NATURE . COM {}

Matching Content Categories {📚}

• Science
• Telecommunications
• Health & Fitness

Content Management System {📝}

What CMS is nature.com built with?

Custom-built

No common CMS systems were detected on Nature.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of nature.com audience?

🌆 Monumental Traffic: 20M - 50M visitors per month


Based on our best estimate, this website will receive around 42,556,742 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Nature.com Make Money? {💸}

Display Ads {🎯}

Direct Advertisers (10)

Reseller Advertisers (38)

How Much Does Nature.com Make? {💰}

Display Ads {🎯}

$536,300 per month
Estimations show Nature.com's display ad online revenue falls between $357,519 and $983,176 per month.

Keywords {🔍}

drug, percs, pubmed, cells, fig, resistance, cancer, erlotinib, article, cell, perc, supplementary, mechanisms, google, scholar, media, cas, response, drugs, persister, central, state, data, genetic, egfr, nature, growth, sensitivity, line, lung, met, drugresistance, drugtolerant, plates, performed, curves, colonies, methods, figs, diverse, treatment, persisters, erlotinibfree, mutations, screen, mutation, inhibitors, analysis, single, multiple,

Topics {✒️}

nature portfolio privacy policy middle grey lines advertising nature 462 nature individual resistance solutions drug-resistance solutions libraries 0/ reprints persister-derived erlotinib-resistant colonies small-cell lung cancer biomek liquid-handling robot synonymous single-nucleotide variant accurate long-read alignment burrows-wheeler alignment tool large-scale drug screen17 reversing melanoma cross-resistance drug-resistant cancer populations resistance-conferring genetic mutations somatic single-nucleotide variants large-scale drug screening drug-tolerant persister state8 sequence read archive small-scale ‘bypass’ experiment transient sirna-mediated knockdown accession number srp068321 interrogate drug-resistance mechanisms diverse drug-resistance mechanisms nci oncology set eliminating fast-growing populations drug-tolerant persister state egf receptor/akt pathway heterogeneous drug-resistance mechanisms 150–200-bp insert library long-term drug holiday diverse drug library permissions drug-category-response score perc drug-resistance mechanisms multiple cell lines smoothed drug-response curves cancer cell populations converting cancer therapies single genetic/epigenetic state tyrosine kinase inhibitors epidermal growth factor eliminating fast-growing cells relative drug-response score varying drug-response scores

