NATURE . COM {}

Matching Content Categories {📚}

• Education
• Science
• Careers

Content Management System {📝}

What CMS is nature.com built with?

Custom-built

No common CMS systems were detected on Nature.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of nature.com audience?

🌆 Monumental Traffic: 20M - 50M visitors per month


Based on our best estimate, this website will receive around 41,362,249 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Nature.com Make Money? {💸}

Display Ads {🎯}

Direct Advertisers (10)

Reseller Advertisers (38)

How Much Does Nature.com Make? {💰}

Display Ads {🎯}

$521,200 per month
Estimations show Nature.com's display ad online revenue falls between $347,485 and $955,583 per month.

Keywords {🔍}

cancer, article, breast, principal, investigator, cambridge, google, scholar, samuel, aparicio, research, nature, university, cas, caldas, supplementary, carlos, data, centre, tables, molecular, institute, british, columbia, curtis, shah, chin, andy, steven, christina, sohrab, gulisa, turashvili, gene, expression, access, cell, department, analysis, lynch, stefan, gräf, mckinney, ads, medicine, simon, tavaré, david, huntsman, content,

Topics {✒️}

nature portfolio permissions reprints privacy policy final editing advertising social media cambridge research institute nature rev gupta nature pseudo-anonymized clinical data hr + /her2− breast cancer nature 463 nature 406 nature 452 nature 486 nature cancer research uk trans-acting aberration hotspots tumorigenesis min-guk chorashmi european genome-phenome archive canada research chair health research fellow long-term clinical follow cancer research author accession number egas00000000083 springerlink instant access immune cell infiltration permissions breast cancer population breast cancer pathophysiologies breast cancer based breast cancer oncogene breast cancer cells breast cancer gabriella inmaculada spiteri �cna-devoid’ subgroup breast cancer res multiple cancer types breast cancer subgroups mps1 checkpoint protein michael smith foundation human breast tumours cambridge cb2 2xz cambridge cb2 0re cambridge cb3 0wa cambridge cb2 2qq breast cancer patients distinct clinical outcomes genome-wide associations

