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         headline:Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk
         description:Mark Caulfield, Paul Elliott and colleagues use data from the UK Biobank to perform genome-wide association analysis for blood pressure traits. They identify and validate 107 novel loci and highlight new biological pathways for potential therapeutic intervention for hypertension. Elevated blood pressure is the leading heritable risk factor for cardiovascular disease worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse pressure) among UK Biobank participants of European ancestry with independent replication in other cohorts, and robust validation of 107 independent loci. We also identify new independent variants at 11 previously reported blood pressure loci. In combination with results from a range of in silico functional analyses and wet bench experiments, our findings highlight new biological pathways for blood pressure regulation enriched for genes expressed in vascular tissues and identify potential therapeutic targets for hypertension. Results from genetic risk score models raise the possibility of a precision medicine approach through early lifestyle intervention to offset the impact of blood pressure–raising genetic variants on future cardiovascular disease risk.
         datePublished:2017-01-30T00:00:00Z
         dateModified:2017-10-01T00:00:00Z
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            Genome-wide association studies
            Hypertension
            Biomedicine
            general
            Human Genetics
            Cancer Research
            Agriculture
            Gene Function
            Animal Genetics and Genomics
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                     address:
                        name:Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
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                     name:Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford
                     address:
                        name:Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK
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                        name:Department of Public Health and Primary Care, Cardiovascular Epidemiology Unit, University of Cambridge, Cambridge, UK
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               name:Patricia B Munroe
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                     name:University of Leicester
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      headline:Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk
      description:Mark Caulfield, Paul Elliott and colleagues use data from the UK Biobank to perform genome-wide association analysis for blood pressure traits. They identify and validate 107 novel loci and highlight new biological pathways for potential therapeutic intervention for hypertension. Elevated blood pressure is the leading heritable risk factor for cardiovascular disease worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse pressure) among UK Biobank participants of European ancestry with independent replication in other cohorts, and robust validation of 107 independent loci. We also identify new independent variants at 11 previously reported blood pressure loci. In combination with results from a range of in silico functional analyses and wet bench experiments, our findings highlight new biological pathways for blood pressure regulation enriched for genes expressed in vascular tissues and identify potential therapeutic targets for hypertension. Results from genetic risk score models raise the possibility of a precision medicine approach through early lifestyle intervention to offset the impact of blood pressure–raising genetic variants on future cardiovascular disease risk.
      datePublished:2017-01-30T00:00:00Z
      dateModified:2017-10-01T00:00:00Z
      pageStart:403
      pageEnd:415
      sameAs:https://doi.org/10.1038/ng.3768
      keywords:
         Genome-wide association studies
         Hypertension
         Biomedicine
         general
         Human Genetics
         Cancer Research
         Agriculture
         Gene Function
         Animal Genetics and Genomics
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      isPartOf:
         name:Nature Genetics
         issn:
            1546-1718
            1061-4036
         volumeNumber:49
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            name:Evangelos Evangelou
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                     name:Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK
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            name:Ron T Gansevoort
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                  address:
                     name:National Institute for Health Research Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, UK
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                  address:
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                  address:
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                  address:
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            name:Caroline Hayward
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                  address:
                     name:MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK
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            name:Pim van der Harst
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                  address:
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            affiliation:
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                  address:
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                  address:
                     name:Centre for Non-Communicable Diseases, Karachi, Pakistan
                     type:PostalAddress
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                  name:University of Cambridge
                  address:
                     name:Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
                     type:PostalAddress
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            type:Person
            name:Rajiv Chowdhury
            affiliation:
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                  address:
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            name:John C Chambers
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                  name:School of Public Health, Imperial College London
                  address:
                     name:Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK
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                  address:
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                  address:
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                  address:
                     name:Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore
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                  address:
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            name:Aravinda Chakravarti
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                  address:
                     name:Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, USA
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            name:Christopher Newton-Cheh
            affiliation:
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                  address:
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                  address:
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            name:Cecilia M Lindgren
