
NATURE . COM {
}
Title:
RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis | Nature Structural & Molecular Biology
Description:
Although cytosine-C5 methylation is a prominent modification of tRNAs, its functional significance has been unclear. Mice that lack both the Dnmt2 and NSun2 tRNA methyltransferases showed developmental and cellular differentiation defects, and loss of Dnmt2 and NSun2 was further associated with tRNA degradation and reduced rates of protein synthesis, suggesting that this modification promotes mouse development by supporting protein synthesis. The function of cytosine-C5 methylation, a widespread modification of tRNAs, has remained obscure, particularly in mammals. We have now developed a mouse strain defective in cytosine-C5 tRNA methylation, by disrupting both the Dnmt2 and the NSun2 tRNA methyltransferases. Although the lack of either enzyme alone has no detectable effects on mouse viability, double mutants showed a synthetic lethal interaction, with an underdeveloped phenotype and impaired cellular differentiation. tRNA methylation analysis of the double-knockout mice demonstrated complementary target-site specificities for Dnmt2 and NSun2 and a complete loss of cytosine-C5 tRNA methylation. Steady-state levels of unmethylated tRNAs were substantially reduced, and loss of Dnmt2 and NSun2 was further associated with reduced rates of overall protein synthesis. These results establish a biologically important function for cytosine-C5 tRNA methylation in mammals and suggest that this modification promotes mouse development by supporting protein synthesis.
Website Age:
30 years and 10 months (reg. 1994-08-11).
Matching Content Categories {๐}
- Education
- Science
- Animals & Wildlife
Content Management System {๐}
What CMS is nature.com built with?
Custom-built
No common CMS systems were detected on Nature.com, and no known web development framework was identified.
Traffic Estimate {๐}
What is the average monthly size of nature.com audience?
๐ Phenomenal Traffic: 5M - 10M visitors per month
Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.
check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush
How Does Nature.com Make Money? {๐ธ}
Display Ads {๐ฏ}
The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.
Ads are managed by yourbow.com. Particular relationships are as follows:
Direct Advertisers (10)
google.com, pmc.com, doceree.com, yourbow.com, audienciad.com, onlinemediasolutions.com, advibe.media, aps.amazon.com, getmediamx.com, onomagic.comReseller Advertisers (38)
conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.comHow Much Does Nature.com Make? {๐ฐ}
Display Ads {๐ฏ}
$63,100 per month
Our analysis indicates Nature.com generates between $42,042 and $115,616 monthly online from display ads.
Keywords {๐}
article, google, scholar, cas, rna, nature, methylation, trna, dnmt, access, dna, cell, nsun, nucleic, acids, res, content, nat, methyltransferase, mol, biol, cookies, lyko, mouse, genet, research, privacy, molecular, biology, protein, schaefer, helm, modification, open, gene, epigenetics, genes, dev, stem, analysis, data, information, promotes, synthesis, cytosinec, trnas, cellular, development, motorin, cells,
Topics {โ๏ธ}
nature portfolio permissions reprints privacy policy stem cell research ovarian research nature advertising social media author information authors italy mediates myc-induced proliferation opioid-induced reward-seeking multisite-specific trna cytosine-c5 trna methylation manage preferences author correspondence trna-derived small rnas long-term opioid withdrawal springerlink instant access trna biology charges m5c methyltransferase rlmi personal data mrna-expression profiling data protection permissions gene expression cytosine-c5 methylation retina development rna cytosine methylation double mutants showed matthias schaefer trna methylation analysis codon-biased translation frank lyko dna methylation landscapes rna nucleotide methylation m5c-methyltransferase steady-state levels privacy embryonic stem cells stefanie kellner stress-induced cleavage reveals evolutionary links rna modification enzymes development competing financial interests dna methyltransferase homologue rnaโmethyltransferase misu rna methyltransferase misu molecular mechanisms
Questions {โ}
- Do all modifications benefit all tRNAs?
- Grand challenge commentary: RNA epigenetics?
Schema {๐บ๏ธ}
WebPage:
mainEntity:
headline:RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis
description:Although cytosine-C5 methylation is a prominent modification of tRNAs, its functional significance has been unclear. Mice that lack both the Dnmt2 and NSun2 tRNA methyltransferases showed developmental and cellular differentiation defects, and loss of Dnmt2 and NSun2 was further associated with tRNA degradation and reduced rates of protein synthesis, suggesting that this modification promotes mouse development by supporting protein synthesis. The function of cytosine-C5 methylation, a widespread modification of tRNAs, has remained obscure, particularly in mammals. We have now developed a mouse strain defective in cytosine-C5 tRNA methylation, by disrupting both the Dnmt2 and the NSun2 tRNA methyltransferases. Although the lack of either enzyme alone has no detectable effects on mouse viability, double mutants showed a synthetic lethal interaction, with an underdeveloped phenotype and impaired cellular differentiation. tRNA methylation analysis of the double-knockout mice demonstrated complementary target-site specificities for Dnmt2 and NSun2 and a complete loss of cytosine-C5 tRNA methylation. Steady-state levels of unmethylated tRNAs were substantially reduced, and loss of Dnmt2 and NSun2 was further associated with reduced rates of overall protein synthesis. These results establish a biologically important function for cytosine-C5 tRNA methylation in mammals and suggest that this modification promotes mouse development by supporting protein synthesis.
