NATURE . COM {}

Matching Content Categories {📚}

• Science
• Education
• Photography

Content Management System {📝}

What CMS is nature.com built with?

Custom-built

No common CMS systems were detected on Nature.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of nature.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Nature.com Make Money? {💸}

Display Ads {🎯}

Direct Advertisers (10)

Reseller Advertisers (38)

How Much Does Nature.com Make? {💰}

Display Ads {🎯}

$63,100 per month
Our calculations suggest that Nature.com earns between $42,042 and $115,616 monthly online from display advertisements.

Keywords {🔍}

article, nature, google, scholar, cas, cells, sgk, cell, kinase, data, access, autoimmune, salt, supplementary, content, expression, information, yosef, serum, differentiation, cookies, gse, privacy, pathogenic, nir, thalhamer, kuchroo, ilr, development, inflammation, biol, glucocorticoidinducible, usa, file, powerpoint, chuan, theresa, aviv, regev, vijay, critical, diseases, role, mechanism, induces, promotes, high, responses, open, gene,

Topics {✒️}

nature portfolio permissions reprints privacy policy accession numbers gse43956 advertising gene expression responses social media glucocorticoid-inducible protein kinase high-salt diet develop nature med nature genet glucocorticoid-inducible kinase isoforms regulating il-23r expression nature immunol salt-sensitive hypertension monica glucocorticoid-inducible kinase sgk1 regulate th17 development nature 479 nature 496 nature integrin-mediated cell adhesion promotes il-23r expression content rubbing salt itk independent development springerlink instant access enhancing th17-mediated immunity regulates adipocyte differentiation glucocorticoid-inducible kinase 1 sgk1–/– data sets microarray data sets immune responses shannon permissions microarray data analysis il-23r expression h3k27me3 reveals specificity salt induces murine high salt memory high salt intake th17 responses promotes tissue inflammation th17 cell specification enhance th17 differentiation privacy personal data trigger tissue inflammation govern na+ transport pathogenic th17 cells th17 cell phenotype gse43957 gse43969

