
NATURE . COM {
}
Title:
RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis | Nature Structural & Molecular Biology
Description:
Although cytosine-C5 methylation is a prominent modification of tRNAs, its functional significance has been unclear. Mice that lack both the Dnmt2 and NSun2 tRNA methyltransferases showed developmental and cellular differentiation defects, and loss of Dnmt2 and NSun2 was further associated with tRNA degradation and reduced rates of protein synthesis, suggesting that this modification promotes mouse development by supporting protein synthesis. The function of cytosine-C5 methylation, a widespread modification of tRNAs, has remained obscure, particularly in mammals. We have now developed a mouse strain defective in cytosine-C5 tRNA methylation, by disrupting both the Dnmt2 and the NSun2 tRNA methyltransferases. Although the lack of either enzyme alone has no detectable effects on mouse viability, double mutants showed a synthetic lethal interaction, with an underdeveloped phenotype and impaired cellular differentiation. tRNA methylation analysis of the double-knockout mice demonstrated complementary target-site specificities for Dnmt2 and NSun2 and a complete loss of cytosine-C5 tRNA methylation. Steady-state levels of unmethylated tRNAs were substantially reduced, and loss of Dnmt2 and NSun2 was further associated with reduced rates of overall protein synthesis. These results establish a biologically important function for cytosine-C5 tRNA methylation in mammals and suggest that this modification promotes mouse development by supporting protein synthesis.
Website Age:
30 years and 10 months (reg. 1994-08-11).
Matching Content Categories {๐}
- Education
- Science
- Animals & Wildlife
Content Management System {๐}
What CMS is nature.com built with?
Custom-built
No common CMS systems were detected on Nature.com, and no known web development framework was identified.
Traffic Estimate {๐}
What is the average monthly size of nature.com audience?
๐ Monumental Traffic: 20M - 50M visitors per month
Based on our best estimate, this website will receive around 42,798,980 visitors per month in the current month.
check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush
How Does Nature.com Make Money? {๐ธ}
Display Ads {๐ฏ}
The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.
Ads are managed by yourbow.com. Particular relationships are as follows:
Direct Advertisers (10)
google.com, pmc.com, doceree.com, yourbow.com, audienciad.com, onlinemediasolutions.com, advibe.media, aps.amazon.com, getmediamx.com, onomagic.comReseller Advertisers (38)
conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.comHow Much Does Nature.com Make? {๐ฐ}
Display Ads {๐ฏ}
$539,300 per month
Our estimates place Nature.com's monthly online earnings from display ads at $359,553 to $988,772.
Keywords {๐}
article, google, scholar, cas, rna, nature, methylation, trna, dnmt, access, dna, cell, nsun, nucleic, acids, res, content, nat, methyltransferase, mol, biol, cookies, lyko, mouse, genet, research, privacy, molecular, biology, protein, schaefer, helm, modification, open, gene, epigenetics, genes, dev, stem, analysis, data, information, promotes, synthesis, cytosinec, trnas, cellular, development, motorin, cells,
Topics {โ๏ธ}
nature portfolio permissions reprints privacy policy stem cell research ovarian research nature advertising social media author information authors italy mediates myc-induced proliferation opioid-induced reward-seeking multisite-specific trna cytosine-c5 trna methylation manage preferences author correspondence trna-derived small rnas long-term opioid withdrawal springerlink instant access trna biology charges m5c methyltransferase rlmi personal data mrna-expression profiling data protection permissions gene expression cytosine-c5 methylation retina development rna cytosine methylation double mutants showed matthias schaefer trna methylation analysis codon-biased translation frank lyko dna methylation landscapes rna nucleotide methylation m5c-methyltransferase steady-state levels privacy embryonic stem cells stefanie kellner stress-induced cleavage reveals evolutionary links rna modification enzymes development competing financial interests dna methyltransferase homologue rnaโmethyltransferase misu rna methyltransferase misu molecular mechanisms
Questions {โ}
- Do all modifications benefit all tRNAs?
- Grand challenge commentary: RNA epigenetics?
Schema {๐บ๏ธ}
WebPage:
mainEntity:
headline:RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis
description:Although cytosine-C5 methylation is a prominent modification of tRNAs, its functional significance has been unclear. Mice that lack both the Dnmt2 and NSun2 tRNA methyltransferases showed developmental and cellular differentiation defects, and loss of Dnmt2 and NSun2 was further associated with tRNA degradation and reduced rates of protein synthesis, suggesting that this modification promotes mouse development by supporting protein synthesis. The function of cytosine-C5 methylation, a widespread modification of tRNAs, has remained obscure, particularly in mammals. We have now developed a mouse strain defective in cytosine-C5 tRNA methylation, by disrupting both the Dnmt2 and the NSun2 tRNA methyltransferases. Although the lack of either enzyme alone has no detectable effects on mouse viability, double mutants showed a synthetic lethal interaction, with an underdeveloped phenotype and impaired cellular differentiation. tRNA methylation analysis of the double-knockout mice demonstrated complementary target-site specificities for Dnmt2 and NSun2 and a complete loss of cytosine-C5 tRNA methylation. Steady-state levels of unmethylated tRNAs were substantially reduced, and loss of Dnmt2 and NSun2 was further associated with reduced rates of overall protein synthesis. These results establish a biologically important function for cytosine-C5 tRNA methylation in mammals and suggest that this modification promotes mouse development by supporting protein synthesis.
