
NATURE . COM {
}
Title:
Diverse drug-resistance mechanisms can emerge from drug-tolerant cancer persister cells | Nature Communications
Description:
Cancer therapy has traditionally focused on eliminating fast-growing populations of cells. Yet, an increasing body of evidence suggests that small subpopulations of cancer cells can evade strong selective drug pressure by entering a ‘persister’ state of negligible growth. This drug-tolerant state has been hypothesized to be part of an initial strategy towards eventual acquisition of bona fide drug-resistance mechanisms. However, the diversity of drug-resistance mechanisms that can expand from a persister bottleneck is unknown. Here we compare persister-derived, erlotinib-resistant colonies that arose from a single, EGFR-addicted lung cancer cell. We find, using a combination of large-scale drug screening and whole-exome sequencing, that our erlotinib-resistant colonies acquired diverse resistance mechanisms, including the most commonly observed clinical resistance mechanisms. Thus, the drug-tolerant persister state does not limit—and may even provide a latent reservoir of cells for—the emergence of heterogeneous drug-resistance mechanisms. Cancer cells that survive initial drug treatment can persist in the presence of drugs. Here, the authors generate persister cells that are resistant to the EGFR tyrosine kinase inhibitor erlotinib and show by single cell analysis that multiple mechanism give rise to the drug-resistant persister state.
Website Age:
30 years and 10 months (reg. 1994-08-11).
Matching Content Categories {📚}
- Science
- Telecommunications
- Health & Fitness
Content Management System {📝}
What CMS is nature.com built with?
Custom-built
No common CMS systems were detected on Nature.com, and no known web development framework was identified.
Traffic Estimate {📈}
What is the average monthly size of nature.com audience?
🌠 Phenomenal Traffic: 5M - 10M visitors per month
Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.
check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush
How Does Nature.com Make Money? {💸}
Display Ads {🎯}
The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.
Ads are managed by yourbow.com. Particular relationships are as follows:
Direct Advertisers (10)
google.com, pmc.com, doceree.com, yourbow.com, audienciad.com, onlinemediasolutions.com, advibe.media, aps.amazon.com, getmediamx.com, onomagic.comReseller Advertisers (38)
conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.comHow Much Does Nature.com Make? {💰}
Display Ads {🎯}
$63,100 per month
Our estimates place Nature.com's monthly online earnings from display ads at $42,042 to $115,616.
Keywords {🔍}
drug, percs, pubmed, cells, fig, resistance, cancer, erlotinib, article, cell, perc, supplementary, mechanisms, google, scholar, media, cas, response, drugs, persister, central, state, data, genetic, egfr, nature, growth, sensitivity, line, lung, met, drugresistance, drugtolerant, plates, performed, curves, colonies, methods, figs, diverse, treatment, persisters, erlotinibfree, mutations, screen, mutation, inhibitors, analysis, single, multiple,
Topics {✒️}
nature portfolio privacy policy middle grey lines advertising nature 462 nature individual resistance solutions drug-resistance solutions libraries 0/ reprints persister-derived erlotinib-resistant colonies small-cell lung cancer biomek liquid-handling robot synonymous single-nucleotide variant accurate long-read alignment burrows-wheeler alignment tool large-scale drug screen17 reversing melanoma cross-resistance drug-resistant cancer populations resistance-conferring genetic mutations somatic single-nucleotide variants large-scale drug screening drug-tolerant persister state8 sequence read archive small-scale ‘bypass’ experiment transient sirna-mediated knockdown accession number srp068321 interrogate drug-resistance mechanisms diverse drug-resistance mechanisms nci oncology set eliminating fast-growing populations drug-tolerant persister state egf receptor/akt pathway heterogeneous drug-resistance mechanisms 150–200-bp insert library long-term drug holiday diverse drug library permissions drug-category-response score perc drug-resistance mechanisms multiple cell lines smoothed drug-response curves cancer cell populations converting cancer therapies single genetic/epigenetic state tyrosine kinase inhibitors epidermal growth factor eliminating fast-growing cells relative drug-response score varying drug-response scores
Questions {❓}
- Second-generation irreversible epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs): a better mousetrap?
- Would different initial cells, passing through the persister bottleneck, give rise to the same resistance landscape?
Schema {🗺️}
WebPage:
mainEntity:
headline:Diverse drug-resistance mechanisms can emerge from drug-tolerant cancer persister cells
description:Cancer therapy has traditionally focused on eliminating fast-growing populations of cells. Yet, an increasing body of evidence suggests that small subpopulations of cancer cells can evade strong selective drug pressure by entering a âpersisterâ state of negligible growth. This drug-tolerant state has been hypothesized to be part of an initial strategy towards eventual acquisition of bona fide drug-resistance mechanisms. However, the diversity of drug-resistance mechanisms that can expand from a persister bottleneck is unknown. Here we compare persister-derived, erlotinib-resistant colonies that arose from a single, EGFR-addicted lung cancer cell. We find, using a combination of large-scale drug screening and whole-exome sequencing, that our erlotinib-resistant colonies acquired diverse resistance mechanisms, including the most commonly observed clinical resistance mechanisms. Thus, the drug-tolerant persister state does not limitâand may even provide a latent reservoir of cells forâthe emergence of heterogeneous drug-resistance mechanisms. Cancer cells that survive initial drug treatment can persist in the presence of drugs. Here, the authors generate persister cells that are resistant to the EGFR tyrosine kinase inhibitor erlotinib and show by single cell analysis that multiple mechanism give rise to the drug-resistant persister state.
