Here's how NATURE.COM makes money* and how much!

*Please read our disclaimer before using our estimates.
Loading...

NATURE . COM {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Nature.com Make Money
  6. How Much Does Nature.com Make
  7. Keywords
  8. Topics
  9. Questions
  10. Schema
  11. Social Networks
  12. External Links
  13. Analytics And Tracking
  14. Libraries
  15. Hosting Providers
  16. CDN Services

We are analyzing https://www.nature.com/articles/nri2607.

Title:
Interdependence of hypoxic and innate immune responses | Nature Reviews Immunology
Description:
At low levels of oxygen at sites of tissue infection, innate immune cells can adapt to survive and even enhance their antimicrobial functions. Recent studies show how this is controlled by hypoxia-inducible factor (HIF) downstream of nuclear factor-κB activation. Hypoxia-inducible factor (HIF) is an important transcriptional regulator of cell metabolism and the adaptation to cellular stress caused by oxygen deficiency (hypoxia). Phagocytic cells have an essential role in innate immune defence against pathogens and this is a battle that takes place mainly in the hypoxic microenvironments of infected tissues. It has now become clear that HIF promotes the bactericidal activities of phagocytic cells and supports the innate immune functions of dendritic cells, mast cells and epithelial cells. In response to microbial pathogens, HIF expression is upregulated through pathways involving the key immune response regulator nuclear factor-κB, highlighting an interdependence of the innate immune and hypoxic responses to infection and tissue damage. In turn, HIF-driven innate immune responses have important consequences for both the pathogen and the host, such that the tissue microenvironment fundamentally influences susceptibility to infectious disease.
Website Age:
30 years and 10 months (reg. 1994-08-11).

Matching Content Categories {📚}

  • Education
  • Science
  • Health & Fitness

Content Management System {📝}

What CMS is nature.com built with?

Custom-built

No common CMS systems were detected on Nature.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of nature.com audience?

🌆 Monumental Traffic: 20M - 50M visitors per month


Based on our best estimate, this website will receive around 42,555,829 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Nature.com Make Money? {💸}


Display Ads {🎯}


The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.

Ads are managed by yourbow.com. Particular relationships are as follows:

Direct Advertisers (10)
google.com, pmc.com, doceree.com, yourbow.com, audienciad.com, onlinemediasolutions.com, advibe.media, aps.amazon.com, getmediamx.com, onomagic.com

Reseller Advertisers (38)
conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.com

How Much Does Nature.com Make? {💰}


Display Ads {🎯}

$536,300 per month
Estimations show Nature.com's display ad online revenue falls between $357,511 and $983,155 per month.

Keywords {🔍}

pubmed, article, google, scholar, cas, factor, central, hypoxiainducible, hifα, cells, hif, cell, nature, hypoxia, expression, innate, hypoxic, activation, immune, human, protein, access, gene, biol, response, transcriptional, role, immunol, epithelial, blood, cancer, sci, essential, content, nizet, infection, macrophages, host, clin, mol, usa, regulates, activity, nfκb, bacterial, factorα, virus, cookies, johnson, conditions,

Topics {✒️}

basic-helix-loop-helix-pas heterodimer regulated nature portfolio permissions reprints privacy policy multi-component protein-degrading complex stabilizing hypoxia-inducible factor-1α advertising hif-1α-dependent nf-κb activity nature med pi3k-hif-1α-vegf axis nature 453 nature social media regional manifestations cytokine-induced hif-1α expression hypoxia-inducible factor 1α hypoxia inducible factor-1α hypoxia-inducible factor-1α z-dna forming microsatellite development epithelial hypoxia-inducible factor-1 hypoxia-induced nfκb activity unstable left-handed form gut ischemia/reperfusion injury o2-regulated prolyl hydroxylation hypoxia-induced neutrophil survival desferrioxamine-stimulated hmc-1 cells hif-1α-null embryos hif-1α expression regulates activation-inducible short isoform nuclear factor induced hif-1α -dependent manner nuclear factor κb personal data protein induces angiogenesis hypoxia-inducible factor 1 hypoxia-inducible factor hypoxia inducible factor hypoxia-inducible factor-1 myeloid cell-mediated inflammation springerlink instant access competing financial interests hif-1α transcriptional activity data protection permissions persistent hif-1α activation innate immune defence murine experimental colitis toxoplasma gondii growth lipopolysaccharide-induced sepsis

