NATURE . COM {}

Matching Content Categories {📚}

• Science
• Education
• Health & Fitness

Content Management System {📝}

What CMS is nature.com built with?

Custom-built

No common CMS systems were detected on Nature.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of nature.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Nature.com Make Money? {💸}

Display Ads {🎯}

Direct Advertisers (10)

Reseller Advertisers (38)

How Much Does Nature.com Make? {💰}

Display Ads {🎯}

$63,100 per month
Our analysis indicates Nature.com generates between $42,042 and $115,616 monthly online from display ads.

Keywords {🔍}

nra, cells, smad, cancer, fig, expression, tgfβ, cell, article, axin, breast, google, scholar, signalling, cas, analysis, metastasis, supplementary, control, stably, nature, receptor, data, tgfβsmad, treated, immunoblot, mefs, expressing, degradation, tgfβinduced, tβri, mdamb, mouse, protein, activity, human, nuclear, invasion, mice, results, tumour, performed, found, ilβ, promotes, arkadia, transcriptional, depletion, shrna, time,

Topics {✒️}

nature portfolio scientific research permissions reprints special diet services privacy policy nr4a1-activated tgf-β/smad signalling regulating tgf-β/smad signalling tgf-β-induced epithelial-mesenchymal transition tgf-β-driven tumour progression36 facilitate tgf-β/smad signalling potentiating tgf-β/smad signalling author information authors nr4a1-depleted mda-mb-231/mcherry cells promote tgf-β-mediated emt smad3-smad4-driven transcriptional reporter smad7/arkadia/rnf12/axin2 complex endogenously nr4a1 potentiated tgf-β-induced open biosystems tgf-β-induced transcriptional response alexafluor593-labelled anti-rabbit antibody carboxy-terminal ligand-binding domain23 mcf10a-ras-transformed cell line advertising putative ngfi-b-response elements tgf-β/smad signal activation pro-oncogenic tgf-β signalling tgf-β-induced phospho-smad2 full access specific ngfi-b-response element tgf-β-induced epithelial tgf-β/smad signalling tgf-β-smad signalling social media activating tgf-β signalling axin2-induced smad3/smad4 response tgf-β-induced emt tgf-β receptor signalling fundamental research funds nr4a1-depleted mda-mb-231 cells tgf-β/smad activation tgf-β-induced effects tgf-β-induced expression tgf-β-dependent manner caga-luc transcriptional reporter tgf-β pathway acts activated tgf-β type smad7/pai-1/ctgf/cxcr4 expression jak1/stat1-mediated pathway aberrant force-induced osteoarthritis mitigating tgf-β signalling6

