akt/pkb ser473 phosphorylation permissions multiple cancer types china akt-mtor signalling axis multiple-step process pin1 mef cells modeling breast cancer suppresses tumor growth arsenic targets pin1 alessi dr human breast cancer breast cancer patients homologue pin1 knockout testa jr privacy supplementary figure s2 supplementary figure s3 prolyl isomerase repressing pin1 expression phosphoinositide-dependent phosphorylation akt protein stability forkhead transcription factors

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         description:The serine/threonine protein kinase B (PKB, also known as Akt) plays a pivotal role in diverse cellular functions. Elevated expression of activated Akt has been detected in a wide variety of human cancers; however, the mechanism of Akt protein stability regulation remains unclear. In this study, we showed a strong correlation between the expression levels of an oncogenic peptidyl-prolyl cis/trans isomerase Pin1 and levels of Akt phosphorylation at S473 in multiple cancer types (P<0.0001). Akt-pS473 status combined with Pin1 expression levels predicted a poorer prognosis than did either one alone in patients with breast cancer (P=0.0052). We further showed that Pin1 regulated Akt stability and phosphorylation on S473 through the phosphorylated Thr-Pro motifs of Akt. These motifs are conserved evolutionary and are required for the maintenance of Akt stability and its interaction with Pin1. In addition, repressing Pin1 expression through either homologue Pin1 knockout or small interfering RNA-mediated knockingdown compromised its ability to protect Akt from degradation. Our results show how Akt protein stability is regulated by the peptidyl-prolyl cis/trans isomerase Pin1 and highlight the importance of this oncogenic network in human disease pathogenesis.
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      name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
      name:Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, USA
      name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
      name:Center for Molecular Medicine and Graduate Institute of Cancer Biology, China Medical University and Hospital, Taichung, Taiwan
      name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
      name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
      name:Department of Pathology, Cancer Hospital, Fudan University, Shanghai, China
      name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
      name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
      name:Center for Molecular Medicine and Graduate Institute of Cancer Biology, China Medical University and Hospital, Taichung, Taiwan
      name:Asia University, Taichung, Taiwan
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