
NATURE . COM {
}
Title:
Peptidyl-prolyl cis/trans isomerase Pin1 is critical for the regulation of PKB/Akt stability and activation phosphorylation | Oncogene
Description:
The serine/threonine protein kinase B (PKB, also known as Akt) plays a pivotal role in diverse cellular functions. Elevated expression of activated Akt has been detected in a wide variety of human cancers; however, the mechanism of Akt protein stability regulation remains unclear. In this study, we showed a strong correlation between the expression levels of an oncogenic peptidyl-prolyl cis/trans isomerase Pin1 and levels of Akt phosphorylation at S473 in multiple cancer types (P<0.0001). Akt-pS473 status combined with Pin1 expression levels predicted a poorer prognosis than did either one alone in patients with breast cancer (P=0.0052). We further showed that Pin1 regulated Akt stability and phosphorylation on S473 through the phosphorylated Thr-Pro motifs of Akt. These motifs are conserved evolutionary and are required for the maintenance of Akt stability and its interaction with Pin1. In addition, repressing Pin1 expression through either homologue Pin1 knockout or small interfering RNA-mediated knockingdown compromised its ability to protect Akt from degradation. Our results show how Akt protein stability is regulated by the peptidyl-prolyl cis/trans isomerase Pin1 and highlight the importance of this oncogenic network in human disease pathogenesis.
Website Age:
30 years and 10 months (reg. 1994-08-11).
Matching Content Categories {π}
- Education
- Health & Fitness
- Telecommunications
Content Management System {π}
What CMS is nature.com built with?
Custom-built
No common CMS systems were detected on Nature.com, and no known web development framework was identified.
Traffic Estimate {π}
What is the average monthly size of nature.com audience?
π Monumental Traffic: 20M - 50M visitors per month
Based on our best estimate, this website will receive around 42,554,915 visitors per month in the current month.
check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush
How Does Nature.com Make Money? {πΈ}
Display Ads {π―}
The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.
Ads are managed by yourbow.com. Particular relationships are as follows:
Direct Advertisers (10)
google.com, pmc.com, doceree.com, yourbow.com, audienciad.com, onlinemediasolutions.com, advibe.media, aps.amazon.com, getmediamx.com, onomagic.comReseller Advertisers (38)
conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.comHow Much Does Nature.com Make? {π°}
Display Ads {π―}
$536,300 per month
Our analysis indicates Nature.com generates between $357,503 and $983,134 monthly online from display ads.
Keywords {π}
article, pubmed, cas, google, scholar, cancer, akt, pin, nature, protein, kinase, cell, isomerase, phosphorylation, zhou, access, oncogene, breast, central, stability, human, mol, university, regulation, department, content, activation, liao, usa, center, supplementary, cookies, information, yang, chen, hung, expression, prolyl, tsichlis, privacy, peptidylprolyl, cistrans, pkbakt, role, multiple, open, signalling, targeting, biochem, sci,
Topics {βοΈ}
nature portfolio research development award permissions reprints privacy policy inhibit cancer-driving pathways author information authors editing mmtv-polyoma middle advertising nature 448 nature 419 nature language improvement social media phosphatidylinositol 3-kinase/akt-dependent pathway scientific publication china medical university akt-ps473 status combined prolyl isomerase pin1 serine/threonine protein kinase phosphorylated thr-pro motifs epigallocatechin-3-gallate induces apoptosis personal data springerlink instant access d3 phosphoinositide-regulated kinases dr lu kp data protection akt/pkb ser473 phosphorylation permissions multiple cancer types china akt-mtor signalling axis multiple-step process pin1 mef cells modeling breast cancer suppresses tumor growth arsenic targets pin1 alessi dr human breast cancer breast cancer patients homologue pin1 knockout testa jr privacy supplementary figure s2 supplementary figure s3 prolyl isomerase repressing pin1 expression phosphoinositide-dependent phosphorylation akt protein stability forkhead transcription factors
Questions {β}
- Targeting carcinogenesis: a role for the prolyl isomerase Pin1?
Schema {πΊοΈ}
WebPage:
mainEntity:
headline:Peptidyl-prolyl cis/trans isomerase Pin1 is critical for the regulation of PKB/Akt stability and activation phosphorylation
description:The serine/threonine protein kinase B (PKB, also known as Akt) plays a pivotal role in diverse cellular functions. Elevated expression of activated Akt has been detected in a wide variety of human cancers; however, the mechanism of Akt protein stability regulation remains unclear. In this study, we showed a strong correlation between the expression levels of an oncogenic peptidyl-prolyl cis/trans isomerase Pin1 and levels of Akt phosphorylation at S473 in multiple cancer types (P<0.0001). Akt-pS473 status combined with Pin1 expression levels predicted a poorer prognosis than did either one alone in patients with breast cancer (P=0.0052). We further showed that Pin1 regulated Akt stability and phosphorylation on S473 through the phosphorylated Thr-Pro motifs of Akt. These motifs are conserved evolutionary and are required for the maintenance of Akt stability and its interaction with Pin1. In addition, repressing Pin1 expression through either homologue Pin1 knockout or small interfering RNA-mediated knockingdown compromised its ability to protect Akt from degradation. Our results show how Akt protein stability is regulated by the peptidyl-prolyl cis/trans isomerase Pin1 and highlight the importance of this oncogenic network in human disease pathogenesis.