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                  address:
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                  name:Wellcome Trust Centre for Human Genetics, University of Oxford
                  address:
                     name:Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
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                  name:Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford
                  address:
                     name:Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK
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            type:Person
            name:Daniel Levy
            affiliation:
                  name:Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health
                  address:
                     name:Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, USA
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                  name:National Heart, Lung, and Blood Institute's Framingham Heart Study
                  address:
                     name:National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, USA
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            name:Jaspal S Kooner
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                  address:
                     name:Department of Cardiology, Ealing Hospital NHS Trust, Southall, UK
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                  name:National Heart and Lung Institute, Cardiovascular Sciences, Hammersmith Campus, Imperial College London
                  address:
                     name:National Heart and Lung Institute, Cardiovascular Sciences, Hammersmith Campus, Imperial College London, London, UK
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            name:Bernard Keavney
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                  name:Faculty of Biology, Medicine and Health, University of Manchester
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                     name:Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK
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                  name:Central Manchester NHS Foundation Trust, Manchester Academic Health Science Centre
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            name:Maciej Tomaszewski
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            name:Nilesh J Samani
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                     name:Department of Cardiovascular Sciences, University of Leicester, BHF Cardiovascular Research Centre, Glenfield Hospital, Leicester, UK
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            name:Georg B Ehret
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                  name:Cardiology, Geneva University Hospital
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            name:Louise V Wain
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      name:Nature Genetics
      issn:
         1546-1718
         1061-4036
      volumeNumber:49
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      name:School of Public Health, Imperial College London
      address:
         name:Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK
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      address:
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      name:School of Public Health, Imperial College London
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         name:Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK
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      address:
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      address:
         name:Division of Statistical Genomics, Department of Genetics and Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, USA
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      name:Translational Laboratory in Genetic Medicine, Agency for Science, Technology and Research (A*STAR)
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      name:University of Groningen, University Medical Center Groningen
      address:
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         type:PostalAddress
      name:Program in Medical and Population Genetics, Broad Institute of Harvard and MIT
      address:
         name:Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, USA
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      address:
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      address:
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      address:
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         type:PostalAddress
      name:Data Science Institute, Lancester University
      address:
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         type:PostalAddress
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      address:
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      name:Research Institute, National Center for Global Health and Medicine
      address:
         name:Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan
         type:PostalAddress
      name:Tulane University School of Public Health and Tropical Medicine
      address:
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      address:
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      name:Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh
      address:
         name:Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK
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      address:
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      address:
         name:Estonian Genome Center, University of Tartu, Tartu, Estonia
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      name:School of Medicine, Conway Institute, University College Dublin
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      address:
         name:National Heart and Lung Institute, Imperial College London, London, UK
         type:PostalAddress
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      address:
         name:William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
         type:PostalAddress
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      address:
         name:National Heart and Lung Institute, Imperial College London, London, UK
         type:PostalAddress
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      address:
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         type:PostalAddress
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      address:
         name:Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
         type:PostalAddress
      name:Perelman School of Medicine, University of Pennsylvania
      address:
         name:Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA
         type:PostalAddress
      name:Centre for Non-Communicable Diseases
      address:
         name:Centre for Non-Communicable Diseases, Karachi, Pakistan
         type:PostalAddress
      name:University of Cambridge
      address:
         name:Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
         type:PostalAddress
      name:Cardiovascular Epidemiology Unit, University of Cambridge
      address:
         name:Department of Public Health and Primary Care, Cardiovascular Epidemiology Unit, University of Cambridge, Cambridge, UK
         type:PostalAddress
      name:School of Public Health, Imperial College London
      address:
         name:Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK
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      name:Ealing Hospital National Health Service (NHS) Trust
      address:
         name:Ealing Hospital National Health Service (NHS) Trust, Southall, UK