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Nuclear receptor NR4A1 promotes breast cancer invasion and metastasis by activating TGF-β signalling
         description:In advanced cancers, the TGF-β pathway acts as an oncogenic factor and is considered to be a therapeutic target. Here using a genome-wide cDNA screen, we identify nuclear receptor NR4A1 as a strong activator of TGF-β signalling. NR4A1 promotes TGF-β/SMAD signalling by facilitating AXIN2–RNF12/ARKADIA-induced SMAD7 degradation. NR4A1 interacts with SMAD7 and AXIN2, and potently and directly induces AXIN2 expression. Whereas loss of NR4A1 inhibits TGF-β-induced epithelial-to-mesenchymal transition and metastasis, slight NR4A1 ectopic expression stimulates metastasis in a TGF-β-dependent manner. Importantly, inflammatory cytokines potently induce NR4A1 expression, and potentiate TGF-β-mediated breast cancer cell migration, invasion and metastasis in vitro and in vivo. Notably, NR4A1 expression is elevated in breast cancer patients with high immune infiltration and its expression weakly correlates with phosphorylated SMAD2 levels, and is an indicator of poor prognosis. Our results uncover inflammation-induced NR4A1 as an important determinant for hyperactivation of pro-oncogenic TGF-β signalling in breast cancer. The TGF-β signalling pathway promotes cancer progression in late stage breast cancer, but how the pathway is activated is not always clear. In this study, Zhou et al.identify that the expression of nuclear receptor NR4A1 is induced by inflammation and is an activator of TGF-β-induced metastasis.
         datePublished:2014-03-03T00:00:00Z
         dateModified:2014-03-03T00:00:00Z
         pageStart:1
         pageEnd:13
         sameAs:https://doi.org/10.1038/ncomms4388
         keywords:
            Breast cancer
            Cell invasion
            Cell signalling
            Metastasis
            Science
            Humanities and Social Sciences
            multidisciplinary
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms4388/MediaObjects/41467_2014_Article_BFncomms4388_Figa_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms4388/MediaObjects/41467_2014_Article_BFncomms4388_Fig1_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms4388/MediaObjects/41467_2014_Article_BFncomms4388_Fig2_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms4388/MediaObjects/41467_2014_Article_BFncomms4388_Fig3_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms4388/MediaObjects/41467_2014_Article_BFncomms4388_Fig4_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms4388/MediaObjects/41467_2014_Article_BFncomms4388_Fig5_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms4388/MediaObjects/41467_2014_Article_BFncomms4388_Fig6_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms4388/MediaObjects/41467_2014_Article_BFncomms4388_Fig7_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms4388/MediaObjects/41467_2014_Article_BFncomms4388_Fig8_HTML.jpg
         isPartOf:
            name:Nature Communications
            issn:
               2041-1723
            volumeNumber:5
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Nature Publishing Group UK
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:FangFang Zhou
               affiliation:
                     name:Life Sciences Institute, Zhejiang University
                     address:
                        name:Life Sciences Institute, Zhejiang University, Hangzhou, China
                        type:PostalAddress
                     type:Organization
                     name:Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center
                     address:
                        name:Department of Molecular Cell Biology, Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center, The Netherlands
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Yvette Drabsch
               affiliation:
                     name:Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center
                     address:
                        name:Department of Molecular Cell Biology, Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center, The Netherlands
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Tim J. A. Dekker
               affiliation:
                     name:Leiden University Medical Center
                     address:
                        name:Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Amaya Garcia de Vinuesa
               affiliation:
                     name:Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center
                     address:
                        name:Department of Molecular Cell Biology, Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center, The Netherlands
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Yihao Li
               affiliation:
                     name:Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center
                     address:
                        name:Department of Molecular Cell Biology, Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center, The Netherlands
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Lukas J. A. C. Hawinkels
               affiliation:
                     name:Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center
                     address:
                        name:Department of Molecular Cell Biology, Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center, The Netherlands
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Kelly-Ann Sheppard
               affiliation:
                     name:Novartis Institutes for Biomedical Research
                     address:
                        name:Novartis Institutes for Biomedical Research, Cambridge, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Marie-José Goumans
               affiliation:
                     name:Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center
                     address:
                        name:Department of Molecular Cell Biology, Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center, The Netherlands
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Rodney B. Luwor
               affiliation:
                     name:The University of Melbourne, The Royal Melbourne Hospital 5th Floor Clinical Science Building
                     address:
                        name:Department of Surgery, The University of Melbourne, The Royal Melbourne Hospital 5th Floor Clinical Science Building, Parkville, Victoria, Australia
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Carlie J. de Vries
               affiliation:
                     name:Academic Medical Center, K1-113, University of Amsterdam
                     address:
                        name:Academic Medical Center, K1-113, University of Amsterdam, Amsterdam, The Netherlands
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Wilma E. Mesker
               affiliation:
                     name:Leiden University Medical Center
                     address:
                        name:Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Rob A. E. M. Tollenaar
               affiliation:
                     name:Leiden University Medical Center
                     address:
                        name:Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Peter Devilee
               affiliation:
                     name:Leiden University Medical Center
                     address:
                        name:Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Chris X. Lu
               affiliation:
                     name:Novartis Institutes for Biomedical Research
                     address:
                        name:Novartis Institutes for Biomedical Research, Cambridge, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Hongjian Zhu
               affiliation:
                     name:The University of Melbourne, The Royal Melbourne Hospital 5th Floor Clinical Science Building
                     address:
                        name:Department of Surgery, The University of Melbourne, The Royal Melbourne Hospital 5th Floor Clinical Science Building, Parkville, Victoria, Australia
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Long Zhang
               affiliation:
                     name:Life Sciences Institute, Zhejiang University
                     address:
                        name:Life Sciences Institute, Zhejiang University, Hangzhou, China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Peter ten Dijke
               affiliation:
                     name:Life Sciences Institute, Zhejiang University
                     address:
                        name:Life Sciences Institute, Zhejiang University, Hangzhou, China
                        type:PostalAddress
                     type:Organization
                     name:Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center
                     address:
                        name:Department of Molecular Cell Biology, Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center, The Netherlands
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Nuclear receptor NR4A1 promotes breast cancer invasion and metastasis by activating TGF-β signalling
