NATURE . COM {}

Matching Content Categories {📚}

• Science
• Telecommunications
• Health & Fitness

Content Management System {📝}

What CMS is nature.com built with?

Custom-built

No common CMS systems were detected on Nature.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of nature.com audience?

🌆 Monumental Traffic: 20M - 50M visitors per month


Based on our best estimate, this website will receive around 42,194,993 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Nature.com Make Money? {💸}

Display Ads {🎯}

Direct Advertisers (10)

Reseller Advertisers (38)

How Much Does Nature.com Make? {💰}

Display Ads {🎯}

$531,700 per month
Our analysis indicates Nature.com generates between $354,480 and $974,820 monthly online from display ads.

Keywords {🔍}

drug, percs, pubmed, cells, fig, resistance, cancer, erlotinib, article, cell, perc, supplementary, mechanisms, google, scholar, media, cas, response, drugs, persister, central, state, data, genetic, egfr, nature, growth, sensitivity, line, lung, met, drugresistance, drugtolerant, plates, performed, curves, colonies, methods, figs, diverse, treatment, persisters, erlotinibfree, mutations, screen, mutation, inhibitors, analysis, single, multiple,

Topics {✒️}

nature portfolio privacy policy middle grey lines advertising nature 462 nature individual resistance solutions drug-resistance solutions libraries 0/ reprints persister-derived erlotinib-resistant colonies small-cell lung cancer biomek liquid-handling robot synonymous single-nucleotide variant accurate long-read alignment burrows-wheeler alignment tool large-scale drug screen17 reversing melanoma cross-resistance drug-resistant cancer populations resistance-conferring genetic mutations somatic single-nucleotide variants large-scale drug screening drug-tolerant persister state8 sequence read archive small-scale ‘bypass’ experiment transient sirna-mediated knockdown accession number srp068321 interrogate drug-resistance mechanisms diverse drug-resistance mechanisms nci oncology set eliminating fast-growing populations drug-tolerant persister state egf receptor/akt pathway heterogeneous drug-resistance mechanisms 150–200-bp insert library long-term drug holiday diverse drug library permissions drug-category-response score perc drug-resistance mechanisms multiple cell lines smoothed drug-response curves cancer cell populations converting cancer therapies single genetic/epigenetic state tyrosine kinase inhibitors epidermal growth factor eliminating fast-growing cells relative drug-response score varying drug-response scores

