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nature portfolio permissions reprints privacy policy editing advertising medical research council scripps research institute nature p53-hdm2 protein-protein interaction east hanover author information authors full size image real-time nuclear localization ligand-dependent transcription factor er-coregulator pelp1/mnar c-terminal ligand-binding domain castration-resistant prostate cancer oligoamide alpha-helix mimetics affect dht-induced translocation gb/sa solvation model28 inhibiting androgen-induced activation full access developed oligo-benzamide scaffolds larger oligo-benzamide scaffolds metastatic renal-cell carcinoma phenol-red-free rpmi 1640 genome-wide microarray profiling bis-benzamide-based peptidomimetic d2 author correspondence tae-kyung lee freshly extirpated high-risk protease-mediated proteolytic degradation full-length ar activity sds–polyacrylamide gel electrophoresis ar-mediated transcriptional regulation21 leucine-rich protein-1/modulator jer-tsong hsieh & ganesh androgen-independent prostate cancer prostate cancer development dht-induced genomic activity ar-dependent mechanisms highlight hormone-refractory prostate cancer post-chemotherapy crpc patients38 dht-induced genomic function oligo-benzamide-based peptidomimetics middle panel serum-starvation conditions androgen receptor–coregulator proteins dht-mediated cell proliferation reactions including o-alkylation

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