datePublished:2012-08-12T00:00:00Z
dateModified:2012-08-12T00:00:00Z
pageStart:900
pageEnd:905
sameAs:https://doi.org/10.1038/nsmb.2357
keywords:
Epigenetics
RNA modification
tRNAs
Life Sciences
general
Biochemistry
Protein Structure
Membrane Biology
Biological Microscopy
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb.2357/MediaObjects/41594_2012_Article_BFnsmb2357_Fig1_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb.2357/MediaObjects/41594_2012_Article_BFnsmb2357_Fig2_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb.2357/MediaObjects/41594_2012_Article_BFnsmb2357_Fig3_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb.2357/MediaObjects/41594_2012_Article_BFnsmb2357_Fig4_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb.2357/MediaObjects/41594_2012_Article_BFnsmb2357_Fig5_HTML.jpg
isPartOf:
name:Nature Structural & Molecular Biology
issn:
1545-9985
1545-9993
volumeNumber:19
type:
Periodical
PublicationVolume
publisher:
name:Nature Publishing Group US
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Francesca Tuorto
affiliation:
name:Deutsches Krebsforschungszentrum
address:
name:Division of Epigenetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany
type:PostalAddress
type:Organization
type:Person
name:Reinhard Liebers
affiliation:
name:Deutsches Krebsforschungszentrum
address:
name:Division of Epigenetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany
type:PostalAddress
type:Organization
type:Person
name:Tanja Musch
affiliation:
name:Deutsches Krebsforschungszentrum
address:
name:Division of Epigenetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany
type:PostalAddress
type:Organization
type:Person
name:Matthias Schaefer
affiliation:
name:Deutsches Krebsforschungszentrum
address:
name:Division of Epigenetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany
type:PostalAddress
type:Organization
type:Person
name:Sarah Hofmann
affiliation:
name:Helmholtz Junior Research Group Posttranscriptional Control of Gene Expression, Deutsches Krebsforschungszentrum
address:
name:Helmholtz Junior Research Group Posttranscriptional Control of Gene Expression, Deutsches Krebsforschungszentrum, Heidelberg, Germany
type:PostalAddress
type:Organization
type:Person
name:Stefanie Kellner
affiliation:
name:Institute of Pharmacy, Johannes Gutenberg University of Mainz
address:
name:Institute of Pharmacy, Johannes Gutenberg University of Mainz, Mainz, Germany
type:PostalAddress
type:Organization
type:Person
name:Michaela Frye
affiliation:
name:Wellcome Trust Centre for Stem Cell Research, University of Cambridge
address:
name:Wellcome Trust Centre for Stem Cell Research, University of Cambridge, Cambridge, UK
type:PostalAddress
type:Organization
type:Person
name:Mark Helm
affiliation:
name:Institute of Pharmacy, Johannes Gutenberg University of Mainz
address:
name:Institute of Pharmacy, Johannes Gutenberg University of Mainz, Mainz, Germany
type:PostalAddress
type:Organization
type:Person
name:Georg Stoecklin
affiliation:
name:Helmholtz Junior Research Group Posttranscriptional Control of Gene Expression, Deutsches Krebsforschungszentrum
address:
name:Helmholtz Junior Research Group Posttranscriptional Control of Gene Expression, Deutsches Krebsforschungszentrum, Heidelberg, Germany
type:PostalAddress
type:Organization
type:Person
name:Frank Lyko
affiliation:
name:Deutsches Krebsforschungszentrum
address:
name:Division of Epigenetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany
type:PostalAddress
type:Organization
email:[email protected]
type:Person
isAccessibleForFree:
hasPart:
isAccessibleForFree:
cssSelector:.main-content
type:WebPageElement
type:ScholarlyArticle
context:https://schema.org
ScholarlyArticle:
headline:RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis
description:Although cytosine-C5 methylation is a prominent modification of tRNAs, its functional significance has been unclear. Mice that lack both the Dnmt2 and NSun2 tRNA methyltransferases showed developmental and cellular differentiation defects, and loss of Dnmt2 and NSun2 was further associated with tRNA degradation and reduced rates of protein synthesis, suggesting that this modification promotes mouse development by supporting protein synthesis. The function of cytosine-C5 methylation, a widespread modification of tRNAs, has remained obscure, particularly in mammals. We have now developed a mouse strain defective in cytosine-C5 tRNA methylation, by disrupting both the Dnmt2 and the NSun2 tRNA methyltransferases. Although the lack of either enzyme alone has no detectable effects on mouse viability, double mutants showed a synthetic lethal interaction, with an underdeveloped phenotype and impaired cellular differentiation. tRNA methylation analysis of the double-knockout mice demonstrated complementary target-site specificities for Dnmt2 and NSun2 and a complete loss of cytosine-C5 tRNA methylation. Steady-state levels of unmethylated tRNAs were substantially reduced, and loss of Dnmt2 and NSun2 was further associated with reduced rates of overall protein synthesis. These results establish a biologically important function for cytosine-C5 tRNA methylation in mammals and suggest that this modification promotes mouse development by supporting protein synthesis.
