
DOI . ORG {
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Title[redir]:
Bypass Mechanisms of Resistance to Receptor Tyrosine Kinase Inhibition in Lung Cancer | Science Signaling
Description:
Receptor tyrosine kinases (RTKs) are activated by somatic genetic alterations in a subset of cancers, and such cancers are often sensitive to specific inhibitors of the activated kinase. Two well-e...
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Keywords {🔍}
science, crossref, cancer, web, pubmed, google, scholar, resistance, lung, receptor, kinase, cancers, inhibitors, egfr, signaling, engelman, inhibition, cell, tyrosine, article, news, access, acquired, gefitinib, aaas, sci, usa, jänne, res, information, mutation, settleman, song, lee, miller, mutations, alk, growth, free, view, wang, clin, med, christensen, mechanisms, rtk, therapy, factor, drug, activation,
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research careers compare reviewers librarians manage disease–linked lrrk2-mutant mice authors information authors affiliations matthew mesenchymal transition-induced regulator growth-factor-driven resistance partner full text matrix-attached cancer cells nih/national cancer institute fgf2-fgfr1 autocrine pathway single-cell rna sequencing journals science google scholar social media facebook extracellular signal–regulated kinase braf-mutant colorectal cancers receptor tyrosine kinases comparative analysis small-cell lung cancer egfr-mutated oncogene-addicted egfr-mutant lung cancer science news egfr-mutant lung cancers alk-rearranged lung cancers scholarly commentary activating erbb3 signaling science family account member current issue analysis inferred signaling networks mapk signaling contributes anticancer kinase inhibitors articles check access clinical medicine cell growth arrest anaplastic lymphoma kinase request permissions acknowledgments contents advertisement sign latest news commentary single issue reprints permissions toc alerts institution references view options log igf-binding proteins breast cancer metastasis kinase inhibitor treatment
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