Questions {❓}

• Second-generation irreversible epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs): a better mousetrap?
• Would different initial cells, passing through the persister bottleneck, give rise to the same resistance landscape?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Diverse drug-resistance mechanisms can emerge from drug-tolerant cancer persister cells
         description:Cancer therapy has traditionally focused on eliminating fast-growing populations of cells. Yet, an increasing body of evidence suggests that small subpopulations of cancer cells can evade strong selective drug pressure by entering a ‘persister’ state of negligible growth. This drug-tolerant state has been hypothesized to be part of an initial strategy towards eventual acquisition of bona fide drug-resistance mechanisms. However, the diversity of drug-resistance mechanisms that can expand from a persister bottleneck is unknown. Here we compare persister-derived, erlotinib-resistant colonies that arose from a single, EGFR-addicted lung cancer cell. We find, using a combination of large-scale drug screening and whole-exome sequencing, that our erlotinib-resistant colonies acquired diverse resistance mechanisms, including the most commonly observed clinical resistance mechanisms. Thus, the drug-tolerant persister state does not limit—and may even provide a latent reservoir of cells for—the emergence of heterogeneous drug-resistance mechanisms. Cancer cells that survive initial drug treatment can persist in the presence of drugs. Here, the authors generate persister cells that are resistant to the EGFR tyrosine kinase inhibitor erlotinib and show by single cell analysis that multiple mechanism give rise to the drug-resistant persister state.
         datePublished:2016-02-19T00:00:00Z
         dateModified:2016-02-19T00:00:00Z
         pageStart:1
         pageEnd:8
         license:http://creativecommons.org/licenses/by/4.0/
         sameAs:https://doi.org/10.1038/ncomms10690
         keywords:
            Cancer genetics
            Cancer therapeutic resistance
            Science
            Humanities and Social Sciences
            multidisciplinary
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms10690/MediaObjects/41467_2016_Article_BFncomms10690_Figa_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms10690/MediaObjects/41467_2016_Article_BFncomms10690_Fig1_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms10690/MediaObjects/41467_2016_Article_BFncomms10690_Fig2_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms10690/MediaObjects/41467_2016_Article_BFncomms10690_Fig3_HTML.jpg
         isPartOf:
            name:Nature Communications
            issn:
               2041-1723
            volumeNumber:7
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Nature Publishing Group UK
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Michael Ramirez
               affiliation:
                     name:University of California, San Francisco
                     address:
                        name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
                        type:PostalAddress
                     type:Organization
                     name:Green Center for Systems Biology, University of Texas Southwestern Medical Center
                     address:
                        name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Satwik Rajaram
               affiliation:
                     name:University of California, San Francisco
                     address:
                        name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
                        type:PostalAddress
                     type:Organization
                     name:Green Center for Systems Biology, University of Texas Southwestern Medical Center
                     address:
                        name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Robert J. Steininger
               affiliation:
                     name:Green Center for Systems Biology, University of Texas Southwestern Medical Center
                     address:
                        name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Daria Osipchuk
               affiliation:
                     name:University of California, San Francisco
                     address:
                        name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Maike A. Roth
               affiliation:
                     name:University of California, San Francisco
                     address:
                        name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Leanna S. Morinishi
               affiliation:
                     name:University of California, San Francisco
                     address:
                        name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Louise Evans
               affiliation:
                     name:University of California, San Francisco
                     address:
                        name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Weiyue Ji
               affiliation:
                     name:University of California, San Francisco
                     address:
                        name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Chien-Hsiang Hsu
               affiliation:
                     name:University of California, San Francisco
                     address:
                        name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Kevin Thurley
               affiliation:
                     name:University of California, San Francisco
                     address:
                        name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Shuguang Wei
               affiliation:
                     name:University of Texas Southwestern Medical Center
                     address:
                        name:Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Anwu Zhou
               affiliation:
                     name:University of Texas Southwestern Medical Center
                     address:
                        name:Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Prasad R. Koduru
               affiliation:
                     name:University of Texas Southwestern Medical Center
                     address:
                        name:Department of Pathology, University of Texas Southwestern Medical Center, Dallas, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Bruce A. Posner
               affiliation:
                     name:University of Texas Southwestern Medical Center
                     address:
                        name:Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Lani F. Wu
               affiliation:
                     name:University of California, San Francisco
                     address:
                        name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
                        type:PostalAddress
                     type:Organization
                     name:Green Center for Systems Biology, University of Texas Southwestern Medical Center
                     address:
                        name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Steven J. Altschuler
               affiliation:
                     name:University of California, San Francisco
                     address:
                        name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
                        type:PostalAddress
                     type:Organization
                     name:Green Center for Systems Biology, University of Texas Southwestern Medical Center
                     address:
                        name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Diverse drug-resistance mechanisms can emerge from drug-tolerant cancer persister cells
      description:Cancer therapy has traditionally focused on eliminating fast-growing populations of cells. Yet, an increasing body of evidence suggests that small subpopulations of cancer cells can evade strong selective drug pressure by entering a ‘persister’ state of negligible growth. This drug-tolerant state has been hypothesized to be part of an initial strategy towards eventual acquisition of bona fide drug-resistance mechanisms. However, the diversity of drug-resistance mechanisms that can expand from a persister bottleneck is unknown. Here we compare persister-derived, erlotinib-resistant colonies that arose from a single, EGFR-addicted lung cancer cell. We find, using a combination of large-scale drug screening and whole-exome sequencing, that our erlotinib-resistant colonies acquired diverse resistance mechanisms, including the most commonly observed clinical resistance mechanisms. Thus, the drug-tolerant persister state does not limit—and may even provide a latent reservoir of cells for—the emergence of heterogeneous drug-resistance mechanisms. Cancer cells that survive initial drug treatment can persist in the presence of drugs. Here, the authors generate persister cells that are resistant to the EGFR tyrosine kinase inhibitor erlotinib and show by single cell analysis that multiple mechanism give rise to the drug-resistant persister state.
      datePublished:2016-02-19T00:00:00Z
      dateModified:2016-02-19T00:00:00Z
      pageStart:1
      pageEnd:8
      license:http://creativecommons.org/licenses/by/4.0/
      sameAs:https://doi.org/10.1038/ncomms10690
      keywords:
         Cancer genetics
         Cancer therapeutic resistance
         Science
         Humanities and Social Sciences
         multidisciplinary
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms10690/MediaObjects/41467_2016_Article_BFncomms10690_Figa_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms10690/MediaObjects/41467_2016_Article_BFncomms10690_Fig1_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms10690/MediaObjects/41467_2016_Article_BFncomms10690_Fig2_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms10690/MediaObjects/41467_2016_Article_BFncomms10690_Fig3_HTML.jpg
      isPartOf:
         name:Nature Communications
         issn:
            2041-1723
         volumeNumber:7
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Nature Publishing Group UK
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Michael Ramirez
            affiliation:
                  name:University of California, San Francisco
                  address:
                     name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
                     type:PostalAddress
                  type:Organization
                  name:Green Center for Systems Biology, University of Texas Southwestern Medical Center
                  address:
                     name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Satwik Rajaram
            affiliation:
                  name:University of California, San Francisco
                  address:
                     name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
                     type:PostalAddress
                  type:Organization
                  name:Green Center for Systems Biology, University of Texas Southwestern Medical Center
                  address:
                     name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Robert J. Steininger
            affiliation:
                  name:Green Center for Systems Biology, University of Texas Southwestern Medical Center
                  address:
                     name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Daria Osipchuk
            affiliation:
                  name:University of California, San Francisco
                  address:
                     name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Maike A. Roth
            affiliation:
                  name:University of California, San Francisco
                  address:
                     name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Leanna S. Morinishi
            affiliation:
                  name:University of California, San Francisco
                  address:
                     name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Louise Evans
            affiliation:
                  name:University of California, San Francisco
                  address:
                     name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Weiyue Ji
            affiliation:
                  name:University of California, San Francisco