datePublished:2012-08-12T00:00:00Z
dateModified:2012-08-12T00:00:00Z
pageStart:900
pageEnd:905
sameAs:https://doi.org/10.1038/nsmb.2357
keywords:
Epigenetics
RNA modification
tRNAs
Life Sciences
general
Biochemistry
Protein Structure
Membrane Biology
Biological Microscopy
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb.2357/MediaObjects/41594_2012_Article_BFnsmb2357_Fig1_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb.2357/MediaObjects/41594_2012_Article_BFnsmb2357_Fig2_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb.2357/MediaObjects/41594_2012_Article_BFnsmb2357_Fig3_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb.2357/MediaObjects/41594_2012_Article_BFnsmb2357_Fig4_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb.2357/MediaObjects/41594_2012_Article_BFnsmb2357_Fig5_HTML.jpg
isPartOf:
name:Nature Structural & Molecular Biology
issn:
1545-9985
1545-9993
volumeNumber:19
type:
Periodical
PublicationVolume
publisher:
name:Nature Publishing Group US
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Francesca Tuorto
affiliation:
name:Deutsches Krebsforschungszentrum
address:
name:Division of Epigenetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany
type:PostalAddress
type:Organization
type:Person
name:Reinhard Liebers
affiliation:
name:Deutsches Krebsforschungszentrum
address:
name:Division of Epigenetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany
type:PostalAddress
type:Organization
type:Person
name:Tanja Musch
affiliation:
name:Deutsches Krebsforschungszentrum
address:
name:Division of Epigenetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany
type:PostalAddress
type:Organization
type:Person
name:Matthias Schaefer
affiliation:
name:Deutsches Krebsforschungszentrum
address:
name:Division of Epigenetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany
type:PostalAddress
type:Organization
type:Person
name:Sarah Hofmann
affiliation:
name:Helmholtz Junior Research Group Posttranscriptional Control of Gene Expression, Deutsches Krebsforschungszentrum
address:
name:Helmholtz Junior Research Group Posttranscriptional Control of Gene Expression, Deutsches Krebsforschungszentrum, Heidelberg, Germany
type:PostalAddress
type:Organization
type:Person
name:Stefanie Kellner
affiliation:
name:Institute of Pharmacy, Johannes Gutenberg University of Mainz
address:
name:Institute of Pharmacy, Johannes Gutenberg University of Mainz, Mainz, Germany
type:PostalAddress
type:Organization
type:Person
name:Michaela Frye
affiliation:
name:Wellcome Trust Centre for Stem Cell Research, University of Cambridge
address:
name:Wellcome Trust Centre for Stem Cell Research, University of Cambridge, Cambridge, UK
type:PostalAddress
type:Organization
type:Person
name:Mark Helm
affiliation:
name:Institute of Pharmacy, Johannes Gutenberg University of Mainz
address:
name:Institute of Pharmacy, Johannes Gutenberg University of Mainz, Mainz, Germany
type:PostalAddress
type:Organization
type:Person
name:Georg Stoecklin
affiliation:
name:Helmholtz Junior Research Group Posttranscriptional Control of Gene Expression, Deutsches Krebsforschungszentrum
address:
name:Helmholtz Junior Research Group Posttranscriptional Control of Gene Expression, Deutsches Krebsforschungszentrum, Heidelberg, Germany
type:PostalAddress
type:Organization
type:Person
name:Frank Lyko
affiliation:
name:Deutsches Krebsforschungszentrum
address:
name:Division of Epigenetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany
type:PostalAddress
type:Organization
email:[email protected]
type:Person
isAccessibleForFree:
hasPart:
isAccessibleForFree:
cssSelector:.main-content
type:WebPageElement
["Periodical","PublicationVolume"]:
name:Nature Structural & Molecular Biology
issn:
1545-9985
1545-9993
volumeNumber:19
Organization:
name:Nature Publishing Group US
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
name:Deutsches Krebsforschungszentrum
address:
name:Division of Epigenetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany
type:PostalAddress
name:Deutsches Krebsforschungszentrum
address:
name:Division of Epigenetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany
type:PostalAddress
name:Deutsches Krebsforschungszentrum
address:
name:Division of Epigenetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany
type:PostalAddress
name:Deutsches Krebsforschungszentrum
address:
name:Division of Epigenetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany
type:PostalAddress
name:Helmholtz Junior Research Group Posttranscriptional Control of Gene Expression, Deutsches Krebsforschungszentrum
address:
name:Helmholtz Junior Research Group Posttranscriptional Control of Gene Expression, Deutsches Krebsforschungszentrum, Heidelberg, Germany
type:PostalAddress
name:Institute of Pharmacy, Johannes Gutenberg University of Mainz
address:
name:Institute of Pharmacy, Johannes Gutenberg University of Mainz, Mainz, Germany
type:PostalAddress
name:Wellcome Trust Centre for Stem Cell Research, University of Cambridge
address:
name:Wellcome Trust Centre for Stem Cell Research, University of Cambridge, Cambridge, UK
type:PostalAddress