      description:In advanced cancers, the TGF-β pathway acts as an oncogenic factor and is considered to be a therapeutic target. Here using a genome-wide cDNA screen, we identify nuclear receptor NR4A1 as a strong activator of TGF-β signalling. NR4A1 promotes TGF-β/SMAD signalling by facilitating AXIN2–RNF12/ARKADIA-induced SMAD7 degradation. NR4A1 interacts with SMAD7 and AXIN2, and potently and directly induces AXIN2 expression. Whereas loss of NR4A1 inhibits TGF-β-induced epithelial-to-mesenchymal transition and metastasis, slight NR4A1 ectopic expression stimulates metastasis in a TGF-β-dependent manner. Importantly, inflammatory cytokines potently induce NR4A1 expression, and potentiate TGF-β-mediated breast cancer cell migration, invasion and metastasis in vitro and in vivo. Notably, NR4A1 expression is elevated in breast cancer patients with high immune infiltration and its expression weakly correlates with phosphorylated SMAD2 levels, and is an indicator of poor prognosis. Our results uncover inflammation-induced NR4A1 as an important determinant for hyperactivation of pro-oncogenic TGF-β signalling in breast cancer. The TGF-β signalling pathway promotes cancer progression in late stage breast cancer, but how the pathway is activated is not always clear. In this study, Zhou et al.identify that the expression of nuclear receptor NR4A1 is induced by inflammation and is an activator of TGF-β-induced metastasis.
      datePublished:2014-03-03T00:00:00Z
      dateModified:2014-03-03T00:00:00Z
      pageStart:1
      pageEnd:13
      sameAs:https://doi.org/10.1038/ncomms4388
      keywords:
         Breast cancer
         Cell invasion
         Cell signalling
         Metastasis
         Science
         Humanities and Social Sciences
         multidisciplinary
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms4388/MediaObjects/41467_2014_Article_BFncomms4388_Figa_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms4388/MediaObjects/41467_2014_Article_BFncomms4388_Fig1_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms4388/MediaObjects/41467_2014_Article_BFncomms4388_Fig2_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms4388/MediaObjects/41467_2014_Article_BFncomms4388_Fig3_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms4388/MediaObjects/41467_2014_Article_BFncomms4388_Fig4_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms4388/MediaObjects/41467_2014_Article_BFncomms4388_Fig5_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms4388/MediaObjects/41467_2014_Article_BFncomms4388_Fig6_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms4388/MediaObjects/41467_2014_Article_BFncomms4388_Fig7_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms4388/MediaObjects/41467_2014_Article_BFncomms4388_Fig8_HTML.jpg
      isPartOf:
         name:Nature Communications
         issn:
            2041-1723
         volumeNumber:5
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Nature Publishing Group UK
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:FangFang Zhou
            affiliation:
                  name:Life Sciences Institute, Zhejiang University
                  address:
                     name:Life Sciences Institute, Zhejiang University, Hangzhou, China
                     type:PostalAddress
                  type:Organization
                  name:Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center
                  address:
                     name:Department of Molecular Cell Biology, Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yvette Drabsch
            affiliation:
                  name:Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center
                  address:
                     name:Department of Molecular Cell Biology, Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Tim J. A. Dekker
            affiliation:
                  name:Leiden University Medical Center
                  address:
                     name:Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Amaya Garcia de Vinuesa
            affiliation:
                  name:Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center
                  address:
                     name:Department of Molecular Cell Biology, Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yihao Li
            affiliation:
                  name:Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center
                  address:
                     name:Department of Molecular Cell Biology, Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Lukas J. A. C. Hawinkels
            affiliation:
                  name:Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center
                  address:
                     name:Department of Molecular Cell Biology, Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Kelly-Ann Sheppard
            affiliation:
                  name:Novartis Institutes for Biomedical Research
                  address:
                     name:Novartis Institutes for Biomedical Research, Cambridge, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Marie-José Goumans
            affiliation:
                  name:Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center
                  address:
                     name:Department of Molecular Cell Biology, Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Rodney B. Luwor
            affiliation:
                  name:The University of Melbourne, The Royal Melbourne Hospital 5th Floor Clinical Science Building
                  address:
                     name:Department of Surgery, The University of Melbourne, The Royal Melbourne Hospital 5th Floor Clinical Science Building, Parkville, Victoria, Australia
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Carlie J. de Vries
            affiliation:
                  name:Academic Medical Center, K1-113, University of Amsterdam
                  address:
                     name:Academic Medical Center, K1-113, University of Amsterdam, Amsterdam, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Wilma E. Mesker
            affiliation:
                  name:Leiden University Medical Center
                  address:
                     name:Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Rob A. E. M. Tollenaar
            affiliation:
                  name:Leiden University Medical Center
                  address:
                     name:Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Peter Devilee
            affiliation:
                  name:Leiden University Medical Center
                  address:
                     name:Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Chris X. Lu
            affiliation:
                  name:Novartis Institutes for Biomedical Research
                  address:
                     name:Novartis Institutes for Biomedical Research, Cambridge, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Hongjian Zhu
            affiliation:
                  name:The University of Melbourne, The Royal Melbourne Hospital 5th Floor Clinical Science Building
                  address:
                     name:Department of Surgery, The University of Melbourne, The Royal Melbourne Hospital 5th Floor Clinical Science Building, Parkville, Victoria, Australia
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Long Zhang
            affiliation:
                  name:Life Sciences Institute, Zhejiang University
                  address:
                     name:Life Sciences Institute, Zhejiang University, Hangzhou, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Peter ten Dijke
            affiliation:
                  name:Life Sciences Institute, Zhejiang University
                  address:
                     name:Life Sciences Institute, Zhejiang University, Hangzhou, China
                     type:PostalAddress
                  type:Organization
                  name:Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center
                  address:
                     name:Department of Molecular Cell Biology, Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center, The Netherlands
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Nature Communications
      issn:
         2041-1723
      volumeNumber:5
Organization:
      name:Nature Publishing Group UK
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Life Sciences Institute, Zhejiang University
      address:
         name:Life Sciences Institute, Zhejiang University, Hangzhou, China
         type:PostalAddress
      name:Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center
      address:
         name:Department of Molecular Cell Biology, Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center, The Netherlands
         type:PostalAddress
      name:Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center
      address:
         name:Department of Molecular Cell Biology, Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center, The Netherlands
         type:PostalAddress
      name:Leiden University Medical Center
      address:
         name:Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
         type:PostalAddress
      name:Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center
      address:
         name:Department of Molecular Cell Biology, Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center, The Netherlands
         type:PostalAddress
      name:Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center
      address:
         name:Department of Molecular Cell Biology, Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center, The Netherlands
         type:PostalAddress
      name:Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center
      address:
         name:Department of Molecular Cell Biology, Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center, The Netherlands
         type:PostalAddress
      name:Novartis Institutes for Biomedical Research
      address:
         name:Novartis Institutes for Biomedical Research, Cambridge, USA
         type:PostalAddress
      name:Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center
      address:
         name:Department of Molecular Cell Biology, Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center, The Netherlands
         type:PostalAddress