datePublished:2016-02-19T00:00:00Z
dateModified:2016-02-19T00:00:00Z
pageStart:1
pageEnd:8
license:http://creativecommons.org/licenses/by/4.0/
sameAs:https://doi.org/10.1038/ncomms10690
keywords:
Cancer genetics
Cancer therapeutic resistance
Science
Humanities and Social Sciences
multidisciplinary
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms10690/MediaObjects/41467_2016_Article_BFncomms10690_Figa_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms10690/MediaObjects/41467_2016_Article_BFncomms10690_Fig1_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms10690/MediaObjects/41467_2016_Article_BFncomms10690_Fig2_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms10690/MediaObjects/41467_2016_Article_BFncomms10690_Fig3_HTML.jpg
isPartOf:
name:Nature Communications
issn:
2041-1723
volumeNumber:7
type:
Periodical
PublicationVolume
publisher:
name:Nature Publishing Group UK
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Michael Ramirez
affiliation:
name:University of California, San Francisco
address:
name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
type:PostalAddress
type:Organization
name:Green Center for Systems Biology, University of Texas Southwestern Medical Center
address:
name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
type:PostalAddress
type:Organization
type:Person
name:Satwik Rajaram
affiliation:
name:University of California, San Francisco
address:
name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
type:PostalAddress
type:Organization
name:Green Center for Systems Biology, University of Texas Southwestern Medical Center
address:
name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
type:PostalAddress
type:Organization
type:Person
name:Robert J. Steininger
affiliation:
name:Green Center for Systems Biology, University of Texas Southwestern Medical Center
address:
name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
type:PostalAddress
type:Organization
type:Person
name:Daria Osipchuk
affiliation:
name:University of California, San Francisco
address:
name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
type:PostalAddress
type:Organization
type:Person
name:Maike A. Roth
affiliation:
name:University of California, San Francisco
address:
name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
type:PostalAddress
type:Organization
type:Person
name:Leanna S. Morinishi
affiliation:
name:University of California, San Francisco
address:
name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
type:PostalAddress
type:Organization
type:Person
name:Louise Evans
affiliation:
name:University of California, San Francisco
address:
name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
type:PostalAddress
type:Organization
type:Person
name:Weiyue Ji
affiliation:
name:University of California, San Francisco
address:
name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
type:PostalAddress
type:Organization
type:Person
name:Chien-Hsiang Hsu
affiliation:
name:University of California, San Francisco
address:
name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
type:PostalAddress
type:Organization
type:Person
name:Kevin Thurley
affiliation:
name:University of California, San Francisco
address:
name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
type:PostalAddress
type:Organization
type:Person
name:Shuguang Wei
affiliation:
name:University of Texas Southwestern Medical Center
address:
name:Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, USA
type:PostalAddress
type:Organization
type:Person
name:Anwu Zhou
affiliation:
name:University of Texas Southwestern Medical Center
address:
name:Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, USA
type:PostalAddress
type:Organization
type:Person
name:Prasad R. Koduru
affiliation:
name:University of Texas Southwestern Medical Center
address:
name:Department of Pathology, University of Texas Southwestern Medical Center, Dallas, USA
type:PostalAddress
type:Organization
type:Person
name:Bruce A. Posner
affiliation:
name:University of Texas Southwestern Medical Center
address:
name:Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, USA
type:PostalAddress
type:Organization
type:Person
name:Lani F. Wu
affiliation:
name:University of California, San Francisco
address:
name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
type:PostalAddress
type:Organization
name:Green Center for Systems Biology, University of Texas Southwestern Medical Center
address:
name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
type:PostalAddress
type:Organization
email:[email protected]
type:Person
name:Steven J. Altschuler
affiliation:
name:University of California, San Francisco
address:
name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
type:PostalAddress
type:Organization
name:Green Center for Systems Biology, University of Texas Southwestern Medical Center
address:
name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
type:PostalAddress
type:Organization
email:[email protected]
type:Person
isAccessibleForFree:1
type:ScholarlyArticle
context:https://schema.org
ScholarlyArticle:
headline:Diverse drug-resistance mechanisms can emerge from drug-tolerant cancer persister cells
description:Cancer therapy has traditionally focused on eliminating fast-growing populations of cells. Yet, an increasing body of evidence suggests that small subpopulations of cancer cells can evade strong selective drug pressure by entering a âpersisterâ state of negligible growth. This drug-tolerant state has been hypothesized to be part of an initial strategy towards eventual acquisition of bona fide drug-resistance mechanisms. However, the diversity of drug-resistance mechanisms that can expand from a persister bottleneck is unknown. Here we compare persister-derived, erlotinib-resistant colonies that arose from a single, EGFR-addicted lung cancer cell. We find, using a combination of large-scale drug screening and whole-exome sequencing, that our erlotinib-resistant colonies acquired diverse resistance mechanisms, including the most commonly observed clinical resistance mechanisms. Thus, the drug-tolerant persister state does not limitâand may even provide a latent reservoir of cells forâthe emergence of heterogeneous drug-resistance mechanisms. Cancer cells that survive initial drug treatment can persist in the presence of drugs. Here, the authors generate persister cells that are resistant to the EGFR tyrosine kinase inhibitor erlotinib and show by single cell analysis that multiple mechanism give rise to the drug-resistant persister state.