name:Institute of Pharmacy, Johannes Gutenberg University of Mainz
address:
name:Institute of Pharmacy, Johannes Gutenberg University of Mainz, Mainz, Germany
type:PostalAddress
name:Helmholtz Junior Research Group Posttranscriptional Control of Gene Expression, Deutsches Krebsforschungszentrum
address:
name:Helmholtz Junior Research Group Posttranscriptional Control of Gene Expression, Deutsches Krebsforschungszentrum, Heidelberg, Germany
type:PostalAddress
name:Deutsches Krebsforschungszentrum
address:
name:Division of Epigenetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany
type:PostalAddress
ImageObject:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
name:Francesca Tuorto
affiliation:
name:Deutsches Krebsforschungszentrum
address:
name:Division of Epigenetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany
type:PostalAddress
type:Organization
name:Reinhard Liebers
affiliation:
name:Deutsches Krebsforschungszentrum
address:
name:Division of Epigenetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany
type:PostalAddress
type:Organization
name:Tanja Musch
affiliation:
name:Deutsches Krebsforschungszentrum
address:
name:Division of Epigenetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany
type:PostalAddress
type:Organization
name:Matthias Schaefer
affiliation:
name:Deutsches Krebsforschungszentrum
address:
name:Division of Epigenetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany
type:PostalAddress
type:Organization
name:Sarah Hofmann
affiliation:
name:Helmholtz Junior Research Group Posttranscriptional Control of Gene Expression, Deutsches Krebsforschungszentrum
address:
name:Helmholtz Junior Research Group Posttranscriptional Control of Gene Expression, Deutsches Krebsforschungszentrum, Heidelberg, Germany
type:PostalAddress
type:Organization
name:Stefanie Kellner
affiliation:
name:Institute of Pharmacy, Johannes Gutenberg University of Mainz
address:
name:Institute of Pharmacy, Johannes Gutenberg University of Mainz, Mainz, Germany
type:PostalAddress
type:Organization
name:Michaela Frye
affiliation:
name:Wellcome Trust Centre for Stem Cell Research, University of Cambridge
address:
name:Wellcome Trust Centre for Stem Cell Research, University of Cambridge, Cambridge, UK
type:PostalAddress
type:Organization
name:Mark Helm
affiliation:
name:Institute of Pharmacy, Johannes Gutenberg University of Mainz
address:
name:Institute of Pharmacy, Johannes Gutenberg University of Mainz, Mainz, Germany
type:PostalAddress
type:Organization
name:Georg Stoecklin
affiliation:
name:Helmholtz Junior Research Group Posttranscriptional Control of Gene Expression, Deutsches Krebsforschungszentrum
address:
name:Helmholtz Junior Research Group Posttranscriptional Control of Gene Expression, Deutsches Krebsforschungszentrum, Heidelberg, Germany
type:PostalAddress
type:Organization
name:Frank Lyko
affiliation:
name:Deutsches Krebsforschungszentrum
address:
name:Division of Epigenetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany
type:PostalAddress
type:Organization
email:[email protected]
PostalAddress:
name:Division of Epigenetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany
name:Division of Epigenetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany
name:Division of Epigenetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany
name:Division of Epigenetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany
name:Helmholtz Junior Research Group Posttranscriptional Control of Gene Expression, Deutsches Krebsforschungszentrum, Heidelberg, Germany
name:Institute of Pharmacy, Johannes Gutenberg University of Mainz, Mainz, Germany
name:Wellcome Trust Centre for Stem Cell Research, University of Cambridge, Cambridge, UK
name:Institute of Pharmacy, Johannes Gutenberg University of Mainz, Mainz, Germany
name:Helmholtz Junior Research Group Posttranscriptional Control of Gene Expression, Deutsches Krebsforschungszentrum, Heidelberg, Germany
name:Division of Epigenetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany
WebPageElement:
isAccessibleForFree:
cssSelector:.main-content
External Links {๐}(109)
- What's the revenue for https://link.springer.com/article/10.1038/nsmb.2357?utm_source=nature&utm_medium=referral&utm_campaign=buyArticle?
- How much does http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE36918 pull in monthly?
- How much revenue does https://doi.org/10.1038%2Fnrg2341 bring in?
- How much profit does http://scholar.google.com/scholar_lookup?&title=DNA%20methylation%20landscapes%3A%20provocative%20insights%20from%20epigenomics&journal=Nat.%20Rev.%20Genet.&doi=10.1038%2Fnrg2341&volume=9&pages=465-476&publication_year=2008&author=Suzuki%2CMM&author=Bird%2CA generate?
- What are the total earnings of https://doi.org/10.1016%2Fj.tig.2008.12.005?
- How much money does http://scholar.google.com/scholar_lookup?&title=Genetics%20and%20epigenetics%3A%20stability%20and%20plasticity%20during%20cellular%20differentiation&journal=Trends%20Genet.&doi=10.1016%2Fj.tig.2008.12.005&volume=25&pages=129-136&publication_year=2009&author=Mohn%2CF&author=Schubeler%2CD make?