      name:The University of Melbourne, The Royal Melbourne Hospital 5th Floor Clinical Science Building
      address:
         name:Department of Surgery, The University of Melbourne, The Royal Melbourne Hospital 5th Floor Clinical Science Building, Parkville, Victoria, Australia
         type:PostalAddress
      name:Academic Medical Center, K1-113, University of Amsterdam
      address:
         name:Academic Medical Center, K1-113, University of Amsterdam, Amsterdam, The Netherlands
         type:PostalAddress
      name:Leiden University Medical Center
      address:
         name:Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
         type:PostalAddress
      name:Leiden University Medical Center
      address:
         name:Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
         type:PostalAddress
      name:Leiden University Medical Center
      address:
         name:Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
         type:PostalAddress
      name:Novartis Institutes for Biomedical Research
      address:
         name:Novartis Institutes for Biomedical Research, Cambridge, USA
         type:PostalAddress
      name:The University of Melbourne, The Royal Melbourne Hospital 5th Floor Clinical Science Building
      address:
         name:Department of Surgery, The University of Melbourne, The Royal Melbourne Hospital 5th Floor Clinical Science Building, Parkville, Victoria, Australia
         type:PostalAddress
      name:Life Sciences Institute, Zhejiang University
      address:
         name:Life Sciences Institute, Zhejiang University, Hangzhou, China
         type:PostalAddress
      name:Life Sciences Institute, Zhejiang University
      address:
         name:Life Sciences Institute, Zhejiang University, Hangzhou, China
         type:PostalAddress
      name:Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center
      address:
         name:Department of Molecular Cell Biology, Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center, The Netherlands
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:FangFang Zhou
      affiliation:
            name:Life Sciences Institute, Zhejiang University
            address:
               name:Life Sciences Institute, Zhejiang University, Hangzhou, China
               type:PostalAddress
            type:Organization
            name:Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center
            address:
               name:Department of Molecular Cell Biology, Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center, The Netherlands
               type:PostalAddress
            type:Organization
      name:Yvette Drabsch
      affiliation:
            name:Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center
            address:
               name:Department of Molecular Cell Biology, Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center, The Netherlands
               type:PostalAddress
            type:Organization
      name:Tim J. A. Dekker
      affiliation:
            name:Leiden University Medical Center
            address:
               name:Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
               type:PostalAddress
            type:Organization
      name:Amaya Garcia de Vinuesa
      affiliation:
            name:Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center
            address:
               name:Department of Molecular Cell Biology, Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center, The Netherlands
               type:PostalAddress
            type:Organization
      name:Yihao Li
      affiliation:
            name:Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center
            address:
               name:Department of Molecular Cell Biology, Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center, The Netherlands
               type:PostalAddress
            type:Organization
      name:Lukas J. A. C. Hawinkels
      affiliation:
            name:Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center
            address:
               name:Department of Molecular Cell Biology, Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center, The Netherlands
               type:PostalAddress
            type:Organization
      name:Kelly-Ann Sheppard
      affiliation:
            name:Novartis Institutes for Biomedical Research
            address:
               name:Novartis Institutes for Biomedical Research, Cambridge, USA
               type:PostalAddress
            type:Organization
      name:Marie-José Goumans
      affiliation:
            name:Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center
            address:
               name:Department of Molecular Cell Biology, Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center, The Netherlands
               type:PostalAddress
            type:Organization
      name:Rodney B. Luwor
      affiliation:
            name:The University of Melbourne, The Royal Melbourne Hospital 5th Floor Clinical Science Building
            address:
               name:Department of Surgery, The University of Melbourne, The Royal Melbourne Hospital 5th Floor Clinical Science Building, Parkville, Victoria, Australia
               type:PostalAddress
            type:Organization
      name:Carlie J. de Vries
      affiliation:
            name:Academic Medical Center, K1-113, University of Amsterdam
            address:
               name:Academic Medical Center, K1-113, University of Amsterdam, Amsterdam, The Netherlands
               type:PostalAddress
            type:Organization
      name:Wilma E. Mesker
      affiliation:
            name:Leiden University Medical Center
            address:
               name:Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
               type:PostalAddress
            type:Organization
      name:Rob A. E. M. Tollenaar
      affiliation:
            name:Leiden University Medical Center
            address:
               name:Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
               type:PostalAddress
            type:Organization
      name:Peter Devilee
      affiliation:
            name:Leiden University Medical Center
            address:
               name:Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
               type:PostalAddress
            type:Organization
      name:Chris X. Lu
      affiliation:
            name:Novartis Institutes for Biomedical Research
            address:
               name:Novartis Institutes for Biomedical Research, Cambridge, USA
               type:PostalAddress
            type:Organization
      name:Hongjian Zhu
      affiliation:
            name:The University of Melbourne, The Royal Melbourne Hospital 5th Floor Clinical Science Building
            address:
               name:Department of Surgery, The University of Melbourne, The Royal Melbourne Hospital 5th Floor Clinical Science Building, Parkville, Victoria, Australia
               type:PostalAddress
            type:Organization
      name:Long Zhang
      affiliation:
            name:Life Sciences Institute, Zhejiang University
            address:
               name:Life Sciences Institute, Zhejiang University, Hangzhou, China
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Peter ten Dijke
      affiliation:
            name:Life Sciences Institute, Zhejiang University
            address:
               name:Life Sciences Institute, Zhejiang University, Hangzhou, China
               type:PostalAddress
            type:Organization
            name:Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center
            address:
               name:Department of Molecular Cell Biology, Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center, The Netherlands
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Life Sciences Institute, Zhejiang University, Hangzhou, China
      name:Department of Molecular Cell Biology, Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center, The Netherlands
      name:Department of Molecular Cell Biology, Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center, The Netherlands
      name:Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
      name:Department of Molecular Cell Biology, Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center, The Netherlands
      name:Department of Molecular Cell Biology, Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center, The Netherlands
      name:Department of Molecular Cell Biology, Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center, The Netherlands
      name:Novartis Institutes for Biomedical Research, Cambridge, USA
      name:Department of Molecular Cell Biology, Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center, The Netherlands
      name:Department of Surgery, The University of Melbourne, The Royal Melbourne Hospital 5th Floor Clinical Science Building, Parkville, Victoria, Australia
      name:Academic Medical Center, K1-113, University of Amsterdam, Amsterdam, The Netherlands
      name:Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
      name:Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
      name:Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
      name:Novartis Institutes for Biomedical Research, Cambridge, USA
      name:Department of Surgery, The University of Melbourne, The Royal Melbourne Hospital 5th Floor Clinical Science Building, Parkville, Victoria, Australia
      name:Life Sciences Institute, Zhejiang University, Hangzhou, China
      name:Life Sciences Institute, Zhejiang University, Hangzhou, China
      name:Department of Molecular Cell Biology, Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center, The Netherlands
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

