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Title[redir]:
IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways | Nature Immunology
Description:
Nature Immunology - IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
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Keywords {🔍}
article, cas, google, scholar, cells, nature, interleukin, immunol, cell, differentiation, access, nat, stat, york, development, content, expression, receptor, responses, institute, inflammation, research, cookies, helper, usa, exp, med, immunity, privacy, function, immunology, june, pathways, dan, littman, transcription, mice, cytokine, inflammatory, biol, autoimmune, regulatory, university, medicine, data, information, zhou, ivanov, spolski, leonard,
Topics {✒️}
nature portfolio permissions reprints privacy policy intramural research program advertising social media immunological research asthma research transforming growth factor-β nature 382 nature 380 nature 445 nature 421 nature 441 nature data protection amplify rorγt-dependent differentiation g-csf-dependent differentiation delayed-type hypersensitivity responses author information authors t-bet–ires–gfp il-20r2-dependent mechanisms personal data cell-mediated intestinal inflammation il-21r mutant mice springerlink instant access permissions eighth author author correspondence lymphoid organ development nuclear receptor rorγt il-23-il-17 immune pathway cytokine signaling pathways cell-dependent colitis privacy induces autoimmune inflammation competing financial interests transcription factor gata-3 transcription factor foxp3 pathogenic effector th17 helicobacter hepaticus-induced issue learn explore content subscription content il-6 induced expression vitro differentiation requires inflammatory bowel disease cooperatively enhance expression stat1-induced regulator cell development
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headline:IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
description:T helper cells that produce interleukin 17 (IL-17; 'TH-17 cells') are a distinct subset of proinflammatory cells whose in vivo function requires IL-23 but whose in vitro differentiation requires only IL-6 and transforming growth factor-β (TGF-β). We demonstrate here that IL-6 induced expression of IL-21 that amplified an autocrine loop to induce more IL-21 and IL-23 receptor in naive CD4+ T cells. Both IL-21 and IL-23, along with TGF-β, induced IL-17 expression independently of IL-6. The effects of IL-6 and IL-21 depended on STAT3, a transcription factor required for the differentiation of TH-17 cells in vivo. IL-21 and IL-23 induced the orphan nuclear receptor RORγt, which in synergy with STAT3 promoted IL-17 expression. IL-6 therefore orchestrates a series of 'downstream' cytokine-dependent signaling pathways that, in concert with TGF-β, amplify RORγt-dependent differentiation of TH-17 cells.
datePublished:2007-06-20T00:00:00Z
dateModified:2007-07-05T00:00:00Z
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headline:IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
description:T helper cells that produce interleukin 17 (IL-17; 'TH-17 cells') are a distinct subset of proinflammatory cells whose in vivo function requires IL-23 but whose in vitro differentiation requires only IL-6 and transforming growth factor-β (TGF-β). We demonstrate here that IL-6 induced expression of IL-21 that amplified an autocrine loop to induce more IL-21 and IL-23 receptor in naive CD4+ T cells. Both IL-21 and IL-23, along with TGF-β, induced IL-17 expression independently of IL-6. The effects of IL-6 and IL-21 depended on STAT3, a transcription factor required for the differentiation of TH-17 cells in vivo. IL-21 and IL-23 induced the orphan nuclear receptor RORγt, which in synergy with STAT3 promoted IL-17 expression. IL-6 therefore orchestrates a series of 'downstream' cytokine-dependent signaling pathways that, in concert with TGF-β, amplify RORγt-dependent differentiation of TH-17 cells.
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