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1
         description:Transcriptional profiling of developing TH17 cells identifies serum glucocorticoid kinase 1 (SGK1) as an essential node downstream of IL-23 signalling, and transcriptional analysis shows that a modest increase in salt concentration induces SGK1 expression, promotes IL-23 receptor expression and enhances TH17 cell differentiation, accelerating the development of autoimmunity. Two independent groups have come to the same surprising conclusion: that increased salt concentrations promote autoimmune disease by stimulating the production of interleukin-17-producing helper T (TH17) cells from CD4+ T cells. Chuan Wu et al. show that increases in salt concentrations induce serum glucocorticoid kinase 1 (SGK1) in T cells and enhance TH17 differentiation in vitro and in vivo in mice. Markus Kleinewietfeld et al. find that salt induces murine and human TH17 cells by a mechanism dependent on activation of SGK1 and the p38 MAP kinase/NFAT5 pathway. Mice on a high-salt diet develop a more severe experimental autoimmune encephalomyelitis, a model for brain inflammation, owing to high numbers of infiltrating TH17 cells. These studies raise the possibility that high salt intake might trigger tissue inflammation and autoimmune disease in humans. A further paper from Nir Yosef et al. presents a global view of the gene networks regulating TH17 cell differentiation. TH17 cells (interleukin-17 (IL-17)-producing helper T cells) are highly proinflammatory cells that are critical for clearing extracellular pathogens and for inducing multiple autoimmune diseases1. IL-23 has a critical role in stabilizing and reinforcing the TH17 phenotype by increasing expression of IL-23 receptor (IL-23R) and endowing TH17 cells with pathogenic effector functions2,3. However, the precise molecular mechanism by which IL-23 sustains the TH17 response and induces pathogenic effector functions has not been elucidated. Here we used transcriptional profiling of developing TH17 cells to construct a model of their signalling network and nominate major nodes that regulate TH17 development. We identified serum glucocorticoid kinase 1 (SGK1), a serine/threonine kinase4, as an essential node downstream of IL-23 signalling. SGK1 is critical for regulating IL-23R expression and stabilizing the TH17 cell phenotype by deactivation of mouse Foxo1, a direct repressor of IL-23R expression. SGK1 has been shown to govern Na+ transport and salt (NaCl) homeostasis in other cells5,6,7,8. We show here that a modest increase in salt concentration induces SGK1 expression, promotes IL-23R expression and enhances TH17 cell differentiation in vitro and in vivo, accelerating the development of autoimmunity. Loss of SGK1 abrogated Na+-mediated TH17 differentiation in an IL-23-dependent manner. These data demonstrate that SGK1 has a critical role in the induction of pathogenic TH17 cells and provide a molecular insight into a mechanism by which an environmental factor such as a high salt diet triggers TH17 development and promotes tissue inflammation.
         datePublished:2013-03-06T00:00:00Z
         dateModified:2013-03-06T00:00:00Z
         pageStart:513
         pageEnd:517
         sameAs:https://doi.org/10.1038/nature11984
         keywords:
            Autoimmunity
            Science
            Humanities and Social Sciences
            multidisciplinary
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature11984/MediaObjects/41586_2013_Article_BFnature11984_Fig1_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature11984/MediaObjects/41586_2013_Article_BFnature11984_Fig2_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature11984/MediaObjects/41586_2013_Article_BFnature11984_Fig3_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature11984/MediaObjects/41586_2013_Article_BFnature11984_Fig4_HTML.jpg
         isPartOf:
            name:Nature
            issn:
               1476-4687
               0028-0836
            volumeNumber:496
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Nature Publishing Group UK
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Chuan Wu
               affiliation:
                     name:Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School
                     address:
                        name:Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Nir Yosef
               affiliation:
                     name:Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School
                     address:
                        name:Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA
                        type:PostalAddress
                     type:Organization
                     name:Broad Institute of MIT and Harvard, 7 Cambridge Center
                     address:
                        name:Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Theresa Thalhamer
               affiliation:
                     name:Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School
                     address:
                        name:Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA
                        type:PostalAddress
                     type:Organization
                     name:Present address: Department of Molecular Biology, University of Salzburg, Hellbrunnerstrasse 34, 5020 Salzburg, Austria.
                     address:
                        name:Present address: Department of Molecular Biology, University of Salzburg, Hellbrunnerstrasse 34, 5020 Salzburg, Austria.,
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Chen Zhu
               affiliation:
                     name:Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School
                     address:
                        name:Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Sheng Xiao
               affiliation:
                     name:Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School
                     address:
                        name:Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Yasuhiro Kishi
               affiliation:
                     name:Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School
                     address:
                        name:Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Aviv Regev
               affiliation:
                     name:Broad Institute of MIT and Harvard, 7 Cambridge Center
                     address:
                        name:Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, USA
                        type:PostalAddress
                     type:Organization
                     name:Howard Hughes Medical Institute, Massachusetts Institute of Technology
                     address:
                        name:Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, USA
