NATURE . COM {}

Matching Content Categories {📚}

• Science
• Education
• Telecommunications

Content Management System {📝}

What CMS is nature.com built with?

Custom-built

No common CMS systems were detected on Nature.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of nature.com audience?

🌆 Monumental Traffic: 20M - 50M visitors per month


Based on our best estimate, this website will receive around 42,554,915 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Nature.com Make Money? {💸}

Display Ads {🎯}

Direct Advertisers (10)

Reseller Advertisers (38)

How Much Does Nature.com Make? {💰}

Display Ads {🎯}

$536,300 per month
Our estimates place Nature.com's monthly online earnings from display ads at $357,503 to $983,134.

Keywords {🔍}

data, bar, cells, nfs, article, versus, independent, scholar, google, biological, cell, cas, nature, shnfs, tumours, shrnas, lung, cancer, mdamb, expressing, replicates, shrfp, left, fig, oxygen, relative, representative, source, ferroptosis, levels, york, extended, values, treatment, usa, immunoblots, access, mrna, possemato, tumour, ads, triplicates, images, day, birsoy, richard, ironsulfur, control, targeting, black,

Topics {✒️}

permissions reprints nature portfolio journals privacy policy nature portfolio egfr/kras/alk-negative lung adenocarcinomas integrative cancer research apoptosis inhibitor z-vad-fmk advertising biomedical research kıvanç birsoy & richard possemato social media research pew-stewart scholar grant shgfp ssa/bso treatment parkinsonism/melas overlap syndrome nuclear iron-sulfur proteins nuclear iron–sulfur proteins mda-mb-231 cells grown mda-mb-231 cells embedded select environment-specific adaptations author correction mda-mb-231 cells expressing nature+ nature 508 nature 476 nature 463 nature 483 nature 399 nature 551 nature drive cancer initiation somatic copy-number alteration reactive oxygen species nci-h322 crnfs1 clones multiple cell-essential proteins mda-mb-231 cells stained iron-sulfur cluster environmental oxygen levels context-dependent gene essentiality1 liver kinase b1 nci-h322 data point permissions vitro model systems springerlink instant access regulatory rna sequences cancer cell sensitivity suppresses tumor growth sylvia adams destroy tumor cells mda-mb-231 cells