datePublished:2009-05-18T00:00:00Z
dateModified:2009-05-18T00:00:00Z
pageStart:2436
pageEnd:2445
sameAs:https://doi.org/10.1038/onc.2009.98
keywords:
PKB/Akt
Pin1
peptidyl-prolyl cis/trans isomerase
breast cancer
Medicine/Public Health
general
Internal Medicine
Cell Biology
Human Genetics
Oncology
Apoptosis
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fonc.2009.98/MediaObjects/41388_2009_Article_BFonc200998_Fig1_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fonc.2009.98/MediaObjects/41388_2009_Article_BFonc200998_Fig2_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fonc.2009.98/MediaObjects/41388_2009_Article_BFonc200998_Fig3_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fonc.2009.98/MediaObjects/41388_2009_Article_BFonc200998_Fig4_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fonc.2009.98/MediaObjects/41388_2009_Article_BFonc200998_Fig5_HTML.jpg
isPartOf:
name:Oncogene
issn:
1476-5594
0950-9232
volumeNumber:28
type:
Periodical
PublicationVolume
publisher:
name:Nature Publishing Group UK
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Y Liao
affiliation:
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
type:Organization
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
type:Organization
email:[email protected]
type:Person
name:Y Wei
affiliation:
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
type:Organization
type:Person
name:X Zhou
affiliation:
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
type:Organization
name:Cancer Hospital, Fudan University
address:
name:Department of Pathology, Cancer Hospital, Fudan University, Shanghai, China
type:PostalAddress
type:Organization
type:Person
name:J -Y Yang
affiliation:
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
type:Organization
type:Person
name:C Dai
affiliation:
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
type:Organization
type:Person
name:Y -J Chen
affiliation:
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
type:Organization
name:Center for Molecular Medicine and Graduate Institute of Cancer Biology, China Medical University and Hospital
address:
name:Center for Molecular Medicine and Graduate Institute of Cancer Biology, China Medical University and Hospital, Taichung, Taiwan
type:PostalAddress
type:Organization
type:Person
name:N K Agarwal
affiliation:
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
type:Organization
type:Person
name:D Sarbassov
affiliation:
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
type:Organization
type:Person
name:D Shi
affiliation:
name:Cancer Hospital, Fudan University
address:
name:Department of Pathology, Cancer Hospital, Fudan University, Shanghai, China
type:PostalAddress
type:Organization
type:Person
name:D Yu
affiliation:
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
type:Organization
type:Person
name:M -C Hung
affiliation:
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
type:Organization
name:Center for Molecular Medicine and Graduate Institute of Cancer Biology, China Medical University and Hospital
address:
name:Center for Molecular Medicine and Graduate Institute of Cancer Biology, China Medical University and Hospital, Taichung, Taiwan
type:PostalAddress
type:Organization
name:Asia University
address:
name:Asia University, Taichung, Taiwan
type:PostalAddress
type:Organization
email:[email protected]
type:Person
isAccessibleForFree:
hasPart:
isAccessibleForFree:
cssSelector:.main-content
type:WebPageElement
type:ScholarlyArticle
context:https://schema.org
ScholarlyArticle:
headline:Peptidyl-prolyl cis/trans isomerase Pin1 is critical for the regulation of PKB/Akt stability and activation phosphorylation
description:The serine/threonine protein kinase B (PKB, also known as Akt) plays a pivotal role in diverse cellular functions. Elevated expression of activated Akt has been detected in a wide variety of human cancers; however, the mechanism of Akt protein stability regulation remains unclear. In this study, we showed a strong correlation between the expression levels of an oncogenic peptidyl-prolyl cis/trans isomerase Pin1 and levels of Akt phosphorylation at S473 in multiple cancer types (P<0.0001). Akt-pS473 status combined with Pin1 expression levels predicted a poorer prognosis than did either one alone in patients with breast cancer (P=0.0052). We further showed that Pin1 regulated Akt stability and phosphorylation on S473 through the phosphorylated Thr-Pro motifs of Akt. These motifs are conserved evolutionary and are required for the maintenance of Akt stability and its interaction with Pin1. In addition, repressing Pin1 expression through either homologue Pin1 knockout or small interfering RNA-mediated knockingdown compromised its ability to protect Akt from degradation. Our results show how Akt protein stability is regulated by the peptidyl-prolyl cis/trans isomerase Pin1 and highlight the importance of this oncogenic network in human disease pathogenesis.
datePublished:2009-05-18T00:00:00Z
dateModified:2009-05-18T00:00:00Z
pageStart:2436
pageEnd:2445
sameAs:https://doi.org/10.1038/onc.2009.98
keywords:
PKB/Akt
Pin1
peptidyl-prolyl cis/trans isomerase
breast cancer
Medicine/Public Health
general
Internal Medicine
Cell Biology
Human Genetics
Oncology
Apoptosis
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fonc.2009.98/MediaObjects/41388_2009_Article_BFonc200998_Fig1_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fonc.2009.98/MediaObjects/41388_2009_Article_BFonc200998_Fig2_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fonc.2009.98/MediaObjects/41388_2009_Article_BFonc200998_Fig3_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fonc.2009.98/MediaObjects/41388_2009_Article_BFonc200998_Fig4_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fonc.2009.98/MediaObjects/41388_2009_Article_BFonc200998_Fig5_HTML.jpg
isPartOf:
name:Oncogene
issn:
1476-5594
0950-9232
volumeNumber:28
type:
Periodical
PublicationVolume
publisher:
name:Nature Publishing Group UK
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Y Liao
affiliation:
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
type:Organization
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
type:Organization
email:[email protected]
type:Person
name:Y Wei
affiliation:
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
type:Organization
type:Person
name:X Zhou
affiliation:
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
type:Organization
name:Cancer Hospital, Fudan University
address:
name:Department of Pathology, Cancer Hospital, Fudan University, Shanghai, China
type:PostalAddress
type:Organization
type:Person
name:J -Y Yang
affiliation:
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
type:Organization
type:Person
name:C Dai
affiliation:
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
type:Organization
type:Person
name:Y -J Chen
affiliation:
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
type:Organization
name:Center for Molecular Medicine and Graduate Institute of Cancer Biology, China Medical University and Hospital
address:
name:Center for Molecular Medicine and Graduate Institute of Cancer Biology, China Medical University and Hospital, Taichung, Taiwan