datePublished:2012-08-12T00:00:00Z
dateModified:2012-08-12T00:00:00Z
pageStart:900
pageEnd:905
sameAs:https://doi.org/10.1038/nsmb.2357
keywords:
Epigenetics
RNA modification
tRNAs
Life Sciences
general
Biochemistry
Protein Structure
Membrane Biology
Biological Microscopy
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb.2357/MediaObjects/41594_2012_Article_BFnsmb2357_Fig1_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb.2357/MediaObjects/41594_2012_Article_BFnsmb2357_Fig2_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb.2357/MediaObjects/41594_2012_Article_BFnsmb2357_Fig3_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb.2357/MediaObjects/41594_2012_Article_BFnsmb2357_Fig4_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb.2357/MediaObjects/41594_2012_Article_BFnsmb2357_Fig5_HTML.jpg
isPartOf:
name:Nature Structural & Molecular Biology
issn:
1545-9985
1545-9993
volumeNumber:19
type:
Periodical
PublicationVolume
publisher:
name:Nature Publishing Group US
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Francesca Tuorto
affiliation:
name:Deutsches Krebsforschungszentrum
address:
name:Division of Epigenetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany
type:PostalAddress
type:Organization
type:Person
name:Reinhard Liebers
affiliation:
name:Deutsches Krebsforschungszentrum
address:
name:Division of Epigenetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany
type:PostalAddress
type:Organization
type:Person
name:Tanja Musch
affiliation:
name:Deutsches Krebsforschungszentrum
address:
name:Division of Epigenetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany
type:PostalAddress
type:Organization
type:Person
name:Matthias Schaefer
affiliation:
name:Deutsches Krebsforschungszentrum
address:
name:Division of Epigenetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany
type:PostalAddress
type:Organization
type:Person
name:Sarah Hofmann
affiliation:
name:Helmholtz Junior Research Group Posttranscriptional Control of Gene Expression, Deutsches Krebsforschungszentrum
address:
name:Helmholtz Junior Research Group Posttranscriptional Control of Gene Expression, Deutsches Krebsforschungszentrum, Heidelberg, Germany
type:PostalAddress
type:Organization
type:Person
name:Stefanie Kellner
affiliation:
name:Institute of Pharmacy, Johannes Gutenberg University of Mainz
address:
name:Institute of Pharmacy, Johannes Gutenberg University of Mainz, Mainz, Germany
type:PostalAddress
type:Organization
type:Person
name:Michaela Frye
affiliation:
name:Wellcome Trust Centre for Stem Cell Research, University of Cambridge
address:
name:Wellcome Trust Centre for Stem Cell Research, University of Cambridge, Cambridge, UK
type:PostalAddress
type:Organization
type:Person
name:Mark Helm
affiliation:
name:Institute of Pharmacy, Johannes Gutenberg University of Mainz
address:
name:Institute of Pharmacy, Johannes Gutenberg University of Mainz, Mainz, Germany
type:PostalAddress
type:Organization
type:Person
name:Georg Stoecklin
affiliation:
name:Helmholtz Junior Research Group Posttranscriptional Control of Gene Expression, Deutsches Krebsforschungszentrum
address:
name:Helmholtz Junior Research Group Posttranscriptional Control of Gene Expression, Deutsches Krebsforschungszentrum, Heidelberg, Germany
type:PostalAddress
type:Organization
type:Person
name:Frank Lyko
affiliation:
name:Deutsches Krebsforschungszentrum
address:
name:Division of Epigenetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany
type:PostalAddress
type:Organization
email:[email protected]
type:Person
isAccessibleForFree:
hasPart:
isAccessibleForFree:
cssSelector:.main-content
type:WebPageElement
type:ScholarlyArticle
context:https://schema.org
ScholarlyArticle:
headline:RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis
description:Although cytosine-C5 methylation is a prominent modification of tRNAs, its functional significance has been unclear. Mice that lack both the Dnmt2 and NSun2 tRNA methyltransferases showed developmental and cellular differentiation defects, and loss of Dnmt2 and NSun2 was further associated with tRNA degradation and reduced rates of protein synthesis, suggesting that this modification promotes mouse development by supporting protein synthesis. The function of cytosine-C5 methylation, a widespread modification of tRNAs, has remained obscure, particularly in mammals. We have now developed a mouse strain defective in cytosine-C5 tRNA methylation, by disrupting both the Dnmt2 and the NSun2 tRNA methyltransferases. Although the lack of either enzyme alone has no detectable effects on mouse viability, double mutants showed a synthetic lethal interaction, with an underdeveloped phenotype and impaired cellular differentiation. tRNA methylation analysis of the double-knockout mice demonstrated complementary target-site specificities for Dnmt2 and NSun2 and a complete loss of cytosine-C5 tRNA methylation. Steady-state levels of unmethylated tRNAs were substantially reduced, and loss of Dnmt2 and NSun2 was further associated with reduced rates of overall protein synthesis. These results establish a biologically important function for cytosine-C5 tRNA methylation in mammals and suggest that this modification promotes mouse development by supporting protein synthesis.
