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We are analyzing https://www.nature.com/articles/nchembio.551.

Title:
Cholesterol modulates glycolipid conformation and receptor activity | Nature Chemical Biology
Description:
Experiments on reconstituted liposomes and sperm capacitation, an activation process involving the reduction in membrane cholesterol content and subsequent exposure of surface carbohydrate, show that cholesterol masks the presentation of glycolipid head groups by inducing a conformational shift in the glycan moiety. We document a new dimension of surface recognition in which communication is controlled through the collective behavior of lipids. Membrane cholesterol induces a tilt in glycolipid receptor headgroup, resulting in loss of access for ligand binding. This property appears to organize erythrocyte blood group presentation and glycolipid receptor function during the activation of sperm fertility, suggesting that lipid
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Keywords {🔍}

article, google, scholar, cas, nature, lingwood, access, biol, membrane, content, cholesterol, cookies, biology, chem, grant, privacy, journal, receptor, clifford, cell, molecular, research, toronto, university, data, information, glycolipid, ilpo, vattulainen, simons, open, reprod, department, supplementary, function, advertising, subscribe, chemical, binnington, róg, kai, recognition, lipids, lipid, institution, buy, mol, nat, dev, authors,

Topics {✒️}

nature portfolio permissions reprints privacy policy research institute nature advertising social media author information authors single-molecule imaging kenichi author correspondence personal data data protection permissions springerlink instant access glycolipid receptor headgroup privacy molecular cell biology max planck institute bmbf format grant esf “lipidprod” grant competing financial interests membrane cholesterol induces glycolipid receptor function explore content subscription content european economic area institutional subscriptions read mpi-cbg stipend abnormal transmembrane signals autism spectrum disorder accepting optional cookies molecular life sciences journals search log ilpo vattulainen sperm recognition experiments cell plasma membranes kai simons molecular dynamics simulations membrane biology article lingwood manage preferences aalto university school communication published issue learn content receptor activity tomasz róg ünal coskun lingwood department communications article

Questions {❓}

  • Is cholesterol both the lock and key to abnormal transmembrane signals in Autism Spectrum Disorder?

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      headline:Cholesterol modulates glycolipid conformation and receptor activity
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