datePublished:2016-02-19T00:00:00Z
dateModified:2016-02-19T00:00:00Z
pageStart:1
pageEnd:8
license:http://creativecommons.org/licenses/by/4.0/
sameAs:https://doi.org/10.1038/ncomms10690
keywords:
Cancer genetics
Cancer therapeutic resistance
Science
Humanities and Social Sciences
multidisciplinary
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms10690/MediaObjects/41467_2016_Article_BFncomms10690_Figa_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms10690/MediaObjects/41467_2016_Article_BFncomms10690_Fig1_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms10690/MediaObjects/41467_2016_Article_BFncomms10690_Fig2_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms10690/MediaObjects/41467_2016_Article_BFncomms10690_Fig3_HTML.jpg
isPartOf:
name:Nature Communications
issn:
2041-1723
volumeNumber:7
type:
Periodical
PublicationVolume
publisher:
name:Nature Publishing Group UK
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Michael Ramirez
affiliation:
name:University of California, San Francisco
address:
name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
type:PostalAddress
type:Organization
name:Green Center for Systems Biology, University of Texas Southwestern Medical Center
address:
name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
type:PostalAddress
type:Organization
type:Person
name:Satwik Rajaram
affiliation:
name:University of California, San Francisco
address:
name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
type:PostalAddress
type:Organization
name:Green Center for Systems Biology, University of Texas Southwestern Medical Center
address:
name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
type:PostalAddress
type:Organization
type:Person
name:Robert J. Steininger
affiliation:
name:Green Center for Systems Biology, University of Texas Southwestern Medical Center
address:
name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
type:PostalAddress
type:Organization
type:Person
name:Daria Osipchuk
affiliation:
name:University of California, San Francisco
address:
name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
type:PostalAddress
type:Organization
type:Person
name:Maike A. Roth
affiliation:
name:University of California, San Francisco
address:
name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
type:PostalAddress
type:Organization
type:Person
name:Leanna S. Morinishi
affiliation:
name:University of California, San Francisco
address:
name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
type:PostalAddress
type:Organization
type:Person
name:Louise Evans
affiliation:
name:University of California, San Francisco
address:
name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
type:PostalAddress
type:Organization
type:Person
name:Weiyue Ji
affiliation:
name:University of California, San Francisco
address:
name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
type:PostalAddress
type:Organization
type:Person
name:Chien-Hsiang Hsu
affiliation:
name:University of California, San Francisco
address:
name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
type:PostalAddress
type:Organization
type:Person
name:Kevin Thurley
affiliation:
name:University of California, San Francisco
address:
name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
type:PostalAddress
type:Organization
type:Person
name:Shuguang Wei
affiliation:
name:University of Texas Southwestern Medical Center
address:
name:Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, USA
type:PostalAddress
type:Organization
type:Person
name:Anwu Zhou
affiliation:
name:University of Texas Southwestern Medical Center
address:
name:Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, USA
type:PostalAddress
type:Organization
type:Person
name:Prasad R. Koduru
affiliation:
name:University of Texas Southwestern Medical Center
address:
name:Department of Pathology, University of Texas Southwestern Medical Center, Dallas, USA
type:PostalAddress
type:Organization
type:Person
name:Bruce A. Posner
affiliation:
name:University of Texas Southwestern Medical Center
address:
name:Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, USA
type:PostalAddress
type:Organization
type:Person
name:Lani F. Wu
affiliation:
name:University of California, San Francisco
address:
name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
type:PostalAddress
type:Organization
name:Green Center for Systems Biology, University of Texas Southwestern Medical Center
address:
name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
type:PostalAddress
type:Organization
email:[email protected]
type:Person
name:Steven J. Altschuler
affiliation:
name:University of California, San Francisco
address:
name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
type:PostalAddress
type:Organization
name:Green Center for Systems Biology, University of Texas Southwestern Medical Center
address:
name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
type:PostalAddress
type:Organization
email:[email protected]
type:Person
isAccessibleForFree:1
["Periodical","PublicationVolume"]:
name:Nature Communications
issn:
2041-1723
volumeNumber:7
Organization:
name:Nature Publishing Group UK
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
name:University of California, San Francisco
address:
name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
type:PostalAddress
name:Green Center for Systems Biology, University of Texas Southwestern Medical Center
address:
name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
type:PostalAddress
name:University of California, San Francisco
address:
name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
type:PostalAddress
name:Green Center for Systems Biology, University of Texas Southwestern Medical Center
address:
name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
type:PostalAddress
name:Green Center for Systems Biology, University of Texas Southwestern Medical Center
address:
name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
type:PostalAddress
name:University of California, San Francisco
address:
name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
type:PostalAddress
name:University of California, San Francisco
address:
name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
type:PostalAddress
name:University of California, San Francisco
address:
name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
type:PostalAddress
name:University of California, San Francisco
address:
name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
type:PostalAddress
name:University of California, San Francisco
address:
name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
type:PostalAddress
name:University of California, San Francisco
address:
name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
type:PostalAddress
name:University of California, San Francisco
address:
name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
type:PostalAddress
name:University of Texas Southwestern Medical Center
address:
name:Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, USA
type:PostalAddress
name:University of Texas Southwestern Medical Center
address:
name:Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, USA
type:PostalAddress
name:University of Texas Southwestern Medical Center
address:
name:Department of Pathology, University of Texas Southwestern Medical Center, Dallas, USA
type:PostalAddress
name:University of Texas Southwestern Medical Center
address:
name:Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, USA
type:PostalAddress
name:University of California, San Francisco
address:
name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
type:PostalAddress
name:Green Center for Systems Biology, University of Texas Southwestern Medical Center
address:
name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
type:PostalAddress
name:University of California, San Francisco
address:
name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
type:PostalAddress
name:Green Center for Systems Biology, University of Texas Southwestern Medical Center
address:
name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
type:PostalAddress
ImageObject:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
name:Michael Ramirez
affiliation:
name:University of California, San Francisco
address:
name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