datePublished:2012-08-12T00:00:00Z
dateModified:2012-08-12T00:00:00Z
pageStart:900
pageEnd:905
sameAs:https://doi.org/10.1038/nsmb.2357
keywords:
Epigenetics
RNA modification
tRNAs
Life Sciences
general
Biochemistry
Protein Structure
Membrane Biology
Biological Microscopy
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb.2357/MediaObjects/41594_2012_Article_BFnsmb2357_Fig1_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb.2357/MediaObjects/41594_2012_Article_BFnsmb2357_Fig2_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb.2357/MediaObjects/41594_2012_Article_BFnsmb2357_Fig3_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb.2357/MediaObjects/41594_2012_Article_BFnsmb2357_Fig4_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnsmb.2357/MediaObjects/41594_2012_Article_BFnsmb2357_Fig5_HTML.jpg
isPartOf:
name:Nature Structural & Molecular Biology
issn:
1545-9985
1545-9993
volumeNumber:19
type:
Periodical
PublicationVolume
publisher:
name:Nature Publishing Group US
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Francesca Tuorto
affiliation:
name:Deutsches Krebsforschungszentrum
address:
name:Division of Epigenetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany
type:PostalAddress
type:Organization
type:Person
name:Reinhard Liebers
affiliation:
name:Deutsches Krebsforschungszentrum
address:
name:Division of Epigenetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany
type:PostalAddress
type:Organization
type:Person
name:Tanja Musch
affiliation:
name:Deutsches Krebsforschungszentrum
address:
name:Division of Epigenetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany
type:PostalAddress
type:Organization
type:Person
name:Matthias Schaefer
affiliation:
name:Deutsches Krebsforschungszentrum
address:
name:Division of Epigenetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany
type:PostalAddress
type:Organization
type:Person
name:Sarah Hofmann
affiliation:
name:Helmholtz Junior Research Group Posttranscriptional Control of Gene Expression, Deutsches Krebsforschungszentrum
address:
name:Helmholtz Junior Research Group Posttranscriptional Control of Gene Expression, Deutsches Krebsforschungszentrum, Heidelberg, Germany
type:PostalAddress
type:Organization
type:Person
name:Stefanie Kellner
affiliation:
name:Institute of Pharmacy, Johannes Gutenberg University of Mainz
address:
name:Institute of Pharmacy, Johannes Gutenberg University of Mainz, Mainz, Germany
type:PostalAddress
type:Organization
type:Person
name:Michaela Frye
affiliation:
name:Wellcome Trust Centre for Stem Cell Research, University of Cambridge
address:
name:Wellcome Trust Centre for Stem Cell Research, University of Cambridge, Cambridge, UK
type:PostalAddress
type:Organization
type:Person
name:Mark Helm
affiliation:
name:Institute of Pharmacy, Johannes Gutenberg University of Mainz
address:
name:Institute of Pharmacy, Johannes Gutenberg University of Mainz, Mainz, Germany
type:PostalAddress
type:Organization
type:Person
name:Georg Stoecklin
affiliation:
name:Helmholtz Junior Research Group Posttranscriptional Control of Gene Expression, Deutsches Krebsforschungszentrum
address:
name:Helmholtz Junior Research Group Posttranscriptional Control of Gene Expression, Deutsches Krebsforschungszentrum, Heidelberg, Germany
type:PostalAddress
type:Organization
type:Person
name:Frank Lyko
affiliation:
name:Deutsches Krebsforschungszentrum
address:
name:Division of Epigenetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany
type:PostalAddress
type:Organization
email:[email protected]
type:Person
isAccessibleForFree:
hasPart:
isAccessibleForFree:
cssSelector:.main-content
type:WebPageElement
["Periodical","PublicationVolume"]:
name:Nature Structural & Molecular Biology
issn:
1545-9985
1545-9993
volumeNumber:19
Organization:
name:Nature Publishing Group US
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
name:Deutsches Krebsforschungszentrum
address:
name:Division of Epigenetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany
type:PostalAddress
name:Deutsches Krebsforschungszentrum
address:
name:Division of Epigenetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany
type:PostalAddress
name:Deutsches Krebsforschungszentrum
address:
name:Division of Epigenetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany
type:PostalAddress
name:Deutsches Krebsforschungszentrum
address:
name:Division of Epigenetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany
type:PostalAddress
name:Helmholtz Junior Research Group Posttranscriptional Control of Gene Expression, Deutsches Krebsforschungszentrum
address:
name:Helmholtz Junior Research Group Posttranscriptional Control of Gene Expression, Deutsches Krebsforschungszentrum, Heidelberg, Germany
type:PostalAddress
name:Institute of Pharmacy, Johannes Gutenberg University of Mainz
address:
name:Institute of Pharmacy, Johannes Gutenberg University of Mainz, Mainz, Germany
type:PostalAddress
name:Wellcome Trust Centre for Stem Cell Research, University of Cambridge
address:
name:Wellcome Trust Centre for Stem Cell Research, University of Cambridge, Cambridge, UK
type:PostalAddress
