We are analyzing https://link.springer.com/article/10.1007/s12016-007-0037-4.

Title:
Innate Immunity: A Cutaneous Perspective | Clinical Reviews in Allergy & Immunology
Description:
The first responsibility for protection against microbial infection rests on the normal function of the innate immune system. This system establishes an antimicrobial barrier, recognizes attempts to breach this barrier, and responds rapidly to danger, all based on an innate defense system. Here, we review this system as it applies to mammalian skin, highlighting how a physical, cellular, and chemical barrier is formed to resist infection. When challenged, the diverse cellular components of the skin recognize the nature of the challenge and respond with an appropriate antimicrobial program including the release of antimicrobial peptides and, when necessary, recruitment and coordination with adaptive immune responses. Recent insights into these processes have advanced the understanding of disease pathogenesis and provided new therapeutic options for a variety of skin diseases.
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28 years and 1 months (reg. 1997-05-29).

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Keywords {🔍}

google, scholar, pubmed, cas, innate, immune, cells, system, immunity, adaptive, human, response, antimicrobial, skin, tlr, immunol, receptors, cell, inflammatory, tlrs, activation, cytokines, role, receptor, recognition, amps, defense, responses, disease, important, pathogens, molecules, complement, expression, bacterial, peptides, gallo, infection, production, keratinocytes, cellular, components, elements, family, cytokine, biol, function, recognize, signaling, nod,

Topics {✒️}

cd44/ha-dependent primary adhesion recognizes double-stranded rna phospholipase c-dependent pathway age-related macular degeneration gut-derived sepsis caused serum mannose-binding protein transcription factor nf-κb conformation-dependent antibacterial activity proline-rich antimicrobial peptide human beta-defensin-2 functions transcription factor nf-kb short-lived effector cells arginine-rich antimicrobial peptides turn activates mapk-kinases full size image epithelial cell-derived cathelicidin soluble/secretory/chemical group cathelicidin-derived antimicrobial peptides ligand-binding domains composed janeway ca jr c-type lectin family lethal gram-positive infection lymphoid cells pkr activates nf-kb low-molecular-weight ha nod1/apaf-1 family member tumor necrosis factor gram-positive bacterial ligands trif-related adaptor molecule human beta-defensin-3 de jong dj immune response modifier privacy choices/manage cookies increased antigen-presenting capacity mannose-binding protein cell proliferation/cytokine production ifn-alpha/beta rich-ss rna innate immune responses leucine-rich repeats protein kinase rip2 familial cold urticaria adaptive immune responses macrophage mannose receptor beta-defensin-2 expression defining protective responses protein kinase receptor mannose-rich isolate human card4 protein bacterial cell walls

Questions {❓}

How Does Innate Immunity Work?
How Separate Really are Innate and Adaptive Immune Systems?
Why Do We Care?

Schema {🗺️}

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         headline:Innate Immunity: A Cutaneous Perspective
         description:The first responsibility for protection against microbial infection rests on the normal function of the innate immune system. This system establishes an antimicrobial barrier, recognizes attempts to breach this barrier, and responds rapidly to danger, all based on an innate defense system. Here, we review this system as it applies to mammalian skin, highlighting how a physical, cellular, and chemical barrier is formed to resist infection. When challenged, the diverse cellular components of the skin recognize the nature of the challenge and respond with an appropriate antimicrobial program including the release of antimicrobial peptides and, when necessary, recruitment and coordination with adaptive immune responses. Recent insights into these processes have advanced the understanding of disease pathogenesis and provided new therapeutic options for a variety of skin diseases.
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      description:The first responsibility for protection against microbial infection rests on the normal function of the innate immune system. This system establishes an antimicrobial barrier, recognizes attempts to breach this barrier, and responds rapidly to danger, all based on an innate defense system. Here, we review this system as it applies to mammalian skin, highlighting how a physical, cellular, and chemical barrier is formed to resist infection. When challenged, the diverse cellular components of the skin recognize the nature of the challenge and respond with an appropriate antimicrobial program including the release of antimicrobial peptides and, when necessary, recruitment and coordination with adaptive immune responses. Recent insights into these processes have advanced the understanding of disease pathogenesis and provided new therapeutic options for a variety of skin diseases.
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         Immunology
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