Questions {❓}

  • HIF-1α: a master regulator of innate host defenses?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Interdependence of hypoxic and innate immune responses
         description: At low levels of oxygen at sites of tissue infection, innate immune cells can adapt to survive and even enhance their antimicrobial functions. Recent studies show how this is controlled by hypoxia-inducible factor (HIF) downstream of nuclear factor-κB activation. Hypoxia-inducible factor (HIF) is an important transcriptional regulator of cell metabolism and the adaptation to cellular stress caused by oxygen deficiency (hypoxia). Phagocytic cells have an essential role in innate immune defence against pathogens and this is a battle that takes place mainly in the hypoxic microenvironments of infected tissues. It has now become clear that HIF promotes the bactericidal activities of phagocytic cells and supports the innate immune functions of dendritic cells, mast cells and epithelial cells. In response to microbial pathogens, HIF expression is upregulated through pathways involving the key immune response regulator nuclear factor-κB, highlighting an interdependence of the innate immune and hypoxic responses to infection and tissue damage. In turn, HIF-driven innate immune responses have important consequences for both the pathogen and the host, such that the tissue microenvironment fundamentally influences susceptibility to infectious disease.
         datePublished:
         dateModified:
         pageStart:609
         pageEnd:617
         sameAs:https://doi.org/10.1038/nri2607
         keywords:
            Biomedicine
            general
            Immunology
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnri2607/MediaObjects/41577_2009_Article_BFnri2607_Fig1_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnri2607/MediaObjects/41577_2009_Article_BFnri2607_Fig2_HTML.jpg
         isPartOf:
            name:Nature Reviews Immunology
            issn:
               1474-1741
               1474-1733
            volumeNumber:9
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Nature Publishing Group UK
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Victor Nizet
               affiliation:
                     name:Department of Pediatrics
                     address:
                        name:Department of Pediatrics, La Jolla, USA
                        type:PostalAddress
                     type:Organization
                     name:Skaggs School of Pharmacy and Pharmaceutical Sciences
                     address:
                        name:Skaggs School of Pharmacy and Pharmaceutical Sciences, La Jolla, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Randall S. Johnson
               affiliation:
                     name:Department of Pediatrics
                     address:
                        name:Department of Pediatrics, La Jolla, USA
                        type:PostalAddress
                     type:Organization
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Interdependence of hypoxic and innate immune responses
      description: At low levels of oxygen at sites of tissue infection, innate immune cells can adapt to survive and even enhance their antimicrobial functions. Recent studies show how this is controlled by hypoxia-inducible factor (HIF) downstream of nuclear factor-κB activation. Hypoxia-inducible factor (HIF) is an important transcriptional regulator of cell metabolism and the adaptation to cellular stress caused by oxygen deficiency (hypoxia). Phagocytic cells have an essential role in innate immune defence against pathogens and this is a battle that takes place mainly in the hypoxic microenvironments of infected tissues. It has now become clear that HIF promotes the bactericidal activities of phagocytic cells and supports the innate immune functions of dendritic cells, mast cells and epithelial cells. In response to microbial pathogens, HIF expression is upregulated through pathways involving the key immune response regulator nuclear factor-κB, highlighting an interdependence of the innate immune and hypoxic responses to infection and tissue damage. In turn, HIF-driven innate immune responses have important consequences for both the pathogen and the host, such that the tissue microenvironment fundamentally influences susceptibility to infectious disease.
      datePublished:
      dateModified:
      pageStart:609
      pageEnd:617
      sameAs:https://doi.org/10.1038/nri2607
      keywords:
         Biomedicine
         general
         Immunology
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnri2607/MediaObjects/41577_2009_Article_BFnri2607_Fig1_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnri2607/MediaObjects/41577_2009_Article_BFnri2607_Fig2_HTML.jpg
      isPartOf:
         name:Nature Reviews Immunology
         issn:
            1474-1741
            1474-1733
         volumeNumber:9
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Nature Publishing Group UK
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Victor Nizet
            affiliation:
                  name:Department of Pediatrics
                  address:
                     name:Department of Pediatrics, La Jolla, USA
                     type:PostalAddress
                  type:Organization
                  name:Skaggs School of Pharmacy and Pharmaceutical Sciences
                  address:
                     name:Skaggs School of Pharmacy and Pharmaceutical Sciences, La Jolla, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Randall S. Johnson
            affiliation:
                  name:Department of Pediatrics
                  address:
                     name:Department of Pediatrics, La Jolla, USA
                     type:PostalAddress
                  type:Organization
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Nature Reviews Immunology
      issn:
         1474-1741
         1474-1733
      volumeNumber:9
Organization:
      name:Nature Publishing Group UK
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Department of Pediatrics
      address:
         name:Department of Pediatrics, La Jolla, USA
         type:PostalAddress
      name:Skaggs School of Pharmacy and Pharmaceutical Sciences
      address:
         name:Skaggs School of Pharmacy and Pharmaceutical Sciences, La Jolla, USA
         type:PostalAddress
      name:Department of Pediatrics
      address:
         name:Department of Pediatrics, La Jolla, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Victor Nizet
      affiliation:
            name:Department of Pediatrics
            address:
               name:Department of Pediatrics, La Jolla, USA
               type:PostalAddress
            type:Organization
            name:Skaggs School of Pharmacy and Pharmaceutical Sciences
            address:
               name:Skaggs School of Pharmacy and Pharmaceutical Sciences, La Jolla, USA
               type:PostalAddress
            type:Organization
      name:Randall S. Johnson
      affiliation:
            name:Department of Pediatrics
            address:
               name:Department of Pediatrics, La Jolla, USA
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Department of Pediatrics, La Jolla, USA
      name:Skaggs School of Pharmacy and Pharmaceutical Sciences, La Jolla, USA
      name:Department of Pediatrics, La Jolla, USA
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

Social Networks {👍}(2)

External Links {🔗}(299)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Foundation
  • Prism.js
  • Zoom.js

Emails and Hosting {✉️}

Mail Servers:

  • mxa-002c5801.gslb.pphosted.com
  • mxb-002c5801.gslb.pphosted.com

Name Servers:

  • pdns1.ultradns.net
  • pdns2.ultradns.net
  • pdns3.ultradns.org
  • pdns4.ultradns.org
  • pdns5.ultradns.info
  • pdns6.ultradns.co.uk

CDN Services {📦}

  • Crossref

6.34s.