Social Networks {👍}(2)

• https://www.facebook.com/NatureCommunications
• https://twitter.com/NatureComms

External Links {🔗}(148)

• What's the income generated by https://doi.org/10.1016%2Fj.cell.2008.07.001 each month?
• http://scholar.google.com/scholar_lookup?&title=TGF%CE%B2%20in%20Cancer&journal=Cell&doi=10.1016%2Fj.cell.2008.07.001&volume=134&pages=215-230&publication_year=2008&author=Massagu%C3%A9%2CJ's financial summary
• Find out how much https://doi.org/10.1242%2Fdev.030338 earns monthly
• Financial intake of http://scholar.google.com/scholar_lookup?&title=The%20regulation%20of%20TGF%CE%B2%20signal%20transduction&journal=Development&doi=10.1242%2Fdev.030338&volume=136&pages=3699-3714&publication_year=2009&author=Moustakas%2CA&author=Heldin%2CCH
• Income figures for https://doi.org/10.1038%2Fncb434
• What's the profit of http://scholar.google.com/scholar_lookup?&title=Differentiation%20plasticity%20regulated%20by%20TGF-%CE%B2%20family%20proteins%20in%20development%20and%20disease&journal=Nat.%20Cell%20Biol.&doi=10.1038%2Fncb434&volume=9&pages=1000-1004&publication_year=2007&author=Derynck%2CR&author=Akhurst%2CRJ?
• How much profit does https://doi.org/10.1038%2Fnrm2297 generate?
• What's the financial intake of http://scholar.google.com/scholar_lookup?&title=TGF%CE%B2-SMAD%20signal%20transduction%3A%20molecular%20specificity%20and%20functional%20flexibility&journal=Nat.%20Rev.%20Mol.%20Cell%20Biol.&doi=10.1038%2Fnrm2297&volume=8&pages=970-982&publication_year=2007&author=Schmierer%2CB&author=Hill%2CCS?
• What's https://doi.org/10.1016%2Fj.tcb.2009.05.008's gross income?
• How much income does http://scholar.google.com/scholar_lookup?&title=New%20regulatory%20mechanisms%20of%20TGF-%CE%B2%20receptor%20function&journal=Trends%20Cell%20Biol.&doi=10.1016%2Fj.tcb.2009.05.008&volume=19&pages=385-394&publication_year=2009&author=Kang%2CJS&author=Liu%2CC&author=Derynck%2CR have?
• Check the income stats for https://doi.org/10.1016%2FS1097-2765%2800%2900134-9
• Check the income stats for http://scholar.google.com/scholar_lookup?&title=Smad7%20binds%20to%20Smurf2%20to%20form%20an%20E3%20ubiquitin%20ligase%20that%20targets%20the%20TGF%CE%B2%20receptor%20for%20degradation&journal=Mol.%20Cell.&doi=10.1016%2FS1097-2765%2800%2900134-9&volume=6&pages=1365-1375&publication_year=2000&author=Kavsak%2CP
• Income figures for https://doi.org/10.1074%2Fjbc.C100008200
• How much revenue does http://scholar.google.com/scholar_lookup?&title=Smurf1%20interacts%20with%20transforming%20growth%20factor-%CE%B2%20type%20I%20receptor%20through%20Smad7%20and%20induces%20receptor%20degradation&journal=J.%20Biol.%20Chem.&doi=10.1074%2Fjbc.C100008200&volume=276&pages=12477-12480&publication_year=2001&author=Ebisawa%2CT generate?
• What are the total earnings of https://doi.org/10.1093%2Femboj%2Fcdg632?
• See how much http://scholar.google.com/scholar_lookup?&title=Arkadia%20amplifies%20TGF-%CE%B2%20superfamily%20signalling%20through%20degradation%20of%20Smad7&journal=EMBO%20J.&doi=10.1093%2Femboj%2Fcdg632&volume=22&pages=6458-6470&publication_year=2003&author=Koinuma%2CD makes per month
• Learn how profitable https://doi.org/10.1016%2Fj.molcel.2012.04.003 is on a monthly basis
• Financial intake of http://scholar.google.com/scholar_lookup?&title=RNF12%20controls%20embryonic%20stem%20cell%20fate%20and%20morphogenesis%20in%20zebrafish%20embryos%20by%20targeting%20Smad7%20for%20degradation&journal=Mol.%20Cell&doi=10.1016%2Fj.molcel.2012.04.003&volume=46&pages=650-661&publication_year=2012&author=Zhang%2CL
• How much cash flow does https://doi.org/10.1002%2Fpath.2785 have monthly?
• How much does http://scholar.google.com/scholar_lookup?&title=The%20dynamic%20roles%20of%20TGF-%CE%B2%20in%20cancer&journal=J.%20Pathol.&doi=10.1002%2Fpath.2785&volume=223&pages=205-218&publication_year=2011&author=Meulmeester%2CE&author=Ten%20Dijke%2CP earn?
• How much does https://doi.org/10.1016%2FS0092-8674%2802%2900710-9 rake in every month?
• http://scholar.google.com/scholar_lookup?&title=Nuclear%20hormone%20receptors%20in%20T%20lymphocytes&journal=Cell&doi=10.1016%2FS0092-8674%2802%2900710-9&volume=109&pages=S57-S66&publication_year=2002&author=Winoto%2CA&author=Littman%2CDR income
• How much does https://doi.org/10.1038%2F367281a0 net monthly?
• http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1994Natur.367..281L income
• Financial intake of http://scholar.google.com/scholar_lookup?&title=Apoptotic%20signals%20delivered%20through%20the%20T-cell%20receptor%20of%20a%20T-cell%20hybrid%20require%20the%20immediate-early%20gene%20nur77&journal=Nature&doi=10.1038%2F367281a0&volume=367&pages=281-284&publication_year=1994&author=Liu%2CZG&author=Smith%2CSW&author=McLaughlin%2CK%20A&author=Schwartz%2CLM&author=Osborne%2CBA
• What are the total earnings of https://doi.org/10.1038%2F367277a0?
• How much income does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1994Natur.367..277W have?
• What's the income generated by http://scholar.google.com/scholar_lookup?&title=Requirement%20for%20the%20orphan%20steroid%20receptor%20Nur77%20in%20apoptosis%20of%20T-cell%20hybridomas&journal=Nature&doi=10.1038%2F367277a0&volume=367&pages=277-281&publication_year=1994&author=Woronicz%2CJD&author=Calnan%2CB&author=Ngo%2CV&author=Winoto%2CA each month?
• Learn about the earnings of https://doi.org/10.1016%2FS0092-8674%2804%2900162-X
• How much revenue does http://scholar.google.com/scholar_lookup?&title=Conversion%20of%20Bcl-2%20from%20protector%20to%20killer%20by%20interaction%20with%20nuclear%20orphan%20receptor%20Nur77%2FTR3&journal=Cell&doi=10.1016%2FS0092-8674%2804%2900162-X&volume=116&pages=527-540&publication_year=2004&author=Lin%2CB generate?
• How much profit is https://doi.org/10.1038%2Fnm1579 making per month?
• What's the income of http://scholar.google.com/scholar_lookup?&title=Abrogation%20of%20nuclear%20receptors%20Nr4a3%20and%20Nr4a1%20leads%20to%20development%20of%20acute%20myeloid%20leukemia&journal=Nat.%20Med.&doi=10.1038%2Fnm1579&volume=13&pages=730-735&publication_year=2007&author=Mullican%2CSE?
• How much does https://doi.org/10.1096%2Ffj.10-166462 make?