Questions {❓}

• Is hydroxyl radical generated by the Fenton reaction in vivo?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis
         description:Cancers growing in high-oxygen environments, such as lung adenocarcinomas, select for the iron–sulfur cluster synthesizing enzyme NFS1 to support malignant proliferation and to protect from oxidative damage. Cancer cells often select environment-specific adaptations in order to grow in different contexts. The authors show that tumours growing in high oxygen settings, such as lung cancers or metastasis, usually show elevated NFS1 signalling. NFS1 maintains the iron–sulfur clusters in proteins that are essential for protecting them from oxidative damage. Inactivating NFS1 or iron–sulfur clusters can trigger ferroptosis, a non-apoptotic form of cell death, in cancer cells. Environmental nutrient levels impact cancer cell metabolism, resulting in context-dependent gene essentiality1,2. Here, using loss-of-function screening based on RNA interference, we show that environmental oxygen levels are a major driver of differential essentiality between in vitro model systems and in vivo tumours. Above the 3–8% oxygen concentration typical of most tissues, we find that cancer cells depend on high levels of the iron–sulfur cluster biosynthetic enzyme NFS1. Mammary or subcutaneous tumours grow despite suppression of NFS1, whereas metastatic or primary lung tumours do not. Consistent with a role in surviving the high oxygen environment of incipient lung tumours, NFS1 lies in a region of genomic amplification present in lung adenocarcinoma and is most highly expressed in well-differentiated adenocarcinomas. NFS1 activity is particularly important for maintaining the iron–sulfur co-factors present in multiple cell-essential proteins upon exposure to oxygen compared to other forms of oxidative damage. Furthermore, insufficient iron–sulfur cluster maintenance robustly activates the iron-starvation response and, in combination with inhibition of glutathione biosynthesis, triggers ferroptosis, a non-apoptotic form of cell death. Suppression of NFS1 cooperates with inhibition of cysteine transport to trigger ferroptosis in vitro and slow tumour growth. Therefore, lung adenocarcinomas select for expression of a pathway that confers resistance to high oxygen tension and protects cells from undergoing ferroptosis in response to oxidative damage.
         datePublished:2017-11-22T00:00:00Z
         dateModified:2022-09-14T00:00:00Z
         pageStart:639
         pageEnd:643
         sameAs:https://doi.org/10.1038/nature24637
         keywords:
            Cancer metabolism
            Metabolomics
            Science
            Humanities and Social Sciences
            multidisciplinary
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature24637/MediaObjects/41586_2017_Article_BFnature24637_Fig1_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature24637/MediaObjects/41586_2017_Article_BFnature24637_Fig2_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature24637/MediaObjects/41586_2017_Article_BFnature24637_Fig3_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature24637/MediaObjects/41586_2017_Article_BFnature24637_Fig4_HTML.jpg
         isPartOf:
            name:Nature
            issn:
               1476-4687
               0028-0836
            volumeNumber:551
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Nature Publishing Group UK
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Samantha W. Alvarez
               affiliation:
                     name:New York University School of Medicine
                     address:
                        name:Department of Pathology, New York University School of Medicine, New York, USA
                        type:PostalAddress
                     type:Organization
                     name:Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine
                     address:
                        name:Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine, New York, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Vladislav O. Sviderskiy
               affiliation:
                     name:New York University School of Medicine
                     address:
                        name:Department of Pathology, New York University School of Medicine, New York, USA
                        type:PostalAddress
                     type:Organization
                     name:Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine
                     address:
                        name:Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine, New York, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Erdem M. Terzi
               affiliation:
                     name:New York University School of Medicine
                     address:
                        name:Department of Pathology, New York University School of Medicine, New York, USA
                        type:PostalAddress
                     type:Organization
                     name:Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine
                     address:
                        name:Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine, New York, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Thales Papagiannakopoulos
               affiliation:
                     name:New York University School of Medicine
                     address:
                        name:Department of Pathology, New York University School of Medicine, New York, USA
                        type:PostalAddress
                     type:Organization
                     name:Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine
                     address:
                        name:Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine, New York, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Andre L. Moreira
               affiliation:
                     name:New York University School of Medicine
                     address:
                        name:Department of Pathology, New York University School of Medicine, New York, USA
                        type:PostalAddress
                     type:Organization
                     name:Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine
                     address:
                        name:Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine, New York, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Sylvia Adams
               affiliation:
                     name:New York University School of Medicine
                     address:
                        name:Department of Pathology, New York University School of Medicine, New York, USA
                        type:PostalAddress
                     type:Organization
                     name:Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine
                     address:
                        name:Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine, New York, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:David M. Sabatini
               affiliation:
                     name:Whitehead Institute for Biomedical Research, Nine Cambridge Center
                     address:
                        name:Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, USA
                        type:PostalAddress
                     type:Organization
                     name:Howard Hughes Medical Institute, Massachusetts Institute of Technology
                     address:
                        name:Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, USA
                        type:PostalAddress
                     type:Organization
                     name:The David H. Koch Institute for Integrative Cancer Research
                     address:
                        name:The David H. Koch Institute for Integrative Cancer Research, Cambridge, USA
                        type:PostalAddress
                     type:Organization
                     name:Massachusetts Institute of Technology
                     address:
                        name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
                        type:PostalAddress
                     type:Organization
                     name:Broad Institute of Harvard and Massachusetts Institute of Technology, Seven Cambridge Center
                     address:
                        name:Broad Institute of Harvard and Massachusetts Institute of Technology, Seven Cambridge Center, Cambridge, USA
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Kıvanç Birsoy
               affiliation:
                     name:Whitehead Institute for Biomedical Research, Nine Cambridge Center
                     address:
                        name:Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, USA
                        type:PostalAddress
                     type:Organization
                     name:Howard Hughes Medical Institute, Massachusetts Institute of Technology
                     address:
                        name:Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, USA
                        type:PostalAddress
                     type:Organization
                     name:The David H. Koch Institute for Integrative Cancer Research
                     address:
                        name:The David H. Koch Institute for Integrative Cancer Research, Cambridge, USA
                        type:PostalAddress
                     type:Organization
                     name:Massachusetts Institute of Technology
                     address:
                        name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
                        type:PostalAddress
                     type:Organization
                     name:Broad Institute of Harvard and Massachusetts Institute of Technology, Seven Cambridge Center
                     address:
                        name:Broad Institute of Harvard and Massachusetts Institute of Technology, Seven Cambridge Center, Cambridge, USA
                        type:PostalAddress
                     type:Organization
                     name:Laboratory of Metabolic Regulation and Genetics, The Rockefeller University
                     address:
                        name:Laboratory of Metabolic Regulation and Genetics, The Rockefeller University, USA
                        type:PostalAddress
                     type:Organization
                     name:The Rockefeller University
                     address:
                        name:Laboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, USA
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Richard Possemato
               affiliation:
                     name:New York University School of Medicine
                     address:
                        name:Department of Pathology, New York University School of Medicine, New York, USA
                        type:PostalAddress
                     type:Organization
                     name:Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine
                     address:
                        name:Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine, New York, USA
                        type:PostalAddress
                     type:Organization
                     name:Whitehead Institute for Biomedical Research, Nine Cambridge Center
                     address:
                        name:Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, USA
                        type:PostalAddress
                     type:Organization
                     name:Howard Hughes Medical Institute, Massachusetts Institute of Technology
                     address:
                        name:Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, USA
                        type:PostalAddress
                     type:Organization
                     name:The David H. Koch Institute for Integrative Cancer Research
                     address:
                        name:The David H. Koch Institute for Integrative Cancer Research, Cambridge, USA
                        type:PostalAddress
                     type:Organization
                     name:Massachusetts Institute of Technology
                     address:
                        name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
                        type:PostalAddress
                     type:Organization
                     name:Broad Institute of Harvard and Massachusetts Institute of Technology, Seven Cambridge Center
                     address:
                        name:Broad Institute of Harvard and Massachusetts Institute of Technology, Seven Cambridge Center, Cambridge, USA
                        type:PostalAddress
                     type:Organization
                     name:New York University School of Medicine
                     address:
                        name:Department of Pathology, New York University School of Medicine, New York, USA
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis
      description:Cancers growing in high-oxygen environments, such as lung adenocarcinomas, select for the iron–sulfur cluster synthesizing enzyme NFS1 to support malignant proliferation and to protect from oxidative damage. Cancer cells often select environment-specific adaptations in order to grow in different contexts. The authors show that tumours growing in high oxygen settings, such as lung cancers or metastasis, usually show elevated NFS1 signalling. NFS1 maintains the iron–sulfur clusters in proteins that are essential for protecting them from oxidative damage. Inactivating NFS1 or iron–sulfur clusters can trigger ferroptosis, a non-apoptotic form of cell death, in cancer cells. Environmental nutrient levels impact cancer cell metabolism, resulting in context-dependent gene essentiality1,2. Here, using loss-of-function screening based on RNA interference, we show that environmental oxygen levels are a major driver of differential essentiality between in vitro model systems and in vivo tumours. Above the 3–8% oxygen concentration typical of most tissues, we find that cancer cells depend on high levels of the iron–sulfur cluster biosynthetic enzyme NFS1. Mammary or subcutaneous tumours grow despite suppression of NFS1, whereas metastatic or primary lung tumours do not. Consistent with a role in surviving the high oxygen environment of incipient lung tumours, NFS1 lies in a region of genomic amplification present in lung adenocarcinoma and is most highly expressed in well-differentiated adenocarcinomas. NFS1 activity is particularly important for maintaining the iron–sulfur co-factors present in multiple cell-essential proteins upon exposure to oxygen compared to other forms of oxidative damage. Furthermore, insufficient iron–sulfur cluster maintenance robustly activates the iron-starvation response and, in combination with inhibition of glutathione biosynthesis, triggers ferroptosis, a non-apoptotic form of cell death. Suppression of NFS1 cooperates with inhibition of cysteine transport to trigger ferroptosis in vitro and slow tumour growth. Therefore, lung adenocarcinomas select for expression of a pathway that confers resistance to high oxygen tension and protects cells from undergoing ferroptosis in response to oxidative damage.
      datePublished:2017-11-22T00:00:00Z
      dateModified:2022-09-14T00:00:00Z
      pageStart:639
      pageEnd:643
      sameAs:https://doi.org/10.1038/nature24637
      keywords:
         Cancer metabolism
         Metabolomics
         Science
         Humanities and Social Sciences
         multidisciplinary
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature24637/MediaObjects/41586_2017_Article_BFnature24637_Fig1_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature24637/MediaObjects/41586_2017_Article_BFnature24637_Fig2_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature24637/MediaObjects/41586_2017_Article_BFnature24637_Fig3_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature24637/MediaObjects/41586_2017_Article_BFnature24637_Fig4_HTML.jpg
      isPartOf:
         name:Nature
         issn:
            1476-4687
            0028-0836
         volumeNumber:551
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Nature Publishing Group UK
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Samantha W. Alvarez
            affiliation:
                  name:New York University School of Medicine
                  address:
                     name:Department of Pathology, New York University School of Medicine, New York, USA
                     type:PostalAddress
                  type:Organization
                  name:Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine
                  address:
                     name:Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine, New York, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Vladislav O. Sviderskiy
            affiliation:
                  name:New York University School of Medicine
                  address:
                     name:Department of Pathology, New York University School of Medicine, New York, USA
                     type:PostalAddress
                  type:Organization
                  name:Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine
                  address:
                     name:Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine, New York, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Erdem M. Terzi
            affiliation:
                  name:New York University School of Medicine
                  address:
                     name:Department of Pathology, New York University School of Medicine, New York, USA
                     type:PostalAddress
                  type:Organization
                  name:Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine
                  address:
                     name:Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine, New York, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Thales Papagiannakopoulos
            affiliation:
                  name:New York University School of Medicine
                  address:
                     name:Department of Pathology, New York University School of Medicine, New York, USA
                     type:PostalAddress
                  type:Organization
                  name:Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine
                  address:
                     name:Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine, New York, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Andre L. Moreira
            affiliation:
                  name:New York University School of Medicine
                  address:
                     name:Department of Pathology, New York University School of Medicine, New York, USA
                     type:PostalAddress
                  type:Organization
                  name:Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine
                  address:
                     name:Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine, New York, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Sylvia Adams
            affiliation:
                  name:New York University School of Medicine
                  address:
                     name:Department of Pathology, New York University School of Medicine, New York, USA
                     type:PostalAddress
                  type:Organization
                  name:Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine
                  address:
                     name:Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine, New York, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:David M. Sabatini
            affiliation:
                  name:Whitehead Institute for Biomedical Research, Nine Cambridge Center
                  address:
                     name:Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, USA
                     type:PostalAddress
                  type:Organization
                  name:Howard Hughes Medical Institute, Massachusetts Institute of Technology
                  address:
                     name:Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, USA
                     type:PostalAddress
                  type:Organization
                  name:The David H. Koch Institute for Integrative Cancer Research
                  address:
                     name:The David H. Koch Institute for Integrative Cancer Research, Cambridge, USA
                     type:PostalAddress
                  type:Organization
                  name:Massachusetts Institute of Technology
                  address:
                     name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
                     type:PostalAddress
                  type:Organization
                  name:Broad Institute of Harvard and Massachusetts Institute of Technology, Seven Cambridge Center
                  address:
                     name:Broad Institute of Harvard and Massachusetts Institute of Technology, Seven Cambridge Center, Cambridge, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Kıvanç Birsoy
            affiliation:
                  name:Whitehead Institute for Biomedical Research, Nine Cambridge Center
                  address:
                     name:Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, USA
                     type:PostalAddress