type:PostalAddress
type:Organization
type:Person
name:N K Agarwal
affiliation:
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
type:Organization
type:Person
name:D Sarbassov
affiliation:
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
type:Organization
type:Person
name:D Shi
affiliation:
name:Cancer Hospital, Fudan University
address:
name:Department of Pathology, Cancer Hospital, Fudan University, Shanghai, China
type:PostalAddress
type:Organization
type:Person
name:D Yu
affiliation:
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
type:Organization
type:Person
name:M -C Hung
affiliation:
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
type:Organization
name:Center for Molecular Medicine and Graduate Institute of Cancer Biology, China Medical University and Hospital
address:
name:Center for Molecular Medicine and Graduate Institute of Cancer Biology, China Medical University and Hospital, Taichung, Taiwan
type:PostalAddress
type:Organization
name:Asia University
address:
name:Asia University, Taichung, Taiwan
type:PostalAddress
type:Organization
email:[email protected]
type:Person
isAccessibleForFree:
hasPart:
isAccessibleForFree:
cssSelector:.main-content
type:WebPageElement
["Periodical","PublicationVolume"]:
name:Oncogene
issn:
1476-5594
0950-9232
volumeNumber:28
Organization:
name:Nature Publishing Group UK
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
name:Cancer Hospital, Fudan University
address:
name:Department of Pathology, Cancer Hospital, Fudan University, Shanghai, China
type:PostalAddress
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
name:Center for Molecular Medicine and Graduate Institute of Cancer Biology, China Medical University and Hospital
address:
name:Center for Molecular Medicine and Graduate Institute of Cancer Biology, China Medical University and Hospital, Taichung, Taiwan
type:PostalAddress
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
name:Cancer Hospital, Fudan University
address:
name:Department of Pathology, Cancer Hospital, Fudan University, Shanghai, China
type:PostalAddress
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
name:Center for Molecular Medicine and Graduate Institute of Cancer Biology, China Medical University and Hospital
address:
name:Center for Molecular Medicine and Graduate Institute of Cancer Biology, China Medical University and Hospital, Taichung, Taiwan
type:PostalAddress
name:Asia University
address:
name:Asia University, Taichung, Taiwan
type:PostalAddress
ImageObject:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
name:Y Liao
affiliation:
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
type:Organization
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
type:Organization
email:[email protected]
name:Y Wei
affiliation:
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
type:Organization
name:X Zhou
affiliation:
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
type:Organization
name:Cancer Hospital, Fudan University
address:
name:Department of Pathology, Cancer Hospital, Fudan University, Shanghai, China
type:PostalAddress
type:Organization
name:J -Y Yang
affiliation:
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
type:Organization
name:C Dai
affiliation:
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
type:Organization
name:Y -J Chen
affiliation:
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
type:Organization
name:Center for Molecular Medicine and Graduate Institute of Cancer Biology, China Medical University and Hospital
address:
name:Center for Molecular Medicine and Graduate Institute of Cancer Biology, China Medical University and Hospital, Taichung, Taiwan
type:PostalAddress
type:Organization
name:N K Agarwal
affiliation:
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
type:Organization
name:D Sarbassov
affiliation:
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
type:Organization
name:D Shi
affiliation:
name:Cancer Hospital, Fudan University
address:
name:Department of Pathology, Cancer Hospital, Fudan University, Shanghai, China
type:PostalAddress
type:Organization
name:D Yu
affiliation:
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
type:Organization
name:M -C Hung
affiliation:
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
type:Organization
name:Center for Molecular Medicine and Graduate Institute of Cancer Biology, China Medical University and Hospital
address:
name:Center for Molecular Medicine and Graduate Institute of Cancer Biology, China Medical University and Hospital, Taichung, Taiwan
type:PostalAddress
type:Organization
name:Asia University
address:
name:Asia University, Taichung, Taiwan
type:PostalAddress
type:Organization
email:[email protected]
PostalAddress:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
name:Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, USA
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
name:Department of Pathology, Cancer Hospital, Fudan University, Shanghai, China
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
name:Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, USA
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
name:Center for Molecular Medicine and Graduate Institute of Cancer Biology, China Medical University and Hospital, Taichung, Taiwan
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
name:Department of Pathology, Cancer Hospital, Fudan University, Shanghai, China
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
name:Center for Molecular Medicine and Graduate Institute of Cancer Biology, China Medical University and Hospital, Taichung, Taiwan
name:Asia University, Taichung, Taiwan
WebPageElement:
isAccessibleForFree:
cssSelector:.main-content
External Links {π}(183)
- How much money does https://link.springer.com/article/10.1038/onc.2009.98?utm_source=nature&utm_medium=referral&utm_campaign=buyArticle generate?
- What's the monthly income of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=8978681?
- What's the income of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC452479?
- Discover the revenue of http://scholar.google.com/scholar_lookup?&title=Mechanism%20of%20activation%20of%20protein%20kinase%20B%20by%20insulin%20and%20IGF-1&journal=EMBO%20J&volume=15&pages=6541-6551&publication_year=1996&author=Alessi%2CDR&author=Andjelkovic%2CM&author=Caudwell%2CB&author=Cron%2CP&author=Morrice%2CN&author=Cohen%2CP
- What's https://doi.org/10.1016%2FS0002-9440%2810%2963731-5's gross income?
- How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15111319 pull in?
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1615639 income
- http://scholar.google.com/scholar_lookup?&title=Prevalent%20overexpression%20of%20prolyl%20isomerase%20Pin1%20in%20human%20cancers&journal=Am%20J%20Pathol&doi=10.1016%2FS0002-9440%2810%2963731-5&volume=164&pages=1727-1737&publication_year=2004&author=Bao%2CL&author=Kimzey%2CA&author=Sauter%2CG&author=Sowadski%2CJM&author=Lu%2CKP&author=Wang%2CDG's financial summary
- Check the income stats for https://doi.org/10.1016%2Fj.molcel.2005.03.020
- How much revenue does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15837416 generate?