Questions {❓}

• Addiction biotypes: a paradigm shift for future treatment strategies?
• Are clusters found in one dataset present in another dataset?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups
         description:The elucidation of breast cancer subgroups and their molecular drivers requires integrated views of the genome and transcriptome from representative numbers of patients. We present an integrated analysis of copy number and gene expression in a discovery and validation set of 997 and 995 primary breast tumours, respectively, with long-term clinical follow-up. Inherited variants (copy number variants and single nucleotide polymorphisms) and acquired somatic copy number aberrations (CNAs) were associated with expression in ∼40% of genes, with the landscape dominated by cis- and trans-acting CNAs. By delineating expression outlier genes driven in cis by CNAs, we identified putative cancer genes, including deletions in PPP2R2A, MTAP and MAP2K4. Unsupervised analysis of paired DNA–RNA profiles revealed novel subgroups with distinct clinical outcomes, which reproduced in the validation cohort. These include a high-risk, oestrogen-receptor-positive 11q13/14 cis-acting subgroup and a favourable prognosis subgroup devoid of CNAs. Trans-acting aberration hotspots were found to modulate subgroup-specific gene networks, including a TCR deletion-mediated adaptive immune response in the ‘CNA-devoid’ subgroup and a basal-specific chromosome 5 deletion-associated mitotic network. Our results provide a novel molecular stratification of the breast cancer population, derived from the impact of somatic CNAs on the transcriptome. Integrative analysis of copy number and gene expression in 2,000 primary breast tumours with long-term clinical follow-up revealed putative cis-acting driver genes, novel subgroups and trans-acting aberration hotspots that modulate subgroup-specific gene networks.
         datePublished:2012-04-18T00:00:00Z
         dateModified:2012-06-20T00:00:00Z
         pageStart:346
         pageEnd:352
         sameAs:https://doi.org/10.1038/nature10983
         keywords:
            Breast cancer
            Cancer genomics
            Epidemiology
            Transcriptomics
            Science
            Humanities and Social Sciences
            multidisciplinary
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature10983/MediaObjects/41586_2012_Article_BFnature10983_Fig1_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature10983/MediaObjects/41586_2012_Article_BFnature10983_Fig2_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature10983/MediaObjects/41586_2012_Article_BFnature10983_Fig3_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature10983/MediaObjects/41586_2012_Article_BFnature10983_Fig4_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature10983/MediaObjects/41586_2012_Article_BFnature10983_Fig5_HTML.jpg
         isPartOf:
            name:Nature
            issn:
               1476-4687
               0028-0836
            volumeNumber:486
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Nature Publishing Group UK
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Christina Curtis
               affiliation:
                     name:University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK
                     address:
                        name:Department of Oncology, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK,
                        type:PostalAddress
                     type:Organization
                     name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
                     address:
                        name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
                        type:PostalAddress
                     type:Organization
                     name:Present addresses: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA (Ch.C.); University College London, Genetics Institute, WC1E 6BT, UK (D.S.).
                     address:
                        name:Present addresses: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA (Ch.C.); University College London, Genetics Institute, WC1E 6BT, UK (D.S.).,
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Sohrab P. Shah
               affiliation:
                     name:University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
                     address:
                        name:Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada,
                        type:PostalAddress
                     type:Organization
                     name: Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada
                     address:
                        name: Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada ,
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Suet-Feung Chin
               affiliation:
                     name:University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK
                     address:
                        name:Department of Oncology, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK,
                        type:PostalAddress
                     type:Organization
                     name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
                     address:
                        name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Gulisa Turashvili
               affiliation:
                     name:University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
                     address:
                        name:Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada,
                        type:PostalAddress
                     type:Organization
                     name: Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada
                     address:
                        name: Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada ,
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Oscar M. Rueda
               affiliation:
                     name:University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK
                     address:
                        name:Department of Oncology, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK,
                        type:PostalAddress
                     type:Organization
                     name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
                     address:
                        name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Mark J. Dunning
               affiliation:
                     name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
                     address:
                        name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Doug Speed
               affiliation:
                     name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
                     address:
                        name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
                        type:PostalAddress
                     type:Organization
                     name:University of Cambridge, Centre for Mathematical Sciences, Cambridge CB3 0WA, UK
                     address:
                        name:Department of Applied Mathematics and Theoretical Physics, University of Cambridge, Centre for Mathematical Sciences, Cambridge CB3 0WA, UK,
                        type:PostalAddress
                     type:Organization
                     name:Present addresses: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA (Ch.C.); University College London, Genetics Institute, WC1E 6BT, UK (D.S.).
                     address:
                        name:Present addresses: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA (Ch.C.); University College London, Genetics Institute, WC1E 6BT, UK (D.S.).,
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Andy G. Lynch
               affiliation:
                     name:University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK
                     address:
                        name:Department of Oncology, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK,
                        type:PostalAddress
                     type:Organization
                     name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
                     address:
                        name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Shamith Samarajiwa
               affiliation:
                     name:University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK
                     address:
                        name:Department of Oncology, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK,
                        type:PostalAddress
                     type:Organization
                     name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
                     address:
                        name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Yinyin Yuan
               affiliation:
                     name:University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK
                     address:
                        name:Department of Oncology, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK,
                        type:PostalAddress
                     type:Organization
                     name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
                     address:
                        name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Stefan Gräf
               affiliation:
                     name:University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK
                     address:
                        name:Department of Oncology, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK,
                        type:PostalAddress
                     type:Organization
                     name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
                     address:
                        name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Gavin Ha
               affiliation:
                     name:University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
                     address:
                        name:Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada,
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Gholamreza Haffari
               affiliation:
                     name:University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
                     address:
                        name:Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada,
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Ali Bashashati
               affiliation:
                     name:University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
                     address:
                        name:Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada,
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Roslin Russell
               affiliation:
                     name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
                     address:
                        name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Steven McKinney
               affiliation:
                     name:University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
                     address:
                        name:Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada,
                        type:PostalAddress
                     type:Organization
                     name: Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada
                     address:
                        name: Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada ,
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Anita Langerød
               affiliation:
                     name:Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Montebello, 0310 Oslo, Norway
                     address:
                        name:Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Montebello, 0310 Oslo, Norway,
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Andrew Green
               affiliation:
                     name:School of Molecular Medical Sciences, University of Nottingham, Nottingham NG5 1PB, UK
                     address:
                        name:Department of Histopathology, School of Molecular Medical Sciences, University of Nottingham, Nottingham NG5 1PB, UK,
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Elena Provenzano
               affiliation:
                     name: Cambridge Breast Unit, Addenbrooke’s Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 2QQ, UK
                     address:
                        name: Cambridge Breast Unit, Addenbrooke’s Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 2QQ, UK ,
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Gordon Wishart
               affiliation:
                     name: Cambridge Breast Unit, Addenbrooke’s Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 2QQ, UK
                     address:
                        name: Cambridge Breast Unit, Addenbrooke’s Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 2QQ, UK ,
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Sarah Pinder
               affiliation:
                     name: King’s College London, Breakthrough Breast Cancer Research Unit, London WC2R 2LS, UK
                     address:
                        name: King’s College London, Breakthrough Breast Cancer Research Unit, London WC2R 2LS, UK ,
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Peter Watson
               affiliation:
                     name:University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
                     address:
                        name:Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada,
                        type:PostalAddress
                     type:Organization
                     name: Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada
                     address:
                        name: Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada ,
                        type:PostalAddress
                     type:Organization
                     name:Manitoba Institute of Cell Biology, University of Manitoba
                     address:
                        name:Manitoba Institute of Cell Biology, University of Manitoba, Manitoba R3E 0V9, Canada
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Florian Markowetz
               affiliation:
                     name:University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK
                     address:
                        name:Department of Oncology, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK,
                        type:PostalAddress
                     type:Organization
                     name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
                     address:
                        name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Leigh Murphy
               affiliation:
                     name:Manitoba Institute of Cell Biology, University of Manitoba
                     address:
                        name:Manitoba Institute of Cell Biology, University of Manitoba, Manitoba R3E 0V9, Canada
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Ian Ellis
               affiliation:
                     name:School of Molecular Medical Sciences, University of Nottingham, Nottingham NG5 1PB, UK
                     address:
                        name:Department of Histopathology, School of Molecular Medical Sciences, University of Nottingham, Nottingham NG5 1PB, UK,
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Arnie Purushotham
               affiliation:
                     name: King’s College London, Breakthrough Breast Cancer Research Unit, London WC2R 2LS, UK
                     address:
                        name: King’s College London, Breakthrough Breast Cancer Research Unit, London WC2R 2LS, UK ,
                        type:PostalAddress
                     type:Organization
                     name: NIHR Comprehensive Biomedical Research Centre at Guy’s and St Thomas’ NHS Foundation Trust and King’s College London, London WC2R 2LS, UK
                     address:
                        name: NIHR Comprehensive Biomedical Research Centre at Guy’s and St Thomas’ NHS Foundation Trust and King’s College London, London WC2R 2LS, UK ,
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Anne-Lise Børresen-Dale
               affiliation:
                     name:Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Montebello, 0310 Oslo, Norway
                     address:
                        name:Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Montebello, 0310 Oslo, Norway,
                        type:PostalAddress
                     type:Organization
                     name: Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, 0316 Oslo, Norway
                     address:
                        name: Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, 0316 Oslo, Norway ,
                        type:PostalAddress
                     type:Organization
               type:Person
               name:James D. Brenton
               affiliation:
                     name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
                     address:
                        name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
                        type:PostalAddress
                     type:Organization
                     name: Cambridge Experimental Cancer Medicine Centre, Cambridge CB2 0RE, UK
                     address:
                        name: Cambridge Experimental Cancer Medicine Centre, Cambridge CB2 0RE, UK ,
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Simon Tavaré
               affiliation:
                     name:University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK
                     address:
                        name:Department of Oncology, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK,
                        type:PostalAddress
                     type:Organization
                     name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
                     address:
                        name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
                        type:PostalAddress
                     type:Organization
                     name:University of Cambridge, Centre for Mathematical Sciences, Cambridge CB3 0WA, UK
                     address:
                        name:Department of Applied Mathematics and Theoretical Physics, University of Cambridge, Centre for Mathematical Sciences, Cambridge CB3 0WA, UK,
                        type:PostalAddress
                     type:Organization
                     name:Molecular and Computational Biology Program, University of Southern California
                     address:
                        name:Molecular and Computational Biology Program, University of Southern California, Los Angeles, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Carlos Caldas
               affiliation:
                     name:University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK
                     address:
                        name:Department of Oncology, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK,
                        type:PostalAddress
                     type:Organization
                     name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
                     address:
                        name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
                        type:PostalAddress
                     type:Organization
                     name: Cambridge Breast Unit, Addenbrooke’s Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 2QQ, UK