                  type:Organization
                  name:Howard Hughes Medical Institute, Massachusetts Institute of Technology
                  address:
                     name:Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, USA
                     type:PostalAddress
                  type:Organization
                  name:The David H. Koch Institute for Integrative Cancer Research
                  address:
                     name:The David H. Koch Institute for Integrative Cancer Research, Cambridge, USA
                     type:PostalAddress
                  type:Organization
                  name:Massachusetts Institute of Technology
                  address:
                     name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
                     type:PostalAddress
                  type:Organization
                  name:Broad Institute of Harvard and Massachusetts Institute of Technology, Seven Cambridge Center
                  address:
                     name:Broad Institute of Harvard and Massachusetts Institute of Technology, Seven Cambridge Center, Cambridge, USA
                     type:PostalAddress
                  type:Organization
                  name:Laboratory of Metabolic Regulation and Genetics, The Rockefeller University
                  address:
                     name:Laboratory of Metabolic Regulation and Genetics, The Rockefeller University, USA
                     type:PostalAddress
                  type:Organization
                  name:The Rockefeller University
                  address:
                     name:Laboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Richard Possemato
            affiliation:
                  name:New York University School of Medicine
                  address:
                     name:Department of Pathology, New York University School of Medicine, New York, USA
                     type:PostalAddress
                  type:Organization
                  name:Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine
                  address:
                     name:Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine, New York, USA
                     type:PostalAddress
                  type:Organization
                  name:Whitehead Institute for Biomedical Research, Nine Cambridge Center
                  address:
                     name:Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, USA
                     type:PostalAddress
                  type:Organization
                  name:Howard Hughes Medical Institute, Massachusetts Institute of Technology
                  address:
                     name:Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, USA
                     type:PostalAddress
                  type:Organization
                  name:The David H. Koch Institute for Integrative Cancer Research
                  address:
                     name:The David H. Koch Institute for Integrative Cancer Research, Cambridge, USA
                     type:PostalAddress
                  type:Organization
                  name:Massachusetts Institute of Technology
                  address:
                     name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
                     type:PostalAddress
                  type:Organization
                  name:Broad Institute of Harvard and Massachusetts Institute of Technology, Seven Cambridge Center
                  address:
                     name:Broad Institute of Harvard and Massachusetts Institute of Technology, Seven Cambridge Center, Cambridge, USA
                     type:PostalAddress
                  type:Organization
                  name:New York University School of Medicine
                  address:
                     name:Department of Pathology, New York University School of Medicine, New York, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Nature
      issn:
         1476-4687
         0028-0836
      volumeNumber:551
Organization:
      name:Nature Publishing Group UK
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:New York University School of Medicine
      address:
         name:Department of Pathology, New York University School of Medicine, New York, USA
         type:PostalAddress
      name:Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine
      address:
         name:Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine, New York, USA
         type:PostalAddress
      name:New York University School of Medicine
      address:
         name:Department of Pathology, New York University School of Medicine, New York, USA
         type:PostalAddress
      name:Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine
      address:
         name:Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine, New York, USA
         type:PostalAddress
      name:New York University School of Medicine
      address:
         name:Department of Pathology, New York University School of Medicine, New York, USA
         type:PostalAddress
      name:Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine
      address:
         name:Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine, New York, USA
         type:PostalAddress
      name:New York University School of Medicine
      address:
         name:Department of Pathology, New York University School of Medicine, New York, USA
         type:PostalAddress
      name:Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine
      address:
         name:Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine, New York, USA
         type:PostalAddress
      name:New York University School of Medicine
      address:
         name:Department of Pathology, New York University School of Medicine, New York, USA
         type:PostalAddress
      name:Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine
      address:
         name:Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine, New York, USA
         type:PostalAddress
      name:New York University School of Medicine
      address:
         name:Department of Pathology, New York University School of Medicine, New York, USA
         type:PostalAddress
      name:Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine
      address:
         name:Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine, New York, USA
         type:PostalAddress
      name:Whitehead Institute for Biomedical Research, Nine Cambridge Center
      address:
         name:Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, USA
         type:PostalAddress
      name:Howard Hughes Medical Institute, Massachusetts Institute of Technology
      address:
         name:Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, USA
         type:PostalAddress
      name:The David H. Koch Institute for Integrative Cancer Research
      address:
         name:The David H. Koch Institute for Integrative Cancer Research, Cambridge, USA
         type:PostalAddress
      name:Massachusetts Institute of Technology
      address:
         name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
         type:PostalAddress
      name:Broad Institute of Harvard and Massachusetts Institute of Technology, Seven Cambridge Center
      address:
         name:Broad Institute of Harvard and Massachusetts Institute of Technology, Seven Cambridge Center, Cambridge, USA
         type:PostalAddress
      name:Whitehead Institute for Biomedical Research, Nine Cambridge Center
      address:
         name:Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, USA
         type:PostalAddress
      name:Howard Hughes Medical Institute, Massachusetts Institute of Technology
      address:
         name:Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, USA
         type:PostalAddress
      name:The David H. Koch Institute for Integrative Cancer Research
      address:
         name:The David H. Koch Institute for Integrative Cancer Research, Cambridge, USA
         type:PostalAddress
      name:Massachusetts Institute of Technology
      address:
         name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
         type:PostalAddress
      name:Broad Institute of Harvard and Massachusetts Institute of Technology, Seven Cambridge Center
      address:
         name:Broad Institute of Harvard and Massachusetts Institute of Technology, Seven Cambridge Center, Cambridge, USA
         type:PostalAddress
      name:Laboratory of Metabolic Regulation and Genetics, The Rockefeller University
      address:
         name:Laboratory of Metabolic Regulation and Genetics, The Rockefeller University, USA
         type:PostalAddress
      name:The Rockefeller University
      address:
         name:Laboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, USA
         type:PostalAddress
      name:New York University School of Medicine
      address:
         name:Department of Pathology, New York University School of Medicine, New York, USA
         type:PostalAddress
      name:Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine
      address:
         name:Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine, New York, USA
         type:PostalAddress
      name:Whitehead Institute for Biomedical Research, Nine Cambridge Center
      address:
         name:Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, USA
         type:PostalAddress
      name:Howard Hughes Medical Institute, Massachusetts Institute of Technology
      address:
         name:Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, USA
         type:PostalAddress
      name:The David H. Koch Institute for Integrative Cancer Research
      address:
         name:The David H. Koch Institute for Integrative Cancer Research, Cambridge, USA
         type:PostalAddress
      name:Massachusetts Institute of Technology
      address:
         name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
         type:PostalAddress
      name:Broad Institute of Harvard and Massachusetts Institute of Technology, Seven Cambridge Center
      address:
         name:Broad Institute of Harvard and Massachusetts Institute of Technology, Seven Cambridge Center, Cambridge, USA
         type:PostalAddress
      name:New York University School of Medicine
      address:
         name:Department of Pathology, New York University School of Medicine, New York, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Samantha W. Alvarez
      affiliation:
            name:New York University School of Medicine
            address:
               name:Department of Pathology, New York University School of Medicine, New York, USA
               type:PostalAddress
            type:Organization