                  address:
                     name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Chien-Hsiang Hsu
            affiliation:
                  name:University of California, San Francisco
                  address:
                     name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Kevin Thurley
            affiliation:
                  name:University of California, San Francisco
                  address:
                     name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Shuguang Wei
            affiliation:
                  name:University of Texas Southwestern Medical Center
                  address:
                     name:Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Anwu Zhou
            affiliation:
                  name:University of Texas Southwestern Medical Center
                  address:
                     name:Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Prasad R. Koduru
            affiliation:
                  name:University of Texas Southwestern Medical Center
                  address:
                     name:Department of Pathology, University of Texas Southwestern Medical Center, Dallas, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Bruce A. Posner
            affiliation:
                  name:University of Texas Southwestern Medical Center
                  address:
                     name:Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Lani F. Wu
            affiliation:
                  name:University of California, San Francisco
                  address:
                     name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
                     type:PostalAddress
                  type:Organization
                  name:Green Center for Systems Biology, University of Texas Southwestern Medical Center
                  address:
                     name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Steven J. Altschuler
            affiliation:
                  name:University of California, San Francisco
                  address:
                     name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
                     type:PostalAddress
                  type:Organization
                  name:Green Center for Systems Biology, University of Texas Southwestern Medical Center
                  address:
                     name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Nature Communications
      issn:
         2041-1723
      volumeNumber:7
Organization:
      name:Nature Publishing Group UK
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:University of California, San Francisco
      address:
         name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
         type:PostalAddress
      name:Green Center for Systems Biology, University of Texas Southwestern Medical Center
      address:
         name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
         type:PostalAddress
      name:University of California, San Francisco
      address:
         name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
         type:PostalAddress
      name:Green Center for Systems Biology, University of Texas Southwestern Medical Center
      address:
         name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
         type:PostalAddress
      name:Green Center for Systems Biology, University of Texas Southwestern Medical Center
      address:
         name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
         type:PostalAddress
      name:University of California, San Francisco
      address:
         name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
         type:PostalAddress
      name:University of California, San Francisco
      address:
         name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
         type:PostalAddress
      name:University of California, San Francisco
      address:
         name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
         type:PostalAddress
      name:University of California, San Francisco
      address:
         name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
         type:PostalAddress
      name:University of California, San Francisco
      address:
         name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
         type:PostalAddress
      name:University of California, San Francisco
      address:
         name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
         type:PostalAddress
      name:University of California, San Francisco
      address:
         name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
         type:PostalAddress
      name:University of Texas Southwestern Medical Center
      address:
         name:Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, USA
         type:PostalAddress
      name:University of Texas Southwestern Medical Center
      address:
         name:Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, USA
         type:PostalAddress
      name:University of Texas Southwestern Medical Center
      address:
         name:Department of Pathology, University of Texas Southwestern Medical Center, Dallas, USA
         type:PostalAddress
      name:University of Texas Southwestern Medical Center
      address:
         name:Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, USA
         type:PostalAddress
      name:University of California, San Francisco
      address:
         name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
         type:PostalAddress
      name:Green Center for Systems Biology, University of Texas Southwestern Medical Center
      address:
         name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
         type:PostalAddress
      name:University of California, San Francisco
      address:
         name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
         type:PostalAddress
      name:Green Center for Systems Biology, University of Texas Southwestern Medical Center
      address:
         name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Michael Ramirez
      affiliation:
            name:University of California, San Francisco
            address:
               name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
               type:PostalAddress
            type:Organization
            name:Green Center for Systems Biology, University of Texas Southwestern Medical Center
            address:
               name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
               type:PostalAddress
            type:Organization
      name:Satwik Rajaram
      affiliation:
            name:University of California, San Francisco
            address:
               name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
               type:PostalAddress
            type:Organization
            name:Green Center for Systems Biology, University of Texas Southwestern Medical Center
            address:
               name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
               type:PostalAddress
            type:Organization
      name:Robert J. Steininger
      affiliation:
            name:Green Center for Systems Biology, University of Texas Southwestern Medical Center
            address:
               name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
               type:PostalAddress
            type:Organization
      name:Daria Osipchuk
      affiliation:
            name:University of California, San Francisco
            address:
               name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
               type:PostalAddress
            type:Organization
      name:Maike A. Roth
      affiliation:
            name:University of California, San Francisco
            address:
               name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
               type:PostalAddress
            type:Organization
      name:Leanna S. Morinishi
      affiliation:
            name:University of California, San Francisco
            address:
               name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
               type:PostalAddress
            type:Organization
      name:Louise Evans
      affiliation:
            name:University of California, San Francisco
            address:
               name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
               type:PostalAddress
            type:Organization
      name:Weiyue Ji
      affiliation:
            name:University of California, San Francisco
            address:
               name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
               type:PostalAddress
            type:Organization
      name:Chien-Hsiang Hsu
      affiliation:
            name:University of California, San Francisco
            address:
               name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
               type:PostalAddress
            type:Organization
      name:Kevin Thurley
      affiliation:
            name:University of California, San Francisco
            address:
               name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
               type:PostalAddress
            type:Organization
      name:Shuguang Wei
      affiliation:
            name:University of Texas Southwestern Medical Center
            address:
               name:Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, USA
               type:PostalAddress
            type:Organization
      name:Anwu Zhou
      affiliation:
            name:University of Texas Southwestern Medical Center
            address:
               name:Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, USA
               type:PostalAddress
            type:Organization
      name:Prasad R. Koduru
      affiliation:
            name:University of Texas Southwestern Medical Center
            address:
               name:Department of Pathology, University of Texas Southwestern Medical Center, Dallas, USA
               type:PostalAddress
            type:Organization
      name:Bruce A. Posner
      affiliation:
            name:University of Texas Southwestern Medical Center
            address:
               name:Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, USA
               type:PostalAddress
            type:Organization
      name:Lani F. Wu
      affiliation:
            name:University of California, San Francisco
            address:
               name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
               type:PostalAddress
            type:Organization
            name:Green Center for Systems Biology, University of Texas Southwestern Medical Center
            address:
               name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Steven J. Altschuler
      affiliation:
            name:University of California, San Francisco
            address:
               name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
               type:PostalAddress
            type:Organization
            name:Green Center for Systems Biology, University of Texas Southwestern Medical Center
            address:
               name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
      name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
      name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
      name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
      name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
      name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
      name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
      name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
      name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
      name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
      name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
      name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
      name:Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, USA
      name:Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, USA
      name:Department of Pathology, University of Texas Southwestern Medical Center, Dallas, USA
      name:Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, USA
      name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
      name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
      name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
      name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA

Social Networks {👍}(2)

• https://www.facebook.com/NatureCommunications
• https://twitter.com/NatureComms

External Links {🔗}(200)

• What's the financial intake of http://www.ncbi.nlm.nih.gov/sra?term=SRP068321?
• What is the monthly revenue of https://doi.org/10.1016%2Fj.cell.2012.02.015?
• What is the monthly revenue of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=22424221?
• Get to know http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465702's earnings
• Find out how much http://scholar.google.com/scholar_lookup?&title=Converting%20cancer%20therapies%20into%20cures%3A%20lessons%20from%20infectious%20diseases&journal=Cell&doi=10.1016%2Fj.cell.2012.02.015&volume=148&pages=1089-1098&publication_year=2012&author=Glickman%2CMS&author=Sawyers%2CCL earns monthly
• https://doi.org/10.1056%2FNEJMoa1113205's total income per month
• How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=22397650 make?
• What's the monthly income of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878653?
• How much does http://scholar.google.com/scholar_lookup?&title=Intratumor%20heterogeneity%20and%20branched%20evolution%20revealed%20by%20multiregion%20sequencing&journal=N.%20Engl.%20J.%20Med.&doi=10.1056%2FNEJMoa1113205&volume=366&pages=883-892&publication_year=2012&author=Gerlinger%2CM pull in monthly?
• How much profit does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=19931353 make?
• Revenue of http://scholar.google.com/scholar_lookup?&title=Tumor%20heterogeneity%3A%20causes%20and%20consequences&journal=Biochim.%20Biophys.%20Acta&volume=1805&pages=105-117&publication_year=2010&author=Marusyk%2CA&author=Polyak%2CK
• What's the profit of https://doi.org/10.1073%2Fpnas.0710370104?
• How much does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2007PNAS..10420932B net monthly?
• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18093943's revenue stream
• What's the financial outcome of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409244?
• How much does http://scholar.google.com/scholar_lookup?&title=MET%20amplification%20occurs%20with%20or%20without%20T790M%20mutations%20in%20EGFR%20mutant%20lung%20tumors%20with%20acquired%20resistance%20to%20gefitinib%20or%20erlotinib&journal=Proc.%20Natl%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.0710370104&volume=104&pages=20932-20937&publication_year=2007&author=Bean%2CJ earn?
• What's the financial gain of https://doi.org/10.1038%2Fnm.3841?
• Revenue of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=25849130
• Find out how much http://scholar.google.com/scholar_lookup?&title=Studying%20clonal%20dynamics%20in%20response%20to%20cancer%20therapy%20using%20high-complexity%20barcoding&journal=Nat.%20Med.&doi=10.1038%2Fnm.3841&volume=21&pages=440-448&publication_year=2015&author=Bhang%2CHE earns monthly
• See how much https://doi.org/10.1016%2Fj.ccr.2009.11.022 makes per month
• Income figures for http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=20129249
• What are the total earnings of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2980857?
• What is the earnings of http://scholar.google.com/scholar_lookup?&title=Preexistence%20and%20clonal%20selection%20of%20MET%20amplification%20in%20EGFR%20mutant%20NSCLC&journal=Cancer%20Cell&doi=10.1016%2Fj.ccr.2009.11.022&volume=17&pages=77-88&publication_year=2010&author=Turke%2CAB?
• What are the total earnings of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=22970367?
• What's the financial intake of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437267?
• Explore the financials of http://scholar.google.com/scholar_lookup?&title=Mechanisms%20of%20resistance%20to%20epidermal%20growth%20factor%20receptor%20inhibitors%20and%20novel%20therapeutic%20strategies%20to%20overcome%20resistance%20in%20NSCLC%20Patients&journal=Chemother.%20Res.%20Pract.&volume=2012&publication_year=2012&author=Lin%2CL&author=Bivona%2CTG
• How much does https://doi.org/10.1016%2Fj.cell.2010.02.027 generate monthly?
• How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=20371346 bring in each month?
• What is the monthly revenue of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851638?
• http://scholar.google.com/scholar_lookup?&title=A%20chromatin-mediated%20reversible%20drug-tolerant%20state%20in%20cancer%20cell%20subpopulations&journal=Cell&doi=10.1016%2Fj.cell.2010.02.027&volume=141&pages=69-80&publication_year=2010&author=Sharma%2CSV's financial summary
• What are the total earnings of https://doi.org/10.1371%2Fjournal.ppat.1002121?
• How much money does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=21829345 generate?
• How much money does http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3145784 generate?
• How much revenue does http://scholar.google.com/scholar_lookup?&title=%E2%80%98Persisters%E2%80%99%3A%20survival%20at%20the%20cellular%20level&journal=PLoS%20Pathog.&doi=10.1371%2Fjournal.ppat.1002121&volume=7&publication_year=2011&author=Dawson%2CCC&author=Intapa%2CC&author=Jabra-Rizk%2CMA bring in?
• What is the earnings of https://doi.org/10.1126%2Fscience.1099390?
• How much profit does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2004Sci...305.1622B make?
• Income figures for http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15308767
• How much does http://scholar.google.com/scholar_lookup?&title=Bacterial%20persistence%20as%20a%20phenotypic%20switch&journal=Science&doi=10.1126%2Fscience.1099390&volume=305&pages=1622-1625&publication_year=2004&author=Balaban%2CNQ&author=Merrin%2CJ&author=Chait%2CR&author=Kowalik%2CL&author=Leibler%2CS bring in each month?
• Explore the financials of https://doi.org/10.1158%2F0008-5472.CAN-15-1113
• Find out how much http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=26490646 earns monthly
