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Drugging the 'undruggable' cancer targets | Nature Reviews Cancer
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Nature Reviews Cancer - In this Viewpoint article, we asked four scientists working to target important, but so-called
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nature portfolio journals permissions reprints privacy policy nature portfolio advertising kras-g12c-targeting drugs licensed scientific founder social media european research council tki-treated lung adenocarcinoma small-cell lung cancer cancer research ras/mek/erk pathways prolongs rbc half-life her2-elf3-kras axis nature+ nature 503 nature 497 nature 468 nature 538 nature 514 nature 535 nature 455 nature small-molecule inhibitors personal data research viewpoint article data protection permissions androgen receptor inhibitors ras-transformed cells springerlink instant access targeted protein degradation ras superfamily gefs privacy targeting disordered proteins dragging ras back oncogene ews–fli1 oncogenic kras output subscription content small molecules targeting cancer genome landscapes diverse cancer models laura soucek oncogenic kras addiction explore content 'undruggable' cancer targets development institutional subscriptions read
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- Drugging the undruggable RAS: mission possible?
- How to unleash mitochondrial apoptotic blockades to kill cancers?
- Is NF-κB a good target for cancer therapy?
- Nanoparticle-siRNA: a potential cancer therapy?
- Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?
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headline:Drugging the 'undruggable' cancer targets
description:In this Viewpoint article, we asked four scientists working to target important, but so-called 'undruggable', proteins in cancer for their opinions on the most crucial advances, as well as the challenges and what the future holds for this important area of cancer research. The term 'undruggable' was coined to describe proteins that could not be targeted pharmacologically. However, progress is being made to 'drug' many of these targets, and therefore more appropriate terms might be 'difficult to drug' or 'yet to be drugged'. Many desirable targets in cancer fall into this category, including the RAS and MYC oncogenes, and pharmacologically targeting these intractable proteins is now a key challenge in cancer research that requires innovation and the development of new technologies. In this Viewpoint article, we asked four scientists working in this field for their opinions on the most crucial advances, as well as the challenges and what the future holds for this important area of research.
datePublished:2017-06-23T00:00:00Z
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Drug development
Oncogenes
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headline:Drugging the 'undruggable' cancer targets
description:In this Viewpoint article, we asked four scientists working to target important, but so-called 'undruggable', proteins in cancer for their opinions on the most crucial advances, as well as the challenges and what the future holds for this important area of cancer research. The term 'undruggable' was coined to describe proteins that could not be targeted pharmacologically. However, progress is being made to 'drug' many of these targets, and therefore more appropriate terms might be 'difficult to drug' or 'yet to be drugged'. Many desirable targets in cancer fall into this category, including the RAS and MYC oncogenes, and pharmacologically targeting these intractable proteins is now a key challenge in cancer research that requires innovation and the development of new technologies. In this Viewpoint article, we asked four scientists working in this field for their opinions on the most crucial advances, as well as the challenges and what the future holds for this important area of research.
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Drug development
Oncogenes
Targeted therapies
Tumour-suppressor proteins
Biomedicine
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