name:Institute of Pharmacy, Johannes Gutenberg University of Mainz
address:
name:Institute of Pharmacy, Johannes Gutenberg University of Mainz, Mainz, Germany
type:PostalAddress
name:Helmholtz Junior Research Group Posttranscriptional Control of Gene Expression, Deutsches Krebsforschungszentrum
address:
name:Helmholtz Junior Research Group Posttranscriptional Control of Gene Expression, Deutsches Krebsforschungszentrum, Heidelberg, Germany
type:PostalAddress
name:Deutsches Krebsforschungszentrum
address:
name:Division of Epigenetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany
type:PostalAddress
ImageObject:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
name:Francesca Tuorto
affiliation:
name:Deutsches Krebsforschungszentrum
address:
name:Division of Epigenetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany
type:PostalAddress
type:Organization
name:Reinhard Liebers
affiliation:
name:Deutsches Krebsforschungszentrum
address:
name:Division of Epigenetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany
type:PostalAddress
type:Organization
name:Tanja Musch
affiliation:
name:Deutsches Krebsforschungszentrum
address:
name:Division of Epigenetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany
type:PostalAddress
type:Organization
name:Matthias Schaefer
affiliation:
name:Deutsches Krebsforschungszentrum
address:
name:Division of Epigenetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany
type:PostalAddress
type:Organization
name:Sarah Hofmann
affiliation:
name:Helmholtz Junior Research Group Posttranscriptional Control of Gene Expression, Deutsches Krebsforschungszentrum
address:
name:Helmholtz Junior Research Group Posttranscriptional Control of Gene Expression, Deutsches Krebsforschungszentrum, Heidelberg, Germany
type:PostalAddress
type:Organization
name:Stefanie Kellner
affiliation:
name:Institute of Pharmacy, Johannes Gutenberg University of Mainz
address:
name:Institute of Pharmacy, Johannes Gutenberg University of Mainz, Mainz, Germany
type:PostalAddress
type:Organization
name:Michaela Frye
affiliation:
name:Wellcome Trust Centre for Stem Cell Research, University of Cambridge
address:
name:Wellcome Trust Centre for Stem Cell Research, University of Cambridge, Cambridge, UK
type:PostalAddress
type:Organization
name:Mark Helm
affiliation:
name:Institute of Pharmacy, Johannes Gutenberg University of Mainz
address:
name:Institute of Pharmacy, Johannes Gutenberg University of Mainz, Mainz, Germany
type:PostalAddress
type:Organization
name:Georg Stoecklin
affiliation:
name:Helmholtz Junior Research Group Posttranscriptional Control of Gene Expression, Deutsches Krebsforschungszentrum
address:
name:Helmholtz Junior Research Group Posttranscriptional Control of Gene Expression, Deutsches Krebsforschungszentrum, Heidelberg, Germany
type:PostalAddress
type:Organization
name:Frank Lyko
affiliation:
name:Deutsches Krebsforschungszentrum
address:
name:Division of Epigenetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany
type:PostalAddress
type:Organization
email:[email protected]
PostalAddress:
name:Division of Epigenetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany
name:Division of Epigenetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany
name:Division of Epigenetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany
name:Division of Epigenetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany
name:Helmholtz Junior Research Group Posttranscriptional Control of Gene Expression, Deutsches Krebsforschungszentrum, Heidelberg, Germany
name:Institute of Pharmacy, Johannes Gutenberg University of Mainz, Mainz, Germany
name:Wellcome Trust Centre for Stem Cell Research, University of Cambridge, Cambridge, UK
name:Institute of Pharmacy, Johannes Gutenberg University of Mainz, Mainz, Germany
name:Helmholtz Junior Research Group Posttranscriptional Control of Gene Expression, Deutsches Krebsforschungszentrum, Heidelberg, Germany
name:Division of Epigenetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany
WebPageElement:
isAccessibleForFree:
cssSelector:.main-content
External Links {๐}(109)
- Learn how profitable https://link.springer.com/article/10.1038/nsmb.2357?utm_source=nature&utm_medium=referral&utm_campaign=buyArticle is on a monthly basis
- Discover the revenue of http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE36918
- How much does https://doi.org/10.1038%2Fnrg2341 make?
- What's the financial gain of http://scholar.google.com/scholar_lookup?&title=DNA%20methylation%20landscapes%3A%20provocative%20insights%20from%20epigenomics&journal=Nat.%20Rev.%20Genet.&doi=10.1038%2Fnrg2341&volume=9&pages=465-476&publication_year=2008&author=Suzuki%2CMM&author=Bird%2CA?
- How much does https://doi.org/10.1016%2Fj.tig.2008.12.005 net monthly?
- Financial intake of http://scholar.google.com/scholar_lookup?&title=Genetics%20and%20epigenetics%3A%20stability%20and%20plasticity%20during%20cellular%20differentiation&journal=Trends%20Genet.&doi=10.1016%2Fj.tig.2008.12.005&volume=25&pages=129-136&publication_year=2009&author=Mohn%2CF&author=Schubeler%2CD
- How much income does https://doi.org/10.1038%2Fnrg3230 have?