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Vijay K. Kuchroo
               affiliation:
                     name:Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School
                     address:
                        name:Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA
                        type:PostalAddress
                     type:Organization
                     name:Broad Institute of MIT and Harvard, 7 Cambridge Center
                     address:
                        name:Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, USA
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1
      description:Transcriptional profiling of developing TH17 cells identifies serum glucocorticoid kinase 1 (SGK1) as an essential node downstream of IL-23 signalling, and transcriptional analysis shows that a modest increase in salt concentration induces SGK1 expression, promotes IL-23 receptor expression and enhances TH17 cell differentiation, accelerating the development of autoimmunity. Two independent groups have come to the same surprising conclusion: that increased salt concentrations promote autoimmune disease by stimulating the production of interleukin-17-producing helper T (TH17) cells from CD4+ T cells. Chuan Wu et al. show that increases in salt concentrations induce serum glucocorticoid kinase 1 (SGK1) in T cells and enhance TH17 differentiation in vitro and in vivo in mice. Markus Kleinewietfeld et al. find that salt induces murine and human TH17 cells by a mechanism dependent on activation of SGK1 and the p38 MAP kinase/NFAT5 pathway. Mice on a high-salt diet develop a more severe experimental autoimmune encephalomyelitis, a model for brain inflammation, owing to high numbers of infiltrating TH17 cells. These studies raise the possibility that high salt intake might trigger tissue inflammation and autoimmune disease in humans. A further paper from Nir Yosef et al. presents a global view of the gene networks regulating TH17 cell differentiation. TH17 cells (interleukin-17 (IL-17)-producing helper T cells) are highly proinflammatory cells that are critical for clearing extracellular pathogens and for inducing multiple autoimmune diseases1. IL-23 has a critical role in stabilizing and reinforcing the TH17 phenotype by increasing expression of IL-23 receptor (IL-23R) and endowing TH17 cells with pathogenic effector functions2,3. However, the precise molecular mechanism by which IL-23 sustains the TH17 response and induces pathogenic effector functions has not been elucidated. Here we used transcriptional profiling of developing TH17 cells to construct a model of their signalling network and nominate major nodes that regulate TH17 development. We identified serum glucocorticoid kinase 1 (SGK1), a serine/threonine kinase4, as an essential node downstream of IL-23 signalling. SGK1 is critical for regulating IL-23R expression and stabilizing the TH17 cell phenotype by deactivation of mouse Foxo1, a direct repressor of IL-23R expression. SGK1 has been shown to govern Na+ transport and salt (NaCl) homeostasis in other cells5,6,7,8. We show here that a modest increase in salt concentration induces SGK1 expression, promotes IL-23R expression and enhances TH17 cell differentiation in vitro and in vivo, accelerating the development of autoimmunity. Loss of SGK1 abrogated Na+-mediated TH17 differentiation in an IL-23-dependent manner. These data demonstrate that SGK1 has a critical role in the induction of pathogenic TH17 cells and provide a molecular insight into a mechanism by which an environmental factor such as a high salt diet triggers TH17 development and promotes tissue inflammation.
      datePublished:2013-03-06T00:00:00Z
      dateModified:2013-03-06T00:00:00Z
      pageStart:513
      pageEnd:517
      sameAs:https://doi.org/10.1038/nature11984
      keywords:
         Autoimmunity
         Science
         Humanities and Social Sciences
         multidisciplinary
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature11984/MediaObjects/41586_2013_Article_BFnature11984_Fig1_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature11984/MediaObjects/41586_2013_Article_BFnature11984_Fig2_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature11984/MediaObjects/41586_2013_Article_BFnature11984_Fig3_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature11984/MediaObjects/41586_2013_Article_BFnature11984_Fig4_HTML.jpg
      isPartOf:
         name:Nature
         issn:
            1476-4687
            0028-0836
         volumeNumber:496
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Nature Publishing Group UK
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Chuan Wu
            affiliation:
                  name:Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School
                  address:
                     name:Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Nir Yosef
            affiliation:
                  name:Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School
                  address:
                     name:Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA
                     type:PostalAddress
                  type:Organization
                  name:Broad Institute of MIT and Harvard, 7 Cambridge Center
                  address:
                     name:Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Theresa Thalhamer
            affiliation:
                  name:Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School
                  address:
                     name:Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA
                     type:PostalAddress
                  type:Organization
                  name:Present address: Department of Molecular Biology, University of Salzburg, Hellbrunnerstrasse 34, 5020 Salzburg, Austria.
                  address:
                     name:Present address: Department of Molecular Biology, University of Salzburg, Hellbrunnerstrasse 34, 5020 Salzburg, Austria.,
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Chen Zhu
            affiliation:
                  name:Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School
                  address:
                     name:Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Sheng Xiao
            affiliation:
                  name:Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School
                  address:
                     name:Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yasuhiro Kishi
            affiliation:
                  name:Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School
                  address:
                     name:Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Aviv Regev
            affiliation:
                  name:Broad Institute of MIT and Harvard, 7 Cambridge Center
