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Title:
Androgen Receptor Coactivators and Prostate Cancer | SpringerLink
Description:
Among USA men, prostate cancer (PC) is the second most common cause of death from cancer. Thus, the etiology, prevention, and treatment of the disease are a major health concern. Development and differentiation of the prostate is androgen dependent and PC, too, is...
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Topics {✒️}

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Schema {🗺️}

ScholarlyArticle:
      headline:Androgen Receptor Coactivators and Prostate Cancer
      pageEnd:255
      pageStart:245
      image:https://media.springernature.com/w153/springer-static/cover/book/978-0-387-69080-3.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Hormonal Carcinogenesis V
         isbn:
            978-0-387-69080-3
            978-0-387-69078-0
         type:Book
      publisher:
         name:Springer New York
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Irina U. Agoulnik
            affiliation:
            type:Person
            name:Nancy L. Weigel
            affiliation:
                  name:Baylor College of Medicne
                  address:
                     name:Dept. of Molecular and Cellular Biology, Baylor College of Medicne, Houston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
      keywords:Prostate Cancer, Androgen Receptor, LNCaP Cell, Steroid Receptor, DU145 Cell
      description:Among USA men, prostate cancer (PC) is the second most common cause of death from cancer. Thus, the etiology, prevention, and treatment of the disease are a major health concern. Development and differentiation of the prostate is androgen dependent and PC, too, is androgen dependent (1). Consequently, some form of androgen deprivation is the primary treatment for metastatic PC. Although effective initially in reducing tumor burden, the tumors become resistant to androgen deprivation and recur within a relatively short period of time. The actions of androgens are mediated by the androgen receptor (AR) a hormone-activated transcription factor, which belongs to the large nuclear receptor superfamily of ligand-activated transcription factors (2, 3). AR differs from many of the other receptors in that it has two natural endogenous ligands. Testosterone (T) (Fig. 1) is the major circulating androgen and is the major hormone in most tissues. T is produced in the testis and is converted to 5α-dihydrotestosterone (DHT) (Fig. 1) by the enzyme 5α-reductase in the prostate as well as in selected other tissues including skin. DHT is a higher affinity ligand and is functionally the most important androgen in the prostate. In addition, there are a number of androgen metabolites including DHEA and androstenediol, which have much lower affinities for AR. Although these androgens are not thought to play a major role in AR action in androgen-repleted males, they may activate the AR when levels of T and DHT are reduced as a result of androgen ablation therapy.
      datePublished:2008
      isAccessibleForFree:
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         type:WebPageElement
      context:https://schema.org
Book:
      name:Hormonal Carcinogenesis V
      isbn:
         978-0-387-69080-3
         978-0-387-69078-0
Organization:
      name:Springer New York
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Baylor College of Medicne
      address:
         name:Dept. of Molecular and Cellular Biology, Baylor College of Medicne, Houston, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Irina U. Agoulnik
      affiliation:
      name:Nancy L. Weigel
      affiliation:
            name:Baylor College of Medicne
            address:
               name:Dept. of Molecular and Cellular Biology, Baylor College of Medicne, Houston, USA
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Dept. of Molecular and Cellular Biology, Baylor College of Medicne, Houston, USA
WebPageElement:
      isAccessibleForFree:
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