- What's the financial outcome of http://scholar.google.com/scholar_lookup?&title=Functions%20of%20DNA%20methylation%3A%20islands%2C%20start%20sites%2C%20gene%20bodies%20and%20beyond&journal=Nat.%20Rev.%20Genet.&doi=10.1038%2Fnrg3230&volume=13&pages=484-492&publication_year=2012&author=Jones%2CPA?
- See how much https://doi.org/10.1101%2Fgad.1956510 makes per month
- How much revenue does http://scholar.google.com/scholar_lookup?&title=tRNA%20biology%20charges%20to%20the%20front&journal=Genes%20Dev.&doi=10.1101%2Fgad.1956510&volume=24&pages=1832-1860&publication_year=2010&author=Phizicky%2CEM&author=Hopper%2CAK produce monthly?
- https://doi.org/10.1093%2Fnar%2Fgkp1117's financial summary
- Get to know http://scholar.google.com/scholar_lookup?&title=5-methylcytosine%20in%20RNA%3A%20detection%2C%20enzymatic%20formation%20and%20biological%20functions&journal=Nucleic%20Acids%20Res.&doi=10.1093%2Fnar%2Fgkp1117&volume=38&pages=1415-1430&publication_year=2010&author=Motorin%2CY&author=Lyko%2CF&author=Helm%2CM's earnings
- What's the monthly money flow for https://doi.org/10.1126%2Fscience.1120976?
- How much cash flow does http://scholar.google.com/scholar_lookup?&title=Methylation%20of%20tRNAAsp%20by%20the%20DNA%20methyltransferase%20homolog%20Dnmt2&journal=Science&doi=10.1126%2Fscience.1120976&volume=311&pages=395-398&publication_year=2006&author=Goll%2CMG have monthly?
- Get to know what's the income of https://doi.org/10.1101%2Fgad.586710
- How much money does http://scholar.google.com/scholar_lookup?&title=RNA%20methylation%20by%20Dnmt2%20protects%20transfer%20RNAs%20against%20stress-induced%20cleavage&journal=Genes%20Dev.&doi=10.1101%2Fgad.586710&volume=24&pages=1590-1595&publication_year=2010&author=Schaefer%2CM generate?
- How much does https://doi.org/10.1093%2Fnar%2F23.2.203 make?
- What's the financial gain of http://scholar.google.com/scholar_lookup?&title=The%20fission%20yeast%20gene%20pmt1%2B%20encodes%20a%20DNA%20methyltransferase%20homologue&journal=Nucleic%20Acids%20Res.&doi=10.1093%2Fnar%2F23.2.203&volume=23&pages=203-210&publication_year=1995&author=Wilkinson%2CCR&author=Bartlett%2CR&author=Nurse%2CP&author=Bird%2CAP?
- https://doi.org/10.1093%2Fhmg%2F7.2.279's financial summary
- http://scholar.google.com/scholar_lookup?&title=A%20candidate%20mammalian%20DNA%20methyltransferase%20related%20to%20pmt1p%20of%20fission%20yeast&journal=Hum.%20Mol.%20Genet.&doi=10.1093%2Fhmg%2F7.2.279&volume=7&pages=279-284&publication_year=1998&author=Yoder%2CJA&author=Bestor%2CTH's financial summary
- https://doi.org/10.1093%2Fnar%2F26.11.2536's revenue stream
- How much does http://scholar.google.com/scholar_lookup?&title=Dnmt2%20is%20not%20required%20for%20de%20novo%20and%20maintenance%20methylation%20of%20viral%20DNA%20in%20embryonic%20stem%20cells&journal=Nucleic%20Acids%20Res.&doi=10.1093%2Fnar%2F26.11.2536&volume=26&pages=2536-2540&publication_year=1998&author=Okano%2CM&author=Xie%2CS&author=Li%2CE bring in each month?
- Earnings of https://doi.org/10.1261%2Frna.970408
- How much does http://scholar.google.com/scholar_lookup?&title=Human%20DNMT2%20methylates%20tRNAAsp%20molecules%20using%20a%20DNA%20methyltransferase-like%20catalytic%20mechanism&journal=RNA&doi=10.1261%2Frna.970408&volume=14&pages=1663-1670&publication_year=2008&author=Jurkowski%2CTP rake in every month?
- Get to know what's the income of https://doi.org/10.1016%2Fj.jmb.2008.08.062
- What's the financial outcome of http://scholar.google.com/scholar_lookup?&title=Crystal%20structure%20of%20the%20Escherichia%20coli%2023S%20rRNA%3Am5C%20methyltransferase%20RlmI%20%28YccW%29%20reveals%20evolutionary%20links%20between%20RNA%20modification%20enzymes&journal=J.%20Mol.%20Biol.&doi=10.1016%2Fj.jmb.2008.08.062&volume=383&pages=652-666&publication_year=2008&author=Sunita%2CS?
- How much income is https://doi.org/10.1016%2FB978-0-12-387685-0.00002-0 earning monthly?