Questions {❓}

• Second-generation irreversible epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs): a better mousetrap?
• Would different initial cells, passing through the persister bottleneck, give rise to the same resistance landscape?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Diverse drug-resistance mechanisms can emerge from drug-tolerant cancer persister cells
         description:Cancer therapy has traditionally focused on eliminating fast-growing populations of cells. Yet, an increasing body of evidence suggests that small subpopulations of cancer cells can evade strong selective drug pressure by entering a ‘persister’ state of negligible growth. This drug-tolerant state has been hypothesized to be part of an initial strategy towards eventual acquisition of bona fide drug-resistance mechanisms. However, the diversity of drug-resistance mechanisms that can expand from a persister bottleneck is unknown. Here we compare persister-derived, erlotinib-resistant colonies that arose from a single, EGFR-addicted lung cancer cell. We find, using a combination of large-scale drug screening and whole-exome sequencing, that our erlotinib-resistant colonies acquired diverse resistance mechanisms, including the most commonly observed clinical resistance mechanisms. Thus, the drug-tolerant persister state does not limit—and may even provide a latent reservoir of cells for—the emergence of heterogeneous drug-resistance mechanisms. Cancer cells that survive initial drug treatment can persist in the presence of drugs. Here, the authors generate persister cells that are resistant to the EGFR tyrosine kinase inhibitor erlotinib and show by single cell analysis that multiple mechanism give rise to the drug-resistant persister state.
         datePublished:2016-02-19T00:00:00Z
         dateModified:2016-02-19T00:00:00Z
         pageStart:1
         pageEnd:8
         license:http://creativecommons.org/licenses/by/4.0/
         sameAs:https://doi.org/10.1038/ncomms10690
         keywords:
            Cancer genetics
            Cancer therapeutic resistance
            Science
            Humanities and Social Sciences
            multidisciplinary
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms10690/MediaObjects/41467_2016_Article_BFncomms10690_Figa_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms10690/MediaObjects/41467_2016_Article_BFncomms10690_Fig1_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms10690/MediaObjects/41467_2016_Article_BFncomms10690_Fig2_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms10690/MediaObjects/41467_2016_Article_BFncomms10690_Fig3_HTML.jpg
         isPartOf:
            name:Nature Communications
            issn:
               2041-1723
            volumeNumber:7
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Nature Publishing Group UK
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Michael Ramirez
               affiliation:
                     name:University of California, San Francisco
                     address:
                        name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
                        type:PostalAddress
                     type:Organization
                     name:Green Center for Systems Biology, University of Texas Southwestern Medical Center
                     address:
                        name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Satwik Rajaram
               affiliation:
                     name:University of California, San Francisco
                     address:
                        name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
                        type:PostalAddress
                     type:Organization
                     name:Green Center for Systems Biology, University of Texas Southwestern Medical Center
                     address:
                        name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Robert J. Steininger
               affiliation:
                     name:Green Center for Systems Biology, University of Texas Southwestern Medical Center
                     address:
                        name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Daria Osipchuk
               affiliation:
                     name:University of California, San Francisco
                     address:
                        name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Maike A. Roth
               affiliation:
                     name:University of California, San Francisco
                     address:
                        name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Leanna S. Morinishi
               affiliation:
                     name:University of California, San Francisco
                     address:
                        name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Louise Evans
               affiliation:
                     name:University of California, San Francisco
                     address:
                        name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Weiyue Ji
               affiliation:
                     name:University of California, San Francisco
                     address:
                        name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Chien-Hsiang Hsu
               affiliation:
                     name:University of California, San Francisco
                     address:
                        name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Kevin Thurley
               affiliation:
                     name:University of California, San Francisco
                     address:
                        name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Shuguang Wei
               affiliation:
                     name:University of Texas Southwestern Medical Center
                     address:
                        name:Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Anwu Zhou
               affiliation:
                     name:University of Texas Southwestern Medical Center
                     address:
                        name:Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Prasad R. Koduru
               affiliation:
                     name:University of Texas Southwestern Medical Center
                     address:
                        name:Department of Pathology, University of Texas Southwestern Medical Center, Dallas, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Bruce A. Posner
               affiliation:
                     name:University of Texas Southwestern Medical Center
                     address:
                        name:Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Lani F. Wu
               affiliation:
                     name:University of California, San Francisco
                     address:
                        name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
                        type:PostalAddress
                     type:Organization
                     name:Green Center for Systems Biology, University of Texas Southwestern Medical Center
                     address:
                        name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Steven J. Altschuler
               affiliation:
                     name:University of California, San Francisco
                     address:
                        name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
                        type:PostalAddress
                     type:Organization
                     name:Green Center for Systems Biology, University of Texas Southwestern Medical Center
                     address:
                        name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Diverse drug-resistance mechanisms can emerge from drug-tolerant cancer persister cells
      description:Cancer therapy has traditionally focused on eliminating fast-growing populations of cells. Yet, an increasing body of evidence suggests that small subpopulations of cancer cells can evade strong selective drug pressure by entering a ‘persister’ state of negligible growth. This drug-tolerant state has been hypothesized to be part of an initial strategy towards eventual acquisition of bona fide drug-resistance mechanisms. However, the diversity of drug-resistance mechanisms that can expand from a persister bottleneck is unknown. Here we compare persister-derived, erlotinib-resistant colonies that arose from a single, EGFR-addicted lung cancer cell. We find, using a combination of large-scale drug screening and whole-exome sequencing, that our erlotinib-resistant colonies acquired diverse resistance mechanisms, including the most commonly observed clinical resistance mechanisms. Thus, the drug-tolerant persister state does not limit—and may even provide a latent reservoir of cells for—the emergence of heterogeneous drug-resistance mechanisms. Cancer cells that survive initial drug treatment can persist in the presence of drugs. Here, the authors generate persister cells that are resistant to the EGFR tyrosine kinase inhibitor erlotinib and show by single cell analysis that multiple mechanism give rise to the drug-resistant persister state.
      datePublished:2016-02-19T00:00:00Z
      dateModified:2016-02-19T00:00:00Z
      pageStart:1
      pageEnd:8
      license:http://creativecommons.org/licenses/by/4.0/
      sameAs:https://doi.org/10.1038/ncomms10690
      keywords:
         Cancer genetics
         Cancer therapeutic resistance
         Science
         Humanities and Social Sciences
         multidisciplinary
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms10690/MediaObjects/41467_2016_Article_BFncomms10690_Figa_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms10690/MediaObjects/41467_2016_Article_BFncomms10690_Fig1_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms10690/MediaObjects/41467_2016_Article_BFncomms10690_Fig2_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms10690/MediaObjects/41467_2016_Article_BFncomms10690_Fig3_HTML.jpg
      isPartOf:
         name:Nature Communications
         issn:
            2041-1723
         volumeNumber:7
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Nature Publishing Group UK
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Michael Ramirez
            affiliation:
                  name:University of California, San Francisco
                  address:
                     name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
                     type:PostalAddress
                  type:Organization
                  name:Green Center for Systems Biology, University of Texas Southwestern Medical Center
                  address:
                     name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Satwik Rajaram
            affiliation:
                  name:University of California, San Francisco
                  address:
                     name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
                     type:PostalAddress
                  type:Organization
                  name:Green Center for Systems Biology, University of Texas Southwestern Medical Center
                  address:
                     name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Robert J. Steininger
            affiliation:
                  name:Green Center for Systems Biology, University of Texas Southwestern Medical Center
                  address:
                     name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Daria Osipchuk
            affiliation:
                  name:University of California, San Francisco
                  address:
                     name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Maike A. Roth
            affiliation:
                  name:University of California, San Francisco
                  address:
                     name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Leanna S. Morinishi
            affiliation:
                  name:University of California, San Francisco
                  address:
                     name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Louise Evans
            affiliation:
                  name:University of California, San Francisco
                  address:
                     name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Weiyue Ji
            affiliation:
                  name:University of California, San Francisco