                     address:
                        name: Cambridge Breast Unit, Addenbrooke’s Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 2QQ, UK ,
                        type:PostalAddress
                     type:Organization
                     name: Cambridge Experimental Cancer Medicine Centre, Cambridge CB2 0RE, UK
                     address:
                        name: Cambridge Experimental Cancer Medicine Centre, Cambridge CB2 0RE, UK ,
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Samuel Aparicio
               affiliation:
                     name:University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
                     address:
                        name:Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada,
                        type:PostalAddress
                     type:Organization
                     name: Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada
                     address:
                        name: Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada ,
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups
      description:The elucidation of breast cancer subgroups and their molecular drivers requires integrated views of the genome and transcriptome from representative numbers of patients. We present an integrated analysis of copy number and gene expression in a discovery and validation set of 997 and 995 primary breast tumours, respectively, with long-term clinical follow-up. Inherited variants (copy number variants and single nucleotide polymorphisms) and acquired somatic copy number aberrations (CNAs) were associated with expression in ∼40% of genes, with the landscape dominated by cis- and trans-acting CNAs. By delineating expression outlier genes driven in cis by CNAs, we identified putative cancer genes, including deletions in PPP2R2A, MTAP and MAP2K4. Unsupervised analysis of paired DNA–RNA profiles revealed novel subgroups with distinct clinical outcomes, which reproduced in the validation cohort. These include a high-risk, oestrogen-receptor-positive 11q13/14 cis-acting subgroup and a favourable prognosis subgroup devoid of CNAs. Trans-acting aberration hotspots were found to modulate subgroup-specific gene networks, including a TCR deletion-mediated adaptive immune response in the ‘CNA-devoid’ subgroup and a basal-specific chromosome 5 deletion-associated mitotic network. Our results provide a novel molecular stratification of the breast cancer population, derived from the impact of somatic CNAs on the transcriptome. Integrative analysis of copy number and gene expression in 2,000 primary breast tumours with long-term clinical follow-up revealed putative cis-acting driver genes, novel subgroups and trans-acting aberration hotspots that modulate subgroup-specific gene networks.
      datePublished:2012-04-18T00:00:00Z
      dateModified:2012-06-20T00:00:00Z
      pageStart:346
      pageEnd:352
      sameAs:https://doi.org/10.1038/nature10983
      keywords:
         Breast cancer
         Cancer genomics
         Epidemiology
         Transcriptomics
         Science
         Humanities and Social Sciences
         multidisciplinary
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature10983/MediaObjects/41586_2012_Article_BFnature10983_Fig1_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature10983/MediaObjects/41586_2012_Article_BFnature10983_Fig2_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature10983/MediaObjects/41586_2012_Article_BFnature10983_Fig3_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature10983/MediaObjects/41586_2012_Article_BFnature10983_Fig4_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature10983/MediaObjects/41586_2012_Article_BFnature10983_Fig5_HTML.jpg
      isPartOf:
         name:Nature
         issn:
            1476-4687
            0028-0836
         volumeNumber:486
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Nature Publishing Group UK
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Christina Curtis
            affiliation:
                  name:University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK
                  address:
                     name:Department of Oncology, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK,
                     type:PostalAddress
                  type:Organization
                  name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
                  address:
                     name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
                     type:PostalAddress
                  type:Organization
                  name:Present addresses: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA (Ch.C.); University College London, Genetics Institute, WC1E 6BT, UK (D.S.).
                  address:
                     name:Present addresses: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA (Ch.C.); University College London, Genetics Institute, WC1E 6BT, UK (D.S.).,
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Sohrab P. Shah
            affiliation:
                  name:University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
                  address:
                     name:Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada,
                     type:PostalAddress
                  type:Organization
                  name: Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada
                  address:
                     name: Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada ,
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Suet-Feung Chin
            affiliation:
                  name:University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK
                  address:
                     name:Department of Oncology, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK,
                     type:PostalAddress
                  type:Organization
                  name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
                  address:
                     name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Gulisa Turashvili
            affiliation:
                  name:University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
                  address:
                     name:Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada,
                     type:PostalAddress
                  type:Organization
                  name: Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada
                  address:
                     name: Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada ,
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Oscar M. Rueda
            affiliation:
                  name:University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK
                  address:
                     name:Department of Oncology, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK,
                     type:PostalAddress
                  type:Organization
                  name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
                  address:
                     name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Mark J. Dunning
            affiliation:
                  name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
                  address:
                     name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Doug Speed
            affiliation:
                  name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
                  address:
                     name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
                     type:PostalAddress
                  type:Organization
                  name:University of Cambridge, Centre for Mathematical Sciences, Cambridge CB3 0WA, UK
                  address:
                     name:Department of Applied Mathematics and Theoretical Physics, University of Cambridge, Centre for Mathematical Sciences, Cambridge CB3 0WA, UK,
                     type:PostalAddress
                  type:Organization
                  name:Present addresses: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA (Ch.C.); University College London, Genetics Institute, WC1E 6BT, UK (D.S.).
                  address:
                     name:Present addresses: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA (Ch.C.); University College London, Genetics Institute, WC1E 6BT, UK (D.S.).,
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Andy G. Lynch
            affiliation:
                  name:University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK
                  address:
                     name:Department of Oncology, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK,
                     type:PostalAddress
                  type:Organization
                  name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
                  address:
                     name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Shamith Samarajiwa
            affiliation:
                  name:University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK
                  address:
                     name:Department of Oncology, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK,
                     type:PostalAddress
                  type:Organization
                  name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
                  address:
                     name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yinyin Yuan
            affiliation:
                  name:University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK
                  address:
                     name:Department of Oncology, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK,
                     type:PostalAddress
                  type:Organization