- What is the earnings of http://scholar.google.com/scholar_lookup?&title=Natural%20history%20of%20eukaryotic%20DNA%20methylation%20systems&journal=Prog.%20Mol.%20Biol.%20Transl.%20Sci.&doi=10.1016%2FB978-0-12-387685-0.00002-0&volume=101&pages=25-104&publication_year=2011&author=Iyer%2CLM&author=Abhiman%2CS&author=Aravind%2CL?
- https://doi.org/10.1371%2Fjournal.pone.0028104 income
- What's the profit of http://scholar.google.com/scholar_lookup?&title=On%20the%20evolutionary%20origin%20of%20eukaryotic%20DNA%20methyltransferases%20and%20Dnmt2&journal=PLoS%20ONE&doi=10.1371%2Fjournal.pone.0028104&volume=6&publication_year=2011&author=Jurkowski%2CTP&author=Jeltsch%2CA?
- How much income is https://link.springer.com/doi/10.1007/s00412-009-0240-6 earning monthly?
- Find out how much http://scholar.google.com/scholar_lookup?&title=Solving%20the%20Dnmt2%20enigma&journal=Chromosoma.&doi=10.1007%2Fs00412-009-0240-6&volume=119&pages=35-40&publication_year=2010&author=Schaefer%2CM&author=Lyko%2CF earns monthly
- See how much https://doi.org/10.1093%2Fnar%2Fgkl765 makes per month
- Get to know http://scholar.google.com/scholar_lookup?&title=Identification%20of%20human%20tRNA%3Am5C%20methyltransferase%20catalysing%20intron-dependent%20m5C%20formation%20in%20the%20first%20position%20of%20the%20anticodon%20of%20the%20pre-tRNA%20Leu%20%28CAA%29&journal=Nucleic%20Acids%20Res.&doi=10.1093%2Fnar%2Fgkl765&volume=34&pages=6034-6043&publication_year=2006&author=Brzezicha%2CB's earnings
- How much cash flow does https://doi.org/10.1371%2Fjournal.pgen.1002403 have monthly?
- What are the earnings of http://scholar.google.com/scholar_lookup?&title=The%20RNA%E2%80%93methyltransferase%20Misu%20%28NSun2%29%20poises%20epidermal%20stem%20cells%20to%20differentiate&journal=PLoS%20Genet.&doi=10.1371%2Fjournal.pgen.1002403&volume=7&publication_year=2011&author=Blanco%2CS?
- How much does https://doi.org/10.1017%2FS1355838299982201 generate monthly?
- How much profit is http://scholar.google.com/scholar_lookup?&title=Multisite-specific%20tRNA%3Am5C-methyltransferase%20%28Trm4%29%20in%20yeast%20Saccharomyces%20cerevisiae%3A%20identification%20of%20the%20gene%20and%20substrate%20specificity%20of%20the%20enzyme&journal=RNA&doi=10.1017%2FS1355838299982201&volume=5&pages=1105-1118&publication_year=1999&author=Motorin%2CY&author=Grosjean%2CH making per month?
- Monthly income for https://doi.org/10.1016%2Fj.cub.2006.04.027
- http://scholar.google.com/scholar_lookup?&title=The%20RNA%20methyltransferase%20Misu%20%28NSun2%29%20mediates%20Myc-induced%20proliferation%20and%20is%20upregulated%20in%20tumors&journal=Curr.%20Biol.&doi=10.1016%2Fj.cub.2006.04.027&volume=16&pages=971-981&publication_year=2006&author=Frye%2CM&author=Watt%2CFM's total income per month
- Revenue of https://doi.org/10.1093%2Fnar%2Fgks144
- How much income does http://scholar.google.com/scholar_lookup?&title=Widespread%20occurrence%20of%205-methylcytosine%20in%20human%20coding%20and%20non-coding%20RNA&journal=Nucleic%20Acids%20Res.&doi=10.1093%2Fnar%2Fgks144&volume=40&pages=5023-5033&publication_year=2012&author=Squires%2CJE have?
- How much profit does https://doi.org/10.1038%2Fncomms1692 make?
- How much money does http://scholar.google.com/scholar_lookup?&title=The%20tRNA%20methyltransferase%20NSun2%20stabilizes%20p16%28INK4%29%20mRNA%20by%20methylating%20the%203%E2%80%B2-untranslated%20region%20of%20p16&journal=Nat%20Commun.&doi=10.1038%2Fncomms1692&volume=3&publication_year=2012&author=Zhang%2CX make?
- What are the total earnings of https://doi.org/10.1093%2Fnar%2Fgkn954?
- What's the revenue for http://scholar.google.com/scholar_lookup?&title=RNA%20cytosine%20methylation%20analysis%20by%20bisulfite%20sequencing&journal=Nucleic%20Acids%20Res.&doi=10.1093%2Fnar%2Fgkn954&volume=37&publication_year=2009&author=Schaefer%2CM&author=Pollex%2CT&author=Hanna%2CK&author=Lyko%2CF?
- How much income does https://doi.org/10.1093%2Fnar%2Fgki012 have?
- Get to know what's the income of http://scholar.google.com/scholar_lookup?&title=Compilation%20of%20tRNA%20sequences%20and%20sequences%20of%20tRNA%20genes&journal=Nucleic%20Acids%20Res.&doi=10.1093%2Fnar%2Fgki012&volume=33&pages=D139-D140&publication_year=2005&author=Sprinzl%2CM&author=Vassilenko%2CKS
- What are the earnings of https://doi.org/10.1002%2Fwrna.79?
