NATURE . COM {}

Analyzed Page
Matching Content Categories
CMS
Monthly Traffic Estimate
How Does Nature.com Make Money
How Much Does Nature.com Make
Keywords
Topics
Schema
Social Networks
External Links
Analytics And Tracking
Libraries
Hosting Providers
CDN Services

We are analyzing https://www.nature.com/articles/nsmb1100.

Title:
PUF proteins bind Pop2p to regulate messenger RNAs | Nature Structural & Molecular Biology
Description:
PUF proteins, a family of RNA-binding proteins, interact with the 3′ untranslated regions (UTRs) of specific mRNAs to control their translation and stability. PUF protein action is commonly correlated with removal of the poly(A) tail of target mRNAs. Here, we focus on how PUF proteins enhance deadenylation and mRNA decay. We show that a yeast PUF protein physically binds Pop2p, which is a component of the Ccr4p–Pop2p–Not deadenylase complex, and that Pop2p is required for PUF repression activity. By binding Pop2p, the PUF protein simultaneously recruits the Ccr4p deadenylase and two other enzymes involved in mRNA regulation, Dcp1p and Dhh1p. We reconstitute regulated deadenylation in vitro and demonstrate that the PUF-Pop2p interaction is conserved in yeast, worms and humans. We suggest that the PUF-Pop2p interaction underlies regulated deadenylation, mRNA decay and repression by PUF proteins.
Website Age:
30 years and 10 months (reg. 1994-08-11).

Matching Content Categories {📚}

Education
Science
Photography

Content Management System {📝}

What CMS is nature.com built with?

Custom-built

No common CMS systems were detected on Nature.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of nature.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,058 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Nature.com Make Money? {💸}

Display Ads {🎯}

The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.

Ads are managed by yourbow.com. Particular relationships are as follows:

Direct Advertisers (10)

google.com, pmc.com, doceree.com, yourbow.com, audienciad.com, onlinemediasolutions.com, advibe.media, aps.amazon.com, getmediamx.com, onomagic.com

Reseller Advertisers (38)

conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.com

How Much Does Nature.com Make? {💰}

Display Ads {🎯}

$63,100 per month
Our analysis indicates Nature.com generates between $42,042 and $115,617 monthly online from display ads.

Keywords {🔍}

pubmed, article, google, scholar, cas, nature, central, mrna, puf, yeast, proteins, access, deadenylase, protein, rna, biol, molecular, wickens, cell, content, biology, deadenylation, complex, translational, cookies, control, polya, regulation, mol, parker, drosophila, gene, caf, privacy, popp, family, decay, binding, open, pumilio, embo, regulates, function, data, structural, goldstrohm, hook, translation, nat, development,

Topics {✒️}

nature portfolio permissions reprints research grant privacy policy advertising nature 417 nature 425 nature social media author information authors author correspondence personal data molecular biology seay & marvin wickens translation factor eif-4e springerlink instant access data protection puf-pop2p interaction permissions puf protein action reconstitute regulated deadenylation controls postsynaptic accumulation elegans puf protein larval development puf family portrait post-transcriptional regulation rna-binding proteins yeast pop2 protein privacy regulate messenger rnas promoting posterior deadenylation competing financial interests messenger rna occur explore content subscription content drosophila body pattern saccharomyces cerevisiae permit drosophila oogenesis marvin wickens regulates cyclin poly development 124 development 132 european economic area institutional subscriptions read x-ray structure nucleic acid res nucleic acids res oligo-astheno-teratozoospermia mice lacking cnot7 dead box helicase