                  address:
                     name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Chien-Hsiang Hsu
            affiliation:
                  name:University of California, San Francisco
                  address:
                     name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Kevin Thurley
            affiliation:
                  name:University of California, San Francisco
                  address:
                     name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Shuguang Wei
            affiliation:
                  name:University of Texas Southwestern Medical Center
                  address:
                     name:Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Anwu Zhou
            affiliation:
                  name:University of Texas Southwestern Medical Center
                  address:
                     name:Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Prasad R. Koduru
            affiliation:
                  name:University of Texas Southwestern Medical Center
                  address:
                     name:Department of Pathology, University of Texas Southwestern Medical Center, Dallas, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Bruce A. Posner
            affiliation:
                  name:University of Texas Southwestern Medical Center
                  address:
                     name:Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Lani F. Wu
            affiliation:
                  name:University of California, San Francisco
                  address:
                     name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
                     type:PostalAddress
                  type:Organization
                  name:Green Center for Systems Biology, University of Texas Southwestern Medical Center
                  address:
                     name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Steven J. Altschuler
            affiliation:
                  name:University of California, San Francisco
                  address:
                     name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
                     type:PostalAddress
                  type:Organization
                  name:Green Center for Systems Biology, University of Texas Southwestern Medical Center
                  address:
                     name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Nature Communications
      issn:
         2041-1723
      volumeNumber:7
Organization:
      name:Nature Publishing Group UK
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:University of California, San Francisco
      address:
         name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
         type:PostalAddress
      name:Green Center for Systems Biology, University of Texas Southwestern Medical Center
      address:
         name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
         type:PostalAddress
      name:University of California, San Francisco
      address:
         name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
         type:PostalAddress
      name:Green Center for Systems Biology, University of Texas Southwestern Medical Center
      address:
         name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
         type:PostalAddress
      name:Green Center for Systems Biology, University of Texas Southwestern Medical Center
      address:
         name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
         type:PostalAddress
      name:University of California, San Francisco
      address:
         name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
         type:PostalAddress
      name:University of California, San Francisco
      address:
         name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
         type:PostalAddress
      name:University of California, San Francisco
      address:
         name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
         type:PostalAddress
      name:University of California, San Francisco
      address:
         name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
         type:PostalAddress
      name:University of California, San Francisco
      address:
         name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
         type:PostalAddress
      name:University of California, San Francisco
      address:
         name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
         type:PostalAddress
      name:University of California, San Francisco
      address:
         name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
         type:PostalAddress
      name:University of Texas Southwestern Medical Center
      address:
         name:Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, USA
         type:PostalAddress
      name:University of Texas Southwestern Medical Center
      address:
         name:Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, USA
         type:PostalAddress
      name:University of Texas Southwestern Medical Center
      address:
         name:Department of Pathology, University of Texas Southwestern Medical Center, Dallas, USA
         type:PostalAddress
      name:University of Texas Southwestern Medical Center
      address:
         name:Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, USA
         type:PostalAddress
      name:University of California, San Francisco
      address:
         name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
         type:PostalAddress
      name:Green Center for Systems Biology, University of Texas Southwestern Medical Center
      address:
         name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
         type:PostalAddress
      name:University of California, San Francisco
      address:
         name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
         type:PostalAddress
      name:Green Center for Systems Biology, University of Texas Southwestern Medical Center
      address:
         name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Michael Ramirez
      affiliation:
            name:University of California, San Francisco
            address:
               name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
               type:PostalAddress
            type:Organization
            name:Green Center for Systems Biology, University of Texas Southwestern Medical Center
            address:
               name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
               type:PostalAddress
            type:Organization
      name:Satwik Rajaram
      affiliation:
            name:University of California, San Francisco
            address:
               name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
               type:PostalAddress
            type:Organization
            name:Green Center for Systems Biology, University of Texas Southwestern Medical Center
            address:
               name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
               type:PostalAddress
            type:Organization
      name:Robert J. Steininger
      affiliation:
            name:Green Center for Systems Biology, University of Texas Southwestern Medical Center
            address:
               name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
               type:PostalAddress
            type:Organization
      name:Daria Osipchuk
      affiliation:
            name:University of California, San Francisco
            address:
               name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
               type:PostalAddress
            type:Organization
      name:Maike A. Roth
      affiliation:
            name:University of California, San Francisco
            address:
               name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
               type:PostalAddress
            type:Organization
      name:Leanna S. Morinishi
      affiliation:
            name:University of California, San Francisco
            address:
               name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
               type:PostalAddress
            type:Organization
      name:Louise Evans
      affiliation:
            name:University of California, San Francisco
            address:
               name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
               type:PostalAddress
            type:Organization
      name:Weiyue Ji
      affiliation:
            name:University of California, San Francisco
            address:
               name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
               type:PostalAddress
            type:Organization
      name:Chien-Hsiang Hsu
      affiliation:
            name:University of California, San Francisco
            address:
               name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
               type:PostalAddress
            type:Organization
      name:Kevin Thurley
      affiliation:
            name:University of California, San Francisco
            address:
               name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
               type:PostalAddress
            type:Organization
      name:Shuguang Wei
      affiliation:
            name:University of Texas Southwestern Medical Center
            address:
               name:Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, USA
               type:PostalAddress
            type:Organization
      name:Anwu Zhou
      affiliation:
            name:University of Texas Southwestern Medical Center
            address:
               name:Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, USA
               type:PostalAddress
            type:Organization
      name:Prasad R. Koduru
      affiliation:
            name:University of Texas Southwestern Medical Center
            address:
               name:Department of Pathology, University of Texas Southwestern Medical Center, Dallas, USA
               type:PostalAddress
            type:Organization
      name:Bruce A. Posner
      affiliation:
            name:University of Texas Southwestern Medical Center
            address:
               name:Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, USA
               type:PostalAddress
            type:Organization
      name:Lani F. Wu
      affiliation:
            name:University of California, San Francisco
            address:
               name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
               type:PostalAddress
            type:Organization
            name:Green Center for Systems Biology, University of Texas Southwestern Medical Center
            address:
               name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Steven J. Altschuler
      affiliation:
            name:University of California, San Francisco
            address:
               name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
               type:PostalAddress
            type:Organization
            name:Green Center for Systems Biology, University of Texas Southwestern Medical Center
            address:
               name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
      name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
      name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
      name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
      name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
      name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
      name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
      name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
      name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
      name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
      name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
      name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
      name:Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, USA
      name:Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, USA
      name:Department of Pathology, University of Texas Southwestern Medical Center, Dallas, USA
      name:Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, USA
      name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
      name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
      name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
      name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA

Social Networks {👍}(2)

• https://www.facebook.com/NatureCommunications
• https://twitter.com/NatureComms

External Links {🔗}(200)

• What's the financial intake of http://www.ncbi.nlm.nih.gov/sra?term=SRP068321?
• https://doi.org/10.1016%2Fj.cell.2012.02.015's financial summary
• What's the monthly income of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=22424221?
• What's the total monthly financial gain of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465702?
• What's the income generated by http://scholar.google.com/scholar_lookup?&title=Converting%20cancer%20therapies%20into%20cures%3A%20lessons%20from%20infectious%20diseases&journal=Cell&doi=10.1016%2Fj.cell.2012.02.015&volume=148&pages=1089-1098&publication_year=2012&author=Glickman%2CMS&author=Sawyers%2CCL each month?
• How much does https://doi.org/10.1056%2FNEJMoa1113205 net monthly?
• How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=22397650 net monthly?
• What's the income generated by http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878653 each month?
• How much income does http://scholar.google.com/scholar_lookup?&title=Intratumor%20heterogeneity%20and%20branched%20evolution%20revealed%20by%20multiregion%20sequencing&journal=N.%20Engl.%20J.%20Med.&doi=10.1056%2FNEJMoa1113205&volume=366&pages=883-892&publication_year=2012&author=Gerlinger%2CM have?
• Financial intake of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=19931353
• See how much http://scholar.google.com/scholar_lookup?&title=Tumor%20heterogeneity%3A%20causes%20and%20consequences&journal=Biochim.%20Biophys.%20Acta&volume=1805&pages=105-117&publication_year=2010&author=Marusyk%2CA&author=Polyak%2CK makes per month
• What's the monthly income of https://doi.org/10.1073%2Fpnas.0710370104?
• What's the monthly income of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2007PNAS..10420932B?
• Get to know http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18093943's earnings
• Profit of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409244
• http://scholar.google.com/scholar_lookup?&title=MET%20amplification%20occurs%20with%20or%20without%20T790M%20mutations%20in%20EGFR%20mutant%20lung%20tumors%20with%20acquired%20resistance%20to%20gefitinib%20or%20erlotinib&journal=Proc.%20Natl%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.0710370104&volume=104&pages=20932-20937&publication_year=2007&author=Bean%2CJ's financial summary
• What's the revenue for https://doi.org/10.1038%2Fnm.3841?
• Learn about the earnings of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=25849130
• How much does http://scholar.google.com/scholar_lookup?&title=Studying%20clonal%20dynamics%20in%20response%20to%20cancer%20therapy%20using%20high-complexity%20barcoding&journal=Nat.%20Med.&doi=10.1038%2Fnm.3841&volume=21&pages=440-448&publication_year=2015&author=Bhang%2CHE pull in?
• https://doi.org/10.1016%2Fj.ccr.2009.11.022's financial summary
• What is the earnings of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=20129249?
• http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2980857's financial summary
• Profit of http://scholar.google.com/scholar_lookup?&title=Preexistence%20and%20clonal%20selection%20of%20MET%20amplification%20in%20EGFR%20mutant%20NSCLC&journal=Cancer%20Cell&doi=10.1016%2Fj.ccr.2009.11.022&volume=17&pages=77-88&publication_year=2010&author=Turke%2CAB
• What's the monthly money flow for http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=22970367?
• Find out how much http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437267 earns monthly
• What's the income generated by http://scholar.google.com/scholar_lookup?&title=Mechanisms%20of%20resistance%20to%20epidermal%20growth%20factor%20receptor%20inhibitors%20and%20novel%20therapeutic%20strategies%20to%20overcome%20resistance%20in%20NSCLC%20Patients&journal=Chemother.%20Res.%20Pract.&volume=2012&publication_year=2012&author=Lin%2CL&author=Bivona%2CTG each month?
• Monthly income for https://doi.org/10.1016%2Fj.cell.2010.02.027
• How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=20371346 pull in monthly?
• How much profit does http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851638 generate?
• Income figures for http://scholar.google.com/scholar_lookup?&title=A%20chromatin-mediated%20reversible%20drug-tolerant%20state%20in%20cancer%20cell%20subpopulations&journal=Cell&doi=10.1016%2Fj.cell.2010.02.027&volume=141&pages=69-80&publication_year=2010&author=Sharma%2CSV
• How much cash flow does https://doi.org/10.1371%2Fjournal.ppat.1002121 have monthly?
• Get to know http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=21829345's earnings
• Profit of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3145784
• What's http://scholar.google.com/scholar_lookup?&title=%E2%80%98Persisters%E2%80%99%3A%20survival%20at%20the%20cellular%20level&journal=PLoS%20Pathog.&doi=10.1371%2Fjournal.ppat.1002121&volume=7&publication_year=2011&author=Dawson%2CCC&author=Intapa%2CC&author=Jabra-Rizk%2CMA's gross income?
• How much profit does https://doi.org/10.1126%2Fscience.1099390 generate?
• How much revenue does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2004Sci...305.1622B bring in?
• What's http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15308767's gross income?
• What is the earnings of http://scholar.google.com/scholar_lookup?&title=Bacterial%20persistence%20as%20a%20phenotypic%20switch&journal=Science&doi=10.1126%2Fscience.1099390&volume=305&pages=1622-1625&publication_year=2004&author=Balaban%2CNQ&author=Merrin%2CJ&author=Chait%2CR&author=Kowalik%2CL&author=Leibler%2CS?
• How much money does https://doi.org/10.1158%2F0008-5472.CAN-15-1113 generate?
• What's the financial gain of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=26490646?