• What's the total monthly financial gain of http://scholar.google.com/scholar_lookup?&title=Regulation%20of%20Nur77%20expression%20by%20%CE%B2-catenin%20and%20its%20mitogenic%20effect%20in%20colon%20cancer%20cells&journal=FASEB%20J.&doi=10.1096%2Ffj.10-166462&volume=25&pages=192-205&publication_year=2011&author=Wu%2CH?
• See how much https://doi.org/10.1158%2F0008-5472.CAN-10-1992 makes per month
• What's http://scholar.google.com/scholar_lookup?&title=Inactivation%20of%20the%20orphan%20nuclear%20receptor%20TR3%2FNur77%20inhibits%20pancreatic%20cancer%20cell%20and%20tumor%20growth&journal=Cancer%20Res.&doi=10.1158%2F0008-5472.CAN-10-1992&volume=70&pages=6824-6836&publication_year=2010&author=Lee%2CSO's gross income?
• How much revenue does https://doi.org/10.1126%2Fscience.286.5439.455 produce monthly?
• What is the monthly revenue of http://scholar.google.com/scholar_lookup?&title=The%20mammalian%20gene%20collection&journal=Science&doi=10.1126%2Fscience.286.5439.455&volume=286&pages=455-457&publication_year=1999&author=Strausberg%2CRL&author=Feingold%2CEA&author=Klausner%2CRD&author=Collins%2CFS?
• How much income does https://doi.org/10.1038%2Fncb975 have?
• How much income does http://scholar.google.com/scholar_lookup?&title=Distinct%20endocytic%20pathways%20regulate%20TGF-%CE%B2%20receptor%20signalling%20and%20turnover&journal=Nat.%20Cell%20Biol.&doi=10.1038%2Fncb975&volume=5&pages=410-421&publication_year=2003&author=Di%20Guglielmo%2CGM&author=Le%20Roy%2CC&author=Goodfellow%2CA%20F&author=Wrana%2CJ%20L have?
• What's the monthly income of https://doi.org/10.1038%2F35071103?
• Get to know http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2001Natur.410..830N's earnings
• Profit of http://scholar.google.com/scholar_lookup?&title=Arkadia%20enhances%20nodal-related%20signalling%20to%20induce%20mesendoderm&journal=Nature&doi=10.1038%2F35071103&volume=410&pages=830-834&publication_year=2001&author=Niederlander%2CC&author=Walsh%2CJJ&author=Episkopou%2CV&author=Jones%2CCM
• How much profit does https://doi.org/10.1038%2F35071095 make?
• What's the income of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2001Natur.410..825E?
• How much profit does http://scholar.google.com/scholar_lookup?&title=Induction%20of%20the%20mammalian%20node%20requires%20Arkadia%20function%20in%20the%20extraembryonic%20lineages&journal=Nature&doi=10.1038%2F35071095&volume=410&pages=825-830&publication_year=2001&author=Episkopou%2CV make?
• How much does https://doi.org/10.1038%2Fsj.emboj.7601057 generate monthly?
• What are the earnings of http://scholar.google.com/scholar_lookup?&title=Axin%20is%20a%20scaffold%20protein%20in%20TGF-%CE%B2%20signaling%20that%20promotes%20degradation%20of%20Smad7%20by%20Arkadia&journal=EMBO%20J.&doi=10.1038%2Fsj.emboj.7601057&volume=25&pages=1646-1658&publication_year=2006&author=Liu%2CW?
• How much revenue does https://doi.org/10.1210%2Fmend-5-6-854 generate?
• Monthly income for http://scholar.google.com/scholar_lookup?&title=Transcriptional%20activation%20by%20Nur77%2C%20a%20growth%20factor-inducible%20member%20of%20the%20steroid%20hormone%20receptor%20superfamily&journal=Mol.%20Endocrinol.&doi=10.1210%2Fmend-5-6-854&volume=5&pages=854-859&publication_year=1991&author=Davis%2CIJ&author=Hazel%2CTG&author=Lau%2CL%20F
• Learn about the earnings of https://doi.org/10.1038%2Fnm1471
• How much profit does http://www.ams.org/mathscinet-getitem?mr=2223171 generate?
• How much does http://scholar.google.com/scholar_lookup?&title=NR4A%20orphan%20nuclear%20receptors%20are%20transcriptional%20regulators%20of%20hepatic%20glucose%20metabolism&journal=Nat.%20Med.&doi=10.1038%2Fnm1471&volume=12&pages=1048-1055&publication_year=2006&author=Pei%2CL gross monthly?
• Check the income stats for https://doi.org/10.1074%2Fjbc.M502606200
• How profitable is http://scholar.google.com/scholar_lookup?&title=Induction%20of%20NR4A%20orphan%20nuclear%20receptor%20expression%20in%20macrophages%20in%20response%20to%20inflammatory%20stimuli&journal=J.%20Biol.%20Chem.&doi=10.1074%2Fjbc.M502606200&volume=280&pages=29256-29262&publication_year=2005&author=Pei%2CL&author=Castrillo%2CA&author=Chen%2CM&author=Hoffmann%2CA&author=Tontonoz%2CP?
• What's the income generated by https://doi.org/10.1038%2Fnrc2853 each month?
• Profit of http://scholar.google.com/scholar_lookup?&title=TGF%CE%B2%20signalling%3A%20a%20complex%20web%20in%20cancer%20progression&journal=Nat.%20Rev.%20Cancer&doi=10.1038%2Fnrc2853&volume=10&pages=415-424&publication_year=2010&author=Ikushima%2CH&author=Miyazono%2CK
• How much revenue does https://doi.org/10.1038%2Fcr.2009.5 bring in?
• How much does http://scholar.google.com/scholar_lookup?&title=TGF-%CE%B2-induced%20epithelial%20to%20mesenchymal%20transition&journal=Cell.%20Res&doi=10.1038%2Fcr.2009.5&volume=19&pages=156-172&publication_year=2009&author=Xu%2CJ&author=Lamouille%2CS&author=Derynck%2CR pull in?
• Income figures for https://doi.org/10.1016%2Fj.cell.2009.11.007
• Financial intake of http://scholar.google.com/scholar_lookup?&title=Epithelial-mesenchymal%20transitions%20in%20development%20and%20disease&journal=Cell&doi=10.1016%2Fj.cell.2009.11.007&volume=139&pages=871-890&publication_year=2009&author=Thiery%2CJP&author=Acloque%2CH&author=Huang%2CRY&author=Nieto%2CMA
• How much revenue does https://doi.org/10.1016%2FS1535-6108%2803%2900132-6 generate?
• How much income does http://scholar.google.com/scholar_lookup?&title=A%20multigenic%20program%20mediating%20breast%20cancer%20metastasis%20to%20bone&journal=Cancer%20Cell&doi=10.1016%2FS1535-6108%2803%2900132-6&volume=3&pages=537-549&publication_year=2003&author=Kang%2CY have?
• How much does https://doi.org/10.1158%2F0008-5472.CAN-05-3565 generate monthly?
• http://scholar.google.com/scholar_lookup?&title=Inhibition%20of%20pulmonary%20and%20skeletal%20metastasis%20by%20a%20transforming%20growth%20factor-%CE%B2%20type%20I%20receptor%20kinase%20inhibitor&journal=Cancer%20Res.&doi=10.1158%2F0008-5472.CAN-05-3565&volume=66&pages=6714-6721&publication_year=2006&author=Bandyopadhyay%2CA's financial summary
• Profit of https://doi.org/10.1038%2Fncb2522