- What is the earnings of http://scholar.google.com/scholar_lookup?&title=Regulation%20of%20Akt%2FPKB%20Ser473%20phosphorylation&journal=Mol%20Cell&doi=10.1016%2Fj.molcel.2005.03.020&volume=18&pages=143-145&publication_year=2005&author=Bayascas%2CJR&author=Alessi%2CDR?
- How much income does https://doi.org/10.1038%2Fsj.onc.1201947 have?
- What's the financial gain of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=9690513?
- How profitable is http://scholar.google.com/scholar_lookup?&title=Akt%20activation%20by%20growth%20factors%20is%20a%20multiple-step%20process%3A%20the%20role%20of%20the%20PH%20domain&journal=Oncogene&doi=10.1038%2Fsj.onc.1201947&volume=17&pages=313-325&publication_year=1998&author=Bellacosa%2CA&author=Chan%2CTO&author=Ahmed%2CNN&author=Datta%2CK&author=Malstrom%2CS&author=Stokoe%2CD?
- Learn about the earnings of https://doi.org/10.1016%2FS0065-230X%2805%2994002-5
- Earnings of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=16095999
- Income figures for http://scholar.google.com/scholar_lookup?&title=Activation%20of%20AKT%20kinases%20in%20cancer%3A%20implications%20for%20therapeutic%20targeting&journal=Adv%20Cancer%20Res&doi=10.1016%2FS0065-230X%2805%2994002-5&volume=94&pages=29-86&publication_year=2005&author=Bellacosa%2CA&author=Kumar%2CCC&author=Di%20Cristofano%2CA&author=Testa%2CJR
- https://doi.org/10.1016%2Fj.devcel.2007.03.020 income
- How much profit does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17419990 make?
- Revenue of http://scholar.google.com/scholar_lookup?&title=The%20two%20TORCs%20and%20Akt&journal=Dev%20Cell&doi=10.1016%2Fj.devcel.2007.03.020&volume=12&pages=487-502&publication_year=2007&author=Bhaskar%2CPT&author=Hay%2CN
- How much does https://doi.org/10.1016%2Fj.tibs.2004.03.006 bring in each month?
- See how much http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15130559 makes per month
- Get to know http://scholar.google.com/scholar_lookup?&title=Advances%20in%20protein%20kinase%20B%20signalling%3A%20AKTion%20on%20multiple%20fronts&journal=Trends%20Biochem%20Sci&doi=10.1016%2Fj.tibs.2004.03.006&volume=29&pages=233-242&publication_year=2004&author=Brazil%2CDP&author=Yang%2CZZ&author=Hemmings%2CBA's earnings
- How much does https://doi.org/10.1016%2Fj.molcel.2007.02.017 gross monthly?
- What's the revenue for http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17386267?
- Discover the revenue of http://scholar.google.com/scholar_lookup?&title=PHLPP%20and%20a%20second%20isoform%2C%20PHLPP2%2C%20differentially%20attenuate%20the%20amplitude%20of%20Akt%20signaling%20by%20regulating%20distinct%20Akt%20isoforms&journal=Mol%20Cell&doi=10.1016%2Fj.molcel.2007.02.017&volume=25&pages=917-931&publication_year=2007&author=Brognard%2CJ&author=Sierecki%2CE&author=Gao%2CT&author=Newton%2CAC
- What's the financial intake of https://doi.org/10.1189%2Fjlb.1202629?
- What's the income of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12773501?
- How much does http://scholar.google.com/scholar_lookup?&title=Decisions%20on%20life%20and%20death%3A%20FOXO%20Forkhead%20transcription%20factors%20are%20in%20command%20when%20PKB%2FAkt%20is%20off%20duty&journal=J%20Leukoc%20Biol&doi=10.1189%2Fjlb.1202629&volume=73&pages=689-701&publication_year=2003&author=Burgering%2CBM&author=Medema%2CRH make?
- What is the monthly revenue of https://doi.org/10.1038%2Fnature05933?
- How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17611497 gross monthly?
- What's the income of http://scholar.google.com/scholar_lookup?&title=A%20transforming%20mutation%20in%20the%20pleckstrin%20homology%20domain%20of%20AKT1%20in%20cancer&journal=Nature&doi=10.1038%2Fnature05933&volume=448&pages=439-444&publication_year=2007&author=Carpten%2CJD&author=Faber%2CAL&author=Horn%2CC&author=Donoho%2CGP&author=Briggs%2CSL&author=Robbins%2CCM?
- How profitable is https://doi.org/10.1126%2Fscience.1118947?
- How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=16224021 make?
- Income figures for http://scholar.google.com/scholar_lookup?&title=Akt-mediated%20phosphorylation%20of%20EZH2%20suppresses%20methylation%20of%20lysine%2027%20in%20histone%20H3&journal=Science&doi=10.1126%2Fscience.1118947&volume=310&pages=306-310&publication_year=2005&author=Cha%2CTL&author=Zhou%2CBP&author=Xia%2CW&author=Wu%2CY&author=Yang%2CCC&author=Chen%2CCT
- Learn how profitable https://doi.org/10.1146%2Fannurev.biochem.68.1.965 is on a monthly basis
- Learn how profitable http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10872470 is on a monthly basis
- How much money does http://scholar.google.com/scholar_lookup?&title=AKT%2FPKB%20and%20other%20D3%20phosphoinositide-regulated%20kinases%3A%20kinase%20activation%20by%20phosphoinositide-dependent%20phosphorylation&journal=Annu%20Rev%20Biochem&doi=10.1146%2Fannurev.biochem.68.1.965&volume=68&pages=965-1014&publication_year=1999&author=Chan%2CTO&author=Rittenhouse%2CSE&author=Tsichlis%2CPN make?
- How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11752635 pull in?
