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We are analyzing https://www.nature.com/articles/nri2607.

Title:
Interdependence of hypoxic and innate immune responses | Nature Reviews Immunology
Description:
At low levels of oxygen at sites of tissue infection, innate immune cells can adapt to survive and even enhance their antimicrobial functions. Recent studies show how this is controlled by hypoxia-inducible factor (HIF) downstream of nuclear factor-κB activation. Hypoxia-inducible factor (HIF) is an important transcriptional regulator of cell metabolism and the adaptation to cellular stress caused by oxygen deficiency (hypoxia). Phagocytic cells have an essential role in innate immune defence against pathogens and this is a battle that takes place mainly in the hypoxic microenvironments of infected tissues. It has now become clear that HIF promotes the bactericidal activities of phagocytic cells and supports the innate immune functions of dendritic cells, mast cells and epithelial cells. In response to microbial pathogens, HIF expression is upregulated through pathways involving the key immune response regulator nuclear factor-κB, highlighting an interdependence of the innate immune and hypoxic responses to infection and tissue damage. In turn, HIF-driven innate immune responses have important consequences for both the pathogen and the host, such that the tissue microenvironment fundamentally influences susceptibility to infectious disease.
Website Age:
30 years and 10 months (reg. 1994-08-11).

Matching Content Categories {📚}

  • Education
  • Science
  • Health & Fitness

Content Management System {📝}

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Custom-built

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🌆 Monumental Traffic: 20M - 50M visitors per month


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How Much Does Nature.com Make? {💰}


Display Ads {🎯}

$536,300 per month
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Keywords {🔍}

pubmed, article, google, scholar, cas, factor, central, hypoxiainducible, hifα, cells, hif, cell, nature, hypoxia, expression, innate, hypoxic, activation, immune, human, protein, access, gene, biol, response, transcriptional, role, immunol, epithelial, blood, cancer, sci, essential, content, nizet, infection, macrophages, host, clin, mol, usa, regulates, activity, nfκb, bacterial, factorα, virus, cookies, johnson, conditions,

Topics {✒️}

basic-helix-loop-helix-pas heterodimer regulated nature portfolio permissions reprints privacy policy multi-component protein-degrading complex stabilizing hypoxia-inducible factor-1α advertising hif-1α-dependent nf-κb activity nature med pi3k-hif-1α-vegf axis nature 453 nature social media regional manifestations cytokine-induced hif-1α expression hypoxia-inducible factor 1α hypoxia inducible factor-1α hypoxia-inducible factor-1α z-dna forming microsatellite development epithelial hypoxia-inducible factor-1 hypoxia-induced nfκb activity unstable left-handed form gut ischemia/reperfusion injury o2-regulated prolyl hydroxylation hypoxia-induced neutrophil survival desferrioxamine-stimulated hmc-1 cells hif-1α-null embryos hif-1α expression regulates activation-inducible short isoform nuclear factor induced hif-1α -dependent manner nuclear factor κb personal data protein induces angiogenesis hypoxia-inducible factor 1 hypoxia-inducible factor hypoxia inducible factor hypoxia-inducible factor-1 myeloid cell-mediated inflammation springerlink instant access competing financial interests hif-1α transcriptional activity data protection permissions persistent hif-1α activation innate immune defence murine experimental colitis toxoplasma gondii growth lipopolysaccharide-induced sepsis

Questions {❓}

  • HIF-1α: a master regulator of innate host defenses?

Schema {🗺️}

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         description: At low levels of oxygen at sites of tissue infection, innate immune cells can adapt to survive and even enhance their antimicrobial functions. Recent studies show how this is controlled by hypoxia-inducible factor (HIF) downstream of nuclear factor-κB activation. Hypoxia-inducible factor (HIF) is an important transcriptional regulator of cell metabolism and the adaptation to cellular stress caused by oxygen deficiency (hypoxia). Phagocytic cells have an essential role in innate immune defence against pathogens and this is a battle that takes place mainly in the hypoxic microenvironments of infected tissues. It has now become clear that HIF promotes the bactericidal activities of phagocytic cells and supports the innate immune functions of dendritic cells, mast cells and epithelial cells. In response to microbial pathogens, HIF expression is upregulated through pathways involving the key immune response regulator nuclear factor-κB, highlighting an interdependence of the innate immune and hypoxic responses to infection and tissue damage. In turn, HIF-driven innate immune responses have important consequences for both the pathogen and the host, such that the tissue microenvironment fundamentally influences susceptibility to infectious disease.
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Emails and Hosting {✉️}

Mail Servers:

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