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Drugging the 'undruggable' cancer targets | Nature Reviews Cancer
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Nature Reviews Cancer - In this Viewpoint article, we asked four scientists working to target important, but so-called
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- Drugging the undruggable RAS: mission possible?
- How to unleash mitochondrial apoptotic blockades to kill cancers?
- Is NF-κB a good target for cancer therapy?
- Nanoparticle-siRNA: a potential cancer therapy?
- Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?
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headline:Drugging the 'undruggable' cancer targets
description:In this Viewpoint article, we asked four scientists working to target important, but so-called 'undruggable', proteins in cancer for their opinions on the most crucial advances, as well as the challenges and what the future holds for this important area of cancer research. The term 'undruggable' was coined to describe proteins that could not be targeted pharmacologically. However, progress is being made to 'drug' many of these targets, and therefore more appropriate terms might be 'difficult to drug' or 'yet to be drugged'. Many desirable targets in cancer fall into this category, including the RAS and MYC oncogenes, and pharmacologically targeting these intractable proteins is now a key challenge in cancer research that requires innovation and the development of new technologies. In this Viewpoint article, we asked four scientists working in this field for their opinions on the most crucial advances, as well as the challenges and what the future holds for this important area of research.
datePublished:2017-06-23T00:00:00Z
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Drug development
Oncogenes
Targeted therapies
Tumour-suppressor proteins
Biomedicine
general
Cancer Research
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headline:Drugging the 'undruggable' cancer targets
description:In this Viewpoint article, we asked four scientists working to target important, but so-called 'undruggable', proteins in cancer for their opinions on the most crucial advances, as well as the challenges and what the future holds for this important area of cancer research. The term 'undruggable' was coined to describe proteins that could not be targeted pharmacologically. However, progress is being made to 'drug' many of these targets, and therefore more appropriate terms might be 'difficult to drug' or 'yet to be drugged'. Many desirable targets in cancer fall into this category, including the RAS and MYC oncogenes, and pharmacologically targeting these intractable proteins is now a key challenge in cancer research that requires innovation and the development of new technologies. In this Viewpoint article, we asked four scientists working in this field for their opinions on the most crucial advances, as well as the challenges and what the future holds for this important area of research.
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Drug development
Oncogenes
Targeted therapies
Tumour-suppressor proteins
Biomedicine
general
Cancer Research
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