• Profit of http://scholar.google.com/scholar_lookup?&title=Inhibition%20of%20casein%20kinase%201%20alpha%20prevents%20acquired%20drug%20resistance%20to%20erlotinib%20in%20EGFR-mutant%20non-small%20cell%20lung%20cancer&journal=Cancer%20Res.&doi=10.1158%2F0008-5472.CAN-15-1113&volume=75&pages=4937-4948&publication_year=2015&author=Lantermann%2CAB
• Monthly income for https://doi.org/10.1080%2F15384101.2015.1090063
• What's the income generated by http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=26566863 each month?
• What's the income of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825557?
• Explore the financials of http://scholar.google.com/scholar_lookup?&title=The%20histone%20demethylase%20KDM5A%20is%20a%20key%20factor%20for%20the%20resistance%20to%20temozolomide%20in%20glioblastoma&journal=Cell%20Cycle&doi=10.1080%2F15384101.2015.1090063&volume=14&pages=3418-3429&publication_year=2015&author=Banelli%2CB
• https://doi.org/10.1016%2Fj.phrs.2015.09.022 income
• What are the earnings of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=26453958?
• How much income does http://scholar.google.com/scholar_lookup?&title=AKT%20inactivation%20causes%20persistent%20drug%20tolerance%20to%20EGFR%20inhibitors&journal=Pharmacol.%20Res.&doi=10.1016%2Fj.phrs.2015.09.022&volume=102&pages=132-137&publication_year=2015&author=Tetsu%2CO&author=Phuchareon%2CJ&author=Eisele%2CDW&author=Hangauer%2CMJ&author=McCormick%2CF have?
• Get to know https://doi.org/10.1038%2Fnrclinonc.2014.104's earnings
• How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=24981256 pull in monthly?
• Explore the financials of http://scholar.google.com/scholar_lookup?&title=Acquired%20resistance%20to%20TKIs%20in%20solid%20tumours%3A%20learning%20from%20lung%20cancer&journal=Nat.%20Rev.%20Clin.%20Oncol.&doi=10.1038%2Fnrclinonc.2014.104&volume=11&pages=473-481&publication_year=2014&author=Camidge%2CDR&author=Pao%2CW&author=Sequist%2CLV
• What's the monthly money flow for http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15078990?
• Profit of http://scholar.google.com/scholar_lookup?&title=Sensitivity%20to%20gefitinib%20%28Iressa%2C%20ZD1839%29%20in%20non-small%20cell%20lung%20cancer%20cell%20lines%20correlates%20with%20dependence%20on%20the%20epidermal%20growth%20factor%20%28EGF%29%20receptor%2Fextracellular%20signal-regulated%20kinase%201%2F2%20and%20EGF%20receptor%2FAkt%20pathway%20for%20proliferation&journal=Mol.%20Cancer%20Ther.&volume=3&pages=465-472&publication_year=2004&author=Ono%2CM
• Financial intake of https://doi.org/10.1126%2Fscitranslmed.3002356
• What's the profit of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=21734175?
• Revenue of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500629
• How much does http://scholar.google.com/scholar_lookup?&title=Optimization%20of%20dosing%20for%20EGFR-mutant%20non-small%20cell%20lung%20cancer%20with%20evolutionary%20cancer%20modeling&journal=Sci.%20Transl.%20Med.&doi=10.1126%2Fscitranslmed.3002356&volume=3&publication_year=2011&author=Chmielecki%2CJ pull in?
• What's the financial outcome of https://doi.org/10.1126%2Fscience.1254721?
• How much does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2014Sci...346.1480C pull in?
• What's http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=25394791's gross income?
• How much does http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388482 rake in every month?
• What's the income generated by http://scholar.google.com/scholar_lookup?&title=Patient-derived%20models%20of%20acquired%20resistance%20can%20identify%20effective%20drug%20combinations%20for%20cancer&journal=Science&doi=10.1126%2Fscience.1254721&volume=346&pages=1480-1486&publication_year=2014&author=Crystal%2CAS each month?
• How much does https://doi.org/10.1038%2Fnature08622 bring in each month?
• Revenue of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2009Natur.462.1070Z
• What is the earnings of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=20033049?
• Learn about the earnings of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2879581
• Learn how profitable http://scholar.google.com/scholar_lookup?&title=Novel%20mutant-selective%20EGFR%20kinase%20inhibitors%20against%20EGFR%20T790M&journal=Nature&doi=10.1038%2Fnature08622&volume=462&pages=1070-1074&publication_year=2009&author=Zhou%2CW is on a monthly basis
• Profit of https://doi.org/10.1016%2Fj.critrevonc.2011.11.010
• How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=22257651 gross monthly?
• Learn how profitable http://scholar.google.com/scholar_lookup?&title=Second-generation%20irreversible%20epidermal%20growth%20factor%20receptor%20%28EGFR%29%20tyrosine%20kinase%20inhibitors%20%28TKIs%29%3A%20a%20better%20mousetrap%3F%20A%20review%20of%20the%20clinical%20evidence&journal=Crit.%20Rev.%20Oncol.%20Hematol.&doi=10.1016%2Fj.critrevonc.2011.11.010&volume=83&pages=407-421&publication_year=2012&author=Ou%2CSH is on a monthly basis
• What's https://doi.org/10.1371%2Fjournal.pmed.0020017's gross income?
• What's the revenue for http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15696205?
• What is the earnings of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC545207?
• How much does http://scholar.google.com/scholar_lookup?&title=KRAS%20mutations%20and%20primary%20resistance%20of%20lung%20adenocarcinomas%20to%20gefitinib%20or%20erlotinib&journal=PLoS%20Med.&doi=10.1371%2Fjournal.pmed.0020017&volume=2&publication_year=2005&author=Pao%2CW generate monthly?
• Get to know what's the income of https://doi.org/10.1056%2FNEJMoa044238
• Financial intake of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15728811
• What are the earnings of http://scholar.google.com/scholar_lookup?&title=EGFR%20mutation%20and%20resistance%20of%20non-small-cell%20lung%20cancer%20to%20gefitinib&journal=N.%20Engl.%20J.%20Med.&doi=10.1056%2FNEJMoa044238&volume=352&pages=786-792&publication_year=2005&author=Kobayashi%2CS?