• Financial intake of http://scholar.google.com/scholar_lookup?&title=USP4%20is%20regulated%20by%20AKT%20phosphorylation%20and%20directly%20deubiquitylates%20TGF-%CE%B2%20type%20I%20receptor&journal=Nat.%20Cell%20Biol.&doi=10.1038%2Fncb2522&volume=14&pages=717-726&publication_year=2012&author=Zhang%2CL
• See how much https://doi.org/10.1073%2Fpnas.1203015109 makes per month
• http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2012PNAS..10911312W's financial summary
• What's the financial gain of http://scholar.google.com/scholar_lookup?&title=Canonical%20Wnt%20suppressor%2C%20Axin2%2C%20promotes%20colon%20carcinoma%20oncogenic%20activity&journal=Proc.%20Natl%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.1203015109&volume=109&pages=11312-11317&publication_year=2012&author=Wu%2CZQ?
• What's the revenue for https://doi.org/10.1101%2Fgad.1590908?
• Get to know http://scholar.google.com/scholar_lookup?&title=Axin%20and%20GSK3-%20control%20Smad3%20protein%20stability%20and%20modulate%20TGF-%CE%B2%20signaling&journal=Genes%20Dev.&doi=10.1101%2Fgad.1590908&volume=22&pages=106-120&publication_year=2008&author=Guo%2CX's earnings
• https://doi.org/10.1038%2Fnature01322's total income per month
• Learn how profitable http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2002Natur.420..860C is on a monthly basis
• How much does http://scholar.google.com/scholar_lookup?&title=Inflammation%20and%20cancer&journal=Nature&doi=10.1038%2Fnature01322&volume=420&pages=860-867&publication_year=2002&author=Coussens%2CLM&author=Werb%2CZ pull in monthly?
• How much does https://doi.org/10.1038%2Fnrd2372 net monthly?
• How much does http://scholar.google.com/scholar_lookup?&title=Strategies%20for%20the%20discovery%20and%20development%20of%20therapies%20for%20metastatic%20breast%20cancer&journal=Nat.%20Rev.%20Drug%20Discov.&doi=10.1038%2Fnrd2372&volume=11&pages=479-497&publication_year=2012&author=Eckhardt%2CBL&author=Francis%2CPA&author=Parker%2CBS&author=Anderson%2CRL make?
• What's https://doi.org/10.1016%2Fj.semcancer.2012.05.004's gross income?
• What's the monthly income of http://scholar.google.com/scholar_lookup?&title=TGF-%CE%B2-induced%20epithelial-mesenchymal%20transition%3A%20A%20link%20between%20cancer%20and%20inflammation&journal=Semin.%20Cancer%20Biol.&doi=10.1016%2Fj.semcancer.2012.05.004&volume=22&pages=455-461&publication_year=2012&author=Fuxe%2CJ&author=Karlsson%2CMCI?
• What are the earnings of https://doi.org/10.1038%2Fnature07205?
• Monthly income for http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2008Natur.454..436M
• Explore the financials of http://scholar.google.com/scholar_lookup?&title=Cancer-related%20inflammation&journal=Nature&doi=10.1038%2Fnature07205&volume=454&pages=436-444&publication_year=2008&author=Mantovani%2CA&author=Allavena%2CP&author=Sica%2CA&author=Balkwill%2CF
• How much does https://doi.org/10.1038%2F17826 earn?
• Discover the revenue of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1999Natur.397..710U
• What's the profit of http://scholar.google.com/scholar_lookup?&title=Inhibition%20of%20transforming%20growth%20factor-%CE%B2%2FSMAD%20signalling%20by%20the%20interferon-gamma%2FSTAT%20pathway&journal=Nature&doi=10.1038%2F17826&volume=397&pages=710-713&publication_year=1999&author=Ulloa%2CL&author=Doody%2CJ&author=Massagu%C3%A9%2CJ?
• What's the financial outcome of https://doi.org/10.1016%2FS1359-6101%2801%2900038-7?
• Revenue of http://scholar.google.com/scholar_lookup?&title=The%20roles%20of%20IFN%20gamma%20in%20protection%20against%20tumor%20development%20and%20cancer%20immunoediting&journal=Cytokine%20Growth%20Factor%20Rev.&doi=10.1016%2FS1359-6101%2801%2900038-7&volume=13&pages=95-109&publication_year=2002&author=Ikeda%2CH&author=Old%2CLJ&author=Schreiber%2CR%20D
• How much does https://doi.org/10.1126%2Fscience.7624775 net monthly?
• Check the income stats for http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1995Sci...269..532L
• What is the monthly revenue of http://scholar.google.com/scholar_lookup?&title=Unimpaired%20thymic%20and%20peripheral%20T%20cell%20death%20in%20mice%20lacking%20the%20nuclear%20receptor%20NGFI-B%20%28Nur77%29&journal=Science&doi=10.1126%2Fscience.7624775&volume=269&pages=532-535&publication_year=1995&author=Lee%2CSL?
• How much does https://doi.org/10.1016%2Fj.bbrc.2007.12.039 gross monthly?
• Check the income stats for http://scholar.google.com/scholar_lookup?&title=Nur77%20modulates%20hepatic%20lipid%20metabolism%20through%20suppression%20of%20SREBP1c%20activity&journal=Biochem.%20Biophys.%20Res.%20Commun.&doi=10.1016%2Fj.bbrc.2007.12.039&volume=366&pages=910-916&publication_year=2008&author=Pols%2CTW
• Find out how much https://doi.org/10.1126%2Fscience.1100569 earns monthly
• What are the total earnings of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2004Sci...306..114Z?
• See how much http://scholar.google.com/scholar_lookup?&title=Zebrafish%20Dpr2%20inhibits%20mesoderm%20induction%20by%20promoting%20degradation%20of%20nodal%20receptors&journal=Science&doi=10.1126%2Fscience.1100569&volume=306&pages=114-117&publication_year=2004&author=Zhang%2CL makes per month
• Revenue of https://doi.org/10.1091%2Fmbc.e11-06-0483
• How much does http://scholar.google.com/scholar_lookup?&title=GSK3%CE%B2%20inactivation%20induces%20apoptosis%20of%20leukemia%20cells%20by%20repressing%20the%20function%20of%20c-Myb&journal=Mol.%20Biol.%20Cell&doi=10.1091%2Fmbc.e11-06-0483&volume=22&pages=3533-3540&publication_year=2011&author=Zhou%2CF&author=Zhang%2CL&author=van%20Laar%2CT&author=van%20Dam%2CH&author=Ten%20Dijke%2CP make?
• What is the monthly revenue of https://doi.org/10.1002%2Fpath.4013?
• How much does http://scholar.google.com/scholar_lookup?&title=Neutrophil-mediated%20experimental%20metastasis%20is%20enhanced%20by%20VEGFR%20inhibition%20in%20a%20zebrafish%20xenograft%20model&journal=J.%20Pathol.&doi=10.1002%2Fpath.4013&volume=227&pages=431-445&publication_year=2012&author=He%2CS make?
• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=3180096's financial summary
