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We began analyzing https://www.nature.com/articles/367277a0, but it redirected us to https://www.nature.com/articles/367277a0. The analysis below is for the second page.

Title[redir]:
Requirement for the orphan steroid receptor Nur77 in apoptosis of T-cell hybridomas | Nature
Description:
APOPTOSIS is a phenomenon observed during development of many cell types in many organisms. It is an internal, programmed cell death characterized by DNA fragmentation into nucleosome-size pieces1–3. Anti-CD3-induced apoptosis in T-cell hybridomas and immature thymocytes requires new gene transcription and may be related to negative selection during T-cell development4–6. Using subtractive hybridization, we isolated a complementary DNA clone encoding the orphan steroid receptor Nur77 (refs 7–9). It shows different patterns of messenger RNA induction between apoptotic and stimulated T cells. We report here the use of gel shift analysis to demonstrate that the Nur77 protein is present at high levels in apoptotic T-cell hybridomas and apoptotic thymocytes, but not in growing T cells or stimulated splenocytes. A Nur77 dominant negative protected T-cell hybridomas from activation-induced apoptosis. Hence Nur77 is necessary for induced apoptosis in T-cell hybridomas.

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article, google, scholar, cas, nature, cell, ads, access, tcell, content, apoptosis, usa, cookies, hybridomas, death, immun, proc, natn, acad, sci, privacy, milbrandt, research, data, receptor, winoto, development, open, science, advertising, analysis, information, subscribe, orphan, steroid, woronicz, calnan, ngo, thymocytes, apoptotic, cells, institution, buy, differentiation, laboratory, press, permissions, optional, media, personal,

Topics {✒️}

nature portfolio permissions reprints cancer research laboratory privacy policy pharmacal research advertising subscribe nature social media nature 337 nature 353 nature 362 nature 367 nature cell development t-cell receptor signaling t-cell hybridomas john mitochondria-shaping protein opa1 apoptotic t-cell hybridomas anti-cd3-induced apoptosis personal data springerlink instant access data protection permissions t-cell hybridomas development gel shift analysis t-cell development4–6 privacy cell death explore content subscription content european economic area nucleosome-size pieces1–3 messenger rna induction institutional subscriptions read dimensional chromatin architecture nucleic acids res nr4a nuclear receptors sumo-triggered ubiquitination activation-induced apoptosis accepting optional cookies journals search log issue learn manage preferences immature thymocytes requires article purchase content access usage analysis article cite

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