Schema {🗺️}

WebPage:
      mainEntity:
         headline:PUF proteins bind Pop2p to regulate messenger RNAs
         description:PUF proteins, a family of RNA-binding proteins, interact with the 3â² untranslated regions (UTRs) of specific mRNAs to control their translation and stability. PUF protein action is commonly correlated with removal of the poly(A) tail of target mRNAs. Here, we focus on how PUF proteins enhance deadenylation and mRNA decay. We show that a yeast PUF protein physically binds Pop2p, which is a component of the Ccr4pâPop2pâNot deadenylase complex, and that Pop2p is required for PUF repression activity. By binding Pop2p, the PUF protein simultaneously recruits the Ccr4p deadenylase and two other enzymes involved in mRNA regulation, Dcp1p and Dhh1p. We reconstitute regulated deadenylation in vitro and demonstrate that the PUF-Pop2p interaction is conserved in yeast, worms and humans. We suggest that the PUF-Pop2p interaction underlies regulated deadenylation, mRNA decay and repression by PUF proteins.
         datePublished:2006-05-21T00:00:00Z
         dateModified:2006-05-21T00:00:00Z
         pageStart:533
         pageEnd:539
         sameAs:https://doi.org/10.1038/nsmb1100
         keywords:
            Life Sciences
            general
            Biochemistry
            Protein Structure
            Membrane Biology
            Biological Microscopy
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb1100/MediaObjects/41594_2006_Article_BFnsmb1100_Fig1_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb1100/MediaObjects/41594_2006_Article_BFnsmb1100_Fig2_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb1100/MediaObjects/41594_2006_Article_BFnsmb1100_Fig3_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb1100/MediaObjects/41594_2006_Article_BFnsmb1100_Fig4_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb1100/MediaObjects/41594_2006_Article_BFnsmb1100_Fig5_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb1100/MediaObjects/41594_2006_Article_BFnsmb1100_Fig6_HTML.jpg
         isPartOf:
            name:Nature Structural & Molecular Biology
            issn:
               1545-9985
               1545-9993
            volumeNumber:13
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Nature Publishing Group US
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Aaron C Goldstrohm
               affiliation:
                     name:433 Babcock Drive, University of Wisconsin
                     address:
                        name:Department of Biochemistry, 433 Babcock Drive, University of Wisconsin, Madison, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Brad A Hook
               affiliation:
                     name:433 Babcock Drive, University of Wisconsin
                     address:
                        name:Department of Biochemistry, 433 Babcock Drive, University of Wisconsin, Madison, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Daniel J Seay
               affiliation:
                     name:433 Babcock Drive, University of Wisconsin
                     address:
                        name:Department of Biochemistry, 433 Babcock Drive, University of Wisconsin, Madison, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Marvin Wickens
               affiliation:
                     name:433 Babcock Drive, University of Wisconsin
                     address:
                        name:Department of Biochemistry, 433 Babcock Drive, University of Wisconsin, Madison, USA
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:PUF proteins bind Pop2p to regulate messenger RNAs
      description:PUF proteins, a family of RNA-binding proteins, interact with the 3â² untranslated regions (UTRs) of specific mRNAs to control their translation and stability. PUF protein action is commonly correlated with removal of the poly(A) tail of target mRNAs. Here, we focus on how PUF proteins enhance deadenylation and mRNA decay. We show that a yeast PUF protein physically binds Pop2p, which is a component of the Ccr4pâPop2pâNot deadenylase complex, and that Pop2p is required for PUF repression activity. By binding Pop2p, the PUF protein simultaneously recruits the Ccr4p deadenylase and two other enzymes involved in mRNA regulation, Dcp1p and Dhh1p. We reconstitute regulated deadenylation in vitro and demonstrate that the PUF-Pop2p interaction is conserved in yeast, worms and humans. We suggest that the PUF-Pop2p interaction underlies regulated deadenylation, mRNA decay and repression by PUF proteins.
      datePublished:2006-05-21T00:00:00Z
      dateModified:2006-05-21T00:00:00Z
      pageStart:533
      pageEnd:539
      sameAs:https://doi.org/10.1038/nsmb1100
      keywords:
         Life Sciences
         general
         Biochemistry
         Protein Structure
         Membrane Biology
         Biological Microscopy