- https://doi.org/10.1038%2Fnrg3230 income
- Income figures for http://scholar.google.com/scholar_lookup?&title=Functions%20of%20DNA%20methylation%3A%20islands%2C%20start%20sites%2C%20gene%20bodies%20and%20beyond&journal=Nat.%20Rev.%20Genet.&doi=10.1038%2Fnrg3230&volume=13&pages=484-492&publication_year=2012&author=Jones%2CPA
- How much profit does https://doi.org/10.1101%2Fgad.1956510 make?
- How much does http://scholar.google.com/scholar_lookup?&title=tRNA%20biology%20charges%20to%20the%20front&journal=Genes%20Dev.&doi=10.1101%2Fgad.1956510&volume=24&pages=1832-1860&publication_year=2010&author=Phizicky%2CEM&author=Hopper%2CAK rake in every month?
- https://doi.org/10.1093%2Fnar%2Fgkp1117's total income per month
- How much does http://scholar.google.com/scholar_lookup?&title=5-methylcytosine%20in%20RNA%3A%20detection%2C%20enzymatic%20formation%20and%20biological%20functions&journal=Nucleic%20Acids%20Res.&doi=10.1093%2Fnar%2Fgkp1117&volume=38&pages=1415-1430&publication_year=2010&author=Motorin%2CY&author=Lyko%2CF&author=Helm%2CM pull in?
- How profitable is https://doi.org/10.1126%2Fscience.1120976?
- Earnings of http://scholar.google.com/scholar_lookup?&title=Methylation%20of%20tRNAAsp%20by%20the%20DNA%20methyltransferase%20homolog%20Dnmt2&journal=Science&doi=10.1126%2Fscience.1120976&volume=311&pages=395-398&publication_year=2006&author=Goll%2CMG
- How much money does https://doi.org/10.1101%2Fgad.586710 generate?
- Earnings of http://scholar.google.com/scholar_lookup?&title=RNA%20methylation%20by%20Dnmt2%20protects%20transfer%20RNAs%20against%20stress-induced%20cleavage&journal=Genes%20Dev.&doi=10.1101%2Fgad.586710&volume=24&pages=1590-1595&publication_year=2010&author=Schaefer%2CM
- How much does https://doi.org/10.1093%2Fnar%2F23.2.203 rake in every month?
- How much profit is http://scholar.google.com/scholar_lookup?&title=The%20fission%20yeast%20gene%20pmt1%2B%20encodes%20a%20DNA%20methyltransferase%20homologue&journal=Nucleic%20Acids%20Res.&doi=10.1093%2Fnar%2F23.2.203&volume=23&pages=203-210&publication_year=1995&author=Wilkinson%2CCR&author=Bartlett%2CR&author=Nurse%2CP&author=Bird%2CAP making per month?
- Financial intake of https://doi.org/10.1093%2Fhmg%2F7.2.279
- Get to know http://scholar.google.com/scholar_lookup?&title=A%20candidate%20mammalian%20DNA%20methyltransferase%20related%20to%20pmt1p%20of%20fission%20yeast&journal=Hum.%20Mol.%20Genet.&doi=10.1093%2Fhmg%2F7.2.279&volume=7&pages=279-284&publication_year=1998&author=Yoder%2CJA&author=Bestor%2CTH's earnings
- https://doi.org/10.1093%2Fnar%2F26.11.2536's total income per month
- How much income is http://scholar.google.com/scholar_lookup?&title=Dnmt2%20is%20not%20required%20for%20de%20novo%20and%20maintenance%20methylation%20of%20viral%20DNA%20in%20embryonic%20stem%20cells&journal=Nucleic%20Acids%20Res.&doi=10.1093%2Fnar%2F26.11.2536&volume=26&pages=2536-2540&publication_year=1998&author=Okano%2CM&author=Xie%2CS&author=Li%2CE earning monthly?
- What's the profit of https://doi.org/10.1261%2Frna.970408?
- What's the monthly income of http://scholar.google.com/scholar_lookup?&title=Human%20DNMT2%20methylates%20tRNAAsp%20molecules%20using%20a%20DNA%20methyltransferase-like%20catalytic%20mechanism&journal=RNA&doi=10.1261%2Frna.970408&volume=14&pages=1663-1670&publication_year=2008&author=Jurkowski%2CTP?
- How much cash flow does https://doi.org/10.1016%2Fj.jmb.2008.08.062 have monthly?
- How much does http://scholar.google.com/scholar_lookup?&title=Crystal%20structure%20of%20the%20Escherichia%20coli%2023S%20rRNA%3Am5C%20methyltransferase%20RlmI%20%28YccW%29%20reveals%20evolutionary%20links%20between%20RNA%20modification%20enzymes&journal=J.%20Mol.%20Biol.&doi=10.1016%2Fj.jmb.2008.08.062&volume=383&pages=652-666&publication_year=2008&author=Sunita%2CS gross monthly?
- What's the financial intake of https://doi.org/10.1016%2FB978-0-12-387685-0.00002-0?
- What's the income of http://scholar.google.com/scholar_lookup?&title=Natural%20history%20of%20eukaryotic%20DNA%20methylation%20systems&journal=Prog.%20Mol.%20Biol.%20Transl.%20Sci.&doi=10.1016%2FB978-0-12-387685-0.00002-0&volume=101&pages=25-104&publication_year=2011&author=Iyer%2CLM&author=Abhiman%2CS&author=Aravind%2CL?