type:PostalAddress
type:Organization
name:Green Center for Systems Biology, University of Texas Southwestern Medical Center
address:
name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
type:PostalAddress
type:Organization
name:Satwik Rajaram
affiliation:
name:University of California, San Francisco
address:
name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
type:PostalAddress
type:Organization
name:Green Center for Systems Biology, University of Texas Southwestern Medical Center
address:
name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
type:PostalAddress
type:Organization
name:Robert J. Steininger
affiliation:
name:Green Center for Systems Biology, University of Texas Southwestern Medical Center
address:
name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
type:PostalAddress
type:Organization
name:Daria Osipchuk
affiliation:
name:University of California, San Francisco
address:
name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
type:PostalAddress
type:Organization
name:Maike A. Roth
affiliation:
name:University of California, San Francisco
address:
name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
type:PostalAddress
type:Organization
name:Leanna S. Morinishi
affiliation:
name:University of California, San Francisco
address:
name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
type:PostalAddress
type:Organization
name:Louise Evans
affiliation:
name:University of California, San Francisco
address:
name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
type:PostalAddress
type:Organization
name:Weiyue Ji
affiliation:
name:University of California, San Francisco
address:
name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
type:PostalAddress
type:Organization
name:Chien-Hsiang Hsu
affiliation:
name:University of California, San Francisco
address:
name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
type:PostalAddress
type:Organization
name:Kevin Thurley
affiliation:
name:University of California, San Francisco
address:
name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
type:PostalAddress
type:Organization
name:Shuguang Wei
affiliation:
name:University of Texas Southwestern Medical Center
address:
name:Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, USA
type:PostalAddress
type:Organization
name:Anwu Zhou
affiliation:
name:University of Texas Southwestern Medical Center
address:
name:Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, USA
type:PostalAddress
type:Organization
name:Prasad R. Koduru
affiliation:
name:University of Texas Southwestern Medical Center
address:
name:Department of Pathology, University of Texas Southwestern Medical Center, Dallas, USA
type:PostalAddress
type:Organization
name:Bruce A. Posner
affiliation:
name:University of Texas Southwestern Medical Center
address:
name:Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, USA
type:PostalAddress
type:Organization
name:Lani F. Wu
affiliation:
name:University of California, San Francisco
address:
name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
type:PostalAddress
type:Organization
name:Green Center for Systems Biology, University of Texas Southwestern Medical Center
address:
name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
type:PostalAddress
type:Organization
email:[email protected]
name:Steven J. Altschuler
affiliation:
name:University of California, San Francisco
address:
name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
type:PostalAddress
type:Organization
name:Green Center for Systems Biology, University of Texas Southwestern Medical Center
address:
name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
type:PostalAddress
type:Organization
email:[email protected]
PostalAddress:
name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
name:Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, USA
name:Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, USA
name:Department of Pathology, University of Texas Southwestern Medical Center, Dallas, USA
name:Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, USA
name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
name:Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, USA
name:Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, USA
Social Networks {👍}(2)
External Links {🔗}(200)
- How much profit is http://www.ncbi.nlm.nih.gov/sra?term=SRP068321 making per month?
- Find out how much https://doi.org/10.1016%2Fj.cell.2012.02.015 earns monthly
- How much profit does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=22424221 generate?
- How much does http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465702 pull in?
- How much does http://scholar.google.com/scholar_lookup?&title=Converting%20cancer%20therapies%20into%20cures%3A%20lessons%20from%20infectious%20diseases&journal=Cell&doi=10.1016%2Fj.cell.2012.02.015&volume=148&pages=1089-1098&publication_year=2012&author=Glickman%2CMS&author=Sawyers%2CCL generate monthly?
- Learn about the earnings of https://doi.org/10.1056%2FNEJMoa1113205
- How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=22397650 bring in each month?
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878653's revenue stream
- http://scholar.google.com/scholar_lookup?&title=Intratumor%20heterogeneity%20and%20branched%20evolution%20revealed%20by%20multiregion%20sequencing&journal=N.%20Engl.%20J.%20Med.&doi=10.1056%2FNEJMoa1113205&volume=366&pages=883-892&publication_year=2012&author=Gerlinger%2CM's revenue stream
- What is the monthly revenue of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=19931353?
- Learn about the earnings of http://scholar.google.com/scholar_lookup?&title=Tumor%20heterogeneity%3A%20causes%20and%20consequences&journal=Biochim.%20Biophys.%20Acta&volume=1805&pages=105-117&publication_year=2010&author=Marusyk%2CA&author=Polyak%2CK
- Learn about the earnings of https://doi.org/10.1073%2Fpnas.0710370104
- Get to know http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2007PNAS..10420932B's earnings
- What's the profit of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18093943?
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409244 income
- What's the total monthly financial gain of http://scholar.google.com/scholar_lookup?&title=MET%20amplification%20occurs%20with%20or%20without%20T790M%20mutations%20in%20EGFR%20mutant%20lung%20tumors%20with%20acquired%20resistance%20to%20gefitinib%20or%20erlotinib&journal=Proc.%20Natl%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.0710370104&volume=104&pages=20932-20937&publication_year=2007&author=Bean%2CJ?
- How much money does https://doi.org/10.1038%2Fnm.3841 make?
- How much income does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=25849130 have?
- How much does http://scholar.google.com/scholar_lookup?&title=Studying%20clonal%20dynamics%20in%20response%20to%20cancer%20therapy%20using%20high-complexity%20barcoding&journal=Nat.%20Med.&doi=10.1038%2Fnm.3841&volume=21&pages=440-448&publication_year=2015&author=Bhang%2CHE bring in each month?
- How much income is https://doi.org/10.1016%2Fj.ccr.2009.11.022 earning monthly?
- How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=20129249 pull in monthly?
- How much does http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2980857 generate monthly?
- How much profit does http://scholar.google.com/scholar_lookup?&title=Preexistence%20and%20clonal%20selection%20of%20MET%20amplification%20in%20EGFR%20mutant%20NSCLC&journal=Cancer%20Cell&doi=10.1016%2Fj.ccr.2009.11.022&volume=17&pages=77-88&publication_year=2010&author=Turke%2CAB generate?
- What is the monthly revenue of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=22970367?
- See how much http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437267 makes per month
- What's the monthly income of http://scholar.google.com/scholar_lookup?&title=Mechanisms%20of%20resistance%20to%20epidermal%20growth%20factor%20receptor%20inhibitors%20and%20novel%20therapeutic%20strategies%20to%20overcome%20resistance%20in%20NSCLC%20Patients&journal=Chemother.%20Res.%20Pract.&volume=2012&publication_year=2012&author=Lin%2CL&author=Bivona%2CTG?
- How much does https://doi.org/10.1016%2Fj.cell.2010.02.027 bring in each month?
- How much profit does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=20371346 make?