- How much does http://scholar.google.com/scholar_lookup?&title=RNA%20nucleotide%20methylation&journal=Wiley%20Interdiscip.%20Rev.%20RNA&doi=10.1002%2Fwrna.79&volume=2&pages=611-631&publication_year=2011&author=Motorin%2CY&author=Helm%2CM generate monthly?
- What's https://doi.org/10.1016%2Fj.febslet.2009.11.049's gross income?
- How much does http://scholar.google.com/scholar_lookup?&title=Do%20all%20modifications%20benefit%20all%20tRNAs%3F&journal=FEBS%20Lett.&doi=10.1016%2Fj.febslet.2009.11.049&volume=584&pages=265-271&publication_year=2010&author=Phizicky%2CEM&author=Alfonzo%2CJD earn?
- How much income is https://doi.org/10.1016%2Fj.molcel.2005.10.036 earning monthly?
- What's the revenue for http://scholar.google.com/scholar_lookup?&title=Rapid%20tRNA%20decay%20can%20result%20from%20lack%20of%20nonessential%20modifications&journal=Mol.%20Cell&doi=10.1016%2Fj.molcel.2005.10.036&volume=21&pages=87-96&publication_year=2006&author=Alexandrov%2CA?
- How much does https://doi.org/10.1101%2Fgad.1654308 generate monthly?
- What's the total monthly financial gain of http://scholar.google.com/scholar_lookup?&title=Degradation%20of%20several%20hypomodified%20mature%20tRNA%20species%20in%20Saccharomyces%20cerevisiae%20is%20mediated%20by%20Met22%20and%20the%205%E2%80%B2-3%E2%80%B2%20exonucleases%20Rat1%20and%20Xrn1&journal=Genes%20Dev.&doi=10.1101%2Fgad.1654308&volume=22&pages=1369-1380&publication_year=2008&author=Chernyakov%2CI&author=Whipple%2CJM&author=Kotelawala%2CL&author=Grayhack%2CEJ&author=Phizicky%2CEM?
- Check the income stats for https://doi.org/10.1371%2Fjournal.pgen.1001247
- What's the income generated by http://scholar.google.com/scholar_lookup?&title=A%20quantitative%20systems%20approach%20reveals%20dynamic%20control%20of%20tRNA%20modifications%20during%20cellular%20stress&journal=PLoS%20Genet.&doi=10.1371%2Fjournal.pgen.1001247&volume=6&publication_year=2010&author=Chan%2CCT each month?
- How much does https://doi.org/10.1126%2Fscience.1192430 gross monthly?
- http://scholar.google.com/scholar_lookup?&title=Dom34%3AHbs1%20promotes%20subunit%20dissociation%20and%20peptidyl-tRNA%20drop-off%20to%20initiate%20no-go%20decay&journal=Science&doi=10.1126%2Fscience.1192430&volume=330&pages=369-372&publication_year=2010&author=Shoemaker%2CCJ&author=Eyler%2CDE&author=Green%2CR's total income per month
- https://doi.org/10.1016%2Fj.molcel.2011.06.022's revenue stream
- What are the earnings of http://scholar.google.com/scholar_lookup?&title=Angiogenin-induced%20tRNA%20fragments%20inhibit%20translation%20initiation&journal=Mol.%20Cell&doi=10.1016%2Fj.molcel.2011.06.022&volume=43&pages=613-623&publication_year=2011&author=Ivanov%2CP&author=Emara%2CMM&author=Villen%2CJ&author=Gygi%2CSP&author=Anderson%2CP?
- How much income does https://doi.org/10.4161%2Fepi.6.1.13418 have?
- Profit of http://scholar.google.com/scholar_lookup?&title=The%20DNA%20methyltranferase%20Dnmt2%20participates%20in%20RNA%20processing%20during%20cellular%20stress&journal=Epigenetics&doi=10.4161%2Fepi.6.1.13418&volume=6&pages=103-113&publication_year=2011&author=Thiagarajan%2CD&author=Dev%2CRR&author=Khosla%2CS
- What's the total monthly financial gain of https://doi.org/10.1038%2Fncomms1938?
- Financial intake of http://scholar.google.com/scholar_lookup?&title=Reprogramming%20of%20tRNA%20modifications%20controls%20the%20oxidative%20stress%20response%20by%20codon-biased%20translation%20of%20proteins&journal=Nat.%20Commun.&doi=10.1038%2Fncomms1938&volume=3&publication_year=2012&author=Chan%2CCT
- Learn about the earnings of https://doi.org/10.1016%2Fj.stem.2008.03.013
- What is the monthly revenue of http://scholar.google.com/scholar_lookup?&title=A%20hierarchical%20network%20controls%20protein%20translation%20during%20murine%20embryonic%20stem%20cell%20self-renewal%20and%20differentiation&journal=Cell%20Stem%20Cell&doi=10.1016%2Fj.stem.2008.03.013&volume=2&pages=448-460&publication_year=2008&author=Sampath%2CP?