- How much does https://doi.org/10.1371%2Fjournal.pone.0028104 bring in each month?
- What are the total earnings of http://scholar.google.com/scholar_lookup?&title=On%20the%20evolutionary%20origin%20of%20eukaryotic%20DNA%20methyltransferases%20and%20Dnmt2&journal=PLoS%20ONE&doi=10.1371%2Fjournal.pone.0028104&volume=6&publication_year=2011&author=Jurkowski%2CTP&author=Jeltsch%2CA?
- Check the income stats for https://link.springer.com/doi/10.1007/s00412-009-0240-6
- Check the income stats for http://scholar.google.com/scholar_lookup?&title=Solving%20the%20Dnmt2%20enigma&journal=Chromosoma.&doi=10.1007%2Fs00412-009-0240-6&volume=119&pages=35-40&publication_year=2010&author=Schaefer%2CM&author=Lyko%2CF
- What is the earnings of https://doi.org/10.1093%2Fnar%2Fgkl765?
- How much does http://scholar.google.com/scholar_lookup?&title=Identification%20of%20human%20tRNA%3Am5C%20methyltransferase%20catalysing%20intron-dependent%20m5C%20formation%20in%20the%20first%20position%20of%20the%20anticodon%20of%20the%20pre-tRNA%20Leu%20%28CAA%29&journal=Nucleic%20Acids%20Res.&doi=10.1093%2Fnar%2Fgkl765&volume=34&pages=6034-6043&publication_year=2006&author=Brzezicha%2CB gross monthly?
- What's the income of https://doi.org/10.1371%2Fjournal.pgen.1002403?
- What's the income generated by http://scholar.google.com/scholar_lookup?&title=The%20RNA%E2%80%93methyltransferase%20Misu%20%28NSun2%29%20poises%20epidermal%20stem%20cells%20to%20differentiate&journal=PLoS%20Genet.&doi=10.1371%2Fjournal.pgen.1002403&volume=7&publication_year=2011&author=Blanco%2CS each month?
- How much revenue does https://doi.org/10.1017%2FS1355838299982201 produce monthly?
- How much does http://scholar.google.com/scholar_lookup?&title=Multisite-specific%20tRNA%3Am5C-methyltransferase%20%28Trm4%29%20in%20yeast%20Saccharomyces%20cerevisiae%3A%20identification%20of%20the%20gene%20and%20substrate%20specificity%20of%20the%20enzyme&journal=RNA&doi=10.1017%2FS1355838299982201&volume=5&pages=1105-1118&publication_year=1999&author=Motorin%2CY&author=Grosjean%2CH rake in every month?
- What are the earnings of https://doi.org/10.1016%2Fj.cub.2006.04.027?
- http://scholar.google.com/scholar_lookup?&title=The%20RNA%20methyltransferase%20Misu%20%28NSun2%29%20mediates%20Myc-induced%20proliferation%20and%20is%20upregulated%20in%20tumors&journal=Curr.%20Biol.&doi=10.1016%2Fj.cub.2006.04.027&volume=16&pages=971-981&publication_year=2006&author=Frye%2CM&author=Watt%2CFM's revenue stream
- How much profit does https://doi.org/10.1093%2Fnar%2Fgks144 make?
- Discover the revenue of http://scholar.google.com/scholar_lookup?&title=Widespread%20occurrence%20of%205-methylcytosine%20in%20human%20coding%20and%20non-coding%20RNA&journal=Nucleic%20Acids%20Res.&doi=10.1093%2Fnar%2Fgks144&volume=40&pages=5023-5033&publication_year=2012&author=Squires%2CJE
- https://doi.org/10.1038%2Fncomms1692's financial summary
- What's the financial intake of http://scholar.google.com/scholar_lookup?&title=The%20tRNA%20methyltransferase%20NSun2%20stabilizes%20p16%28INK4%29%20mRNA%20by%20methylating%20the%203%E2%80%B2-untranslated%20region%20of%20p16&journal=Nat%20Commun.&doi=10.1038%2Fncomms1692&volume=3&publication_year=2012&author=Zhang%2CX?
- Monthly income for https://doi.org/10.1093%2Fnar%2Fgkn954
- Monthly income for http://scholar.google.com/scholar_lookup?&title=RNA%20cytosine%20methylation%20analysis%20by%20bisulfite%20sequencing&journal=Nucleic%20Acids%20Res.&doi=10.1093%2Fnar%2Fgkn954&volume=37&publication_year=2009&author=Schaefer%2CM&author=Pollex%2CT&author=Hanna%2CK&author=Lyko%2CF
- What are the earnings of https://doi.org/10.1093%2Fnar%2Fgki012?
- Financial intake of http://scholar.google.com/scholar_lookup?&title=Compilation%20of%20tRNA%20sequences%20and%20sequences%20of%20tRNA%20genes&journal=Nucleic%20Acids%20Res.&doi=10.1093%2Fnar%2Fgki012&volume=33&pages=D139-D140&publication_year=2005&author=Sprinzl%2CM&author=Vassilenko%2CKS
- What's the profit of https://doi.org/10.1002%2Fwrna.79?