- Earnings of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851638
- How much revenue does http://scholar.google.com/scholar_lookup?&title=A%20chromatin-mediated%20reversible%20drug-tolerant%20state%20in%20cancer%20cell%20subpopulations&journal=Cell&doi=10.1016%2Fj.cell.2010.02.027&volume=141&pages=69-80&publication_year=2010&author=Sharma%2CSV generate?
- Profit of https://doi.org/10.1371%2Fjournal.ppat.1002121
- What's the revenue for http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=21829345?
- What's the financial intake of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3145784?
- Check the income stats for http://scholar.google.com/scholar_lookup?&title=%E2%80%98Persisters%E2%80%99%3A%20survival%20at%20the%20cellular%20level&journal=PLoS%20Pathog.&doi=10.1371%2Fjournal.ppat.1002121&volume=7&publication_year=2011&author=Dawson%2CCC&author=Intapa%2CC&author=Jabra-Rizk%2CMA
- Profit of https://doi.org/10.1126%2Fscience.1099390
- How much income is http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2004Sci...305.1622B earning monthly?
- How much income is http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15308767 earning monthly?
- What's the financial intake of http://scholar.google.com/scholar_lookup?&title=Bacterial%20persistence%20as%20a%20phenotypic%20switch&journal=Science&doi=10.1126%2Fscience.1099390&volume=305&pages=1622-1625&publication_year=2004&author=Balaban%2CNQ&author=Merrin%2CJ&author=Chait%2CR&author=Kowalik%2CL&author=Leibler%2CS?
- How much does https://doi.org/10.1158%2F0008-5472.CAN-15-1113 pull in monthly?
- Profit of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=26490646
- How much does http://scholar.google.com/scholar_lookup?&title=Inhibition%20of%20casein%20kinase%201%20alpha%20prevents%20acquired%20drug%20resistance%20to%20erlotinib%20in%20EGFR-mutant%20non-small%20cell%20lung%20cancer&journal=Cancer%20Res.&doi=10.1158%2F0008-5472.CAN-15-1113&volume=75&pages=4937-4948&publication_year=2015&author=Lantermann%2CAB rake in every month?
- Find out how much https://doi.org/10.1080%2F15384101.2015.1090063 earns monthly
- How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=26566863 make?
- How much does http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825557 net monthly?
- What's the monthly income of http://scholar.google.com/scholar_lookup?&title=The%20histone%20demethylase%20KDM5A%20is%20a%20key%20factor%20for%20the%20resistance%20to%20temozolomide%20in%20glioblastoma&journal=Cell%20Cycle&doi=10.1080%2F15384101.2015.1090063&volume=14&pages=3418-3429&publication_year=2015&author=Banelli%2CB?
- https://doi.org/10.1016%2Fj.phrs.2015.09.022's revenue stream
- Profit of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=26453958
- How much does http://scholar.google.com/scholar_lookup?&title=AKT%20inactivation%20causes%20persistent%20drug%20tolerance%20to%20EGFR%20inhibitors&journal=Pharmacol.%20Res.&doi=10.1016%2Fj.phrs.2015.09.022&volume=102&pages=132-137&publication_year=2015&author=Tetsu%2CO&author=Phuchareon%2CJ&author=Eisele%2CDW&author=Hangauer%2CMJ&author=McCormick%2CF pull in?
- How much does https://doi.org/10.1038%2Fnrclinonc.2014.104 net monthly?
- How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=24981256 gross monthly?
- How much does http://scholar.google.com/scholar_lookup?&title=Acquired%20resistance%20to%20TKIs%20in%20solid%20tumours%3A%20learning%20from%20lung%20cancer&journal=Nat.%20Rev.%20Clin.%20Oncol.&doi=10.1038%2Fnrclinonc.2014.104&volume=11&pages=473-481&publication_year=2014&author=Camidge%2CDR&author=Pao%2CW&author=Sequist%2CLV bring in each month?
- Get to know what's the income of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15078990
- What's the income of http://scholar.google.com/scholar_lookup?&title=Sensitivity%20to%20gefitinib%20%28Iressa%2C%20ZD1839%29%20in%20non-small%20cell%20lung%20cancer%20cell%20lines%20correlates%20with%20dependence%20on%20the%20epidermal%20growth%20factor%20%28EGF%29%20receptor%2Fextracellular%20signal-regulated%20kinase%201%2F2%20and%20EGF%20receptor%2FAkt%20pathway%20for%20proliferation&journal=Mol.%20Cancer%20Ther.&volume=3&pages=465-472&publication_year=2004&author=Ono%2CM?
- How much revenue does https://doi.org/10.1126%2Fscitranslmed.3002356 produce monthly?
- How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=21734175 net monthly?
- How much does http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500629 make?
- Explore the financials of http://scholar.google.com/scholar_lookup?&title=Optimization%20of%20dosing%20for%20EGFR-mutant%20non-small%20cell%20lung%20cancer%20with%20evolutionary%20cancer%20modeling&journal=Sci.%20Transl.%20Med.&doi=10.1126%2Fscitranslmed.3002356&volume=3&publication_year=2011&author=Chmielecki%2CJ
- How much profit does https://doi.org/10.1126%2Fscience.1254721 make?
- What is the earnings of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2014Sci...346.1480C?
- What's the monthly income of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=25394791?
- How much does http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388482 make?
- What's http://scholar.google.com/scholar_lookup?&title=Patient-derived%20models%20of%20acquired%20resistance%20can%20identify%20effective%20drug%20combinations%20for%20cancer&journal=Science&doi=10.1126%2Fscience.1254721&volume=346&pages=1480-1486&publication_year=2014&author=Crystal%2CAS's gross income?
- What's the total monthly financial gain of https://doi.org/10.1038%2Fnature08622?
- How much profit is http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2009Natur.462.1070Z making per month?
- What are the earnings of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=20033049?