• How much does http://scholar.google.com/scholar_lookup?&title=Inhibition%20of%20casein%20kinase%201%20alpha%20prevents%20acquired%20drug%20resistance%20to%20erlotinib%20in%20EGFR-mutant%20non-small%20cell%20lung%20cancer&journal=Cancer%20Res.&doi=10.1158%2F0008-5472.CAN-15-1113&volume=75&pages=4937-4948&publication_year=2015&author=Lantermann%2CAB bring in each month?
• How much money does https://doi.org/10.1080%2F15384101.2015.1090063 make?
• Discover the revenue of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=26566863
• Discover the revenue of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825557
• How much profit does http://scholar.google.com/scholar_lookup?&title=The%20histone%20demethylase%20KDM5A%20is%20a%20key%20factor%20for%20the%20resistance%20to%20temozolomide%20in%20glioblastoma&journal=Cell%20Cycle&doi=10.1080%2F15384101.2015.1090063&volume=14&pages=3418-3429&publication_year=2015&author=Banelli%2CB generate?
• What's the income of https://doi.org/10.1016%2Fj.phrs.2015.09.022?
• Discover the revenue of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=26453958
• See how much http://scholar.google.com/scholar_lookup?&title=AKT%20inactivation%20causes%20persistent%20drug%20tolerance%20to%20EGFR%20inhibitors&journal=Pharmacol.%20Res.&doi=10.1016%2Fj.phrs.2015.09.022&volume=102&pages=132-137&publication_year=2015&author=Tetsu%2CO&author=Phuchareon%2CJ&author=Eisele%2CDW&author=Hangauer%2CMJ&author=McCormick%2CF makes per month
• Learn about the earnings of https://doi.org/10.1038%2Fnrclinonc.2014.104
• What's the income of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=24981256?
• Profit of http://scholar.google.com/scholar_lookup?&title=Acquired%20resistance%20to%20TKIs%20in%20solid%20tumours%3A%20learning%20from%20lung%20cancer&journal=Nat.%20Rev.%20Clin.%20Oncol.&doi=10.1038%2Fnrclinonc.2014.104&volume=11&pages=473-481&publication_year=2014&author=Camidge%2CDR&author=Pao%2CW&author=Sequist%2CLV
• What's the income generated by http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15078990 each month?
• What is the monthly revenue of http://scholar.google.com/scholar_lookup?&title=Sensitivity%20to%20gefitinib%20%28Iressa%2C%20ZD1839%29%20in%20non-small%20cell%20lung%20cancer%20cell%20lines%20correlates%20with%20dependence%20on%20the%20epidermal%20growth%20factor%20%28EGF%29%20receptor%2Fextracellular%20signal-regulated%20kinase%201%2F2%20and%20EGF%20receptor%2FAkt%20pathway%20for%20proliferation&journal=Mol.%20Cancer%20Ther.&volume=3&pages=465-472&publication_year=2004&author=Ono%2CM?
• How profitable is https://doi.org/10.1126%2Fscitranslmed.3002356?
• How much revenue does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=21734175 generate?
• What's the financial intake of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500629?
• What's the financial outcome of http://scholar.google.com/scholar_lookup?&title=Optimization%20of%20dosing%20for%20EGFR-mutant%20non-small%20cell%20lung%20cancer%20with%20evolutionary%20cancer%20modeling&journal=Sci.%20Transl.%20Med.&doi=10.1126%2Fscitranslmed.3002356&volume=3&publication_year=2011&author=Chmielecki%2CJ?
• How much money does https://doi.org/10.1126%2Fscience.1254721 generate?
• Financial intake of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2014Sci...346.1480C
• Check the income stats for http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=25394791
• How much income does http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388482 have?
• How much money does http://scholar.google.com/scholar_lookup?&title=Patient-derived%20models%20of%20acquired%20resistance%20can%20identify%20effective%20drug%20combinations%20for%20cancer&journal=Science&doi=10.1126%2Fscience.1254721&volume=346&pages=1480-1486&publication_year=2014&author=Crystal%2CAS generate?
• Learn about the earnings of https://doi.org/10.1038%2Fnature08622
• What's the income of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2009Natur.462.1070Z?
• Earnings of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=20033049
• How much income is http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2879581 earning monthly?
• Earnings of http://scholar.google.com/scholar_lookup?&title=Novel%20mutant-selective%20EGFR%20kinase%20inhibitors%20against%20EGFR%20T790M&journal=Nature&doi=10.1038%2Fnature08622&volume=462&pages=1070-1074&publication_year=2009&author=Zhou%2CW
• How much profit does https://doi.org/10.1016%2Fj.critrevonc.2011.11.010 generate?
• How much revenue does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=22257651 generate?
• Get to know what's the income of http://scholar.google.com/scholar_lookup?&title=Second-generation%20irreversible%20epidermal%20growth%20factor%20receptor%20%28EGFR%29%20tyrosine%20kinase%20inhibitors%20%28TKIs%29%3A%20a%20better%20mousetrap%3F%20A%20review%20of%20the%20clinical%20evidence&journal=Crit.%20Rev.%20Oncol.%20Hematol.&doi=10.1016%2Fj.critrevonc.2011.11.010&volume=83&pages=407-421&publication_year=2012&author=Ou%2CSH
• See how much https://doi.org/10.1371%2Fjournal.pmed.0020017 makes per month
• How much profit is http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15696205 making per month?
• http://www.ncbi.nlm.nih.gov/pmc/articles/PMC545207's total income per month
• Learn how profitable http://scholar.google.com/scholar_lookup?&title=KRAS%20mutations%20and%20primary%20resistance%20of%20lung%20adenocarcinomas%20to%20gefitinib%20or%20erlotinib&journal=PLoS%20Med.&doi=10.1371%2Fjournal.pmed.0020017&volume=2&publication_year=2005&author=Pao%2CW is on a monthly basis
• How much does https://doi.org/10.1056%2FNEJMoa044238 pull in?
• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15728811 income
• Income figures for http://scholar.google.com/scholar_lookup?&title=EGFR%20mutation%20and%20resistance%20of%20non-small-cell%20lung%20cancer%20to%20gefitinib&journal=N.%20Engl.%20J.%20Med.&doi=10.1056%2FNEJMoa044238&volume=352&pages=786-792&publication_year=2005&author=Kobayashi%2CS