- Find out how much http://scholar.google.com/scholar_lookup?&title=PDK2%3A%20a%20complex%20tail%20in%20one%20Akt&journal=Sci%20STKE&volume=2001&publication_year=2001&author=Chan%2CTO&author=Tsichlis%2CPN earns monthly
- How much revenue does https://doi.org/10.1038%2Fnrc1819 produce monthly?
- What's the monthly income of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=16453012?
- How much does http://scholar.google.com/scholar_lookup?&title=Beyond%20PTEN%20mutations%3A%20the%20PI3%E2%80%89K%20pathway%20as%20an%20integrator%20of%20multiple%20inputs%20during%20tumorigenesis&journal=Nat%20Rev%20Cancer&doi=10.1038%2Fnrc1819&volume=6&pages=184-192&publication_year=2006&author=Cully%2CM&author=You%2CH&author=Levine%2CAJ&author=Mak%2CTW net monthly?
- Check the income stats for https://doi.org/10.1038%2Fsj.onc.1210202
- How much income is http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17322919 earning monthly?
- How much revenue does http://scholar.google.com/scholar_lookup?&title=The%20phosphatidyl%20inositol%203-kinase%20signaling%20network%3A%20implications%20for%20human%20breast%20cancer&journal=Oncogene&doi=10.1038%2Fsj.onc.1210202&volume=26&pages=1338-1345&publication_year=2007&author=Dillon%2CRL&author=White%2CDE&author=Muller%2CWJ bring in?
- Find out how much https://doi.org/10.1038%2Fsj.onc.1209099 earns monthly
- What's the monthly income of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=16288287?
- What is the earnings of http://scholar.google.com/scholar_lookup?&title=Regulation%20of%20the%20Akt%20kinase%20by%20interacting%20proteins&journal=Oncogene&doi=10.1038%2Fsj.onc.1209099&volume=24&pages=7401-7409&publication_year=2005&author=Du%2CK&author=Tsichlis%2CPN?
- What's the monthly money flow for https://doi.org/10.1042%2FBST0350231?
- What's the financial gain of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17371246?
- How much revenue does http://scholar.google.com/scholar_lookup?&title=Physiological%20roles%20of%20PKB%2FAkt%20isoforms%20in%20development%20and%20disease&journal=Biochem%20Soc%20Trans&doi=10.1042%2FBST0350231&volume=35&pages=231-235&publication_year=2007&author=Dummler%2CB&author=Hemmings%2CBA generate?
- How much revenue does https://doi.org/10.1038%2Femboj.2008.120 bring in?
- How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18566586 earn?
- How much does http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2486276 gross monthly?
- Explore the financials of http://scholar.google.com/scholar_lookup?&title=The%20mammalian%20target%20of%20rapamycin%20complex%202%20controls%20folding%20and%20stability%20of%20Akt%20and%20protein%20kinase%20C&journal=EMBO%20J&doi=10.1038%2Femboj.2008.120&volume=27&pages=1932-1943&publication_year=2008&author=Facchinetti%2CV&author=Ouyang%2CW&author=Wei%2CH&author=Soto%2CN&author=Lazorchak%2CA&author=Gould%2CC
- How much does https://doi.org/10.2174%2F156800908784293622 gross monthly?
- What's the financial gain of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18473735?
- http://scholar.google.com/scholar_lookup?&title=Phosphorylation-specific%20prolyl%20isomerase%20Pin1%20as%20a%20new%20diagnostic%20and%20therapeutic%20target%20for%20cancer&journal=Curr%20Cancer%20Drug%20Targets&doi=10.2174%2F156800908784293622&volume=8&pages=223-229&publication_year=2008&author=Finn%2CG&author=Lu%2CKP's total income per month
- How much profit is https://doi.org/10.1016%2Fj.molcel.2005.03.008 making per month?
- Income figures for http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15808505
- How much does http://scholar.google.com/scholar_lookup?&title=PHLPP%3A%20a%20phosphatase%20that%20directly%20dephosphorylates%20Akt%2C%20promotes%20apoptosis%2C%20and%20suppresses%20tumor%20growth&journal=Mol%20Cell&doi=10.1016%2Fj.molcel.2005.03.008&volume=18&pages=13-24&publication_year=2005&author=Gao%2CT&author=Furnari%2CF&author=Newton%2CAC pull in monthly?
- How much profit is https://doi.org/10.1016%2Fj.molmed.2005.06.007 making per month?
- Earnings of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=16002336
- What's the monthly income of http://scholar.google.com/scholar_lookup?&title=An%20expanding%20role%20for%20mTOR%20in%20cancer&journal=Trends%20Mol%20Med&doi=10.1016%2Fj.molmed.2005.06.007&volume=11&pages=353-361&publication_year=2005&author=Guertin%2CDA&author=Sabatini%2CDM?
- What is the earnings of https://doi.org/10.1038%2Femboj.2008.119?
- What are the earnings of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18566587?
- How much income does http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2486275 have?
- http://scholar.google.com/scholar_lookup?&title=Essential%20function%20of%20TORC2%20in%20PKC%20and%20Akt%20turn%20motif%20phosphorylation%2C%20maturation%20and%20signalling&journal=EMBO%20J&doi=10.1038%2Femboj.2008.119&volume=27&pages=1919-1931&publication_year=2008&author=Ikenoue%2CT&author=Inoki%2CK&author=Yang%2CQ&author=Zhou%2CX&author=Guan%2CKL's revenue stream
- Check the income stats for https://doi.org/10.1073%2Fpnas.0408864102
- How much profit does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15647370 make?
- Find out how much http://www.ncbi.nlm.nih.gov/pmc/articles/PMC545580 earns monthly
- Get to know http://scholar.google.com/scholar_lookup?&title=Phosphatidylinositol%203-kinase%20mutations%20identified%20in%20human%20cancer%20are%20oncogenic&journal=Proc%20Natl%20Acad%20Sci%20USA&doi=10.1073%2Fpnas.0408864102&volume=102&pages=802-807&publication_year=2005&author=Kang%2CS&author=Bader%2CAG&author=Vogt%2CPK's earnings
- How much profit does https://link.springer.com/doi/10.1007/s001099900050 generate?