- Revenue of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2879581
- Income figures for http://scholar.google.com/scholar_lookup?&title=Novel%20mutant-selective%20EGFR%20kinase%20inhibitors%20against%20EGFR%20T790M&journal=Nature&doi=10.1038%2Fnature08622&volume=462&pages=1070-1074&publication_year=2009&author=Zhou%2CW
- What is the monthly revenue of https://doi.org/10.1016%2Fj.critrevonc.2011.11.010?
- Check the income stats for http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=22257651
- Profit of http://scholar.google.com/scholar_lookup?&title=Second-generation%20irreversible%20epidermal%20growth%20factor%20receptor%20%28EGFR%29%20tyrosine%20kinase%20inhibitors%20%28TKIs%29%3A%20a%20better%20mousetrap%3F%20A%20review%20of%20the%20clinical%20evidence&journal=Crit.%20Rev.%20Oncol.%20Hematol.&doi=10.1016%2Fj.critrevonc.2011.11.010&volume=83&pages=407-421&publication_year=2012&author=Ou%2CSH
- How much money does https://doi.org/10.1371%2Fjournal.pmed.0020017 generate?
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15696205's financial summary
- How much does http://www.ncbi.nlm.nih.gov/pmc/articles/PMC545207 generate monthly?
- See how much http://scholar.google.com/scholar_lookup?&title=KRAS%20mutations%20and%20primary%20resistance%20of%20lung%20adenocarcinomas%20to%20gefitinib%20or%20erlotinib&journal=PLoS%20Med.&doi=10.1371%2Fjournal.pmed.0020017&volume=2&publication_year=2005&author=Pao%2CW makes per month
- How much revenue does https://doi.org/10.1056%2FNEJMoa044238 bring in?
- How much money does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15728811 generate?
- What's the financial outcome of http://scholar.google.com/scholar_lookup?&title=EGFR%20mutation%20and%20resistance%20of%20non-small-cell%20lung%20cancer%20to%20gefitinib&journal=N.%20Engl.%20J.%20Med.&doi=10.1056%2FNEJMoa044238&volume=352&pages=786-792&publication_year=2005&author=Kobayashi%2CS?
- See how much https://doi.org/10.1038%2Fsrep05193 makes per month
- How much money does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=24898935 generate?
- How much profit is http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046135 making per month?
- Revenue of http://scholar.google.com/scholar_lookup?&title=Quantitative%20scoring%20of%20differential%20drug%20sensitivity%20for%20individually%20optimized%20anticancer%20therapies&journal=Sci.%20Rep.&doi=10.1038%2Fsrep05193&volume=4&publication_year=2014&author=Yadav%2CB
- Get to know https://doi.org/10.1038%2Fnchembio.1337's earnings
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=24013279's revenue stream
- Get to know http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947796's earnings
- Get to know what's the income of http://scholar.google.com/scholar_lookup?&title=Metrics%20other%20than%20potency%20reveal%20systematic%20variation%20in%20responses%20to%20cancer%20drugs&journal=Nat.%20Chem.%20Biol.&doi=10.1038%2Fnchembio.1337&volume=9&pages=708-714&publication_year=2013&author=Fallahi-Sichani%2CM&author=Honarnejad%2CS&author=Heiser%2CLM&author=Grey%2CJW&author=Sorger%2CPK
- Profit of https://doi.org/10.1038%2Fnchembio.1690
- What's the monthly income of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=25402767?
- What is the earnings of http://scholar.google.com/scholar_lookup?&title=GSK-3%20modulates%20cellular%20responses%20to%20a%20broad%20spectrum%20of%20kinase%20inhibitors&journal=Nat.%20Chem.%20Biol.&doi=10.1038%2Fnchembio.1690&volume=11&pages=58-63&publication_year=2015&author=Thorne%2CCA?
- What's the financial intake of https://doi.org/10.1101%2Fgr.152322.112?
- What are the total earnings of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=23733853?
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759720's total income per month
- How much does http://scholar.google.com/scholar_lookup?&title=Next-generation%20sequencing%20of%20paired%20tyrosine%20kinase%20inhibitor-sensitive%20and%20-resistant%20EGFR%20mutant%20lung%20cancer%20cell%20lines%20identifies%20spectrum%20of%20DNA%20changes%20associated%20with%20drug%20resistance&journal=Genome%20Res.&doi=10.1101%2Fgr.152322.112&volume=23&pages=1434-1445&publication_year=2013&author=Jia%2CP gross monthly?
- How much revenue does https://doi.org/10.1126%2Fscience.1141478 generate?
- What's the revenue for http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2007Sci...316.1039E?
- How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17463250 generate monthly?
- Get to know http://scholar.google.com/scholar_lookup?&title=MET%20amplification%20leads%20to%20gefitinib%20resistance%20in%20lung%20cancer%20by%20activating%20ERBB3%20signaling&journal=Science&doi=10.1126%2Fscience.1141478&volume=316&pages=1039-1043&publication_year=2007&author=Engelman%2CJA's earnings
- How much money does https://doi.org/10.1158%2F2159-8290.CD-12-0103 generate?
- How much profit does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=22961667 make?
- How much profit is http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3477553 making per month?
- What's the income generated by http://scholar.google.com/scholar_lookup?&title=Reactivation%20of%20ERK%20signaling%20causes%20resistance%20to%20EGFR%20kinase%20inhibitors&journal=Cancer%20Discov.&doi=10.1158%2F2159-8290.CD-12-0103&volume=2&pages=934-947&publication_year=2012&author=Ercan%2CD each month?
- How much revenue does https://doi.org/10.1158%2F0008-5472.CAN-14-3167 bring in?
- How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=25870145 generate monthly?
- Explore the financials of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605607
- How much revenue does http://scholar.google.com/scholar_lookup?&title=Acquired%20resistance%20to%20the%20mutant-selective%20EGFR%20inhibitor%20AZD9291%20is%20associated%20with%20increased%20dependence%20on%20RAS%20signaling%20in%20preclinical%20models&journal=Cancer%20Res.&doi=10.1158%2F0008-5472.CAN-14-3167&volume=75&pages=2489-2500&publication_year=2015&author=Eberlein%2CCA produce monthly?