- What's the monthly income of https://doi.org/10.1101%2Fgad.1472907?
- What's the revenue for http://scholar.google.com/scholar_lookup?&title=Dnmt2%20functions%20in%20the%20cytoplasm%20to%20promote%20liver%2C%20brain%2C%20and%20retina%20development%20in%20zebrafish&journal=Genes%20Dev.&doi=10.1101%2Fgad.1472907&volume=21&pages=261-266&publication_year=2007&author=Rai%2CK?
- How profitable is https://doi.org/10.1038%2Fnchembio.482?
- How much does http://scholar.google.com/scholar_lookup?&title=Grand%20challenge%20commentary%3A%20RNA%20epigenetics%3F&journal=Nat.%20Chem.%20Biol.&doi=10.1038%2Fnchembio.482&volume=6&pages=863-865&publication_year=2010&author=He%2CC rake in every month?
- What is the monthly revenue of https://doi.org/10.1083%2Fjcb.17.2.299?
- How much money does http://scholar.google.com/scholar_lookup?&title=Quantitative%20studies%20of%20the%20growth%20of%20mouse%20embryo%20cells%20in%20culture%20and%20their%20development%20into%20established%20lines&journal=J.%20Cell%20Biol.&doi=10.1083%2Fjcb.17.2.299&volume=17&pages=299-313&publication_year=1963&author=Todaro%2CGJ&author=Green%2CH generate?
- What's https://doi.org/10.1093%2Fnar%2Fgkr449's gross income?
- See how much http://scholar.google.com/scholar_lookup?&title=A%20multifunctional%20bioconjugate%20module%20for%20versatile%20photoaffinity%20labeling%20and%20click%20chemistry%20of%20RNA&journal=Nucleic%20Acids%20Res.&doi=10.1093%2Fnar%2Fgkr449&volume=39&pages=7348-7360&publication_year=2011&author=Kellner%2CS&author=Seidu-Larry%2CS&author=Burhenne%2CJ&author=Motorin%2CY&author=Helm%2CM makes per month
- Profit of https://citation-needed.springer.com/v2/references/10.1038/nsmb.2357?format=refman&flavour=references
- How profitable is https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Francesca%20Tuorto?
- How much money does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Francesca%20Tuorto%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en make?
- How much profit is https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Reinhard%20Liebers making per month?
- What's the profit of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Reinhard%20Liebers%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- Revenue of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Tanja%20Musch
- Discover the revenue of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Tanja%20Musch%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
- Financial intake of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Matthias%20Schaefer
- Monthly income for https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Matthias%20Schaefer%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
- What's the income generated by https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Sarah%20Hofmann each month?
- What's https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Sarah%20Hofmann%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en's gross income?
- Financial intake of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Stefanie%20Kellner
- How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Stefanie%20Kellner%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en rake in every month?
- https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Michaela%20Frye's revenue stream
- Earnings of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Michaela%20Frye%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
- What's the monthly income of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Mark%20Helm?
- How profitable is https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Mark%20Helm%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Georg%20Stoecklin gross monthly?
- Monthly income for https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Georg%20Stoecklin%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
- What's the income generated by https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Frank%20Lyko each month?
- What are the total earnings of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Frank%20Lyko%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- Revenue of https://static-content.springer.com/esm/art%3A10.1038%2Fnsmb.2357/MediaObjects/41594_2012_BFnsmb2357_MOESM11_ESM.pdf
- Income figures for https://s100.copyright.com/AppDispatchServlet?title=RNA%20cytosine%20methylation%20by%20Dnmt2%20and%20NSun2%20promotes%20tRNA%20stability%20and%20protein%20synthesis&author=Francesca%20Tuorto%20et%20al&contentID=10.1038%2Fnsmb.2357©right=Springer%20Nature%20America%2C%20Inc.&publication=1545-9993&publicationDate=2012-08-12&publisherName=SpringerNature&orderBeanReset=true
- How much does https://citation-needed.springer.com/v2/references/10.1038/nsmb.2357?format=refman&flavour=citation generate monthly?
- What are the earnings of https://doi.org/10.1038/s41388-024-03069-2?
- What's the income of https://doi.org/10.1038/s41580-023-00690-z?
- Earnings of https://doi.org/10.1038/s41386-024-01813-6
- Learn how profitable https://doi.org/10.1186/s12864-023-09432-z is on a monthly basis
- How much profit is https://doi.org/10.1186/s13048-023-01172-8 making per month?
- How much does https://www.protocols.io/ make?
- Financial intake of https://www.natureindex.com/
- Monthly income for http://www.naturechina.com
- How much profit does https://www.natureasia.com/ja-jp make?
Analytics and Tracking {๐}
- Google Tag Manager
Libraries {๐}
- Prism.js
- Zoom.js
Emails and Hosting {โ๏ธ}
Mail Servers:
- mxa-002c5801.gslb.pphosted.com
- mxb-002c5801.gslb.pphosted.com
Name Servers:
- pdns1.ultradns.net
- pdns2.ultradns.net
- pdns3.ultradns.org
- pdns4.ultradns.org
- pdns5.ultradns.info
- pdns6.ultradns.co.uk
CDN Services {๐ฆ}
- Crossref