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  1. Analyzed Page
  2. Matching Content Categories
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  6. Keywords
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We began analyzing https://link.springer.com/article/10.1007/s12026-023-09361-9, but it redirected us to https://link.springer.com/article/10.1007/s12026-023-09361-9. The analysis below is for the second page.

Title[redir]:
Gallic acid diminishes pro-inflammatory interferon-γ- and interleukin-17-producing sub-populations in vitro in patients with psoriasis | Immunologic Research
Description:
Psoriasis is an inflammation of the skin mediated via the IL-23/Thl17/IL-17 pathway. We have previously demonstrated that the anthocyanin delphinidin diminishes in vitro the IL-17 and IFN-γ production of peripheral monocytes isolated by psoriasis patients (PBMCs). The degradation product of delphinidin is gallic acid (GA). This phenolic acid compound found in fruits, red wine, or green tea exerts pleiotropic antioxidant, anticarcinogenic, antimicrobial, and anti-inflammatory properties. Previous research has demonstrated the inhibitory effect of GA on pro-inflammatory transcription factors, such as STAT3, RORγt, and NF-κB, or cytokines as IL-1β and TNF, which contribute to psoriasis development. We investigated the effect of GA in vitro on PBMCs, which were stimulated ex vivo, from 40 individuals (28 diagnosed with psoriasis vulgaris and 12 healthy controls (HCs)). In our experiments, PBMCs were cultured untreated or were activated in the presence of phorbol 12-myristate 13-acetate/ionomycin with or without GA. We utilized multicolor flow cytometry to assess the production of inteleukin-17 (IL-17) and interferon-γ (IFN-γ) in T and NK cells. GA did not alter the fractions of IL-17- or IFN-γ-producing T and IFN-γ-producing NK cells in HCs. However, in psoriasis patients, the effect of GA on that cell population was significant. Specifically, GA decreased the frequency of IL-17-producing cells within the CD3+ (T) and CD3+CD4+ (Th) compartment; the frequency of IFN-γ-producing cells within the CD3+, CD3+CD4+, and CD3+CD4− (Tc) compartment, and the frequency of IFN-γ-producing cells within the CD3−CD56+ (NK) compartment. Whether GA’s effect also appears in vivo needs to be investigated in future.

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  • Science
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Keywords {🔍}

cells, cell, psoriasis, vitro, acid, gallic, effect, article, cdcd, google, scholar, pbmcs, patients, ifnγproducing, cas, isolated, study, ifnγ, treatment, pubmed, pretreatment, production, flow, subsets, inhibition, internet, untreated, gatreated, proinflammatory, nfκb, cytometry, psoriatic, disease, hcs, significantly, data, tsiogkas, bogdanos, skin, stat, vivo, reported, activity, model, pma, dimitrios, inflammation, delphinidin, inhibitory, investigated,

Topics {✒️}

nuclear factor kappa-light-chain-enhancer apc-cy7-conjugated anti-ifn-γ cd3−cd56+ifn-γ+ cell subset pro-inflammatory feed-forward loop fluorescein isothiocyanate–conjugated anti-cd3 ifn-γ-producing cd3+cd4− cells ifν-γ-producing pbmc subsets il-17-r-bearing cell types ifn-γ-producing nk cells ros-mediated anti-cancer activity ga—pre-treatment reduced il-1β ifn-γ-producing cd3−cd56+ c57bl/6 mice spleen-isolated cd4+ figure 3a presents representative plots figure 4a presents representative plots gallic acid-induced apoptosis ga pre-treatment-induced inhibition pro-inflammatory interferon γ cells expressing ifn-γ ifn-γ-producing νκ disease-specific manner remains paired t-test /science/article/pii/s0273230018303027 ifn-γ-producing cells ameliorates imq-induced psoriasis pbmc pro-inflammatory subpopulations untreated ifn-γ-producing ifn-γ-producing cd3+ gallic-acid-1-phenyl-1h-[1 gallic acid-stearylamine conjugate wilcoxon signed-rank test conjugated anti-il-17a ga-untreated pma-activated subsets pro-inflammatory transcription factors reduces pro-inflammatory cytokines writing—original draft preparation synergistic anti-cancer activity transforming growth factor-beta optimally titrated antibodies gastroprotective anti-inflammatory agents vitro pre-treatment diminished 3]triazol-4-yl methyl esters pma-stimulated cell subsets jak/stat3 signaling pathway article download pdf ga include anti-microbial specific cell subset pro-inflammatory cell populations melanoma-bearing mouse model naturally ga-enriched compound