- See how much http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11389083 makes per month
- How much revenue does http://scholar.google.com/scholar_lookup?&title=High-throughput%20tissue%20microarray%20analysis%20of%203p25%20%28RAF1%29%20and%208p12%20%28FGFR1%29%20copy%20number%20alterations%20in%20urinary%20bladder%20cancer&journal=Cancer%20Res.&volume=61&pages=4514-4519&publication_year=2001&author=Simon%2CR bring in?
- https://doi.org/10.1371%2Fjournal.pone.0028973's financial summary
- http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2011PLoSO...628973A's revenue stream
- How much revenue does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=22194965 bring in?
- What's the total monthly financial gain of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237573?
- How much does http://scholar.google.com/scholar_lookup?&title=Reversing%20melanoma%20cross-resistance%20to%20BRAF%20and%20MEK%20inhibitors%20by%20co-targeting%20the%20AKT%2FmTOR%20pathway&journal=PLoS%20ONE&doi=10.1371%2Fjournal.pone.0028973&volume=6&publication_year=2011&author=Atefi%2CM gross monthly?
- How much does https://doi.org/10.1126%2Fscisignal.2004652 net monthly?
- What's the financial intake of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=24065147?
- What are the earnings of http://scholar.google.com/scholar_lookup?&title=Bypass%20mechanisms%20of%20resistance%20to%20receptor%20tyrosine%20kinase%20inhibition%20in%20lung%20cancer&journal=Sci.%20Signal.&doi=10.1126%2Fscisignal.2004652&volume=6&publication_year=2013&author=Niederst%2CMJ&author=Engelman%2CJA?
- What's the financial intake of https://doi.org/10.1073%2Fpnas.0510857103?
- What are the total earnings of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2006PNAS..103.1475B?
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=16432179's financial summary
- Financial intake of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1360603
- http://scholar.google.com/scholar_lookup?&title=Cancer-specific%20mutations%20in%20PIK3CA%20are%20oncogenic%20in%20vivo&journal=Proc.%20Natl%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.0510857103&volume=103&pages=1475-1479&publication_year=2006&author=Bader%2CAG&author=Kang%2CS&author=Vogt%2CPK's revenue stream
- How much revenue does https://doi.org/10.1158%2F1535-7163.MCT-11-0692 bring in?
- How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=22135231 pull in monthly?
- http://scholar.google.com/scholar_lookup?&title=Coexistence%20of%20PIK3CA%20and%20other%20oncogene%20mutations%20in%20lung%20adenocarcinoma-rationale%20for%20comprehensive%20mutation%20profiling&journal=Mol.%20Cancer%20Ther.&doi=10.1158%2F1535-7163.MCT-11-0692&volume=11&pages=485-491&publication_year=2012&author=Chaft%2CJE income
- What are the earnings of https://doi.org/10.1128%2FMCB.01124-09?
- How much profit does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=19995904 make?
- How much does http://scholar.google.com/scholar_lookup?&title=DNA%20polymerase%20POLN%20participates%20in%20cross-link%20repair%20and%20homologous%20recombination&journal=Mol.%20Cell%20Biol.&doi=10.1128%2FMCB.01124-09&volume=30&pages=1088-1096&publication_year=2010&author=Moldovan%2CGL generate monthly?
- Monthly income for https://doi.org/10.1158%2F0008-5472.CAN-10-0460
- How much cash flow does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=20643779 have monthly?
- How much revenue does http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2932856 generate?
- How much profit does http://scholar.google.com/scholar_lookup?&title=Identification%20of%20optimal%20drug%20combinations%20targeting%20cellular%20networks%3A%20integrating%20phospho-proteomics%20and%20computational%20network%20analysis&journal=Cancer%20Res.&doi=10.1158%2F0008-5472.CAN-10-0460&volume=70&pages=6704-6714&publication_year=2010&author=Iadevaia%2CS&author=Lu%2CY&author=Morales%2CFC&author=Mills%2CGB&author=Ram%2CPT generate?
- How much profit does https://doi.org/10.1371%2Fjournal.pbio.1001296 make?
- Explore the financials of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=22509130
- What's the financial outcome of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317895?
- How much does http://scholar.google.com/scholar_lookup?&title=Nonheritable%20cellular%20variability%20accelerates%20the%20evolutionary%20processes%20of%20cancer&journal=PLoS%20Biol.&doi=10.1371%2Fjournal.pbio.1001296&volume=10&publication_year=2012&author=Frank%2CSA&author=Rosner%2CMR bring in each month?
- Discover the revenue of https://link.springer.com/doi/10.1186/s13029-014-0027-x
- How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=25614758 bring in each month?
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279979's financial summary
- What's http://scholar.google.com/scholar_lookup?&title=Robust%20dose-response%20curve%20estimation%20applied%20to%20high%20content%20screening%20data%20analysis&journal=Source%20Code%20Biol.%20Med.&doi=10.1186%2Fs13029-014-0027-x&volume=9&publication_year=2014&author=Nguyen%2CTT's gross income?
- How much money does https://doi.org/10.1093%2Fbioinformatics%2Fbtp698 generate?
- How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=20080505 make?
- Income figures for http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828108
- What's the financial intake of http://scholar.google.com/scholar_lookup?&title=Fast%20and%20accurate%20long-read%20alignment%20with%20Burrows-Wheeler%20transform&journal=Bioinformatics&doi=10.1093%2Fbioinformatics%2Fbtp698&volume=26&pages=589-595&publication_year=2010&author=Li%2CH&author=Durbin%2CR?
- How much revenue does https://doi.org/10.1038%2Fnbt.2514 bring in?
- What's the profit of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=23396013?