                  address:
                     name:Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, USA
                     type:PostalAddress
                  type:Organization
                  name:Howard Hughes Medical Institute, Massachusetts Institute of Technology
                  address:
                     name:Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Vijay K. Kuchroo
            affiliation:
                  name:Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School
                  address:
                     name:Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA
                     type:PostalAddress
                  type:Organization
                  name:Broad Institute of MIT and Harvard, 7 Cambridge Center
                  address:
                     name:Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Nature
      issn:
         1476-4687
         0028-0836
      volumeNumber:496
Organization:
      name:Nature Publishing Group UK
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School
      address:
         name:Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA
         type:PostalAddress
      name:Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School
      address:
         name:Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA
         type:PostalAddress
      name:Broad Institute of MIT and Harvard, 7 Cambridge Center
      address:
         name:Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, USA
         type:PostalAddress
      name:Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School
      address:
         name:Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA
         type:PostalAddress
      name:Present address: Department of Molecular Biology, University of Salzburg, Hellbrunnerstrasse 34, 5020 Salzburg, Austria.
      address:
         name:Present address: Department of Molecular Biology, University of Salzburg, Hellbrunnerstrasse 34, 5020 Salzburg, Austria.,
         type:PostalAddress
      name:Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School
      address:
         name:Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA
         type:PostalAddress
      name:Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School
      address:
         name:Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA
         type:PostalAddress
      name:Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School
      address:
         name:Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA
         type:PostalAddress
      name:Broad Institute of MIT and Harvard, 7 Cambridge Center
      address:
         name:Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, USA
         type:PostalAddress
      name:Howard Hughes Medical Institute, Massachusetts Institute of Technology
      address:
         name:Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, USA
         type:PostalAddress
      name:Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School
      address:
         name:Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA
         type:PostalAddress
      name:Broad Institute of MIT and Harvard, 7 Cambridge Center
      address:
         name:Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Chuan Wu
      affiliation:
            name:Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School
            address:
               name:Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
      name:Nir Yosef
      affiliation:
            name:Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School
            address:
               name:Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
            name:Broad Institute of MIT and Harvard, 7 Cambridge Center
            address:
               name:Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, USA
               type:PostalAddress
            type:Organization
      name:Theresa Thalhamer
      affiliation:
            name:Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School
            address:
               name:Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
            name:Present address: Department of Molecular Biology, University of Salzburg, Hellbrunnerstrasse 34, 5020 Salzburg, Austria.
            address:
               name:Present address: Department of Molecular Biology, University of Salzburg, Hellbrunnerstrasse 34, 5020 Salzburg, Austria.,
               type:PostalAddress
            type:Organization
      name:Chen Zhu
      affiliation:
            name:Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School
            address:
               name:Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
      name:Sheng Xiao
      affiliation:
            name:Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School
            address:
               name:Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
      name:Yasuhiro Kishi
      affiliation:
            name:Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School
            address:
               name:Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
      name:Aviv Regev
      affiliation:
            name:Broad Institute of MIT and Harvard, 7 Cambridge Center
            address:
               name:Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, USA
               type:PostalAddress
            type:Organization
            name:Howard Hughes Medical Institute, Massachusetts Institute of Technology
            address:
               name:Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Vijay K. Kuchroo
      affiliation:
            name:Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School
            address:
               name:Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
            name:Broad Institute of MIT and Harvard, 7 Cambridge Center
            address:
               name:Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA
      name:Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA
      name:Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, USA
      name:Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA
      name:Present address: Department of Molecular Biology, University of Salzburg, Hellbrunnerstrasse 34, 5020 Salzburg, Austria.,
      name:Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA
      name:Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA
      name:Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA
      name:Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, USA
      name:Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, USA
      name:Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA
      name:Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, USA
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