• How much does https://doi.org/10.1038%2Fsrep05193 pull in monthly?
• How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=24898935 net monthly?
• What is the monthly revenue of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046135?
• Learn how profitable http://scholar.google.com/scholar_lookup?&title=Quantitative%20scoring%20of%20differential%20drug%20sensitivity%20for%20individually%20optimized%20anticancer%20therapies&journal=Sci.%20Rep.&doi=10.1038%2Fsrep05193&volume=4&publication_year=2014&author=Yadav%2CB is on a monthly basis
• What are the total earnings of https://doi.org/10.1038%2Fnchembio.1337?
• What's the total monthly financial gain of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=24013279?
• Explore the financials of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947796
• See how much http://scholar.google.com/scholar_lookup?&title=Metrics%20other%20than%20potency%20reveal%20systematic%20variation%20in%20responses%20to%20cancer%20drugs&journal=Nat.%20Chem.%20Biol.&doi=10.1038%2Fnchembio.1337&volume=9&pages=708-714&publication_year=2013&author=Fallahi-Sichani%2CM&author=Honarnejad%2CS&author=Heiser%2CLM&author=Grey%2CJW&author=Sorger%2CPK makes per month
• What is the monthly revenue of https://doi.org/10.1038%2Fnchembio.1690?
• What's the monthly money flow for http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=25402767?
• Get to know http://scholar.google.com/scholar_lookup?&title=GSK-3%20modulates%20cellular%20responses%20to%20a%20broad%20spectrum%20of%20kinase%20inhibitors&journal=Nat.%20Chem.%20Biol.&doi=10.1038%2Fnchembio.1690&volume=11&pages=58-63&publication_year=2015&author=Thorne%2CCA's earnings
• How much profit does https://doi.org/10.1101%2Fgr.152322.112 generate?
• How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=23733853 make?
• What are the earnings of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759720?
• How profitable is http://scholar.google.com/scholar_lookup?&title=Next-generation%20sequencing%20of%20paired%20tyrosine%20kinase%20inhibitor-sensitive%20and%20-resistant%20EGFR%20mutant%20lung%20cancer%20cell%20lines%20identifies%20spectrum%20of%20DNA%20changes%20associated%20with%20drug%20resistance&journal=Genome%20Res.&doi=10.1101%2Fgr.152322.112&volume=23&pages=1434-1445&publication_year=2013&author=Jia%2CP?
• How much profit does https://doi.org/10.1126%2Fscience.1141478 generate?
• How much does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2007Sci...316.1039E generate monthly?
• How much cash flow does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17463250 have monthly?
• Get to know http://scholar.google.com/scholar_lookup?&title=MET%20amplification%20leads%20to%20gefitinib%20resistance%20in%20lung%20cancer%20by%20activating%20ERBB3%20signaling&journal=Science&doi=10.1126%2Fscience.1141478&volume=316&pages=1039-1043&publication_year=2007&author=Engelman%2CJA's earnings
• Get to know what's the income of https://doi.org/10.1158%2F2159-8290.CD-12-0103
• What are the earnings of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=22961667?
• http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3477553's total income per month
• http://scholar.google.com/scholar_lookup?&title=Reactivation%20of%20ERK%20signaling%20causes%20resistance%20to%20EGFR%20kinase%20inhibitors&journal=Cancer%20Discov.&doi=10.1158%2F2159-8290.CD-12-0103&volume=2&pages=934-947&publication_year=2012&author=Ercan%2CD income
• Find out how much https://doi.org/10.1158%2F0008-5472.CAN-14-3167 earns monthly
• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=25870145 income
• What is the earnings of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605607?
• How much does http://scholar.google.com/scholar_lookup?&title=Acquired%20resistance%20to%20the%20mutant-selective%20EGFR%20inhibitor%20AZD9291%20is%20associated%20with%20increased%20dependence%20on%20RAS%20signaling%20in%20preclinical%20models&journal=Cancer%20Res.&doi=10.1158%2F0008-5472.CAN-14-3167&volume=75&pages=2489-2500&publication_year=2015&author=Eberlein%2CCA generate monthly?
• What's the financial outcome of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11389083?
• http://scholar.google.com/scholar_lookup?&title=High-throughput%20tissue%20microarray%20analysis%20of%203p25%20%28RAF1%29%20and%208p12%20%28FGFR1%29%20copy%20number%20alterations%20in%20urinary%20bladder%20cancer&journal=Cancer%20Res.&volume=61&pages=4514-4519&publication_year=2001&author=Simon%2CR's total income per month
• Profit of https://doi.org/10.1371%2Fjournal.pone.0028973
• How much does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2011PLoSO...628973A gross monthly?
• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=22194965's total income per month
• Monthly income for http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237573
• Get to know http://scholar.google.com/scholar_lookup?&title=Reversing%20melanoma%20cross-resistance%20to%20BRAF%20and%20MEK%20inhibitors%20by%20co-targeting%20the%20AKT%2FmTOR%20pathway&journal=PLoS%20ONE&doi=10.1371%2Fjournal.pone.0028973&volume=6&publication_year=2011&author=Atefi%2CM's earnings
• Get to know what's the income of https://doi.org/10.1126%2Fscisignal.2004652
• Find out how much http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=24065147 earns monthly
• Learn how profitable http://scholar.google.com/scholar_lookup?&title=Bypass%20mechanisms%20of%20resistance%20to%20receptor%20tyrosine%20kinase%20inhibition%20in%20lung%20cancer&journal=Sci.%20Signal.&doi=10.1126%2Fscisignal.2004652&volume=6&publication_year=2013&author=Niederst%2CMJ&author=Engelman%2CJA is on a monthly basis
• Find out how much https://doi.org/10.1073%2Fpnas.0510857103 earns monthly