            name:Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine
            address:
               name:Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine, New York, USA
               type:PostalAddress
            type:Organization
      name:Vladislav O. Sviderskiy
      affiliation:
            name:New York University School of Medicine
            address:
               name:Department of Pathology, New York University School of Medicine, New York, USA
               type:PostalAddress
            type:Organization
            name:Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine
            address:
               name:Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine, New York, USA
               type:PostalAddress
            type:Organization
      name:Erdem M. Terzi
      affiliation:
            name:New York University School of Medicine
            address:
               name:Department of Pathology, New York University School of Medicine, New York, USA
               type:PostalAddress
            type:Organization
            name:Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine
            address:
               name:Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine, New York, USA
               type:PostalAddress
            type:Organization
      name:Thales Papagiannakopoulos
      affiliation:
            name:New York University School of Medicine
            address:
               name:Department of Pathology, New York University School of Medicine, New York, USA
               type:PostalAddress
            type:Organization
            name:Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine
            address:
               name:Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine, New York, USA
               type:PostalAddress
            type:Organization
      name:Andre L. Moreira
      affiliation:
            name:New York University School of Medicine
            address:
               name:Department of Pathology, New York University School of Medicine, New York, USA
               type:PostalAddress
            type:Organization
            name:Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine
            address:
               name:Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine, New York, USA
               type:PostalAddress
            type:Organization
      name:Sylvia Adams
      affiliation:
            name:New York University School of Medicine
            address:
               name:Department of Pathology, New York University School of Medicine, New York, USA
               type:PostalAddress
            type:Organization
            name:Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine
            address:
               name:Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine, New York, USA
               type:PostalAddress
            type:Organization
      name:David M. Sabatini
      affiliation:
            name:Whitehead Institute for Biomedical Research, Nine Cambridge Center
            address:
               name:Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, USA
               type:PostalAddress
            type:Organization
            name:Howard Hughes Medical Institute, Massachusetts Institute of Technology
            address:
               name:Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, USA
               type:PostalAddress
            type:Organization
            name:The David H. Koch Institute for Integrative Cancer Research
            address:
               name:The David H. Koch Institute for Integrative Cancer Research, Cambridge, USA
               type:PostalAddress
            type:Organization
            name:Massachusetts Institute of Technology
            address:
               name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
               type:PostalAddress
            type:Organization
            name:Broad Institute of Harvard and Massachusetts Institute of Technology, Seven Cambridge Center
            address:
               name:Broad Institute of Harvard and Massachusetts Institute of Technology, Seven Cambridge Center, Cambridge, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Kıvanç Birsoy
      affiliation:
            name:Whitehead Institute for Biomedical Research, Nine Cambridge Center
            address:
               name:Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, USA
               type:PostalAddress
            type:Organization
            name:Howard Hughes Medical Institute, Massachusetts Institute of Technology
            address:
               name:Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, USA
               type:PostalAddress
            type:Organization
            name:The David H. Koch Institute for Integrative Cancer Research
            address:
               name:The David H. Koch Institute for Integrative Cancer Research, Cambridge, USA
               type:PostalAddress
            type:Organization
            name:Massachusetts Institute of Technology
            address:
               name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
               type:PostalAddress
            type:Organization
            name:Broad Institute of Harvard and Massachusetts Institute of Technology, Seven Cambridge Center
            address:
               name:Broad Institute of Harvard and Massachusetts Institute of Technology, Seven Cambridge Center, Cambridge, USA
               type:PostalAddress
            type:Organization
            name:Laboratory of Metabolic Regulation and Genetics, The Rockefeller University
            address:
               name:Laboratory of Metabolic Regulation and Genetics, The Rockefeller University, USA
               type:PostalAddress
            type:Organization
            name:The Rockefeller University
            address:
               name:Laboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Richard Possemato
      affiliation:
            name:New York University School of Medicine
            address:
               name:Department of Pathology, New York University School of Medicine, New York, USA
               type:PostalAddress
            type:Organization
            name:Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine
            address:
               name:Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine, New York, USA
               type:PostalAddress
            type:Organization
            name:Whitehead Institute for Biomedical Research, Nine Cambridge Center
            address:
               name:Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, USA
               type:PostalAddress
            type:Organization
            name:Howard Hughes Medical Institute, Massachusetts Institute of Technology
            address:
               name:Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, USA
               type:PostalAddress
            type:Organization
            name:The David H. Koch Institute for Integrative Cancer Research
            address:
               name:The David H. Koch Institute for Integrative Cancer Research, Cambridge, USA
               type:PostalAddress
            type:Organization
            name:Massachusetts Institute of Technology
            address:
               name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
               type:PostalAddress
            type:Organization
            name:Broad Institute of Harvard and Massachusetts Institute of Technology, Seven Cambridge Center
            address:
               name:Broad Institute of Harvard and Massachusetts Institute of Technology, Seven Cambridge Center, Cambridge, USA
               type:PostalAddress
            type:Organization
            name:New York University School of Medicine
            address:
               name:Department of Pathology, New York University School of Medicine, New York, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Pathology, New York University School of Medicine, New York, USA
      name:Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine, New York, USA
      name:Department of Pathology, New York University School of Medicine, New York, USA
      name:Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine, New York, USA
      name:Department of Pathology, New York University School of Medicine, New York, USA
      name:Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine, New York, USA
      name:Department of Pathology, New York University School of Medicine, New York, USA
      name:Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine, New York, USA
      name:Department of Pathology, New York University School of Medicine, New York, USA
      name:Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine, New York, USA
      name:Department of Pathology, New York University School of Medicine, New York, USA
      name:Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine, New York, USA
      name:Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, USA
      name:Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, USA
      name:The David H. Koch Institute for Integrative Cancer Research, Cambridge, USA
      name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
      name:Broad Institute of Harvard and Massachusetts Institute of Technology, Seven Cambridge Center, Cambridge, USA
      name:Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, USA
      name:Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, USA
      name:The David H. Koch Institute for Integrative Cancer Research, Cambridge, USA
      name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
      name:Broad Institute of Harvard and Massachusetts Institute of Technology, Seven Cambridge Center, Cambridge, USA
      name:Laboratory of Metabolic Regulation and Genetics, The Rockefeller University, USA
      name:Laboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, USA
      name:Department of Pathology, New York University School of Medicine, New York, USA
      name:Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine, New York, USA
      name:Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, USA
      name:Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, USA
      name:The David H. Koch Institute for Integrative Cancer Research, Cambridge, USA
      name:Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
      name:Broad Institute of Harvard and Massachusetts Institute of Technology, Seven Cambridge Center, Cambridge, USA
      name:Department of Pathology, New York University School of Medicine, New York, USA
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