Social Networks {👍}(2)

• https://www.facebook.com/Nature
• https://twitter.com/nature

External Links {🔗}(88)

• How much revenue does https://link.springer.com/article/10.1038/nature11984?utm_source=nature&utm_medium=referral&utm_campaign=buyArticle produce monthly?
• How much revenue does http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE43956 bring in?
• How much does http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE43957 net monthly?
• What's the income generated by http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE43969 each month?
• What's the income generated by https://doi.org/10.1146%2Fannurev.immunol.021908.132710 each month?
• How much profit does http://scholar.google.com/scholar_lookup?&title=IL-17%20and%20Th17%20Cells&journal=Annu.%20Rev.%20Immunol.&doi=10.1146%2Fannurev.immunol.021908.132710&volume=27&pages=485-517&publication_year=2009&author=Korn%2CT&author=Bettelli%2CE&author=Oukka%2CM&author=Kuchroo%2CVK generate?
• Revenue of https://doi.org/10.1074%2Fjbc.M207577200
• Discover the revenue of http://scholar.google.com/scholar_lookup?&title=Interleukin-23%20promotes%20a%20distinct%20CD4%20T%20cell%20activation%20state%20characterized%20by%20the%20production%20of%20interleukin-17&journal=J.%20Biol.%20Chem.&doi=10.1074%2Fjbc.M207577200&volume=278&pages=1910-1914&publication_year=2003&author=Aggarwal%2CS&author=Ghilardi%2CN&author=Xie%2CMH&author=de%20Sauvage%2CFJ&author=Gurney%2CAL
• Income figures for https://doi.org/10.1038%2Fni1488
• What's the financial intake of http://scholar.google.com/scholar_lookup?&title=IL-6%20programs%20TH-17%20cell%20differentiation%20by%20promoting%20sequential%20engagement%20of%20the%20IL-21%20and%20IL-23%20pathways&journal=Nature%20Immunol.&doi=10.1038%2Fni1488&volume=8&pages=967-974&publication_year=2007&author=Zhou%2CL?
• How much profit is https://doi.org/10.1152%2Fphysrev.00050.2005 making per month?
• How much profit does http://scholar.google.com/scholar_lookup?&title=%28Patho%29physiological%20significance%20of%20the%20serum-%20and%20glucocorticoid-inducible%20kinase%20isoforms&journal=Physiol.%20Rev.&doi=10.1152%2Fphysrev.00050.2005&volume=86&pages=1151-1178&publication_year=2006&author=Lang%2CF make?
• What's the financial outcome of https://doi.org/10.1172%2FJCI0215696?
• Income figures for http://scholar.google.com/scholar_lookup?&title=Impaired%20renal%20Na%2B%20retention%20in%20the%20sgk1-knockout%20mouse&journal=J.%20Clin.%20Invest.&doi=10.1172%2FJCI0215696&volume=110&pages=1263-1268&publication_year=2002&author=Wulff%2CP
• Discover the revenue of https://doi.org/10.1038%2Fnm.2498
• What is the monthly revenue of http://scholar.google.com/scholar_lookup?&title=Deregulation%20of%20the%20serum-%20and%20glucocorticoid-inducible%20kinase%20SGK1%20in%20the%20endometrium%20causes%20reproductive%20failure&journal=Nature%20Med.&doi=10.1038%2Fnm.2498&volume=17&pages=1509-1513&publication_year=2011&author=Salker%2CMS?
• What's http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15695387's gross income?
• How much does http://scholar.google.com/scholar_lookup?&title=Antiapoptotic%20effect%20of%20serum%20and%20glucocorticoid-inducible%20protein%20kinase%20is%20mediated%20by%20novel%20mechanism%20activating%20I%CE%BAB%20kinase&journal=Cancer%20Res.&volume=65&pages=457-464&publication_year=2005&author=Zhang%2CL&author=Cui%2CR&author=Cheng%2CX&author=Du%2CJ make?
• Discover the revenue of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11956329
• http://scholar.google.com/scholar_lookup?&title=Activation%20of%20SGK1%20by%20HGF%2C%20Rac1%20and%20integrin-mediated%20cell%20adhesion%20in%20MDCK%20cells%3A%20PI-3K-dependent%20and%20-independent%20pathways&journal=J.%20Cell%20Sci.&volume=115&pages=1985-1993&publication_year=2002&author=Shelly%2CC&author=Herrera%2CR's financial summary