- What's the profit of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10569203?
- What is the earnings of http://scholar.google.com/scholar_lookup?&title=Forkhead%20transcription%20factors%3A%20new%20insights%20into%20protein%20kinase%20B%20%28c-akt%29%20signaling&journal=J%20Mol%20Med&doi=10.1007%2Fs001099900050&volume=77&pages=656-665&publication_year=1999&author=Kops%2CGJ&author=Burgering%2CBM?
- Learn how profitable https://doi.org/10.1128%2FMCB.23.19.6836-6848.2003 is on a monthly basis
- What's the profit of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12972603?
- Check the income stats for http://www.ncbi.nlm.nih.gov/pmc/articles/PMC193925
- What are the total earnings of http://scholar.google.com/scholar_lookup?&title=Regulation%20of%20the%20activity%20of%20p38%20mitogen-activated%20protein%20kinase%20by%20Akt%20in%20cancer%20and%20adenoviral%20protein%20E1A-mediated%20sensitization%20to%20apoptosis&journal=Mol%20Cell%20Biol&doi=10.1128%2FMCB.23.19.6836-6848.2003&volume=23&pages=6836-6848&publication_year=2003&author=Liao%2CY&author=Hung%2CMC?
- How much income is https://doi.org/10.1073%2Fpnas.060025397 earning monthly?
- How much profit does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10759547 generate?
- What's the income of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC18221?
- What's the profit of http://scholar.google.com/scholar_lookup?&title=Beta-catenin%2C%20a%20novel%20prognostic%20marker%20for%20breast%20cancer%3A%20its%20roles%20in%20cyclin%20D1%20expression%20and%20cancer%20progression&journal=Proc%20Natl%20Acad%20Sci%20USA&doi=10.1073%2Fpnas.060025397&volume=97&pages=4262-4266&publication_year=2000&author=Lin%2CSY&author=Xia%2CW&author=Wang%2CJC&author=Kwong%2CKY&author=Spohn%2CB&author=Wen%2CY?
- How much does https://doi.org/10.1002%2Fmc.20216 rake in every month?
- Get to know what's the income of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=16652378
- How much income does http://scholar.google.com/scholar_lookup?&title=Targeting%20carcinogenesis%3A%20a%20role%20for%20the%20prolyl%20isomerase%20Pin1%3F&journal=Mol%20Carcinog&doi=10.1002%2Fmc.20216&volume=45&pages=397-402&publication_year=2006&author=Lu%2CKP&author=Suizu%2CF&author=Zhou%2CXZ&author=Finn%2CG&author=Lam%2CP&author=Wulf%2CG have?
- Revenue of https://doi.org/10.1038%2Fnrm2261
- What are the earnings of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17878917?
- How much revenue does http://scholar.google.com/scholar_lookup?&title=The%20prolyl%20isomerase%20PIN1%3A%20a%20pivotal%20new%20twist%20in%20phosphorylation%20signalling%20and%20disease&journal=Nat%20Rev%20Mol%20Cell%20Biol&doi=10.1038%2Fnrm2261&volume=8&pages=904-916&publication_year=2007&author=Lu%2CKP&author=Zhou%2CXZ produce monthly?
- Monthly income for https://doi.org/10.1126%2Fscience.283.5406.1325
- How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10037602 make?
- How much does http://scholar.google.com/scholar_lookup?&title=Function%20of%20WW%20domains%20as%20phosphoserine-%20or%20phosphothreonine-binding%20modules&journal=Science&doi=10.1126%2Fscience.283.5406.1325&volume=283&pages=1325-1328&publication_year=1999&author=Lu%2CPJ&author=Zhou%2CXZ&author=Shen%2CM&author=Lu%2CKP rake in every month?
- What is the monthly revenue of https://doi.org/10.1016%2FS1535-6108%2803%2900248-4?
- Profit of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=14585353
- How much profit does http://scholar.google.com/scholar_lookup?&title=Targeting%20the%20PI3K-Akt%20pathway%20in%20human%20cancer%3A%20rationale%20and%20promise&journal=Cancer%20Cell&doi=10.1016%2FS1535-6108%2803%2900248-4&volume=4&pages=257-262&publication_year=2003&author=Luo%2CJ&author=Manning%2CBD&author=Cantley%2CLC generate?
- Monthly income for https://doi.org/10.1016%2Fj.cell.2007.06.009
- What are the earnings of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17604717?
- Get to know http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2756685's earnings
- What's the financial intake of http://scholar.google.com/scholar_lookup?&title=AKT%2FPKB%20signaling%3A%20navigating%20downstream&journal=Cell&doi=10.1016%2Fj.cell.2007.06.009&volume=129&pages=1261-1274&publication_year=2007&author=Manning%2CBD&author=Cantley%2CLC?
- Find out how much https://doi.org/10.1158%2F0008-5472.CAN-06-3782 earns monthly
- Get to know what's the income of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17210696
- How much does http://scholar.google.com/scholar_lookup?&title=Akt1%20ablation%20inhibits%2C%20whereas%20Akt2%20ablation%20accelerates%2C%20the%20development%20of%20mammary%20adenocarcinomas%20in%20mouse%20mammary%20tumor%20virus%20%28MMTV%29-ErbB2%2Fneu%20and%20MMTV-polyoma%20middle%20T%20transgenic%20mice&journal=Cancer%20Res&doi=10.1158%2F0008-5472.CAN-06-3782&volume=67&pages=167-177&publication_year=2007&author=Maroulakou%2CIG&author=Oemler%2CW&author=Naber%2CSP&author=Tsichlis%2CPN net monthly?
- Explore the financials of https://doi.org/10.1074%2Fjbc.273.45.29864
- What are the earnings of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=9792703?