- What's http://scholar.google.com/scholar_lookup?&title=RNA%20nucleotide%20methylation&journal=Wiley%20Interdiscip.%20Rev.%20RNA&doi=10.1002%2Fwrna.79&volume=2&pages=611-631&publication_year=2011&author=Motorin%2CY&author=Helm%2CM's gross income?
- https://doi.org/10.1016%2Fj.febslet.2009.11.049 income
- http://scholar.google.com/scholar_lookup?&title=Do%20all%20modifications%20benefit%20all%20tRNAs%3F&journal=FEBS%20Lett.&doi=10.1016%2Fj.febslet.2009.11.049&volume=584&pages=265-271&publication_year=2010&author=Phizicky%2CEM&author=Alfonzo%2CJD income
- How much profit is https://doi.org/10.1016%2Fj.molcel.2005.10.036 making per month?
- What's http://scholar.google.com/scholar_lookup?&title=Rapid%20tRNA%20decay%20can%20result%20from%20lack%20of%20nonessential%20modifications&journal=Mol.%20Cell&doi=10.1016%2Fj.molcel.2005.10.036&volume=21&pages=87-96&publication_year=2006&author=Alexandrov%2CA's gross income?
- What is the earnings of https://doi.org/10.1101%2Fgad.1654308?
- What's the financial outcome of http://scholar.google.com/scholar_lookup?&title=Degradation%20of%20several%20hypomodified%20mature%20tRNA%20species%20in%20Saccharomyces%20cerevisiae%20is%20mediated%20by%20Met22%20and%20the%205%E2%80%B2-3%E2%80%B2%20exonucleases%20Rat1%20and%20Xrn1&journal=Genes%20Dev.&doi=10.1101%2Fgad.1654308&volume=22&pages=1369-1380&publication_year=2008&author=Chernyakov%2CI&author=Whipple%2CJM&author=Kotelawala%2CL&author=Grayhack%2CEJ&author=Phizicky%2CEM?
- https://doi.org/10.1371%2Fjournal.pgen.1001247's revenue stream
- How much revenue does http://scholar.google.com/scholar_lookup?&title=A%20quantitative%20systems%20approach%20reveals%20dynamic%20control%20of%20tRNA%20modifications%20during%20cellular%20stress&journal=PLoS%20Genet.&doi=10.1371%2Fjournal.pgen.1001247&volume=6&publication_year=2010&author=Chan%2CCT bring in?
- How much cash flow does https://doi.org/10.1126%2Fscience.1192430 have monthly?
- How much does http://scholar.google.com/scholar_lookup?&title=Dom34%3AHbs1%20promotes%20subunit%20dissociation%20and%20peptidyl-tRNA%20drop-off%20to%20initiate%20no-go%20decay&journal=Science&doi=10.1126%2Fscience.1192430&volume=330&pages=369-372&publication_year=2010&author=Shoemaker%2CCJ&author=Eyler%2CDE&author=Green%2CR net monthly?
- Discover the revenue of https://doi.org/10.1016%2Fj.molcel.2011.06.022
- http://scholar.google.com/scholar_lookup?&title=Angiogenin-induced%20tRNA%20fragments%20inhibit%20translation%20initiation&journal=Mol.%20Cell&doi=10.1016%2Fj.molcel.2011.06.022&volume=43&pages=613-623&publication_year=2011&author=Ivanov%2CP&author=Emara%2CMM&author=Villen%2CJ&author=Gygi%2CSP&author=Anderson%2CP income
- Income figures for https://doi.org/10.4161%2Fepi.6.1.13418
- What's the revenue for http://scholar.google.com/scholar_lookup?&title=The%20DNA%20methyltranferase%20Dnmt2%20participates%20in%20RNA%20processing%20during%20cellular%20stress&journal=Epigenetics&doi=10.4161%2Fepi.6.1.13418&volume=6&pages=103-113&publication_year=2011&author=Thiagarajan%2CD&author=Dev%2CRR&author=Khosla%2CS?
- How much does https://doi.org/10.1038%2Fncomms1938 make?
- How much revenue does http://scholar.google.com/scholar_lookup?&title=Reprogramming%20of%20tRNA%20modifications%20controls%20the%20oxidative%20stress%20response%20by%20codon-biased%20translation%20of%20proteins&journal=Nat.%20Commun.&doi=10.1038%2Fncomms1938&volume=3&publication_year=2012&author=Chan%2CCT generate?
- How much does https://doi.org/10.1016%2Fj.stem.2008.03.013 generate monthly?
- How much does http://scholar.google.com/scholar_lookup?&title=A%20hierarchical%20network%20controls%20protein%20translation%20during%20murine%20embryonic%20stem%20cell%20self-renewal%20and%20differentiation&journal=Cell%20Stem%20Cell&doi=10.1016%2Fj.stem.2008.03.013&volume=2&pages=448-460&publication_year=2008&author=Sampath%2CP pull in?
- How much revenue does https://doi.org/10.1101%2Fgad.1472907 produce monthly?