• What's the income generated by http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2006PNAS..103.1475B each month?
• Financial intake of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=16432179
• Earnings of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1360603
• http://scholar.google.com/scholar_lookup?&title=Cancer-specific%20mutations%20in%20PIK3CA%20are%20oncogenic%20in%20vivo&journal=Proc.%20Natl%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.0510857103&volume=103&pages=1475-1479&publication_year=2006&author=Bader%2CAG&author=Kang%2CS&author=Vogt%2CPK's revenue stream
• What's the income of https://doi.org/10.1158%2F1535-7163.MCT-11-0692?
• How much revenue does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=22135231 bring in?
• Revenue of http://scholar.google.com/scholar_lookup?&title=Coexistence%20of%20PIK3CA%20and%20other%20oncogene%20mutations%20in%20lung%20adenocarcinoma-rationale%20for%20comprehensive%20mutation%20profiling&journal=Mol.%20Cancer%20Ther.&doi=10.1158%2F1535-7163.MCT-11-0692&volume=11&pages=485-491&publication_year=2012&author=Chaft%2CJE
• What's https://doi.org/10.1128%2FMCB.01124-09's gross income?
• See how much http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=19995904 makes per month
• Profit of http://scholar.google.com/scholar_lookup?&title=DNA%20polymerase%20POLN%20participates%20in%20cross-link%20repair%20and%20homologous%20recombination&journal=Mol.%20Cell%20Biol.&doi=10.1128%2FMCB.01124-09&volume=30&pages=1088-1096&publication_year=2010&author=Moldovan%2CGL
• How much income does https://doi.org/10.1158%2F0008-5472.CAN-10-0460 have?
• Financial intake of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=20643779
• What's the financial gain of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2932856?
• What's the income of http://scholar.google.com/scholar_lookup?&title=Identification%20of%20optimal%20drug%20combinations%20targeting%20cellular%20networks%3A%20integrating%20phospho-proteomics%20and%20computational%20network%20analysis&journal=Cancer%20Res.&doi=10.1158%2F0008-5472.CAN-10-0460&volume=70&pages=6704-6714&publication_year=2010&author=Iadevaia%2CS&author=Lu%2CY&author=Morales%2CFC&author=Mills%2CGB&author=Ram%2CPT?
• How much does https://doi.org/10.1371%2Fjournal.pbio.1001296 gross monthly?
• What are the total earnings of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=22509130?
• What's the financial intake of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317895?
• Get to know http://scholar.google.com/scholar_lookup?&title=Nonheritable%20cellular%20variability%20accelerates%20the%20evolutionary%20processes%20of%20cancer&journal=PLoS%20Biol.&doi=10.1371%2Fjournal.pbio.1001296&volume=10&publication_year=2012&author=Frank%2CSA&author=Rosner%2CMR's earnings
• How much income is https://link.springer.com/doi/10.1186/s13029-014-0027-x earning monthly?
• How much income is http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=25614758 earning monthly?
• Income figures for http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279979
• Discover the revenue of http://scholar.google.com/scholar_lookup?&title=Robust%20dose-response%20curve%20estimation%20applied%20to%20high%20content%20screening%20data%20analysis&journal=Source%20Code%20Biol.%20Med.&doi=10.1186%2Fs13029-014-0027-x&volume=9&publication_year=2014&author=Nguyen%2CTT
• What's the financial intake of https://doi.org/10.1093%2Fbioinformatics%2Fbtp698?
• What's the income generated by http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=20080505 each month?
• What's the income of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828108?
• How much money does http://scholar.google.com/scholar_lookup?&title=Fast%20and%20accurate%20long-read%20alignment%20with%20Burrows-Wheeler%20transform&journal=Bioinformatics&doi=10.1093%2Fbioinformatics%2Fbtp698&volume=26&pages=589-595&publication_year=2010&author=Li%2CH&author=Durbin%2CR make?
• How much does https://doi.org/10.1038%2Fnbt.2514 gross monthly?
• What's the income of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=23396013?
• What's the financial intake of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3833702?
• Find out how much http://scholar.google.com/scholar_lookup?&title=Sensitive%20detection%20of%20somatic%20point%20mutations%20in%20impure%20and%20heterogeneous%20cancer%20samples&journal=Nat.%20Biotechnol.&doi=10.1038%2Fnbt.2514&volume=31&pages=213-219&publication_year=2013&author=Cibulskis%2CK earns monthly
• How much income does https://doi.org/10.1093%2Fbioinformatics%2Fbtr462 have?
• Revenue of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=21828086
• How much does http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179661 gross monthly?
• What's the financial intake of http://scholar.google.com/scholar_lookup?&title=Exome%20sequencing-based%20copy-number%20variation%20and%20loss%20of%20heterozygosity%20detection%3A%20ExomeCNV&journal=Bioinformatics&doi=10.1093%2Fbioinformatics%2Fbtr462&volume=27&pages=2648-2654&publication_year=2011&author=Sathirapongsasuti%2CJF?
• How much profit is https://citation-needed.springer.com/v2/references/10.1038/ncomms10690?format=refman&flavour=references making per month?
• Financial intake of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Michael%20Ramirez
• What's the income generated by https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Michael%20Ramirez%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en each month?
• What is the earnings of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Satwik%20Rajaram?
• Profit of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Satwik%20Rajaram%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• What's the income of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Robert%20J.%20Steininger?
