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We are analyzing https://www.nature.com/articles/nm.1851.

Title:
Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function | Nature Medicine
Description:
Chaperone-mediated autophagy (CMA), a mechanism for the lysosomal degradation of proteins, declines in aging cells. Using transgenic mice in which such a decline does not occur in the liver, the authors found that preserving CMA leads to reduced accumulation of damaged proteins and improved organ function in aged mice ( pages 909–910 ). Chaperone-mediated autophagy (CMA), a selective mechanism for degradation of cytosolic proteins in lysosomes, contributes to the removal of altered proteins as part of the cellular quality-control systems1,2. We have previously found that CMA activity declines in aged organisms and have proposed that this failure in cellular clearance could contribute to the accumulation of altered proteins, the abnormal cellular homeostasis and, eventually, the functional loss characteristic of aged organisms. To determine whether these negative features of aging can be prevented by maintaining efficient autophagic activity until late in life, in this work we have corrected the CMA defect in aged rodents. We have generated a double transgenic mouse model in which the amount of the lysosomal receptor for CMA, previously shown to decrease in abundance with age3, can be modulated. We have analyzed in this model the consequences of preventing the age-dependent decrease in receptor abundance in aged rodents at the cellular and organ levels. We show here that CMA activity is maintained until advanced ages if the decrease in the receptor abundance is prevented and that preservation of autophagic activity is associated with lower intracellular accumulation of damaged proteins, better ability to handle protein damage and improved organ function.
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30 years and 10 months (reg. 1994-08-11).

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Keywords {🔍}

article, pubmed, google, scholar, autophagy, cas, nature, chaperonemediated, cuervo, aging, access, biol, content, protein, function, cellular, receptor, dice, cell, cookies, medicine, liver, selective, degradation, privacy, maria, cma, proteins, activity, lysosomal, central, research, data, information, zhang, lysosomes, aged, open, disease, chem, biology, supplementary, advertising, subscribe, hepatic, ana, altered, accumulation, autophagic, mouse,

Topics {✒️}

nature portfolio permissions reprints privacy policy aging research advertising nature 451 nature social media ana maria cuervo chaperone-mediated autophagy depends author information authors author correspondence cellular quality-control systems1 chaperone-mediated autophagy springerlink instant access personal data fatty acid oxidation content live longer data protection permissions article zhang wattiaux-de coninck improved organ function hepatic function cell function hepatic drug metabolism privacy cell-type-specific glenn foundation award maintaining 'clean' cells aging grants ag021904 age-related decline trends cell biol selective mitochondrial autophagy european economic area abnormal cellular homeostasis functional loss characteristic issue learn institutional subscriptions read mutant α-synuclein zoxazolamine-induced paralysis folin phenol reagent albert einstein college kidney diseases dk041918 mtor inhibitors joan gtp energy dependence circadian clock yves explore content subscription content accepting optional cookies

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Age-related changes in liver structure and function: Implications for disease?

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