• What are the earnings of https://doi.org/10.1126%2Fscisignal.2001935?
• Financial intake of http://scholar.google.com/scholar_lookup?&title=ANAT%3A%20a%20tool%20for%20constructing%20and%20analyzing%20functional%20protein%20networks&journal=Sci.%20Signal.&doi=10.1126%2Fscisignal.2001935&volume=4&publication_year=2011&author=Yosef%2CN
• How much does https://doi.org/10.1128%2FMCB.21.3.952-965.2001 make?
• http://scholar.google.com/scholar_lookup?&title=Protein%20kinase%20SGK%20mediates%20survival%20signals%20by%20phosphorylating%20the%20forkhead%20transcription%20factor%20FKHRL1%20%28FOXO3a%29&journal=Mol.%20Cell.%20Biol.&doi=10.1128%2FMCB.21.3.952-965.2001&volume=21&pages=952-965&publication_year=2001&author=Brunet%2CA's revenue stream
• How much cash flow does https://doi.org/10.1016%2Fj.immuni.2008.12.009 have monthly?
• How much does http://scholar.google.com/scholar_lookup?&title=Global%20mapping%20of%20H3K4me3%20and%20H3K27me3%20reveals%20specificity%20and%20plasticity%20in%20lineage%20fate%20determination%20of%20differentiating%20CD4%2B%20T%20cells&journal=Immunity&doi=10.1016%2Fj.immuni.2008.12.009&volume=30&pages=155-167&publication_year=2009&author=Wei%2CG gross monthly?
• How much does https://doi.org/10.1210%2Fme.2009-0265 bring in each month?
• See how much http://scholar.google.com/scholar_lookup?&title=Serum-%20and%20glucocorticoid-inducible%20kinase%201%20%28SGK1%29%20regulates%20adipocyte%20differentiation%20via%20forkhead%20box%20O1&journal=Mol.%20Endocrinol.&doi=10.1210%2Fme.2009-0265&volume=24&pages=370-380&publication_year=2010&author=Di%20Pietro%2CN makes per month
• How profitable is https://doi.org/10.1074%2Fjbc.M808848200?
• How much does http://scholar.google.com/scholar_lookup?&title=The%20transcription%20of%20FOXO%20genes%20is%20stimulated%20by%20FOXO3%20and%20repressed%20by%20growth%20factors&journal=J.%20Biol.%20Chem.&doi=10.1074%2Fjbc.M808848200&volume=284&pages=10334-10342&publication_year=2009&author=Essaghir%2CA&author=Dif%2CN&author=Marbehant%2CCY&author=Coffer%2CPJ&author=Demoulin%2CJB make?
• Monthly income for https://doi.org/10.1016%2Fj.cell.2012.09.016
• How much money does http://scholar.google.com/scholar_lookup?&title=A%20validated%20regulatory%20network%20for%20Th17%20cell%20specification&journal=Cell&doi=10.1016%2Fj.cell.2012.09.016&volume=151&pages=289-303&publication_year=2012&author=Ciofani%2CM make?
• How much does https://doi.org/10.1038%2Fnature10554 net monthly?
• How much profit is http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2011Natur.479..538B making per month?
• Profit of http://scholar.google.com/scholar_lookup?&title=Commensal%20microbiota%20and%20myelin%20autoantigen%20cooperate%20to%20trigger%20autoimmune%20demyelination&journal=Nature&doi=10.1038%2Fnature10554&volume=479&pages=538-541&publication_year=2011&author=Berer%2CK
• How much revenue does https://doi.org/10.1016%2Fj.chom.2011.08.005 generate?
• How much profit does http://scholar.google.com/scholar_lookup?&title=The%20genome%20of%20th17%20cell-inducing%20segmented%20filamentous%20bacteria%20reveals%20extensive%20auxotrophy%20and%20adaptations%20to%20the%20intestinal%20environment&journal=Cell%20Host%20Microbe&doi=10.1016%2Fj.chom.2011.08.005&volume=10&pages=260-272&publication_year=2011&author=Sczesnak%2CA generate?
• How much profit is https://doi.org/10.1073%2Fpnas.0903602106 making per month?
• Learn about the earnings of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2009PNAS..10614942S