Social Networks {👍}(2)

• https://www.facebook.com/Nature
• https://twitter.com/nature

External Links {🔗}(132)

• How much income does https://doi.org/10.1038/s41586-022-05323-7 have?
• What's the income of https://link.springer.com/article/10.1038/nature24637?utm_source=nature&utm_medium=referral&utm_campaign=buyArticle?
• What's the financial gain of https://doi.org/10.1038%2Fnature13110?
• What is the monthly revenue of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2014Natur.508..108B?
• What's the income of http://scholar.google.com/scholar_lookup?&title=Metabolic%20determinants%20of%20cancer%20cell%20sensitivity%20to%20glucose%20limitation%20and%20biguanides&journal=Nature&doi=10.1038%2Fnature13110&volume=508&pages=108-112&publication_year=2014&author=Birsoy%2CK?
• Explore the financials of https://doi.org/10.1016%2Fj.cmet.2016.01.007
• How much revenue does http://scholar.google.com/scholar_lookup?&title=Environment%20impacts%20the%20metabolic%20dependencies%20of%20Ras-driven%20non-small%20cell%20lung%20cancer&journal=Cell%20Metab.&doi=10.1016%2Fj.cmet.2016.01.007&volume=23&pages=517-528&publication_year=2016&author=Davidson%2CSM bring in?
• How much revenue does https://doi.org/10.1073%2Fpnas.1307237110 generate?
• What's the profit of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2013PNAS..110.8882K?
• How much revenue does http://scholar.google.com/scholar_lookup?&title=Hypoxic%20and%20Ras-transformed%20cells%20support%20growth%20by%20scavenging%20unsaturated%20fatty%20acids%20from%20lysophospholipids&journal=Proc.%20Natl%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.1307237110&volume=110&pages=8882-8887&publication_year=2013&author=Kamphorst%2CJJ generate?
• How profitable is http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=2684393?
• How profitable is http://scholar.google.com/scholar_lookup?&title=Blood%20flow%2C%20oxygen%20and%20nutrient%20supply%2C%20and%20metabolic%20microenvironment%20of%20human%20tumors%3A%20a%20review&journal=Cancer%20Res.&volume=49&pages=6449-6465&publication_year=1989&author=Vaupel%2CP&author=Kallinowski%2CF&author=Okunieff%2CP?
• What's the total monthly financial gain of https://doi.org/10.1016%2Fj.biochi.2014.01.010?
• What's the financial outcome of http://scholar.google.com/scholar_lookup?&title=Mitochondrial%20iron%E2%80%93sulfur%20protein%20biogenesis%20and%20human%20disease&journal=Biochimie&doi=10.1016%2Fj.biochi.2014.01.010&volume=100&pages=61-77&publication_year=2014&author=Stehling%2CO&author=Wilbrecht%2CC&author=Lill%2CR?
• How much money does https://doi.org/10.1016%2Fj.tcb.2013.11.005 make?
• How much profit does http://scholar.google.com/scholar_lookup?&title=Maturation%20of%20cytosolic%20and%20nuclear%20iron-sulfur%20proteins&journal=Trends%20Cell%20Biol.&doi=10.1016%2Fj.tcb.2013.11.005&volume=24&pages=303-312&publication_year=2014&author=Netz%2CDJ&author=Mascarenhas%2CJ&author=Stehling%2CO&author=Pierik%2CAJ&author=Lill%2CR make?
• How much income does https://doi.org/10.1111%2Fj.1365-2958.2006.05028.x have?
• Learn how profitable http://scholar.google.com/scholar_lookup?&title=Iron%E2%80%93sulfur%20clusters%20and%20the%20problem%20with%20oxygen&journal=Mol.%20Microbiol.&doi=10.1111%2Fj.1365-2958.2006.05028.x&volume=59&pages=1073-1082&publication_year=2006&author=Imlay%2CJA is on a monthly basis
• How much revenue does https://doi.org/10.1093%2Fnar%2Fgku1221 produce monthly?
• How much money does http://scholar.google.com/scholar_lookup?&title=CDD%3A%20NCBI%E2%80%99s%20conserved%20domain%20database&journal=Nucleic%20Acids%20Res.&doi=10.1093%2Fnar%2Fgku1221&volume=43&pages=D222-D226&publication_year=2015&author=Marchler-Bauer%2CA make?
• Revenue of https://doi.org/10.1016%2Fj.bbamcr.2014.12.018
• How much income does http://scholar.google.com/scholar_lookup?&title=Biogenesis%20of%20cytosolic%20and%20nuclear%20iron%E2%80%93sulfur%20proteins%20and%20their%20role%20in%20genome%20stability&journal=Biochim.%20Biophys.%20Acta&doi=10.1016%2Fj.bbamcr.2014.12.018&volume=1853&pages=1528-1539&publication_year=2015&author=Paul%2CVD&author=Lill%2CR have?
• How profitable is https://doi.org/10.1074%2Fjbc.M804064200?
• Income figures for http://scholar.google.com/scholar_lookup?&title=A%20novel%20role%20for%20human%20Nfs1%20in%20the%20cytoplasm%3A%20Nfs1%20acts%20as%20a%20sulfur%20donor%20for%20MOCS3%2C%20a%20protein%20involved%20in%20molybdenum%20cofactor%20biosynthesis&journal=J.%20Biol.%20Chem.&doi=10.1074%2Fjbc.M804064200&volume=283&pages=25178-25185&publication_year=2008&author=Marelja%2CZ&author=St%C3%B6cklein%2CW&author=Nimtz%2CM&author=Leimk%C3%BChler%2CS
• How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=2040005 make?
• Financial intake of http://scholar.google.com/scholar_lookup?&title=Oxygenation%20of%20human%20tumors%3A%20evaluation%20of%20tissue%20oxygen%20distribution%20in%20breast%20cancers%20by%20computerized%20O2%20tension%20measurements&journal=Cancer%20Res.&volume=51&pages=3316-3322&publication_year=1991&author=Vaupel%2CP&author=Schlenger%2CK&author=Knoop%2CC&author=H%C3%B6ckel%2CM
• What are the earnings of https://doi.org/10.1038%2Fng.2760?
• How much revenue does http://scholar.google.com/scholar_lookup?&title=Pan-cancer%20patterns%20of%20somatic%20copy%20number%20alteration&journal=Nat.%20Genet.&doi=10.1038%2Fng.2760&volume=45&pages=1134-1140&publication_year=2013&author=Zack%2CTI bring in?
• Get to know https://doi.org/10.1002%2F1531-8249%28199901%2945%3A1%3C130%3A%3AAID-ART21%3E3.0.CO%3B2-Z's earnings
• Find out how much http://scholar.google.com/scholar_lookup?&title=A%204-base%20pair%20deletion%20in%20the%20mitochondrial%20cytochrome%20b%20gene%20associated%20with%20parkinsonism%2FMELAS%20overlap%20syndrome&journal=Ann.%20Neurol.&doi=10.1002%2F1531-8249%28199901%2945%3A1%3C130%3A%3AAID-ART21%3E3.0.CO%3B2-Z&volume=45&pages=130-133&publication_year=1999&author=De%20Coo%2CIF earns monthly
• Learn about the earnings of https://doi.org/10.1073%2Fpnas.83.11.3820
• http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1986PNAS...83.3820V's revenue stream
• See how much http://scholar.google.com/scholar_lookup?&title=A%20yeast%20mutant%20lacking%20mitochondrial%20manganese-superoxide%20dismutase%20is%20hypersensitive%20to%20oxygen&journal=Proc.%20Natl%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.83.11.3820&volume=83&pages=3820-3824&publication_year=1986&author=van%20Loon%2CAP&author=Pesold-Hurt%2CB&author=Schatz%2CG makes per month
• What's the financial outcome of https://doi.org/10.1016%2F0006-291X%2885%2990449-8?
• How much cash flow does http://scholar.google.com/scholar_lookup?&title=Is%20hydroxyl%20radical%20generated%20by%20the%20Fenton%20reaction%20in%20vivo%3F&journal=Biochem.%20Biophys.%20Res.%20Commun.&doi=10.1016%2F0006-291X%2885%2990449-8&volume=130&pages=533-539&publication_year=1985&author=Bili%C5%84ski%2CT&author=Krawiec%2CZ&author=Liczma%C5%84ski%2CA&author=Litwi%C5%84ska%2CJ have monthly?
• What's the income of https://doi.org/10.1016%2FS0021-9258%2818%2982394-8?
• How much profit does http://scholar.google.com/scholar_lookup?&title=The%20role%20and%20properties%20of%20the%20iron-sulfur%20cluster%20in%20Escherichia%20coli%20dihydroxy-acid%20dehydratase&journal=J.%20Biol.%20Chem.&doi=10.1016%2FS0021-9258%2818%2982394-8&volume=268&pages=14732-14742&publication_year=1993&author=Flint%2CDH&author=Emptage%2CMH&author=Finnegan%2CMG&author=Fu%2CW&author=Johnson%2CMK generate?