• https://doi.org/10.1038%2Fsrep05193 income
• How profitable is http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=24898935?
• How much cash flow does http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046135 have monthly?
• See how much http://scholar.google.com/scholar_lookup?&title=Quantitative%20scoring%20of%20differential%20drug%20sensitivity%20for%20individually%20optimized%20anticancer%20therapies&journal=Sci.%20Rep.&doi=10.1038%2Fsrep05193&volume=4&publication_year=2014&author=Yadav%2CB makes per month
• What's the monthly income of https://doi.org/10.1038%2Fnchembio.1337?
• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=24013279's total income per month
• What's the monthly money flow for http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947796?
• How much does http://scholar.google.com/scholar_lookup?&title=Metrics%20other%20than%20potency%20reveal%20systematic%20variation%20in%20responses%20to%20cancer%20drugs&journal=Nat.%20Chem.%20Biol.&doi=10.1038%2Fnchembio.1337&volume=9&pages=708-714&publication_year=2013&author=Fallahi-Sichani%2CM&author=Honarnejad%2CS&author=Heiser%2CLM&author=Grey%2CJW&author=Sorger%2CPK earn?
• What are the earnings of https://doi.org/10.1038%2Fnchembio.1690?
• Get to know http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=25402767's earnings
• How much does http://scholar.google.com/scholar_lookup?&title=GSK-3%20modulates%20cellular%20responses%20to%20a%20broad%20spectrum%20of%20kinase%20inhibitors&journal=Nat.%20Chem.%20Biol.&doi=10.1038%2Fnchembio.1690&volume=11&pages=58-63&publication_year=2015&author=Thorne%2CCA pull in?
• Get to know https://doi.org/10.1101%2Fgr.152322.112's earnings
• How much income is http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=23733853 earning monthly?
• What's the monthly income of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759720?
• Monthly income for http://scholar.google.com/scholar_lookup?&title=Next-generation%20sequencing%20of%20paired%20tyrosine%20kinase%20inhibitor-sensitive%20and%20-resistant%20EGFR%20mutant%20lung%20cancer%20cell%20lines%20identifies%20spectrum%20of%20DNA%20changes%20associated%20with%20drug%20resistance&journal=Genome%20Res.&doi=10.1101%2Fgr.152322.112&volume=23&pages=1434-1445&publication_year=2013&author=Jia%2CP
• How much money does https://doi.org/10.1126%2Fscience.1141478 generate?
• What's the revenue for http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2007Sci...316.1039E?
• Income figures for http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17463250
• What's the financial intake of http://scholar.google.com/scholar_lookup?&title=MET%20amplification%20leads%20to%20gefitinib%20resistance%20in%20lung%20cancer%20by%20activating%20ERBB3%20signaling&journal=Science&doi=10.1126%2Fscience.1141478&volume=316&pages=1039-1043&publication_year=2007&author=Engelman%2CJA?
• How much income is https://doi.org/10.1158%2F2159-8290.CD-12-0103 earning monthly?
• What are the total earnings of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=22961667?
• What is the monthly revenue of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3477553?
• How much money does http://scholar.google.com/scholar_lookup?&title=Reactivation%20of%20ERK%20signaling%20causes%20resistance%20to%20EGFR%20kinase%20inhibitors&journal=Cancer%20Discov.&doi=10.1158%2F2159-8290.CD-12-0103&volume=2&pages=934-947&publication_year=2012&author=Ercan%2CD make?
• Financial intake of https://doi.org/10.1158%2F0008-5472.CAN-14-3167
• What are the earnings of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=25870145?
• What's the monthly income of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605607?
• How much revenue does http://scholar.google.com/scholar_lookup?&title=Acquired%20resistance%20to%20the%20mutant-selective%20EGFR%20inhibitor%20AZD9291%20is%20associated%20with%20increased%20dependence%20on%20RAS%20signaling%20in%20preclinical%20models&journal=Cancer%20Res.&doi=10.1158%2F0008-5472.CAN-14-3167&volume=75&pages=2489-2500&publication_year=2015&author=Eberlein%2CCA produce monthly?
• What's the income of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11389083?
• How much does http://scholar.google.com/scholar_lookup?&title=High-throughput%20tissue%20microarray%20analysis%20of%203p25%20%28RAF1%29%20and%208p12%20%28FGFR1%29%20copy%20number%20alterations%20in%20urinary%20bladder%20cancer&journal=Cancer%20Res.&volume=61&pages=4514-4519&publication_year=2001&author=Simon%2CR pull in monthly?
• Learn about the earnings of https://doi.org/10.1371%2Fjournal.pone.0028973
• How much revenue does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2011PLoSO...628973A generate?
• What is the monthly revenue of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=22194965?
• How much does http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237573 earn?
• http://scholar.google.com/scholar_lookup?&title=Reversing%20melanoma%20cross-resistance%20to%20BRAF%20and%20MEK%20inhibitors%20by%20co-targeting%20the%20AKT%2FmTOR%20pathway&journal=PLoS%20ONE&doi=10.1371%2Fjournal.pone.0028973&volume=6&publication_year=2011&author=Atefi%2CM's total income per month
• How much income does https://doi.org/10.1126%2Fscisignal.2004652 have?
• Monthly income for http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=24065147
• How much income does http://scholar.google.com/scholar_lookup?&title=Bypass%20mechanisms%20of%20resistance%20to%20receptor%20tyrosine%20kinase%20inhibition%20in%20lung%20cancer&journal=Sci.%20Signal.&doi=10.1126%2Fscisignal.2004652&volume=6&publication_year=2013&author=Niederst%2CMJ&author=Engelman%2CJA have?
• What's the income generated by https://doi.org/10.1073%2Fpnas.0510857103 each month?