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb1100/MediaObjects/41594_2006_Article_BFnsmb1100_Fig1_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb1100/MediaObjects/41594_2006_Article_BFnsmb1100_Fig2_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb1100/MediaObjects/41594_2006_Article_BFnsmb1100_Fig3_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb1100/MediaObjects/41594_2006_Article_BFnsmb1100_Fig4_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb1100/MediaObjects/41594_2006_Article_BFnsmb1100_Fig5_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb1100/MediaObjects/41594_2006_Article_BFnsmb1100_Fig6_HTML.jpg
      isPartOf:
         name:Nature Structural & Molecular Biology
         issn:
            1545-9985
            1545-9993
         volumeNumber:13
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Nature Publishing Group US
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Aaron C Goldstrohm
            affiliation:
                  name:433 Babcock Drive, University of Wisconsin
                  address:
                     name:Department of Biochemistry, 433 Babcock Drive, University of Wisconsin, Madison, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Brad A Hook
            affiliation:
                  name:433 Babcock Drive, University of Wisconsin
                  address:
                     name:Department of Biochemistry, 433 Babcock Drive, University of Wisconsin, Madison, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Daniel J Seay
            affiliation:
                  name:433 Babcock Drive, University of Wisconsin
                  address:
                     name:Department of Biochemistry, 433 Babcock Drive, University of Wisconsin, Madison, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Marvin Wickens
            affiliation:
                  name:433 Babcock Drive, University of Wisconsin
                  address:
                     name:Department of Biochemistry, 433 Babcock Drive, University of Wisconsin, Madison, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Nature Structural & Molecular Biology
      issn:
         1545-9985
         1545-9993
      volumeNumber:13
Organization:
      name:Nature Publishing Group US
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:433 Babcock Drive, University of Wisconsin
      address:
         name:Department of Biochemistry, 433 Babcock Drive, University of Wisconsin, Madison, USA
         type:PostalAddress
      name:433 Babcock Drive, University of Wisconsin
      address:
         name:Department of Biochemistry, 433 Babcock Drive, University of Wisconsin, Madison, USA
         type:PostalAddress
      name:433 Babcock Drive, University of Wisconsin
      address:
         name:Department of Biochemistry, 433 Babcock Drive, University of Wisconsin, Madison, USA
         type:PostalAddress
      name:433 Babcock Drive, University of Wisconsin
      address:
         name:Department of Biochemistry, 433 Babcock Drive, University of Wisconsin, Madison, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Aaron C Goldstrohm
      affiliation:
            name:433 Babcock Drive, University of Wisconsin
            address:
               name:Department of Biochemistry, 433 Babcock Drive, University of Wisconsin, Madison, USA
               type:PostalAddress
            type:Organization
      name:Brad A Hook
      affiliation:
            name:433 Babcock Drive, University of Wisconsin
            address:
               name:Department of Biochemistry, 433 Babcock Drive, University of Wisconsin, Madison, USA
               type:PostalAddress
            type:Organization
      name:Daniel J Seay
      affiliation:
            name:433 Babcock Drive, University of Wisconsin
            address:
               name:Department of Biochemistry, 433 Babcock Drive, University of Wisconsin, Madison, USA
               type:PostalAddress
            type:Organization
      name:Marvin Wickens
      affiliation:
            name:433 Babcock Drive, University of Wisconsin
            address:
               name:Department of Biochemistry, 433 Babcock Drive, University of Wisconsin, Madison, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Biochemistry, 433 Babcock Drive, University of Wisconsin, Madison, USA
      name:Department of Biochemistry, 433 Babcock Drive, University of Wisconsin, Madison, USA
      name:Department of Biochemistry, 433 Babcock Drive, University of Wisconsin, Madison, USA
      name:Department of Biochemistry, 433 Babcock Drive, University of Wisconsin, Madison, USA
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

Social Networks {👍}(1)

https://twitter.com/NatureSMB

External Links {🔗}(138)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Prism.js
Zoom.js

Emails and Hosting {✉️}

Mail Servers:

mxa-002c5801.gslb.pphosted.com
mxb-002c5801.gslb.pphosted.com

Name Servers:

pdns1.ultradns.net
pdns2.ultradns.net
pdns3.ultradns.org
pdns4.ultradns.org
pdns5.ultradns.info
pdns6.ultradns.co.uk

CDN Services {📦}

Crossref

6.03s.