         type:PostalAddress
      name:Imperial College Healthcare NHS Trust
      address:
         name:Imperial College Healthcare NHS Trust, London, UK
         type:PostalAddress
      name:Lee Kong Chian School of Medicine, Nanyang Technological University
      address:
         name:Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore
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      name:Brigham and Women's Hospital
      address:
         name:Division of Preventive Medicine, Brigham and Women's Hospital, Boston, USA
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      name:Harvard Medical School
      address:
         name:Harvard Medical School, Boston, USA
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      address:
         name:Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, USA
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      address:
         name:Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, USA
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         name:National Heart and Lung Institute, Cardiovascular Sciences, Hammersmith Campus, Imperial College London, London, UK
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      address:
         name:Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK
         type:PostalAddress
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      address:
         name:Division of Medicine, Central Manchester NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK
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         name:NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, UK
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      address:
         name:Department of Health Sciences, University of Leicester, Leicester, UK
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      address:
         name:William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
         type:PostalAddress
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         name:National Institute for Health Research Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, UK
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      address:
         name:Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, USA
         type:PostalAddress
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      address:
         name:Department of Medicine, Cardiology, Geneva University Hospital, Geneva, Switzerland
         type:PostalAddress
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      address:
         name:Department of Health Sciences, University of Leicester, Leicester, UK
         type:PostalAddress
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               name:William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
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               name:William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
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               name:William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
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               name:Boston University School of Public Health, Boston, USA
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               name:National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, USA
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      name:James P Cook
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            name:University of Liverpool
            address:
               name:Department of Biostatistics, University of Liverpool, Liverpool, UK
               type:PostalAddress
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      name:Aldi T Kraja
      affiliation:
            name:Washington University School of Medicine
            address:
               name:Division of Statistical Genomics, Department of Genetics and Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, USA
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      name:Fotios Drenos
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            name:MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol
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               name:MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, UK
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            name:Centre for Cardiovascular Genetics, Institute of Cardiovascular Science, University College London
            address:
               name:Centre for Cardiovascular Genetics, Institute of Cardiovascular Science, University College London, London, UK
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      name:Marie Loh
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            name:School of Public Health, Imperial College London
            address:
               name:Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK
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            name:Translational Laboratory in Genetic Medicine, Agency for Science, Technology and Research (A*STAR)
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               name:Translational Laboratory in Genetic Medicine, Agency for Science, Technology and Research (A*STAR), Singapore
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      name:Niek Verweij
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            name:University of Groningen, University Medical Center Groningen
            address:
               name:Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
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            name:Program in Medical and Population Genetics, Broad Institute of Harvard and MIT
            address:
               name:Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, USA
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            name:Center for Human Genetic Research, Massachusetts General Hospital
            address:
               name:Center for Human Genetic Research, Massachusetts General Hospital, Boston, USA
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            name:Cardiovascular Research Center, Massachusetts General Hospital
            address:
               name:Cardiovascular Research Center, Massachusetts General Hospital, Boston, USA
               type:PostalAddress
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      name:Jonathan Marten
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            name:MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh
            address:
               name:MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK
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      name:Ibrahim Karaman
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            name:School of Public Health, Imperial College London
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               name:Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK
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      name:Marcelo P Segura Lepe
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            name:School of Public Health, Imperial College London
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               name:Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK
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               name:Bayer Pharma, Berlin, Germany
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            name:Institute of Psychiatry, Psychology and Neuroscience, King's College London
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               name:Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK
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               name:Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan
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            name:Tulane University School of Public Health and Tropical Medicine
            address:
               name:Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, USA
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      name:E Shyong Tai
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               name:Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore
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               name:Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
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      name:M Abdullah Said
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            name:University of Groningen, University Medical Center Groningen
            address:
               name:Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
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               name:Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK
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               name:Imperial Clinical Trials Unit, School of Public Health, Imperial College London, London, UK
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            name:Wellcome Trust Centre for Human Genetics, University of Oxford
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               name:Division of Cardiovascular Medicine, Radcliffe Department of Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
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      name:Ron T Gansevoort
      affiliation:
            name:University of Groningen, University Medical Center Groningen
            address:
               name:Department of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
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               name:Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland
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      name:John Connell
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            name:Ninewells Hospital and Medical School, University of Dundee
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               name:Ninewells Hospital and Medical School, University of Dundee, Dundee, UK
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      name:Stephan J L Bakker
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            name:University of Groningen, University Medical Center Groningen
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               name:Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
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            name:Estonian Genome Center, University of Tartu
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               name:Estonian Genome Center, University of Tartu, Tartu, Estonia
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      name:Denis C Shields
      affiliation:
            name:School of Medicine, Conway Institute, University College Dublin
            address:
               name:School of Medicine, Conway Institute, University College Dublin, Dublin, Ireland
               type:PostalAddress
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      name:Simon Thom
      url:http://orcid.org/0000-0002-3020-1351
      affiliation:
            name:National Heart and Lung Institute, Imperial College London
            address:
               name:National Heart and Lung Institute, Imperial College London, London, UK
               type:PostalAddress
            type:Organization
      name:Morris Brown
      affiliation:
            name:William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
            address:
               name:William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
               type:PostalAddress
            type:Organization
            name:National Institute for Health Research Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London
            address:
               name:National Institute for Health Research Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, UK
               type:PostalAddress
            type:Organization
      name:Peter Sever
      affiliation:
            name:National Heart and Lung Institute, Imperial College London
            address:
               name:National Heart and Lung Institute, Imperial College London, London, UK
               type:PostalAddress
            type:Organization
      name:Tõnu Esko
      affiliation:
            name:Program in Medical and Population Genetics, Broad Institute of Harvard and MIT
            address:
               name:Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, USA
               type:PostalAddress
            type:Organization
            name:Estonian Genome Center, University of Tartu
            address:
               name:Estonian Genome Center, University of Tartu, Tartu, Estonia
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      name:Caroline Hayward
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            name:MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh
            address:
               name:MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK
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      name:Pim van der Harst
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            name:University of Groningen, University Medical Center Groningen
            address:
               name:Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
               type:PostalAddress
            type:Organization
      name:Danish Saleheen
      affiliation:
            name:Perelman School of Medicine, University of Pennsylvania
            address:
               name:Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA
               type:PostalAddress
            type:Organization
            name:Centre for Non-Communicable Diseases
            address:
               name:Centre for Non-Communicable Diseases, Karachi, Pakistan
               type:PostalAddress
            type:Organization
            name:University of Cambridge
            address:
               name:Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
               type:PostalAddress
            type:Organization
      name:Rajiv Chowdhury
      affiliation:
            name:Cardiovascular Epidemiology Unit, University of Cambridge
            address:
               name:Department of Public Health and Primary Care, Cardiovascular Epidemiology Unit, University of Cambridge, Cambridge, UK
               type:PostalAddress
            type:Organization
      name:John C Chambers
      affiliation:
            name:School of Public Health, Imperial College London
            address:
               name:Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK
               type:PostalAddress
            type:Organization
            name:Ealing Hospital National Health Service (NHS) Trust
            address:
               name:Ealing Hospital National Health Service (NHS) Trust, Southall, UK
               type:PostalAddress
            type:Organization
            name:Imperial College Healthcare NHS Trust
            address:
               name:Imperial College Healthcare NHS Trust, London, UK
               type:PostalAddress
            type:Organization
            name:Lee Kong Chian School of Medicine, Nanyang Technological University
            address:
               name:Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore
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      name:Daniel I Chasman
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            name:Brigham and Women's Hospital
            address:
