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Keywords {🔍}

pubmed, cancer, google, scholar, cas, nature, central, article, myc, drug, targeting, access, cell, soucek, nat, targets, research, therapy, rev, content, undruggable, inhibitors, dang, kras, usa, cookies, drugging, laura, proteins, ras, resistance, therapeutic, biol, res, molecular, privacy, information, shokat, development, target, clin, discov, chem, data, reviews, chi, reddy, future, open, references,

Topics {✒️}

nature portfolio journals permissions reprints privacy policy nature portfolio advertising kras-g12c-targeting drugs licensed scientific founder social media european research council tki-treated lung adenocarcinoma small-cell lung cancer cancer research ras/mek/erk pathways prolongs rbc half-life her2-elf3-kras axis nature+ nature 503 nature 497 nature 468 nature 538 nature 514 nature 535 nature 455 nature small-molecule inhibitors personal data research data protection androgen receptor inhibitors ras-transformed cells viewpoint article springerlink instant access subscription content targeted protein degradation explore content ras superfamily gefs privacy targeting disordered proteins dragging ras back oncogene ews–fli1 oncogenic kras output small molecules targeting laura soucek cancer genome landscapes diverse cancer models permissions oncogenic kras addiction 'undruggable' cancer targets development institutional subscriptions read

Questions {❓}

• Drugging the undruggable RAS: mission possible?
• How to unleash mitochondrial apoptotic blockades to kill cancers?
• Is NF-κB a good target for cancer therapy?
• Nanoparticle-siRNA: a potential cancer therapy?
• Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?

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