• Get to know https://doi.org/10.1126%2Fscience.2452485's earnings
• How much does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1988Sci...240..924C make?
• What's the revenue for http://scholar.google.com/scholar_lookup?&title=Iron-responsive%20elements%3A%20regulatory%20RNA%20sequences%20that%20control%20mRNA%20levels%20and%20translation&journal=Science&doi=10.1126%2Fscience.2452485&volume=240&pages=924-928&publication_year=1988&author=Casey%2CJL?
• How much profit is https://doi.org/10.1126%2Fscience.1103786 making per month?
• What is the monthly revenue of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2004Sci...306.2087M?
• Monthly income for http://scholar.google.com/scholar_lookup?&title=Mammalian%20tissue%20oxygen%20levels%20modulate%20iron-regulatory%20protein%20activities%20in%20vivo&journal=Science&doi=10.1126%2Fscience.1103786&volume=306&pages=2087-2090&publication_year=2004&author=Meyron-Holtz%2CEG&author=Ghosh%2CMC&author=Rouault%2CTA
• What's the monthly income of https://doi.org/10.1073%2Fpnas.95.20.11715?
• Get to know http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1998PNAS...9511715C's earnings
• What are the earnings of http://scholar.google.com/scholar_lookup?&title=Mitochondrial%20reactive%20oxygen%20species%20trigger%20hypoxia-induced%20transcription&journal=Proc.%20Natl%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.95.20.11715&volume=95&pages=11715-11720&publication_year=1998&author=Chandel%2CNS?
• What's the total monthly financial gain of https://doi.org/10.1016%2F0009-2797%2889%2990087-2?
• What is the earnings of http://scholar.google.com/scholar_lookup?&title=The%20role%20of%20iron%20in%20oxygen%20radical%20mediated%20lipid%20peroxidation&journal=Chem.%20Biol.%20Interact.&doi=10.1016%2F0009-2797%2889%2990087-2&volume=71&pages=1-19&publication_year=1989&author=Minotti%2CG&author=Aust%2CSD?
• Get to know https://doi.org/10.1016%2Fj.tcb.2015.10.014's earnings
• How much money does http://scholar.google.com/scholar_lookup?&title=Ferroptosis%3A%20death%20by%20lipid%20peroxidation&journal=Trends%20Cell%20Biol.&doi=10.1016%2Fj.tcb.2015.10.014&volume=26&pages=165-176&publication_year=2016&author=Yang%2CWS&author=Stockwell%2CBR generate?
• How much revenue does https://doi.org/10.1016%2Fj.cell.2013.12.010 bring in?
• How much money does http://scholar.google.com/scholar_lookup?&title=Regulation%20of%20ferroptotic%20cancer%20cell%20death%20by%20GPX4&journal=Cell&doi=10.1016%2Fj.cell.2013.12.010&volume=156&pages=317-331&publication_year=2014&author=Yang%2CWS generate?
• What's the financial gain of https://doi.org/10.1016%2Fj.cell.2012.03.042?
• What is the monthly revenue of http://scholar.google.com/scholar_lookup?&title=Ferroptosis%3A%20an%20iron-dependent%20form%20of%20nonapoptotic%20cell%20death&journal=Cell&doi=10.1016%2Fj.cell.2012.03.042&volume=149&pages=1060-1072&publication_year=2012&author=Dixon%2CSJ?
• How much does https://doi.org/10.1038%2Fnm.4232 net monthly?
• What's the financial gain of http://scholar.google.com/scholar_lookup?&title=Systemic%20depletion%20of%20l-cyst%28e%29ine%20with%20cyst%28e%29inase%20increases%20reactive%20oxygen%20species%20and%20suppresses%20tumor%20growth&journal=Nat.%20Med.&doi=10.1038%2Fnm.4232&volume=23&pages=120-127&publication_year=2017&author=Cramer%2CSL?
• What are the earnings of https://doi.org/10.1016%2Fj.ccell.2014.11.019?
• How much does http://scholar.google.com/scholar_lookup?&title=Glutathione%20and%20thioredoxin%20antioxidant%20pathways%20synergize%20to%20drive%20cancer%20initiation%20and%20progression&journal=Cancer%20Cell&doi=10.1016%2Fj.ccell.2014.11.019&volume=27&pages=211-222&publication_year=2015&author=Harris%2CIS pull in?
• How much does https://doi.org/10.1038%2Fnature10350 pull in monthly?
• How much does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2011Natur.476..346P generate monthly?
• What are the earnings of http://scholar.google.com/scholar_lookup?&title=Functional%20genomics%20reveal%20that%20the%20serine%20synthesis%20pathway%20is%20essential%20in%20breast%20cancer&journal=Nature&doi=10.1038%2Fnature10350&volume=476&pages=346-350&publication_year=2011&author=Possemato%2CR?
• What's the financial gain of https://link.springer.com/doi/10.1186/gb-2006-7-10-r100?
• How much money does http://scholar.google.com/scholar_lookup?&title=CellProfiler%3A%20image%20analysis%20software%20for%20identifying%20and%20quantifying%20cell%20phenotypes&journal=Genome%20Biol.&doi=10.1186%2Fgb-2006-7-10-r100&volume=7&publication_year=2006&author=Carpenter%2CAE make?
• How much money does https://doi.org/10.1038%2Fnature08822 make?
• Earnings of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2010Natur.463..899B
• How much does http://scholar.google.com/scholar_lookup?&title=The%20landscape%20of%20somatic%20copy-number%20alteration%20across%20human%20cancers&journal=Nature&doi=10.1038%2Fnature08822&volume=463&pages=899-905&publication_year=2010&author=Beroukhim%2CR generate monthly?
• https://doi.org/10.1158%2F0008-5472.CAN-11-1403 income
• How much does http://scholar.google.com/scholar_lookup?&title=Identification%20of%20genes%20upregulated%20in%20ALK-positive%20and%20EGFR%2FKRAS%2FALK-negative%20lung%20adenocarcinomas&journal=Cancer%20Res.&doi=10.1158%2F0008-5472.CAN-11-1403&volume=72&pages=100-111&publication_year=2012&author=Okayama%2CH generate monthly?
• What's the monthly income of https://doi.org/10.1038%2Fnature11003?
• How much revenue does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2012Natur.483..603B generate?
• How much profit is http://scholar.google.com/scholar_lookup?&title=The%20Cancer%20Cell%20Line%20Encyclopedia%20enables%20predictive%20modelling%20of%20anticancer%20drug%20sensitivity&journal=Nature&doi=10.1038%2Fnature11003&volume=483&pages=603-607&publication_year=2012&author=Barretina%2CJ making per month?
• What are the earnings of https://doi.org/10.1038%2Fnprot.2009.95?
• What's the monthly money flow for http://scholar.google.com/scholar_lookup?&title=Conditional%20mouse%20lung%20cancer%20models%20using%20adenoviral%20or%20lentiviral%20delivery%20of%20Cre%20recombinase&journal=Nat.%20Protocols&doi=10.1038%2Fnprot.2009.95&volume=4&pages=1064-1072&publication_year=2009&author=DuPage%2CM&author=Dooley%2CAL&author=Jacks%2CT?
• What's the revenue for https://doi.org/10.1074%2Fjbc.M306104200?
• http://scholar.google.com/scholar_lookup?&title=AMP-activated%20protein%20kinase%20activity%20is%20critical%20for%20hypoxia-inducible%20factor-1%20transcriptional%20activity%20and%20its%20target%20gene%20expression%20under%20hypoxic%20conditions%20in%20DU145%20cells&journal=J.%20Biol.%20Chem.&doi=10.1074%2Fjbc.M306104200&volume=278&pages=39653-39661&publication_year=2003&author=Lee%2CM's financial summary
• How much does https://doi.org/10.1038%2F20459 gross monthly?
• Find out how much http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1999Natur.399..271M earns monthly
• How much money does http://scholar.google.com/scholar_lookup?&title=The%20tumour%20suppressor%20protein%20VHL%20targets%20hypoxia-inducible%20factors%20for%20oxygen-dependent%20proteolysis&journal=Nature&doi=10.1038%2F20459&volume=399&pages=271-275&publication_year=1999&author=Maxwell%2CPH make?
• What's the profit of https://doi.org/10.1126%2Fscience.aac7041?
• How much does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2015Sci...350.1096W bring in each month?