• What is the monthly revenue of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Robert%20J.%20Steininger%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• What's the monthly money flow for https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Daria%20Osipchuk?
• What are the total earnings of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Daria%20Osipchuk%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• What is the earnings of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Maike%20A.%20Roth?
• How much income is https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Maike%20A.%20Roth%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en earning monthly?
• Revenue of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Leanna%20S.%20Morinishi
• How much profit is https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Leanna%20S.%20Morinishi%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en making per month?
• Financial intake of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Louise%20Evans
• How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Louise%20Evans%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en make?
• What's the monthly money flow for https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Weiyue%20Ji?
• What's the monthly money flow for https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Weiyue%20Ji%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• Financial intake of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Chien-Hsiang%20Hsu
• What's the financial gain of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Chien-Hsiang%20Hsu%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Kevin%20Thurley's total income per month
• Get to know what's the income of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Kevin%20Thurley%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• How much revenue does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Shuguang%20Wei bring in?
• Revenue of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Shuguang%20Wei%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• Discover the revenue of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Anwu%20Zhou
• What's the financial gain of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Anwu%20Zhou%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• How much income is https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Prasad%20R.%20Koduru earning monthly?
• How much profit does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Prasad%20R.%20Koduru%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en generate?
• Explore the financials of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Bruce%20A.%20Posner
• How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Bruce%20A.%20Posner%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en pull in monthly?
• What's https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Lani%20F.%20Wu's gross income?
• What's the financial outcome of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Lani%20F.%20Wu%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• What's the total monthly financial gain of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Steven%20J.%20Altschuler?
• Revenue of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Steven%20J.%20Altschuler%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• Learn how profitable https://static-content.springer.com/esm/art%3A10.1038%2Fncomms10690/MediaObjects/41467_2016_BFncomms10690_MOESM1080_ESM.pdf is on a monthly basis
• How much revenue does https://static-content.springer.com/esm/art%3A10.1038%2Fncomms10690/MediaObjects/41467_2016_BFncomms10690_MOESM1081_ESM.xls produce monthly?
• Financial intake of https://static-content.springer.com/esm/art%3A10.1038%2Fncomms10690/MediaObjects/41467_2016_BFncomms10690_MOESM1082_ESM.txt
• How much does https://static-content.springer.com/esm/art%3A10.1038%2Fncomms10690/MediaObjects/41467_2016_BFncomms10690_MOESM1083_ESM.txt rake in every month?
• Profit of https://static-content.springer.com/esm/art%3A10.1038%2Fncomms10690/MediaObjects/41467_2016_BFncomms10690_MOESM1084_ESM.txt
• What's the financial outcome of http://creativecommons.org/licenses/by/4.0/?
• How much money does https://s100.copyright.com/AppDispatchServlet?title=Diverse%20drug-resistance%20mechanisms%20can%20emerge%20from%20drug-tolerant%20cancer%20persister%20cells&author=Michael%20Ramirez%20et%20al&contentID=10.1038%2Fncomms10690©right=The%20Author%28s%29&publication=2041-1723&publicationDate=2016-02-19&publisherName=SpringerNature&orderBeanReset=true&oa=CC%20BY generate?
• Get to know https://crossmark.crossref.org/dialog/?doi=10.1038/ncomms10690's earnings
• Discover the revenue of https://citation-needed.springer.com/v2/references/10.1038/ncomms10690?format=refman&flavour=citation
• Learn about the earnings of https://doi.org/10.1038/s41588-023-01592-8
• Financial intake of https://doi.org/10.1186/s40164-023-00434-x
• Get to know what's the income of https://doi.org/10.1038/s41698-023-00350-7
• How much does https://doi.org/10.1038/s41598-023-34438-8 make?
• Check the income stats for https://doi.org/10.1038/s41418-022-01064-2
• What's the financial gain of https://www.protocols.io/?
• Profit of https://www.natureindex.com/
• How much does http://www.naturechina.com pull in monthly?
• How much cash flow does https://www.natureasia.com/ja-jp have monthly?

Analytics and Tracking {📊}

• Google Tag Manager

Libraries {📚}

• Prism.js
• Zoom.js

Emails and Hosting {✉️}

Mail Servers:

• mxa-002c5801.gslb.pphosted.com
• mxb-002c5801.gslb.pphosted.com

Name Servers:

• pdns1.ultradns.net
• pdns2.ultradns.net
• pdns3.ultradns.org
• pdns4.ultradns.org
• pdns5.ultradns.info
• pdns6.ultradns.co.uk

CDN Services {📦}

• Crossref