- What are the earnings of http://scholar.google.com/scholar_lookup?&title=Cyclin%20D%20expression%20is%20controlled%20post-transcriptionally%20via%20a%20phosphatidylinositol%203-kinase%2FAkt-dependent%20pathway&journal=J%20Biol%20Chem&doi=10.1074%2Fjbc.273.45.29864&volume=273&pages=29864-29872&publication_year=1998&author=Muise-Helmericks%2CR&author=Grimes%2CHL&author=Bellacosa%2CA&author=Malstrom%2CSE&author=Tsichlis%2CPN?
- Check the income stats for https://doi.org/10.1042%2Fbj20021626
- Get to know http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12495431's earnings
- What's the financial intake of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1223206?
- What's the monthly income of http://scholar.google.com/scholar_lookup?&title=Regulation%20of%20ABC%20kinases%20by%20phosphorylation%3A%20protein%20kinase%20C%20as%20a%20paradigm&journal=Biochem%20J&doi=10.1042%2Fbj20021626&volume=370&pages=361-371&publication_year=2003&author=Newton%2CAC?
- Learn about the earnings of https://doi.org/10.1126%2Fscience.1106148
- Find out how much http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15718470 earns monthly
- How much money does http://scholar.google.com/scholar_lookup?&title=Phosphorylation%20and%20regulation%20of%20Akt%2FPKB%20by%20the%20rictor-mTOR%20complex&journal=Science&doi=10.1126%2Fscience.1106148&volume=307&pages=1098-1101&publication_year=2005&author=Sarbassov%2CDD&author=Guertin%2CDA&author=Ali%2CSM&author=Sabatini%2CDM generate?
- https://doi.org/10.1159%2F000096289's total income per month
- How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17047397 gross monthly?
- What's the financial gain of http://scholar.google.com/scholar_lookup?&title=Mutational%20analysis%20of%20AKT1%2C%20AKT2%20and%20AKT3%20genes%20in%20common%20human%20carcinomas&journal=Oncology&doi=10.1159%2F000096289&volume=70&pages=285-289&publication_year=2006&author=Soung%2CYH&author=Lee%2CJW&author=Nam%2CSW&author=Lee%2CJY&author=Yoo%2CNJ&author=Lee%2CSH?
- How much does https://link.springer.com/doi/10.1007/s00018-007-7270-0 rake in every month?
- How much money does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17965833 make?
- What is the earnings of http://scholar.google.com/scholar_lookup?&title=Prolyl%20isomerase%2C%20Pin1%3A%20new%20findings%20of%20post-translational%20modifications%20and%20physiological%20substrates%20in%20cancer%2C%20asthma%20and%20Alzheimer%2Fs%20disease&journal=Cell%20Mol%20Life%20Sci&doi=10.1007%2Fs00018-007-7270-0&volume=65&pages=359-375&publication_year=2008&author=Takahashi%2CK&author=Uchida%2CC&author=Shin%2CRW&author=Shimazaki%2CK&author=Uchida%2CT?
- How much revenue does https://doi.org/10.1038%2Fsj.onc.1209100 produce monthly?
- Get to know http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=16288285's earnings
- http://scholar.google.com/scholar_lookup?&title=AKT%20signaling%20in%20normal%20and%20malignant%20cells&journal=Oncogene&doi=10.1038%2Fsj.onc.1209100&volume=24&pages=7391-7393&publication_year=2005&author=Testa%2CJR&author=Tsichlis%2CPN income
- https://doi.org/10.2174%2F156800908783497140's revenue stream
- What's the income of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18288941?
- Discover the revenue of http://scholar.google.com/scholar_lookup?&title=Deregulation%20of%20the%20Akt%20pathway%20in%20human%20cancer&journal=Curr%20Cancer%20Drug%20Targets&doi=10.2174%2F156800908783497140&volume=8&pages=27-36&publication_year=2008&author=Tokunaga%2CE&author=Oki%2CE&author=Egashira%2CA&author=Sadanaga%2CN&author=Morita%2CM&author=Kakeji%2CY
- How much revenue does https://doi.org/10.1038%2Fsj.emboj.7600323 generate?
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15257284's revenue stream
- How much does http://www.ncbi.nlm.nih.gov/pmc/articles/PMC514501 rake in every month?
- http://scholar.google.com/scholar_lookup?&title=Modeling%20breast%20cancer%20in%20vivo%20and%20ex%20vivo%20reveals%20an%20essential%20role%20of%20Pin1%20in%20tumorigenesis&journal=EMBO%20J&doi=10.1038%2Fsj.emboj.7600323&volume=23&pages=3397-3407&publication_year=2004&author=Wulf%2CG&author=Garg%2CP&author=Liou%2CYC&author=Iglehart%2CD&author=Lu%2CKP's revenue stream
- How much revenue does https://doi.org/10.1158%2F1078-0432.CCR-03-0527 bring in?
- How much profit does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15173090 make?
- How profitable is http://scholar.google.com/scholar_lookup?&title=Phosphorylation%2Fcytoplasmic%20localization%20of%20p21Cip1%2FWAF1%20is%20associated%20with%20HER2%2Fneu%20overexpression%20and%20provides%20a%20novel%20combination%20predictor%20for%20poor%20prognosis%20in%20breast%20cancer%20patients&journal=Clin%20Cancer%20Res&doi=10.1158%2F1078-0432.CCR-03-0527&volume=10&pages=3815-3824&publication_year=2004&author=Xia%2CW&author=Chen%2CJS&author=Zhou%2CX&author=Sun%2CPR&author=Lee%2CDF&author=Liao%2CY?
- https://doi.org/10.1042%2Fbst0320350 income
- What's the income of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15046607?
- Discover the revenue of http://scholar.google.com/scholar_lookup?&title=Physiological%20functions%20of%20protein%20kinase%20B%2FAkt&journal=Biochem%20Soc%20Trans&doi=10.1042%2Fbst0320350&volume=32&pages=350-354&publication_year=2004&author=Yang%2CZZ&author=Tschopp%2CO&author=Baudry%2CA&author=Dummler%2CB&author=Hynx%2CD&author=Hemmings%2CBA
- How much profit is https://doi.org/10.1038%2Fncb1110 making per month?