                  name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
                  address:
                     name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Stefan Gräf
            affiliation:
                  name:University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK
                  address:
                     name:Department of Oncology, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK,
                     type:PostalAddress
                  type:Organization
                  name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
                  address:
                     name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Gavin Ha
            affiliation:
                  name:University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
                  address:
                     name:Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada,
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Gholamreza Haffari
            affiliation:
                  name:University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
                  address:
                     name:Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada,
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ali Bashashati
            affiliation:
                  name:University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
                  address:
                     name:Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada,
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Roslin Russell
            affiliation:
                  name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
                  address:
                     name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Steven McKinney
            affiliation:
                  name:University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
                  address:
                     name:Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada,
                     type:PostalAddress
                  type:Organization
                  name: Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada
                  address:
                     name: Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada ,
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Anita Langerød
            affiliation:
                  name:Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Montebello, 0310 Oslo, Norway
                  address:
                     name:Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Montebello, 0310 Oslo, Norway,
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Andrew Green
            affiliation:
                  name:School of Molecular Medical Sciences, University of Nottingham, Nottingham NG5 1PB, UK
                  address:
                     name:Department of Histopathology, School of Molecular Medical Sciences, University of Nottingham, Nottingham NG5 1PB, UK,
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Elena Provenzano
            affiliation:
                  name: Cambridge Breast Unit, Addenbrooke’s Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 2QQ, UK
                  address:
                     name: Cambridge Breast Unit, Addenbrooke’s Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 2QQ, UK ,
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Gordon Wishart
            affiliation:
                  name: Cambridge Breast Unit, Addenbrooke’s Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 2QQ, UK
                  address:
                     name: Cambridge Breast Unit, Addenbrooke’s Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 2QQ, UK ,
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Sarah Pinder
            affiliation:
                  name: King’s College London, Breakthrough Breast Cancer Research Unit, London WC2R 2LS, UK
                  address:
                     name: King’s College London, Breakthrough Breast Cancer Research Unit, London WC2R 2LS, UK ,
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Peter Watson
            affiliation:
                  name:University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
                  address:
                     name:Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada,
                     type:PostalAddress
                  type:Organization
                  name: Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada
                  address:
                     name: Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada ,
                     type:PostalAddress
                  type:Organization
                  name:Manitoba Institute of Cell Biology, University of Manitoba
                  address:
                     name:Manitoba Institute of Cell Biology, University of Manitoba, Manitoba R3E 0V9, Canada
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Florian Markowetz
            affiliation:
                  name:University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK
                  address:
                     name:Department of Oncology, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK,
                     type:PostalAddress
                  type:Organization
                  name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
                  address:
                     name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Leigh Murphy
            affiliation:
                  name:Manitoba Institute of Cell Biology, University of Manitoba
                  address:
                     name:Manitoba Institute of Cell Biology, University of Manitoba, Manitoba R3E 0V9, Canada
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ian Ellis
            affiliation:
                  name:School of Molecular Medical Sciences, University of Nottingham, Nottingham NG5 1PB, UK
                  address:
                     name:Department of Histopathology, School of Molecular Medical Sciences, University of Nottingham, Nottingham NG5 1PB, UK,
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Arnie Purushotham
            affiliation:
                  name: King’s College London, Breakthrough Breast Cancer Research Unit, London WC2R 2LS, UK
                  address:
                     name: King’s College London, Breakthrough Breast Cancer Research Unit, London WC2R 2LS, UK ,
                     type:PostalAddress
                  type:Organization
                  name: NIHR Comprehensive Biomedical Research Centre at Guy’s and St Thomas’ NHS Foundation Trust and King’s College London, London WC2R 2LS, UK
                  address:
                     name: NIHR Comprehensive Biomedical Research Centre at Guy’s and St Thomas’ NHS Foundation Trust and King’s College London, London WC2R 2LS, UK ,
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Anne-Lise Børresen-Dale
            affiliation:
                  name:Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Montebello, 0310 Oslo, Norway
                  address:
                     name:Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Montebello, 0310 Oslo, Norway,
                     type:PostalAddress
                  type:Organization
                  name: Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, 0316 Oslo, Norway
                  address:
                     name: Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, 0316 Oslo, Norway ,
                     type:PostalAddress
                  type:Organization
            type:Person
            name:James D. Brenton
            affiliation:
                  name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
                  address:
                     name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
                     type:PostalAddress
                  type:Organization
                  name: Cambridge Experimental Cancer Medicine Centre, Cambridge CB2 0RE, UK
                  address:
                     name: Cambridge Experimental Cancer Medicine Centre, Cambridge CB2 0RE, UK ,
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Simon Tavaré
            affiliation:
                  name:University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK
                  address:
                     name:Department of Oncology, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK,
                     type:PostalAddress
                  type:Organization
                  name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
                  address:
                     name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
                     type:PostalAddress
                  type:Organization
                  name:University of Cambridge, Centre for Mathematical Sciences, Cambridge CB3 0WA, UK
                  address:
                     name:Department of Applied Mathematics and Theoretical Physics, University of Cambridge, Centre for Mathematical Sciences, Cambridge CB3 0WA, UK,
                     type:PostalAddress
                  type:Organization
                  name:Molecular and Computational Biology Program, University of Southern California
                  address:
                     name:Molecular and Computational Biology Program, University of Southern California, Los Angeles, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Carlos Caldas
            affiliation:
                  name:University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK
                  address:
                     name:Department of Oncology, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK,
                     type:PostalAddress
                  type:Organization
                  name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
                  address:
                     name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
                     type:PostalAddress
                  type:Organization
                  name: Cambridge Breast Unit, Addenbrooke’s Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 2QQ, UK
                  address:
                     name: Cambridge Breast Unit, Addenbrooke’s Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 2QQ, UK ,
                     type:PostalAddress
                  type:Organization
                  name: Cambridge Experimental Cancer Medicine Centre, Cambridge CB2 0RE, UK
                  address:
                     name: Cambridge Experimental Cancer Medicine Centre, Cambridge CB2 0RE, UK ,
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Samuel Aparicio
            affiliation:
                  name:University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
                  address:
                     name:Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada,
                     type:PostalAddress
                  type:Organization
                  name: Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada
                  address:
                     name: Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada ,
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Nature
      issn:
         1476-4687
         0028-0836
      volumeNumber:486
Organization:
      name:Nature Publishing Group UK
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK
      address:
         name:Department of Oncology, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK,
         type:PostalAddress
      name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
      address:
         name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
         type:PostalAddress
      name:Present addresses: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA (Ch.C.); University College London, Genetics Institute, WC1E 6BT, UK (D.S.).
      address:
         name:Present addresses: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA (Ch.C.); University College London, Genetics Institute, WC1E 6BT, UK (D.S.).,
         type:PostalAddress
      name:University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
      address:
         name:Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada,
         type:PostalAddress
      name: Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada
      address:
         name: Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada ,
         type:PostalAddress
      name:University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK
      address:
         name:Department of Oncology, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK,
         type:PostalAddress
      name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
      address:
         name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
         type:PostalAddress
      name:University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
      address:
         name:Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada,
         type:PostalAddress
      name: Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada
      address:
         name: Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada ,
         type:PostalAddress
      name:University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK
      address:
         name:Department of Oncology, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK,
         type:PostalAddress
      name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
      address:
         name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
         type:PostalAddress
      name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
      address:
         name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
         type:PostalAddress
      name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
      address:
         name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
         type:PostalAddress
      name:University of Cambridge, Centre for Mathematical Sciences, Cambridge CB3 0WA, UK
      address:
         name:Department of Applied Mathematics and Theoretical Physics, University of Cambridge, Centre for Mathematical Sciences, Cambridge CB3 0WA, UK,
         type:PostalAddress
      name:Present addresses: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA (Ch.C.); University College London, Genetics Institute, WC1E 6BT, UK (D.S.).
      address:
         name:Present addresses: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA (Ch.C.); University College London, Genetics Institute, WC1E 6BT, UK (D.S.).,
         type:PostalAddress
      name:University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK
      address:
         name:Department of Oncology, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK,
         type:PostalAddress
      name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
      address:
         name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
         type:PostalAddress
      name:University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK
      address:
         name:Department of Oncology, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK,
         type:PostalAddress
      name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
      address:
         name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
         type:PostalAddress
      name:University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK
      address:
         name:Department of Oncology, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK,
         type:PostalAddress
      name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
      address:
         name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
         type:PostalAddress
      name:University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK
      address:
         name:Department of Oncology, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK,
         type:PostalAddress
      name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
      address:
         name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
         type:PostalAddress
      name:University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
      address:
         name:Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada,
         type:PostalAddress
      name:University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
      address:
         name:Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada,
         type:PostalAddress
      name:University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
      address:
         name:Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada,
         type:PostalAddress
      name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
      address:
         name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
         type:PostalAddress
      name:University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
      address:
         name:Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada,
         type:PostalAddress
      name: Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada
      address:
         name: Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada ,
         type:PostalAddress
      name:Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Montebello, 0310 Oslo, Norway
      address:
         name:Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Montebello, 0310 Oslo, Norway,
         type:PostalAddress
      name:School of Molecular Medical Sciences, University of Nottingham, Nottingham NG5 1PB, UK
      address:
         name:Department of Histopathology, School of Molecular Medical Sciences, University of Nottingham, Nottingham NG5 1PB, UK,
         type:PostalAddress
      name: Cambridge Breast Unit, Addenbrooke’s Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 2QQ, UK
      address:
         name: Cambridge Breast Unit, Addenbrooke’s Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 2QQ, UK ,
         type:PostalAddress
      name: Cambridge Breast Unit, Addenbrooke’s Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 2QQ, UK
      address:
         name: Cambridge Breast Unit, Addenbrooke’s Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 2QQ, UK ,
         type:PostalAddress
      name: King’s College London, Breakthrough Breast Cancer Research Unit, London WC2R 2LS, UK
      address:
         name: King’s College London, Breakthrough Breast Cancer Research Unit, London WC2R 2LS, UK ,
         type:PostalAddress
      name:University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
      address:
         name:Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada,
         type:PostalAddress
      name: Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada
      address:
         name: Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada ,
         type:PostalAddress
      name:Manitoba Institute of Cell Biology, University of Manitoba
      address:
         name:Manitoba Institute of Cell Biology, University of Manitoba, Manitoba R3E 0V9, Canada
         type:PostalAddress
      name:University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK
      address:
         name:Department of Oncology, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK,
         type:PostalAddress
      name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
      address:
         name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
         type:PostalAddress
      name:Manitoba Institute of Cell Biology, University of Manitoba
      address:
         name:Manitoba Institute of Cell Biology, University of Manitoba, Manitoba R3E 0V9, Canada
         type:PostalAddress
      name:School of Molecular Medical Sciences, University of Nottingham, Nottingham NG5 1PB, UK
      address:
         name:Department of Histopathology, School of Molecular Medical Sciences, University of Nottingham, Nottingham NG5 1PB, UK,
         type:PostalAddress
      name: King’s College London, Breakthrough Breast Cancer Research Unit, London WC2R 2LS, UK
      address:
         name: King’s College London, Breakthrough Breast Cancer Research Unit, London WC2R 2LS, UK ,
         type:PostalAddress
      name: NIHR Comprehensive Biomedical Research Centre at Guy’s and St Thomas’ NHS Foundation Trust and King’s College London, London WC2R 2LS, UK
      address:
         name: NIHR Comprehensive Biomedical Research Centre at Guy’s and St Thomas’ NHS Foundation Trust and King’s College London, London WC2R 2LS, UK ,
         type:PostalAddress
      name:Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Montebello, 0310 Oslo, Norway
      address:
         name:Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Montebello, 0310 Oslo, Norway,
         type:PostalAddress
      name: Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, 0316 Oslo, Norway
      address:
         name: Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, 0316 Oslo, Norway ,
         type:PostalAddress
      name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
      address:
         name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
         type:PostalAddress
      name: Cambridge Experimental Cancer Medicine Centre, Cambridge CB2 0RE, UK
      address:
         name: Cambridge Experimental Cancer Medicine Centre, Cambridge CB2 0RE, UK ,
         type:PostalAddress
      name:University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK
      address:
         name:Department of Oncology, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK,
         type:PostalAddress
      name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
      address:
         name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
         type:PostalAddress
      name:University of Cambridge, Centre for Mathematical Sciences, Cambridge CB3 0WA, UK
      address:
         name:Department of Applied Mathematics and Theoretical Physics, University of Cambridge, Centre for Mathematical Sciences, Cambridge CB3 0WA, UK,
         type:PostalAddress
      name:Molecular and Computational Biology Program, University of Southern California
      address:
         name:Molecular and Computational Biology Program, University of Southern California, Los Angeles, USA
         type:PostalAddress
      name:University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK
      address:
         name:Department of Oncology, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK,
         type:PostalAddress
      name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
      address:
         name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
         type:PostalAddress
      name: Cambridge Breast Unit, Addenbrooke’s Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 2QQ, UK
      address:
         name: Cambridge Breast Unit, Addenbrooke’s Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 2QQ, UK ,
         type:PostalAddress
      name: Cambridge Experimental Cancer Medicine Centre, Cambridge CB2 0RE, UK
      address:
         name: Cambridge Experimental Cancer Medicine Centre, Cambridge CB2 0RE, UK ,
         type:PostalAddress
      name:University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
      address:
         name:Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada,
         type:PostalAddress
      name: Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada
      address:
         name: Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada ,
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Christina Curtis
      affiliation:
            name:University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK
            address:
               name:Department of Oncology, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK,
               type:PostalAddress
            type:Organization
            name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
            address:
               name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
               type:PostalAddress
            type:Organization
            name:Present addresses: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA (Ch.C.); University College London, Genetics Institute, WC1E 6BT, UK (D.S.).
            address:
               name:Present addresses: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA (Ch.C.); University College London, Genetics Institute, WC1E 6BT, UK (D.S.).,
               type:PostalAddress
            type:Organization
      name:Sohrab P. Shah
      affiliation:
            name:University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
            address:
               name:Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada,
               type:PostalAddress
            type:Organization
            name: Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada
            address:
               name: Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada ,
               type:PostalAddress
            type:Organization
      name:Suet-Feung Chin
      affiliation:
            name:University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK
            address:
               name:Department of Oncology, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK,
               type:PostalAddress
            type:Organization
            name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
            address:
               name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
               type:PostalAddress
            type:Organization
      name:Gulisa Turashvili
      affiliation:
            name:University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
            address:
               name:Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada,
               type:PostalAddress
            type:Organization
            name: Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada
            address:
               name: Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada ,
               type:PostalAddress
            type:Organization
      name:Oscar M. Rueda
      affiliation:
            name:University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK
            address:
               name:Department of Oncology, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK,
               type:PostalAddress
            type:Organization
            name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
            address:
               name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
               type:PostalAddress
            type:Organization
      name:Mark J. Dunning
      affiliation:
            name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
            address:
               name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
               type:PostalAddress
            type:Organization
      name:Doug Speed
      affiliation:
            name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
            address:
               name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
               type:PostalAddress
            type:Organization
            name:University of Cambridge, Centre for Mathematical Sciences, Cambridge CB3 0WA, UK
            address:
               name:Department of Applied Mathematics and Theoretical Physics, University of Cambridge, Centre for Mathematical Sciences, Cambridge CB3 0WA, UK,
               type:PostalAddress
            type:Organization
            name:Present addresses: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA (Ch.C.); University College London, Genetics Institute, WC1E 6BT, UK (D.S.).
            address:
               name:Present addresses: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA (Ch.C.); University College London, Genetics Institute, WC1E 6BT, UK (D.S.).,
               type:PostalAddress
            type:Organization
      name:Andy G. Lynch
      affiliation:
            name:University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK
            address:
               name:Department of Oncology, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK,
               type:PostalAddress
            type:Organization
            name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
            address:
               name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
               type:PostalAddress
            type:Organization
      name:Shamith Samarajiwa
      affiliation:
            name:University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK
            address:
               name:Department of Oncology, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK,
               type:PostalAddress
            type:Organization
            name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
            address:
               name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
               type:PostalAddress
            type:Organization
      name:Yinyin Yuan
      affiliation:
            name:University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK
            address:
               name:Department of Oncology, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK,
               type:PostalAddress
            type:Organization
            name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
            address:
               name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
               type:PostalAddress
            type:Organization
      name:Stefan Gräf
      affiliation:
            name:University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK
            address:
               name:Department of Oncology, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK,