• What's the monthly money flow for http://scholar.google.com/scholar_lookup?&title=Role%20of%20the%20renin-angiotensin%20system%20in%20autoimmune%20inflammation%20of%20the%20central%20nervous%20system&journal=Proc.%20Natl%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.0903602106&volume=106&pages=14942-14947&publication_year=2009&author=Stegbauer%2CJ?
• Explore the financials of https://doi.org/10.4049%2Fjimmunol.0802886
• What are the earnings of http://scholar.google.com/scholar_lookup?&title=Aldosterone%20promotes%20autoimmune%20damage%20by%20enhancing%20Th17-mediated%20immunity&journal=J.%20Immunol.&doi=10.4049%2Fjimmunol.0802886&volume=184&pages=191-202&publication_year=2010&author=Herrada%2CAA?
• How much profit does https://doi.org/10.1074%2Fjbc.M403260200 generate?
• How much does http://scholar.google.com/scholar_lookup?&title=A%20novel%20pathway%20of%20epithelial%20sodium%20channel%20activation%20involves%20a%20serum-%20and%20glucocorticoid-inducible%20kinase%20consensus%20motif%20in%20the%20C%20terminus%20of%20the%20channel%27s%20alpha-subunit&journal=J.%20Biol.%20Chem.&doi=10.1074%2Fjbc.M403260200&volume=279&pages=38134-38142&publication_year=2004&author=Diakov%2CA&author=Korbmacher%2CC gross monthly?
• How much profit does https://doi.org/10.1152%2Fajprenal.2001.280.4.F675 make?
• What's the income of http://scholar.google.com/scholar_lookup?&title=Aldosterone%20induces%20rapid%20apical%20translocation%20of%20ENaC%20in%20early%20portion%20of%20renal%20collecting%20system%3A%20possible%20role%20of%20SGK&journal=Am.%20J.%20Physiol.%20Renal%20Physiol.&doi=10.1152%2Fajprenal.2001.280.4.F675&volume=280&pages=F675-F682&publication_year=2001&author=Loffing%2CJ?
• How much profit is https://doi.org/10.1038%2Fng0506-500 making per month?
• Monthly income for http://scholar.google.com/scholar_lookup?&title=GenePattern%202.0&journal=Nature%20Genet.&doi=10.1038%2Fng0506-500&volume=38&pages=500-501&publication_year=2006&author=Reich%2CM
• How much cash flow does https://doi.org/10.1073%2Fpnas.0504609102 have monthly?
• What's the revenue for http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2005PNAS..10212837S?
• Get to know what's the income of http://scholar.google.com/scholar_lookup?&title=Significance%20analysis%20of%20time%20course%20microarray%20experiments&journal=Proc.%20Natl%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.0504609102&volume=102&pages=12837-12842&publication_year=2005&author=Storey%2CJD&author=Xiao%2CW&author=Leek%2CJT&author=Tompkins%2CRG&author=Davis%2CRW
• How much income is https://doi.org/10.1089%2Fcmb.2008.13TT earning monthly?
• Earnings of http://scholar.google.com/scholar_lookup?&title=Timing%20of%20gene%20expression%20responses%20to%20environmental%20changes&journal=J.%20Comput.%20Biol.&doi=10.1089%2Fcmb.2008.13TT&volume=16&pages=279-290&publication_year=2009&author=Chechik%2CG&author=Koller%2CD
• What's the revenue for https://citation-needed.springer.com/v2/references/10.1038/nature11984?format=refman&flavour=references?
• How much profit does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Chuan%20Wu make?
• Earnings of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Chuan%20Wu%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• Monthly income for https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Nir%20Yosef
• How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Nir%20Yosef%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en rake in every month?
• What's the financial outcome of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Theresa%20Thalhamer?
• How much profit does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Theresa%20Thalhamer%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en generate?
• How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Chen%20Zhu rake in every month?