• Discover the revenue of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2006PNAS..103.1475B
• What is the monthly revenue of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=16432179?
• What's the financial gain of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1360603?
• How much cash flow does http://scholar.google.com/scholar_lookup?&title=Cancer-specific%20mutations%20in%20PIK3CA%20are%20oncogenic%20in%20vivo&journal=Proc.%20Natl%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.0510857103&volume=103&pages=1475-1479&publication_year=2006&author=Bader%2CAG&author=Kang%2CS&author=Vogt%2CPK have monthly?
• Learn how profitable https://doi.org/10.1158%2F1535-7163.MCT-11-0692 is on a monthly basis
• What's http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=22135231's gross income?
• How profitable is http://scholar.google.com/scholar_lookup?&title=Coexistence%20of%20PIK3CA%20and%20other%20oncogene%20mutations%20in%20lung%20adenocarcinoma-rationale%20for%20comprehensive%20mutation%20profiling&journal=Mol.%20Cancer%20Ther.&doi=10.1158%2F1535-7163.MCT-11-0692&volume=11&pages=485-491&publication_year=2012&author=Chaft%2CJE?
• What are the earnings of https://doi.org/10.1128%2FMCB.01124-09?
• Monthly income for http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=19995904
• Get to know what's the income of http://scholar.google.com/scholar_lookup?&title=DNA%20polymerase%20POLN%20participates%20in%20cross-link%20repair%20and%20homologous%20recombination&journal=Mol.%20Cell%20Biol.&doi=10.1128%2FMCB.01124-09&volume=30&pages=1088-1096&publication_year=2010&author=Moldovan%2CGL
• How much profit does https://doi.org/10.1158%2F0008-5472.CAN-10-0460 make?
• Financial intake of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=20643779
• What's the income generated by http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2932856 each month?
• How much does http://scholar.google.com/scholar_lookup?&title=Identification%20of%20optimal%20drug%20combinations%20targeting%20cellular%20networks%3A%20integrating%20phospho-proteomics%20and%20computational%20network%20analysis&journal=Cancer%20Res.&doi=10.1158%2F0008-5472.CAN-10-0460&volume=70&pages=6704-6714&publication_year=2010&author=Iadevaia%2CS&author=Lu%2CY&author=Morales%2CFC&author=Mills%2CGB&author=Ram%2CPT earn?
• What's the monthly income of https://doi.org/10.1371%2Fjournal.pbio.1001296?
• How much money does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=22509130 generate?
• What's the financial outcome of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317895?
• What's the income of http://scholar.google.com/scholar_lookup?&title=Nonheritable%20cellular%20variability%20accelerates%20the%20evolutionary%20processes%20of%20cancer&journal=PLoS%20Biol.&doi=10.1371%2Fjournal.pbio.1001296&volume=10&publication_year=2012&author=Frank%2CSA&author=Rosner%2CMR?
• What's the financial intake of https://link.springer.com/doi/10.1186/s13029-014-0027-x?
• How much money does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=25614758 make?
• Check the income stats for http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279979
• How much does http://scholar.google.com/scholar_lookup?&title=Robust%20dose-response%20curve%20estimation%20applied%20to%20high%20content%20screening%20data%20analysis&journal=Source%20Code%20Biol.%20Med.&doi=10.1186%2Fs13029-014-0027-x&volume=9&publication_year=2014&author=Nguyen%2CTT pull in?
• What is the earnings of https://doi.org/10.1093%2Fbioinformatics%2Fbtp698?
• Monthly income for http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=20080505
• How much does http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828108 net monthly?
• How much does http://scholar.google.com/scholar_lookup?&title=Fast%20and%20accurate%20long-read%20alignment%20with%20Burrows-Wheeler%20transform&journal=Bioinformatics&doi=10.1093%2Fbioinformatics%2Fbtp698&volume=26&pages=589-595&publication_year=2010&author=Li%2CH&author=Durbin%2CR generate monthly?
• Discover the revenue of https://doi.org/10.1038%2Fnbt.2514
• What's the financial gain of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=23396013?
• See how much http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3833702 makes per month
• How much does http://scholar.google.com/scholar_lookup?&title=Sensitive%20detection%20of%20somatic%20point%20mutations%20in%20impure%20and%20heterogeneous%20cancer%20samples&journal=Nat.%20Biotechnol.&doi=10.1038%2Fnbt.2514&volume=31&pages=213-219&publication_year=2013&author=Cibulskis%2CK rake in every month?
• What's the income generated by https://doi.org/10.1093%2Fbioinformatics%2Fbtr462 each month?
• What's the financial gain of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=21828086?
• What's the income of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179661?
• Financial intake of http://scholar.google.com/scholar_lookup?&title=Exome%20sequencing-based%20copy-number%20variation%20and%20loss%20of%20heterozygosity%20detection%3A%20ExomeCNV&journal=Bioinformatics&doi=10.1093%2Fbioinformatics%2Fbtr462&volume=27&pages=2648-2654&publication_year=2011&author=Sathirapongsasuti%2CJF
• Get to know what's the income of https://citation-needed.springer.com/v2/references/10.1038/ncomms10690?format=refman&flavour=references
• How much income is https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Michael%20Ramirez earning monthly?
• How much income does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Michael%20Ramirez%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en have?
• https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Satwik%20Rajaram income
• How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Satwik%20Rajaram%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en net monthly?