• How much cash flow does http://scholar.google.com/scholar_lookup?&title=A%20murine%20model%20of%20experimental%20metastasis%20to%20bone%20and%20bone%20marrow&journal=Cancer%20Res.&volume=48&pages=6876-6881&publication_year=1988&author=Arguello%2CF&author=Baggs%2CRB&author=Frantz%2CC%20N have monthly?
• What's the financial outcome of https://citation-needed.springer.com/v2/references/10.1038/ncomms4388?format=refman&flavour=references?
• Earnings of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=FangFang%20Zhou
• How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22FangFang%20Zhou%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en bring in each month?
• Discover the revenue of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Yvette%20Drabsch
• What's the monthly income of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Yvette%20Drabsch%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• How much income does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Tim%20J.%20A.%20Dekker have?
• What's the income generated by https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Tim%20J.%20A.%20Dekker%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en each month?
• Check the income stats for https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Amaya%20Garcia%20de%20Vinuesa
• How much profit is https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Amaya%20Garcia%20de%20Vinuesa%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en making per month?
• How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Yihao%20Li earn?
• How much cash flow does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Yihao%20Li%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en have monthly?
• How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Lukas%20J.%20A.%20C.%20Hawinkels pull in?
• What's the income of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Lukas%20J.%20A.%20C.%20Hawinkels%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• How much cash flow does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Kelly-Ann%20Sheppard have monthly?
• What is the monthly revenue of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Kelly-Ann%20Sheppard%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Marie-Jos%C3%A9%20Goumans rake in every month?
• Revenue of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Marie-Jos%C3%A9%20Goumans%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Rodney%20B.%20Luwor earn?
• How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Rodney%20B.%20Luwor%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en bring in each month?
• What are the total earnings of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Carlie%20J.%20de%20Vries?
• How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Carlie%20J.%20de%20Vries%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en net monthly?
• Earnings of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Wilma%20E.%20Mesker
• Earnings of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Wilma%20E.%20Mesker%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• What's the financial outcome of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Rob%20A.%20E.%20M.%20Tollenaar?
• What's https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Rob%20A.%20E.%20M.%20Tollenaar%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en's gross income?
• How much money does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Peter%20Devilee generate?
• Explore the financials of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Peter%20Devilee%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• Monthly income for https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Chris%20X.%20Lu
• How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Chris%20X.%20Lu%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en earn?
• https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Hongjian%20Zhu's financial summary
• What's the revenue for https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Hongjian%20Zhu%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Long%20Zhang make?
• What's the profit of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Long%20Zhang%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Peter%20ten%20Dijke bring in each month?
• Profit of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Peter%20ten%20Dijke%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• How much money does https://static-content.springer.com/esm/art%3A10.1038%2Fncomms4388/MediaObjects/41467_2014_BFncomms4388_MOESM795_ESM.pdf generate?
• https://s100.copyright.com/AppDispatchServlet?title=Nuclear%20receptor%20NR4A1%20promotes%20breast%20cancer%20invasion%20and%20metastasis%20by%20activating%20TGF-%CE%B2%20signalling&author=FangFang%20Zhou%20et%20al&contentID=10.1038%2Fncomms4388©right=Springer%20Nature%20Limited&publication=2041-1723&publicationDate=2014-03-03&publisherName=SpringerNature&orderBeanReset=true's revenue stream
• What's the financial outcome of https://citation-needed.springer.com/v2/references/10.1038/ncomms4388?format=refman&flavour=citation?
• Earnings of https://doi.org/10.1186/s13040-024-00357-1
• Explore the financials of https://doi.org/10.1038/s41568-023-00568-4
• How much does https://doi.org/10.1007/s43032-022-01134-3 pull in monthly?
• How much does https://doi.org/10.1038/s41368-022-00190-4 generate monthly?
• What's the income of https://doi.org/10.1038/s41420-022-00843-7?
• What's the total monthly financial gain of https://www.protocols.io/?
• Explore the financials of https://www.natureindex.com/
• How much does http://www.naturechina.com gross monthly?
• How much money does https://www.natureasia.com/ja-jp generate?

Analytics and Tracking {📊}

• Google Tag Manager

Libraries {📚}

• Prism.js
• Zoom.js

Emails and Hosting {✉️}

Mail Servers:

• mxa-002c5801.gslb.pphosted.com
• mxb-002c5801.gslb.pphosted.com

Name Servers:

• pdns1.ultradns.net
• pdns2.ultradns.net
• pdns3.ultradns.org
• pdns4.ultradns.org
• pdns5.ultradns.info
• pdns6.ultradns.co.uk

CDN Services {📦}

• Crossref