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3833702's revenue stream
- How much income is http://scholar.google.com/scholar_lookup?&title=Sensitive%20detection%20of%20somatic%20point%20mutations%20in%20impure%20and%20heterogeneous%20cancer%20samples&journal=Nat.%20Biotechnol.&doi=10.1038%2Fnbt.2514&volume=31&pages=213-219&publication_year=2013&author=Cibulskis%2CK earning monthly?
- What's https://doi.org/10.1093%2Fbioinformatics%2Fbtr462's gross income?
- Profit of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=21828086
- See how much http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179661 makes per month
- How much revenue does http://scholar.google.com/scholar_lookup?&title=Exome%20sequencing-based%20copy-number%20variation%20and%20loss%20of%20heterozygosity%20detection%3A%20ExomeCNV&journal=Bioinformatics&doi=10.1093%2Fbioinformatics%2Fbtr462&volume=27&pages=2648-2654&publication_year=2011&author=Sathirapongsasuti%2CJF generate?
- What are the total earnings of https://citation-needed.springer.com/v2/references/10.1038/ncomms10690?format=refman&flavour=references?
- How much revenue does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Michael%20Ramirez bring in?
- How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Michael%20Ramirez%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en generate monthly?
- How much profit does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Satwik%20Rajaram generate?
- Revenue of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Satwik%20Rajaram%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
- How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Robert%20J.%20Steininger pull in monthly?
- How much profit is https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Robert%20J.%20Steininger%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en making per month?
- How profitable is https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Daria%20Osipchuk?
- How much income does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Daria%20Osipchuk%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en have?
- Find out how much https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Maike%20A.%20Roth earns monthly
- How much income is https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Maike%20A.%20Roth%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en earning monthly?
- Monthly income for https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Leanna%20S.%20Morinishi
- Get to know what's the income of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Leanna%20S.%20Morinishi%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
- What's the financial intake of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Louise%20Evans?
- What's the total monthly financial gain of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Louise%20Evans%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- Earnings of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Weiyue%20Ji
- Get to know what's the income of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Weiyue%20Ji%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
- Find out how much https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Chien-Hsiang%20Hsu earns monthly
- Explore the financials of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Chien-Hsiang%20Hsu%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
- Discover the revenue of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Kevin%20Thurley
- Financial intake of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Kevin%20Thurley%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
- What's the income of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Shuguang%20Wei?
- How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Shuguang%20Wei%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en net monthly?
- How profitable is https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Anwu%20Zhou?
- How much money does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Anwu%20Zhou%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en make?
- How much cash flow does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Prasad%20R.%20Koduru have monthly?
- What's the financial intake of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Prasad%20R.%20Koduru%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- How much money does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Bruce%20A.%20Posner generate?
- How much revenue does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Bruce%20A.%20Posner%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en bring in?
- What's the financial gain of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Lani%20F.%20Wu?
- Find out how much https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Lani%20F.%20Wu%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en earns monthly
- What is the monthly revenue of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Steven%20J.%20Altschuler?
- What are the total earnings of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Steven%20J.%20Altschuler%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- What's the monthly income of https://static-content.springer.com/esm/art%3A10.1038%2Fncomms10690/MediaObjects/41467_2016_BFncomms10690_MOESM1080_ESM.pdf?
- Monthly income for https://static-content.springer.com/esm/art%3A10.1038%2Fncomms10690/MediaObjects/41467_2016_BFncomms10690_MOESM1081_ESM.xls
- https://static-content.springer.com/esm/art%3A10.1038%2Fncomms10690/MediaObjects/41467_2016_BFncomms10690_MOESM1082_ESM.txt's revenue stream
- What is the earnings of https://static-content.springer.com/esm/art%3A10.1038%2Fncomms10690/MediaObjects/41467_2016_BFncomms10690_MOESM1083_ESM.txt?
- How much income is https://static-content.springer.com/esm/art%3A10.1038%2Fncomms10690/MediaObjects/41467_2016_BFncomms10690_MOESM1084_ESM.txt earning monthly?
- How much revenue does http://creativecommons.org/licenses/by/4.0/ produce monthly?
- Learn how profitable https://s100.copyright.com/AppDispatchServlet?title=Diverse%20drug-resistance%20mechanisms%20can%20emerge%20from%20drug-tolerant%20cancer%20persister%20cells&author=Michael%20Ramirez%20et%20al&contentID=10.1038%2Fncomms10690©right=The%20Author%28s%29&publication=2041-1723&publicationDate=2016-02-19&publisherName=SpringerNature&orderBeanReset=true&oa=CC%20BY is on a monthly basis
- How much profit does https://crossmark.crossref.org/dialog/?doi=10.1038/ncomms10690 make?
- Profit of https://citation-needed.springer.com/v2/references/10.1038/ncomms10690?format=refman&flavour=citation
- How much does https://doi.org/10.1038/s41588-023-01592-8 rake in every month?
- How much revenue does https://doi.org/10.1186/s40164-023-00434-x generate?
- How much profit does https://doi.org/10.1038/s41698-023-00350-7 generate?
- What's the monthly money flow for https://doi.org/10.1038/s41598-023-34438-8?
- How much revenue does https://doi.org/10.1038/s41418-022-01064-2 bring in?
- How much does https://www.protocols.io/ bring in each month?
- What are the earnings of https://www.natureindex.com/?
- What's http://www.naturechina.com's gross income?
- Find out how much https://www.natureasia.com/ja-jp earns monthly
Analytics and Tracking {📊}
- Google Tag Manager
Libraries {📚}
- Prism.js
- Zoom.js
Emails and Hosting {✉️}
Mail Servers:
- mxa-002c5801.gslb.pphosted.com
- mxb-002c5801.gslb.pphosted.com
Name Servers:
- pdns1.ultradns.net
- pdns2.ultradns.net
- pdns3.ultradns.org
- pdns4.ultradns.org
- pdns5.ultradns.info
- pdns6.ultradns.co.uk
CDN Services {📦}
- Crossref