               name:Division of Preventive Medicine, Brigham and Women's Hospital, Boston, USA
               type:PostalAddress
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            name:Harvard Medical School
            address:
               name:Harvard Medical School, Boston, USA
               type:PostalAddress
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      name:Aravinda Chakravarti
      affiliation:
            name:Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine
            address:
               name:Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, USA
               type:PostalAddress
            type:Organization
      name:Christopher Newton-Cheh
      affiliation:
            name:Program in Medical and Population Genetics, Broad Institute of Harvard and MIT
            address:
               name:Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, USA
               type:PostalAddress
            type:Organization
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            address:
               name:Center for Human Genetic Research, Massachusetts General Hospital, Boston, USA
               type:PostalAddress
            type:Organization
            name:Cardiovascular Research Center, Massachusetts General Hospital
            address:
               name:Cardiovascular Research Center, Massachusetts General Hospital, Boston, USA
               type:PostalAddress
            type:Organization
      name:Cecilia M Lindgren
      affiliation:
            name:Program in Medical and Population Genetics, Broad Institute of Harvard and MIT
            address:
               name:Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, USA
               type:PostalAddress
            type:Organization
            name:Wellcome Trust Centre for Human Genetics, University of Oxford
            address:
               name:Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
               type:PostalAddress
            type:Organization
            name:Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford
            address:
               name:Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK
               type:PostalAddress
            type:Organization
      name:Daniel Levy
      affiliation:
            name:Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health
            address:
               name:Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, USA
               type:PostalAddress
            type:Organization
            name:National Heart, Lung, and Blood Institute's Framingham Heart Study
            address:
               name:National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, USA
               type:PostalAddress
            type:Organization
      name:Jaspal S Kooner
      affiliation:
            name:Imperial College Healthcare NHS Trust
            address:
               name:Imperial College Healthcare NHS Trust, London, UK
               type:PostalAddress
            type:Organization
            name:Ealing Hospital NHS Trust
            address:
               name:Department of Cardiology, Ealing Hospital NHS Trust, Southall, UK
               type:PostalAddress
            type:Organization
            name:National Heart and Lung Institute, Cardiovascular Sciences, Hammersmith Campus, Imperial College London
            address:
               name:National Heart and Lung Institute, Cardiovascular Sciences, Hammersmith Campus, Imperial College London, London, UK
               type:PostalAddress
            type:Organization
      name:Bernard Keavney
      url:http://orcid.org/0000-0001-9573-0812
      affiliation:
            name:Faculty of Biology, Medicine and Health, University of Manchester
            address:
               name:Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK
               type:PostalAddress
            type:Organization
            name:Central Manchester NHS Foundation Trust, Manchester Academic Health Science Centre
            address:
               name:Division of Medicine, Central Manchester NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK
               type:PostalAddress
            type:Organization
      name:Maciej Tomaszewski
      affiliation:
            name:Faculty of Biology, Medicine and Health, University of Manchester
            address:
               name:Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK
               type:PostalAddress
            type:Organization
            name:Central Manchester NHS Foundation Trust, Manchester Academic Health Science Centre
            address:
               name:Division of Medicine, Central Manchester NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK
               type:PostalAddress
            type:Organization
      name:Nilesh J Samani
      affiliation:
            name:University of Leicester, BHF Cardiovascular Research Centre, Glenfield Hospital
            address:
               name:Department of Cardiovascular Sciences, University of Leicester, BHF Cardiovascular Research Centre, Glenfield Hospital, Leicester, UK
               type:PostalAddress
            type:Organization
            name:NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital
            address:
               name:NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, UK
               type:PostalAddress
            type:Organization
      name:Joanna M M Howson
      affiliation:
            name:Cardiovascular Epidemiology Unit, University of Cambridge
            address:
               name:Department of Public Health and Primary Care, Cardiovascular Epidemiology Unit, University of Cambridge, Cambridge, UK
               type:PostalAddress
            type:Organization
      name:Martin D Tobin
      affiliation:
            name:University of Leicester
            address:
               name:Department of Health Sciences, University of Leicester, Leicester, UK
               type:PostalAddress
            type:Organization
      name:Patricia B Munroe
      affiliation:
            name:William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
            address:
               name:William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
               type:PostalAddress
            type:Organization
            name:National Institute for Health Research Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London
            address:
               name:National Institute for Health Research Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, UK
               type:PostalAddress
            type:Organization
      name:Georg B Ehret
      url:http://orcid.org/0000-0002-5730-0675
      affiliation:
            name:Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine
            address:
               name:Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, USA
               type:PostalAddress
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            name:Cardiology, Geneva University Hospital
            address:
               name:Department of Medicine, Cardiology, Geneva University Hospital, Geneva, Switzerland
               type:PostalAddress
            type:Organization
      name:Louise V Wain
      url:http://orcid.org/0000-0003-4951-1867
      affiliation:
            name:University of Leicester
            address:
               name:Department of Health Sciences, University of Leicester, Leicester, UK
               type:PostalAddress
            type:Organization
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      name:William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
      name:National Institute for Health Research Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, UK
