We are analyzing https://link.springer.com/article/10.1007/bf03189996.

Title:
Zoxazolamine-induced paralysis in two rat substrains: differences in hepatic drug metabolism | European Journal of Drug Metabolism and Pharmacokinetics
Description:
Aldehyde dehydrogenase (ALDH) is involved in the metabolism of endogenous and exogenous, aldehydes originating from biogenic amines, lipids, food and drugs. Rat liver contains at least two cytosolic ALDHs that can be stimulated by inducers of drug metabolism. Phenobarbital-type inducers increase ALDH1 activity while polycyclic aromatic hydrocarbons (such as benzo[α]pyrene) an 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) increase ALDH3c isoenzyme activity. Two rat substrains were isolated according to a different induction of hepatic ALDH after treatment with phenobarbital (PB). Animals that responded to treatment (RR) and those that did not respond (rr) were inbred and divided into two homogenous groups. These animals constituted an ideal experimental model due to their common origin. Apart from the dramatic induction of cytosolic ALDH1 and ALDH3c, the effects of PB on pentoxy-, ethoxy-and methoxy-resorufin-O-dealkylase (P-, E-, and MROD) between the two substrains were also studied. 3-Methylcholanthrene (3MC) greatly increased ALDH3c levels in both substrains, although it was slightly more pronounced in the rr rats, in which it was assessed either as ALDH3c or as total cytosolic ALDH. A similar trend was also noted in EROD, PROD and MROD activities. Dealkylation of the methoxy group was found to be statistically different between the two substrains (rr>RR). The relevance of the biochemical findings with the in vivo hepatic capacity for drug metabolism was investigated by measuring the duration of zoxazolamine paralysis. Both animal substrains were tested with zoxazolamine either without pretreatment or after administration of PB or 3MC: the paralysis produced by zoxazolamine lasted for a longer period in rr than in RR rats. After pretreatment with PB, the duration of paralysis was greatly reduced, but the differences between the two substrains remained. Pretreatment with various doses of 3MC produced differences in the duration of paralysis in RR and rr rats, although the time period was much shorter than that observed in control animals.
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Keywords {🔍}

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Topics {✒️}

month download article/chapter mammalian aldehyde-oxidizing capacity methoxy-resorufin-o-dealkylase ö-unsaturated aldehydic products benzo[α]pyrene aldehyde dehydrogenase activity zoxazolamine-induced paralysis article european journal privacy choices/manage cookies full article pdf rat liver cytosol european economic area related subjects vivo hepatic capacity wistar rat scope submit manuscript polycyclic aromatic hydrocarbons reactive oxygen species folin phenol reagent intriguing model substrate conditions privacy policy lipid-oxidation products drug-metabolizing enzymes journal finder publish accepting optional cookies hepatic drug metabolism 8-tetrachlorodibenzo-p-dioxin purified cytochromes p-450 total cytosolic aldh membrane lipid oxidation aldehyde dehydrogenases rat liver check access instant access aldehydic products article pappas article log cytosolic aldh1 medical school dramatic induction zoxazolamine paralysis vasiliou rights article cite zoxazolamine lasted privacy policy 3mc produced differences personal data phenobarbital enhances books a antiradical activity

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         description:Aldehyde dehydrogenase (ALDH) is involved in the metabolism of endogenous and exogenous, aldehydes originating from biogenic amines, lipids, food and drugs. Rat liver contains at least two cytosolic ALDHs that can be stimulated by inducers of drug metabolism. Phenobarbital-type inducers increase ALDH1 activity while polycyclic aromatic hydrocarbons (such as benzo[α]pyrene) an 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) increase ALDH3c isoenzyme activity. Two rat substrains were isolated according to a different induction of hepatic ALDH after treatment with phenobarbital (PB). Animals that responded to treatment (RR) and those that did not respond (rr) were inbred and divided into two homogenous groups. These animals constituted an ideal experimental model due to their common origin. Apart from the dramatic induction of cytosolic ALDH1 and ALDH3c, the effects of PB on pentoxy-, ethoxy-and methoxy-resorufin-O-dealkylase (P-, E-, and MROD) between the two substrains were also studied. 3-Methylcholanthrene (3MC) greatly increased ALDH3c levels in both substrains, although it was slightly more pronounced in the rr rats, in which it was assessed either as ALDH3c or as total cytosolic ALDH. A similar trend was also noted in EROD, PROD and MROD activities. Dealkylation of the methoxy group was found to be statistically different between the two substrains (rr>RR). The relevance of the biochemical findings with the in vivo hepatic capacity for drug metabolism was investigated by measuring the duration of zoxazolamine paralysis. Both animal substrains were tested with zoxazolamine either without pretreatment or after administration of PB or 3MC: the paralysis produced by zoxazolamine lasted for a longer period in rr than in RR rats. After pretreatment with PB, the duration of paralysis was greatly reduced, but the differences between the two substrains remained. Pretreatment with various doses of 3MC produced differences in the duration of paralysis in RR and rr rats, although the time period was much shorter than that observed in control animals.
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         induction
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         Medical Biochemistry
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