- How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15048125 rake in every month?
- What's the financial intake of http://scholar.google.com/scholar_lookup?&title=A%20signalling%20pathway%20controlling%20c-Myc%20degradation%20that%20impacts%20oncogenic%20transformation%20of%20human%20cells&journal=Nat%20Cell%20Biol&doi=10.1038%2Fncb1110&volume=6&pages=308-318&publication_year=2004&author=Yeh%2CE&author=Cunningham%2CM&author=Arnold%2CH&author=Chasse%2CD&author=Monteith%2CT&author=Ivaldi%2CG?
- What's the revenue for https://doi.org/10.1038%2Fnrc2107?
- What are the total earnings of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17410202?
- What is the monthly revenue of http://scholar.google.com/scholar_lookup?&title=PIN1%2C%20the%20cell%20cycle%20and%20cancer&journal=Nat%20Rev%20Cancer&doi=10.1038%2Fnrc2107&volume=7&pages=381-388&publication_year=2007&author=Yeh%2CES&author=Means%2CAR?
- What's the financial gain of https://doi.org/10.1038%2Fnature01120?
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12397362's total income per month
- Check the income stats for http://scholar.google.com/scholar_lookup?&title=The%20prolyl%20isomerase%20Pin1%20reveals%20a%20mechanism%20to%20control%20p53%20functions%20after%20genotoxic%20insults&journal=Nature&doi=10.1038%2Fnature01120&volume=419&pages=853-857&publication_year=2002&author=Zacchi%2CP&author=Gostissa%2CM&author=Uchida%2CT&author=Salvagno%2CC&author=Avolio%2CF&author=Volinia%2CS
- https://citation-needed.springer.com/v2/references/10.1038/onc.2009.98?format=refman&flavour=references's total income per month
- How much income does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Y%20Liao have?
- How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Y%20Liao%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en make?
- How much revenue does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Y%20Wei bring in?
- What's https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Y%20Wei%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en's gross income?
- Find out how much https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=X%20Zhou earns monthly
- How much income is https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22X%20Zhou%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en earning monthly?
- Learn how profitable https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=J%20-Y%20Yang is on a monthly basis
- How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22J%20-Y%20Yang%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en bring in each month?
- What's the financial gain of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=C%20Dai?
- How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22C%20Dai%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en net monthly?
- What's the profit of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Y%20-J%20Chen?
- What's the monthly money flow for https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Y%20-J%20Chen%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- What's the monthly money flow for https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=N%20K%20Agarwal?
- https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22N%20K%20Agarwal%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en income
- https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=D%20Sarbassov's total income per month
- What's the financial outcome of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22D%20Sarbassov%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=D%20Shi's financial summary
- What are the total earnings of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22D%20Shi%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- How much money does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=D%20Yu generate?
- See how much https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22D%20Yu%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en makes per month
- How profitable is https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=M%20-C%20Hung?
- https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22M%20-C%20Hung%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en income
- What are the earnings of https://static-content.springer.com/esm/art%3A10.1038%2Fonc.2009.98/MediaObjects/41388_2009_BFonc200998_MOESM11_ESM.jpg?
- What is the earnings of https://static-content.springer.com/esm/art%3A10.1038%2Fonc.2009.98/MediaObjects/41388_2009_BFonc200998_MOESM12_ESM.jpg?
- https://static-content.springer.com/esm/art%3A10.1038%2Fonc.2009.98/MediaObjects/41388_2009_BFonc200998_MOESM13_ESM.jpg's revenue stream
- Revenue of https://static-content.springer.com/esm/art%3A10.1038%2Fonc.2009.98/MediaObjects/41388_2009_BFonc200998_MOESM14_ESM.jpg
- How much income is https://static-content.springer.com/esm/art%3A10.1038%2Fonc.2009.98/MediaObjects/41388_2009_BFonc200998_MOESM15_ESM.jpg earning monthly?
- How much does https://s100.copyright.com/AppDispatchServlet?title=Peptidyl-prolyl%20cis%2Ftrans%20isomerase%20Pin1%20is%20critical%20for%20the%20regulation%20of%20PKB%2FAkt%20stability%20and%20activation%20phosphorylation&author=Y%20Liao%20et%20al&contentID=10.1038%2Fonc.2009.98©right=Macmillan%20Publishers%20Limited&publication=0950-9232&publicationDate=2009-05-18&publisherName=SpringerNature&orderBeanReset=true make?
- https://citation-needed.springer.com/v2/references/10.1038/onc.2009.98?format=refman&flavour=citation income
- Learn about the earnings of https://doi.org/10.1186/s13045-021-01137-8
- What's the income generated by https://doi.org/10.1038/s41598-021-88478-z each month?
- What's https://doi.org/10.1186/s13045-018-0611-7's gross income?
- What's the financial gain of https://doi.org/10.1038/s41467-018-05402-2?
- How much revenue does https://doi.org/10.1038/srep43639 bring in?
- How much does https://www.protocols.io/ earn?
- How profitable is https://www.natureindex.com/?
- Financial intake of http://www.naturechina.com
- What is the monthly revenue of https://www.natureasia.com/ja-jp?
Analytics and Tracking {π}
- Google Tag Manager
Libraries {π}
- Prism.js
- Zoom.js
Emails and Hosting {βοΈ}
Mail Servers:
- mxa-002c5801.gslb.pphosted.com
- mxb-002c5801.gslb.pphosted.com
Name Servers:
- pdns1.ultradns.net
- pdns2.ultradns.net
- pdns3.ultradns.org
- pdns4.ultradns.org
- pdns5.ultradns.info
- pdns6.ultradns.co.uk
CDN Services {π¦}
- Crossref