• Revenue of http://scholar.google.com/scholar_lookup?&title=Identification%20and%20characterization%20of%20essential%20genes%20in%20the%20human%20genome&journal=Science&doi=10.1126%2Fscience.aac7041&volume=350&pages=1096-1101&publication_year=2015&author=Wang%2CT
• How much does https://citation-needed.springer.com/v2/references/10.1038/nature24637?format=refman&flavour=references bring in each month?
• https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Samantha%20W.%20Alvarez's financial summary
• How profitable is https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Samantha%20W.%20Alvarez%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• What's the profit of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Vladislav%20O.%20Sviderskiy?
• https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Vladislav%20O.%20Sviderskiy%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en's financial summary
• How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Erdem%20M.%20Terzi pull in monthly?
• Monthly income for https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Erdem%20M.%20Terzi%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Thales%20Papagiannakopoulos earn?
• Monthly income for https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Thales%20Papagiannakopoulos%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• What's the profit of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Andre%20L.%20Moreira?
• How much revenue does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Andre%20L.%20Moreira%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en produce monthly?
• How much revenue does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Sylvia%20Adams produce monthly?
• How much revenue does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Sylvia%20Adams%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en generate?
• Learn how profitable https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=David%20M.%20Sabatini is on a monthly basis
• What's the monthly money flow for https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22David%20M.%20Sabatini%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• How much profit does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=K%C4%B1van%C3%A7%20Birsoy make?
• What's the monthly income of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22K%C4%B1van%C3%A7%20Birsoy%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• How much cash flow does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Richard%20Possemato have monthly?
• What's the income generated by https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Richard%20Possemato%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en each month?
• How much does https://static-content.springer.com/esm/art%3A10.1038%2Fnature24637/MediaObjects/41586_2017_BFnature24637_MOESM1_ESM.pdf net monthly?
• How much does https://static-content.springer.com/esm/art%3A10.1038%2Fnature24637/MediaObjects/41586_2017_BFnature24637_MOESM2_ESM.pdf rake in every month?
• How much does https://static-content.springer.com/esm/art%3A10.1038%2Fnature24637/MediaObjects/41586_2017_BFnature24637_MOESM3_ESM.xlsx gross monthly?
• Monthly income for https://static-content.springer.com/esm/art%3A10.1038%2Fnature24637/MediaObjects/41586_2017_BFnature24637_MOESM4_ESM.xlsx
• What's the financial outcome of https://static-content.springer.com/esm/art%3A10.1038%2Fnature24637/MediaObjects/41586_2017_BFnature24637_MOESM5_ESM.xlsx?
• How much revenue does https://static-content.springer.com/esm/art%3A10.1038%2Fnature24637/MediaObjects/41586_2017_BFnature24637_MOESM6_ESM.xlsx bring in?
• How much does https://static-content.springer.com/esm/art%3A10.1038%2Fnature24637/MediaObjects/41586_2017_BFnature24637_MOESM7_ESM.ppt pull in?
• Learn how profitable https://static-content.springer.com/esm/art%3A10.1038%2Fnature24637/MediaObjects/41586_2017_BFnature24637_MOESM8_ESM.ppt is on a monthly basis
• How much does https://static-content.springer.com/esm/art%3A10.1038%2Fnature24637/MediaObjects/41586_2017_BFnature24637_MOESM9_ESM.ppt gross monthly?
• How much does https://static-content.springer.com/esm/art%3A10.1038%2Fnature24637/MediaObjects/41586_2017_BFnature24637_MOESM10_ESM.ppt pull in monthly?
• How much does https://static-content.springer.com/esm/art%3A10.1038%2Fnature24637/MediaObjects/41586_2017_BFnature24637_MOESM11_ESM.xlsx pull in monthly?
• How much does https://static-content.springer.com/esm/art%3A10.1038%2Fnature24637/MediaObjects/41586_2017_BFnature24637_MOESM12_ESM.xlsx bring in each month?
• How much does https://static-content.springer.com/esm/art%3A10.1038%2Fnature24637/MediaObjects/41586_2017_BFnature24637_MOESM13_ESM.xlsx bring in each month?
• How much revenue does https://static-content.springer.com/esm/art%3A10.1038%2Fnature24637/MediaObjects/41586_2017_BFnature24637_MOESM14_ESM.xlsx bring in?
• What are the earnings of https://static-content.springer.com/esm/art%3A10.1038%2Fnature24637/MediaObjects/41586_2017_BFnature24637_MOESM15_ESM.xlsx?
• Income figures for https://static-content.springer.com/esm/art%3A10.1038%2Fnature24637/MediaObjects/41586_2017_BFnature24637_MOESM16_ESM.xlsx
• How much does https://static-content.springer.com/esm/art%3A10.1038%2Fnature24637/MediaObjects/41586_2017_BFnature24637_MOESM17_ESM.xlsx net monthly?
• What is the monthly revenue of https://static-content.springer.com/esm/art%3A10.1038%2Fnature24637/MediaObjects/41586_2017_BFnature24637_MOESM18_ESM.xlsx?
• What's https://static-content.springer.com/esm/art%3A10.1038%2Fnature24637/MediaObjects/41586_2017_BFnature24637_MOESM19_ESM.xlsx's gross income?
• How much does https://static-content.springer.com/esm/art%3A10.1038%2Fnature24637/MediaObjects/41586_2017_BFnature24637_MOESM20_ESM.xlsx bring in each month?
• How much does https://s100.copyright.com/AppDispatchServlet?title=NFS1%20undergoes%20positive%20selection%20in%20lung%20tumours%20and%20protects%20cells%20from%20ferroptosis&author=Samantha%20W.%20Alvarez%20et%20al&contentID=10.1038%2Fnature24637©right=Macmillan%20Publishers%20Limited%2C%20part%20of%20Springer%20Nature.%20All%20rights%20reserved.&publication=0028-0836&publicationDate=2017-11-22&publisherName=SpringerNature&orderBeanReset=true earn?
• How much does https://crossmark.crossref.org/dialog/?doi=10.1038/nature24637 pull in?
• How much profit does https://citation-needed.springer.com/v2/references/10.1038/nature24637?format=refman&flavour=citation generate?
• How profitable is https://doi.org/10.1186/s12935-025-03753-7?
• How much income does https://doi.org/10.1038/s44324-024-00045-y have?
• Financial intake of https://doi.org/10.1038/s41419-025-07692-z
• How much revenue does https://doi.org/10.1038/s41420-025-02415-x generate?
• Earnings of https://doi.org/10.1038/s41401-024-01354-0
• What's the profit of https://www.protocols.io/?
• How much revenue does https://www.natureindex.com/ produce monthly?
• How much does http://www.naturechina.com generate monthly?
• Learn about the earnings of https://www.natureasia.com/ja-jp

Analytics and Tracking {📊}

• Google Tag Manager

Libraries {📚}

• Prism.js
• Zoom.js

Emails and Hosting {✉️}

Mail Servers:

• mxa-002c5801.gslb.pphosted.com
• mxb-002c5801.gslb.pphosted.com

Name Servers:

• pdns1.ultradns.net
• pdns2.ultradns.net
• pdns3.ultradns.org
• pdns4.ultradns.org
• pdns5.ultradns.info
• pdns6.ultradns.co.uk

CDN Services {📦}

• Crossref