• See how much https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Chen%20Zhu%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en makes per month
• How much profit is https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Sheng%20Xiao making per month?
• What's the financial intake of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Sheng%20Xiao%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• Discover the revenue of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Yasuhiro%20Kishi
• How much revenue does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Yasuhiro%20Kishi%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en produce monthly?
• What's the income of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Aviv%20Regev?
• What's the monthly money flow for https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Aviv%20Regev%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• Explore the financials of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Vijay%20K.%20Kuchroo
• Get to know what's the income of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Vijay%20K.%20Kuchroo%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• https://static-content.springer.com/esm/art%3A10.1038%2Fnature11984/MediaObjects/41586_2013_BFnature11984_MOESM24_ESM.pdf income
• What is the monthly revenue of https://static-content.springer.com/esm/art%3A10.1038%2Fnature11984/MediaObjects/41586_2013_BFnature11984_MOESM25_ESM.xlsx?
• Find out how much https://static-content.springer.com/esm/art%3A10.1038%2Fnature11984/MediaObjects/41586_2013_BFnature11984_MOESM26_ESM.xlsx earns monthly
• What is the monthly revenue of https://static-content.springer.com/esm/art%3A10.1038%2Fnature11984/MediaObjects/41586_2013_BFnature11984_MOESM20_ESM.ppt?
• What's the income generated by https://static-content.springer.com/esm/art%3A10.1038%2Fnature11984/MediaObjects/41586_2013_BFnature11984_MOESM21_ESM.ppt each month?
• https://static-content.springer.com/esm/art%3A10.1038%2Fnature11984/MediaObjects/41586_2013_BFnature11984_MOESM22_ESM.ppt's revenue stream
• How much money does https://static-content.springer.com/esm/art%3A10.1038%2Fnature11984/MediaObjects/41586_2013_BFnature11984_MOESM23_ESM.ppt make?
• How much revenue does https://s100.copyright.com/AppDispatchServlet?title=Induction%20of%20pathogenic%20TH17%20cells%20by%20inducible%20salt-sensing%20kinase%20SGK1&author=Chuan%20Wu%20et%20al&contentID=10.1038%2Fnature11984©right=Springer%20Nature%20Limited&publication=0028-0836&publicationDate=2013-03-06&publisherName=SpringerNature&orderBeanReset=true generate?
• How much profit does https://citation-needed.springer.com/v2/references/10.1038/nature11984?format=refman&flavour=citation make?
• How much does https://doi.org/10.1186/s12964-023-01381-0 net monthly?
• What's the financial outcome of https://doi.org/10.1038/s41598-024-51279-1?
• Discover the revenue of https://doi.org/10.1038/s41581-023-00787-w
• Get to know what's the income of https://doi.org/10.1038/s41593-023-01497-z
• Get to know https://doi.org/10.1038/s41577-024-00994-x's earnings
• How much revenue does https://www.protocols.io/ generate?
• Income figures for https://www.natureindex.com/
• What's the revenue for http://www.naturechina.com?
• Learn about the earnings of https://www.natureasia.com/ja-jp

Analytics and Tracking {📊}

• Google Tag Manager

Libraries {📚}

• Prism.js
• Zoom.js

Emails and Hosting {✉️}

Mail Servers:

• mxa-002c5801.gslb.pphosted.com
• mxb-002c5801.gslb.pphosted.com

Name Servers:

• pdns1.ultradns.net
• pdns2.ultradns.net
• pdns3.ultradns.org
• pdns4.ultradns.org
• pdns5.ultradns.info
• pdns6.ultradns.co.uk

CDN Services {📦}

• Crossref