Schema {🗺️}

WebPage:
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         headline:Gallic acid diminishes pro-inflammatory interferon-γ- and interleukin-17-producing sub-populations in vitro in patients with psoriasis
         description:Psoriasis is an inflammation of the skin mediated via the IL-23/Thl17/IL-17 pathway. We have previously demonstrated that the anthocyanin delphinidin diminishes in vitro the IL-17 and IFN-γ production of peripheral monocytes isolated by psoriasis patients (PBMCs). The degradation product of delphinidin is gallic acid (GA). This phenolic acid compound found in fruits, red wine, or green tea exerts pleiotropic antioxidant, anticarcinogenic, antimicrobial, and anti-inflammatory properties. Previous research has demonstrated the inhibitory effect of GA on pro-inflammatory transcription factors, such as STAT3, RORγt, and NF-κB, or cytokines as IL-1β and TNF, which contribute to psoriasis development. We investigated the effect of GA in vitro on PBMCs, which were stimulated ex vivo, from 40 individuals (28 diagnosed with psoriasis vulgaris and 12 healthy controls (HCs)). In our experiments, PBMCs were cultured untreated or were activated in the presence of phorbol 12-myristate 13-acetate/ionomycin with or without GA. We utilized multicolor flow cytometry to assess the production of inteleukin-17 (IL-17) and interferon-γ (IFN-γ) in T and NK cells. GA did not alter the fractions of IL-17- or IFN-γ-producing T and IFN-γ-producing NK cells in HCs. However, in psoriasis patients, the effect of GA on that cell population was significant. Specifically, GA decreased the frequency of IL-17-producing cells within the CD3+ (T) and CD3+CD4+ (Th) compartment; the frequency of IFN-γ-producing cells within the CD3+, CD3+CD4+, and CD3+CD4− (Tc) compartment, and the frequency of IFN-γ-producing cells within the CD3−CD56+ (NK) compartment. Whether GA’s effect also appears in vivo needs to be investigated in future.
         datePublished:2023-02-09T00:00:00Z
         dateModified:2023-02-09T00:00:00Z
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      headline:Gallic acid diminishes pro-inflammatory interferon-γ- and interleukin-17-producing sub-populations in vitro in patients with psoriasis
      description:Psoriasis is an inflammation of the skin mediated via the IL-23/Thl17/IL-17 pathway. We have previously demonstrated that the anthocyanin delphinidin diminishes in vitro the IL-17 and IFN-γ production of peripheral monocytes isolated by psoriasis patients (PBMCs). The degradation product of delphinidin is gallic acid (GA). This phenolic acid compound found in fruits, red wine, or green tea exerts pleiotropic antioxidant, anticarcinogenic, antimicrobial, and anti-inflammatory properties. Previous research has demonstrated the inhibitory effect of GA on pro-inflammatory transcription factors, such as STAT3, RORγt, and NF-κB, or cytokines as IL-1β and TNF, which contribute to psoriasis development. We investigated the effect of GA in vitro on PBMCs, which were stimulated ex vivo, from 40 individuals (28 diagnosed with psoriasis vulgaris and 12 healthy controls (HCs)). In our experiments, PBMCs were cultured untreated or were activated in the presence of phorbol 12-myristate 13-acetate/ionomycin with or without GA. We utilized multicolor flow cytometry to assess the production of inteleukin-17 (IL-17) and interferon-γ (IFN-γ) in T and NK cells. GA did not alter the fractions of IL-17- or IFN-γ-producing T and IFN-γ-producing NK cells in HCs. However, in psoriasis patients, the effect of GA on that cell population was significant. Specifically, GA decreased the frequency of IL-17-producing cells within the CD3+ (T) and CD3+CD4+ (Th) compartment; the frequency of IFN-γ-producing cells within the CD3+, CD3+CD4+, and CD3+CD4− (Tc) compartment, and the frequency of IFN-γ-producing cells within the CD3−CD56+ (NK) compartment. Whether GA’s effect also appears in vivo needs to be investigated in future.
      datePublished:2023-02-09T00:00:00Z
      dateModified:2023-02-09T00:00:00Z
      pageStart:475
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         PBMCs
         Flow cytometry
         Th17
         Th1
         NK
         NKT
         Immunology
         Allergology
         Medicine/Public Health
         general
         Internal Medicine
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                  address:
                     name:Department of Rheumatology and Clinical Immunology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece
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                     name:Department of Rheumatology and Clinical Immunology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece
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                  address:
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                     type:PostalAddress
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            name:Efterpi Zafiriou
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                  name:University of Thessaly
                  address:
                     name:Department of Dermatology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece
                     type:PostalAddress
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            type:Person
            name:Dimitrios P. Bogdanos
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                  address:
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      name:Department of Rheumatology and Clinical Immunology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece
      name:Department of Rheumatology and Clinical Immunology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece
      name:Department of Rheumatology and Clinical Immunology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece
      name:Department of Neurology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece
      name:Department of Dermatology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece
      name:Department of Rheumatology and Clinical Immunology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece

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