- How much revenue does http://scholar.google.com/scholar_lookup?&title=Dnmt2%20functions%20in%20the%20cytoplasm%20to%20promote%20liver%2C%20brain%2C%20and%20retina%20development%20in%20zebrafish&journal=Genes%20Dev.&doi=10.1101%2Fgad.1472907&volume=21&pages=261-266&publication_year=2007&author=Rai%2CK bring in?
- Learn how profitable https://doi.org/10.1038%2Fnchembio.482 is on a monthly basis
- http://scholar.google.com/scholar_lookup?&title=Grand%20challenge%20commentary%3A%20RNA%20epigenetics%3F&journal=Nat.%20Chem.%20Biol.&doi=10.1038%2Fnchembio.482&volume=6&pages=863-865&publication_year=2010&author=He%2CC's revenue stream
- https://doi.org/10.1083%2Fjcb.17.2.299 income
- How much profit does http://scholar.google.com/scholar_lookup?&title=Quantitative%20studies%20of%20the%20growth%20of%20mouse%20embryo%20cells%20in%20culture%20and%20their%20development%20into%20established%20lines&journal=J.%20Cell%20Biol.&doi=10.1083%2Fjcb.17.2.299&volume=17&pages=299-313&publication_year=1963&author=Todaro%2CGJ&author=Green%2CH generate?
- What is the earnings of https://doi.org/10.1093%2Fnar%2Fgkr449?
- Get to know http://scholar.google.com/scholar_lookup?&title=A%20multifunctional%20bioconjugate%20module%20for%20versatile%20photoaffinity%20labeling%20and%20click%20chemistry%20of%20RNA&journal=Nucleic%20Acids%20Res.&doi=10.1093%2Fnar%2Fgkr449&volume=39&pages=7348-7360&publication_year=2011&author=Kellner%2CS&author=Seidu-Larry%2CS&author=Burhenne%2CJ&author=Motorin%2CY&author=Helm%2CM's earnings
- Earnings of https://citation-needed.springer.com/v2/references/10.1038/nsmb.2357?format=refman&flavour=references
- https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Francesca%20Tuorto's revenue stream
- Get to know what's the income of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Francesca%20Tuorto%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
- What's the profit of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Reinhard%20Liebers?
- How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Reinhard%20Liebers%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en pull in?
- What's the financial gain of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Tanja%20Musch?
- Find out how much https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Tanja%20Musch%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en earns monthly
- What are the earnings of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Matthias%20Schaefer?
- How much profit does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Matthias%20Schaefer%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en generate?
- How much money does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Sarah%20Hofmann generate?
- What's the financial intake of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Sarah%20Hofmann%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Stefanie%20Kellner's revenue stream
- What are the total earnings of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Stefanie%20Kellner%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Michaela%20Frye bring in each month?
- How much profit does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Michaela%20Frye%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en generate?
- Find out how much https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Mark%20Helm earns monthly
- What's the profit of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Mark%20Helm%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- How much money does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Georg%20Stoecklin make?
- What's the revenue for https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Georg%20Stoecklin%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- Profit of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Frank%20Lyko
- Get to know what's the income of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Frank%20Lyko%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
- How much does https://static-content.springer.com/esm/art%3A10.1038%2Fnsmb.2357/MediaObjects/41594_2012_BFnsmb2357_MOESM11_ESM.pdf bring in each month?
- How much revenue does https://s100.copyright.com/AppDispatchServlet?title=RNA%20cytosine%20methylation%20by%20Dnmt2%20and%20NSun2%20promotes%20tRNA%20stability%20and%20protein%20synthesis&author=Francesca%20Tuorto%20et%20al&contentID=10.1038%2Fnsmb.2357©right=Springer%20Nature%20America%2C%20Inc.&publication=1545-9993&publicationDate=2012-08-12&publisherName=SpringerNature&orderBeanReset=true bring in?
- How much money does https://citation-needed.springer.com/v2/references/10.1038/nsmb.2357?format=refman&flavour=citation generate?
- Find out how much https://doi.org/10.1038/s41388-024-03069-2 earns monthly
- Get to know what's the income of https://doi.org/10.1038/s41580-023-00690-z
- How much income does https://doi.org/10.1038/s41386-024-01813-6 have?
- Income figures for https://doi.org/10.1186/s12864-023-09432-z
- How much revenue does https://doi.org/10.1186/s13048-023-01172-8 bring in?
- What's the monthly income of https://www.protocols.io/?
- How much does https://www.natureindex.com/ earn?
- What is the earnings of http://www.naturechina.com?
- How profitable is https://www.natureasia.com/ja-jp?
Analytics and Tracking {๐}
- Google Tag Manager
Libraries {๐}
- Prism.js
- Zoom.js
Emails and Hosting {โ๏ธ}
Mail Servers:
- mxa-002c5801.gslb.pphosted.com
- mxb-002c5801.gslb.pphosted.com
Name Servers:
- pdns1.ultradns.net
- pdns2.ultradns.net
- pdns3.ultradns.org
- pdns4.ultradns.org
- pdns5.ultradns.info
- pdns6.ultradns.co.uk
CDN Services {๐ฆ}
- Crossref