      name:Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK
      name:Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece
      name:William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
      name:National Institute for Health Research Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, UK
      name:Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK
      name:MRC-PHE Centre for Environment and Health, Imperial College London, London, UK
      name:William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
      name:National Institute for Health Research Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, UK
      name:William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
      name:William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
      name:Department of Public Health and Primary Care, Cardiovascular Epidemiology Unit, University of Cambridge, Cambridge, UK
      name:Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, USA
      name:Boston University School of Public Health, Boston, USA
      name:National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, USA
      name:Department of Biostatistics, University of Liverpool, Liverpool, UK
      name:Division of Statistical Genomics, Department of Genetics and Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, USA
      name:MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, UK
      name:Centre for Cardiovascular Genetics, Institute of Cardiovascular Science, University College London, London, UK
      name:Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK
      name:Translational Laboratory in Genetic Medicine, Agency for Science, Technology and Research (A*STAR), Singapore
      name:Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
      name:Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, USA
      name:Center for Human Genetic Research, Massachusetts General Hospital, Boston, USA
      name:Cardiovascular Research Center, Massachusetts General Hospital, Boston, USA
      name:MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK
      name:Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK
      name:Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK
      name:Bayer Pharma, Berlin, Germany
      name:Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK
      name:Data Science Institute, Lancester University, Lancaster, UK
      name:Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
      name:Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan
      name:Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, USA
      name:Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore
      name:Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
      name:Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
      name:Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK
      name:Estonian Genome Center, University of Tartu, Tartu, Estonia
      name:Imperial Clinical Trials Unit, School of Public Health, Imperial College London, London, UK
      name:Division of Cardiovascular Medicine, Radcliffe Department of Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
      name:Department of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
      name:Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK
      name:Estonian Genome Center, University of Tartu, Tartu, Estonia
      name:Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland
      name:Ninewells Hospital and Medical School, University of Dundee, Dundee, UK
      name:Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
      name:Estonian Genome Center, University of Tartu, Tartu, Estonia
      name:School of Medicine, Conway Institute, University College Dublin, Dublin, Ireland
      name:National Heart and Lung Institute, Imperial College London, London, UK
      name:William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
      name:National Institute for Health Research Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, UK
      name:National Heart and Lung Institute, Imperial College London, London, UK
      name:Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, USA
      name:Estonian Genome Center, University of Tartu, Tartu, Estonia
      name:MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK
      name:Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
      name:Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA
      name:Centre for Non-Communicable Diseases, Karachi, Pakistan
      name:Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
      name:Department of Public Health and Primary Care, Cardiovascular Epidemiology Unit, University of Cambridge, Cambridge, UK
      name:Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK
      name:Ealing Hospital National Health Service (NHS) Trust, Southall, UK
      name:Imperial College Healthcare NHS Trust, London, UK
      name:Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore
      name:Division of Preventive Medicine, Brigham and Women's Hospital, Boston, USA
      name:Harvard Medical School, Boston, USA
      name:Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, USA
      name:Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, USA
      name:Center for Human Genetic Research, Massachusetts General Hospital, Boston, USA
      name:Cardiovascular Research Center, Massachusetts General Hospital, Boston, USA
      name:Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, USA
      name:Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
      name:Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK
      name:Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, USA
      name:National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, USA
      name:Imperial College Healthcare NHS Trust, London, UK
      name:Department of Cardiology, Ealing Hospital NHS Trust, Southall, UK
      name:National Heart and Lung Institute, Cardiovascular Sciences, Hammersmith Campus, Imperial College London, London, UK
      name:Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK
      name:Division of Medicine, Central Manchester NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK
      name:Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK
      name:Division of Medicine, Central Manchester NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK
      name:Department of Cardiovascular Sciences, University of Leicester, BHF Cardiovascular Research Centre, Glenfield Hospital, Leicester, UK
      name:NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, UK
      name:Department of Public Health and Primary Care, Cardiovascular Epidemiology Unit, University of Cambridge, Cambridge, UK
      name:Department of Health Sciences, University of Leicester, Leicester, UK
      name:William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
      name:National Institute for Health Research Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, UK
      name:Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, USA
      name:Department of Medicine, Cardiology, Geneva University Hospital, Geneva, Switzerland
      name:Department of Health Sciences, University of Leicester, Leicester, UK
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• Financial intake of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Rajiv%20Chowdhury
• What's the income of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Rajiv%20Chowdhury%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
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• https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22John%20C%20Chambers%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en's total income per month
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