• What is the earnings of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Robert%20J.%20Steininger?
• How much income does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Robert%20J.%20Steininger%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en have?
• How profitable is https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Daria%20Osipchuk?
• What's the financial outcome of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Daria%20Osipchuk%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• How much profit is https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Maike%20A.%20Roth making per month?
• Financial intake of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Maike%20A.%20Roth%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• What's the income of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Leanna%20S.%20Morinishi?
• Learn about the earnings of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Leanna%20S.%20Morinishi%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• How much income is https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Louise%20Evans earning monthly?
• How much cash flow does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Louise%20Evans%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en have monthly?
• Get to know https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Weiyue%20Ji's earnings
• How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Weiyue%20Ji%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en gross monthly?
• Earnings of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Chien-Hsiang%20Hsu
• How much cash flow does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Chien-Hsiang%20Hsu%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en have monthly?
• How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Kevin%20Thurley net monthly?
• How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Kevin%20Thurley%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en gross monthly?
• Learn about the earnings of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Shuguang%20Wei
• https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Shuguang%20Wei%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en income
• How much profit does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Anwu%20Zhou make?
• How much income is https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Anwu%20Zhou%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en earning monthly?
• Earnings of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Prasad%20R.%20Koduru
• What's the financial intake of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Prasad%20R.%20Koduru%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Bruce%20A.%20Posner rake in every month?
• How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Bruce%20A.%20Posner%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en net monthly?
• How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Lani%20F.%20Wu generate monthly?
• What's the total monthly financial gain of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Lani%20F.%20Wu%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• Check the income stats for https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Steven%20J.%20Altschuler
• Financial intake of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Steven%20J.%20Altschuler%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• What's the revenue for https://static-content.springer.com/esm/art%3A10.1038%2Fncomms10690/MediaObjects/41467_2016_BFncomms10690_MOESM1080_ESM.pdf?
• How much does https://static-content.springer.com/esm/art%3A10.1038%2Fncomms10690/MediaObjects/41467_2016_BFncomms10690_MOESM1081_ESM.xls net monthly?
• See how much https://static-content.springer.com/esm/art%3A10.1038%2Fncomms10690/MediaObjects/41467_2016_BFncomms10690_MOESM1082_ESM.txt makes per month
• How much money does https://static-content.springer.com/esm/art%3A10.1038%2Fncomms10690/MediaObjects/41467_2016_BFncomms10690_MOESM1083_ESM.txt make?
• How profitable is https://static-content.springer.com/esm/art%3A10.1038%2Fncomms10690/MediaObjects/41467_2016_BFncomms10690_MOESM1084_ESM.txt?
• How much does http://creativecommons.org/licenses/by/4.0/ make?
• How much profit is https://s100.copyright.com/AppDispatchServlet?title=Diverse%20drug-resistance%20mechanisms%20can%20emerge%20from%20drug-tolerant%20cancer%20persister%20cells&author=Michael%20Ramirez%20et%20al&contentID=10.1038%2Fncomms10690©right=The%20Author%28s%29&publication=2041-1723&publicationDate=2016-02-19&publisherName=SpringerNature&orderBeanReset=true&oa=CC%20BY making per month?
• Learn about the earnings of https://crossmark.crossref.org/dialog/?doi=10.1038/ncomms10690
• How much profit does https://citation-needed.springer.com/v2/references/10.1038/ncomms10690?format=refman&flavour=citation make?
• Learn about the earnings of https://doi.org/10.1038/s41588-023-01592-8
• Income figures for https://doi.org/10.1186/s40164-023-00434-x
• What's the financial intake of https://doi.org/10.1038/s41698-023-00350-7?
• How much does https://doi.org/10.1038/s41598-023-34438-8 rake in every month?
• https://doi.org/10.1038/s41418-022-01064-2 income
• How much revenue does https://www.protocols.io/ produce monthly?
• https://www.natureindex.com/'s total income per month
• How much revenue does http://www.naturechina.com generate?
• Check the income stats for https://www.natureasia.com/ja-jp

Analytics and Tracking {📊}

• Google Tag Manager

Libraries {📚}

• Prism.js
• Zoom.js

Emails and Hosting {✉️}

Mail Servers:

• mxa-002c5801.gslb.pphosted.com
• mxb-002c5801.gslb.pphosted.com

Name Servers:

• pdns1.ultradns.net
• pdns2.ultradns.net
• pdns3.ultradns.org
• pdns4.ultradns.org
• pdns5.ultradns.info
• pdns6.ultradns.co.uk

CDN Services {📦}

• Crossref