               type:PostalAddress
            type:Organization
            name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
            address:
               name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
               type:PostalAddress
            type:Organization
      name:Gavin Ha
      affiliation:
            name:University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
            address:
               name:Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada,
               type:PostalAddress
            type:Organization
      name:Gholamreza Haffari
      affiliation:
            name:University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
            address:
               name:Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada,
               type:PostalAddress
            type:Organization
      name:Ali Bashashati
      affiliation:
            name:University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
            address:
               name:Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada,
               type:PostalAddress
            type:Organization
      name:Roslin Russell
      affiliation:
            name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
            address:
               name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
               type:PostalAddress
            type:Organization
      name:Steven McKinney
      affiliation:
            name:University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
            address:
               name:Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada,
               type:PostalAddress
            type:Organization
            name: Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada
            address:
               name: Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada ,
               type:PostalAddress
            type:Organization
      name:Anita Langerød
      affiliation:
            name:Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Montebello, 0310 Oslo, Norway
            address:
               name:Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Montebello, 0310 Oslo, Norway,
               type:PostalAddress
            type:Organization
      name:Andrew Green
      affiliation:
            name:School of Molecular Medical Sciences, University of Nottingham, Nottingham NG5 1PB, UK
            address:
               name:Department of Histopathology, School of Molecular Medical Sciences, University of Nottingham, Nottingham NG5 1PB, UK,
               type:PostalAddress
            type:Organization
      name:Elena Provenzano
      affiliation:
            name: Cambridge Breast Unit, Addenbrooke’s Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 2QQ, UK
            address:
               name: Cambridge Breast Unit, Addenbrooke’s Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 2QQ, UK ,
               type:PostalAddress
            type:Organization
      name:Gordon Wishart
      affiliation:
            name: Cambridge Breast Unit, Addenbrooke’s Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 2QQ, UK
            address:
               name: Cambridge Breast Unit, Addenbrooke’s Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 2QQ, UK ,
               type:PostalAddress
            type:Organization
      name:Sarah Pinder
      affiliation:
            name: King’s College London, Breakthrough Breast Cancer Research Unit, London WC2R 2LS, UK
            address:
               name: King’s College London, Breakthrough Breast Cancer Research Unit, London WC2R 2LS, UK ,
               type:PostalAddress
            type:Organization
      name:Peter Watson
      affiliation:
            name:University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
            address:
               name:Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada,
               type:PostalAddress
            type:Organization
            name: Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada
            address:
               name: Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada ,
               type:PostalAddress
            type:Organization
            name:Manitoba Institute of Cell Biology, University of Manitoba
            address:
               name:Manitoba Institute of Cell Biology, University of Manitoba, Manitoba R3E 0V9, Canada
               type:PostalAddress
            type:Organization
      name:Florian Markowetz
      affiliation:
            name:University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK
            address:
               name:Department of Oncology, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK,
               type:PostalAddress
            type:Organization
            name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
            address:
               name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
               type:PostalAddress
            type:Organization
      name:Leigh Murphy
      affiliation:
            name:Manitoba Institute of Cell Biology, University of Manitoba
            address:
               name:Manitoba Institute of Cell Biology, University of Manitoba, Manitoba R3E 0V9, Canada
               type:PostalAddress
            type:Organization
      name:Ian Ellis
      affiliation:
            name:School of Molecular Medical Sciences, University of Nottingham, Nottingham NG5 1PB, UK
            address:
               name:Department of Histopathology, School of Molecular Medical Sciences, University of Nottingham, Nottingham NG5 1PB, UK,
               type:PostalAddress
            type:Organization
      name:Arnie Purushotham
      affiliation:
            name: King’s College London, Breakthrough Breast Cancer Research Unit, London WC2R 2LS, UK
            address:
               name: King’s College London, Breakthrough Breast Cancer Research Unit, London WC2R 2LS, UK ,
               type:PostalAddress
            type:Organization
            name: NIHR Comprehensive Biomedical Research Centre at Guy’s and St Thomas’ NHS Foundation Trust and King’s College London, London WC2R 2LS, UK
            address:
               name: NIHR Comprehensive Biomedical Research Centre at Guy’s and St Thomas’ NHS Foundation Trust and King’s College London, London WC2R 2LS, UK ,
               type:PostalAddress
            type:Organization
      name:Anne-Lise Børresen-Dale
      affiliation:
            name:Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Montebello, 0310 Oslo, Norway
            address:
               name:Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Montebello, 0310 Oslo, Norway,
               type:PostalAddress
            type:Organization
            name: Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, 0316 Oslo, Norway
            address:
               name: Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, 0316 Oslo, Norway ,
               type:PostalAddress
            type:Organization
      name:James D. Brenton
      affiliation:
            name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
            address:
               name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
               type:PostalAddress
            type:Organization
            name: Cambridge Experimental Cancer Medicine Centre, Cambridge CB2 0RE, UK
            address:
               name: Cambridge Experimental Cancer Medicine Centre, Cambridge CB2 0RE, UK ,
               type:PostalAddress
            type:Organization
      name:Simon Tavaré
      affiliation:
            name:University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK
            address:
               name:Department of Oncology, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK,
               type:PostalAddress
            type:Organization
            name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
            address:
               name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
               type:PostalAddress
            type:Organization
            name:University of Cambridge, Centre for Mathematical Sciences, Cambridge CB3 0WA, UK
            address:
               name:Department of Applied Mathematics and Theoretical Physics, University of Cambridge, Centre for Mathematical Sciences, Cambridge CB3 0WA, UK,
               type:PostalAddress
            type:Organization
            name:Molecular and Computational Biology Program, University of Southern California
            address:
               name:Molecular and Computational Biology Program, University of Southern California, Los Angeles, USA
               type:PostalAddress
            type:Organization
      name:Carlos Caldas
      affiliation:
            name:University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK
            address:
               name:Department of Oncology, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK,
               type:PostalAddress
            type:Organization
            name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
            address:
               name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
               type:PostalAddress
            type:Organization
            name: Cambridge Breast Unit, Addenbrooke’s Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 2QQ, UK
            address:
               name: Cambridge Breast Unit, Addenbrooke’s Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 2QQ, UK ,
               type:PostalAddress
            type:Organization
            name: Cambridge Experimental Cancer Medicine Centre, Cambridge CB2 0RE, UK
            address:
               name: Cambridge Experimental Cancer Medicine Centre, Cambridge CB2 0RE, UK ,
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Samuel Aparicio
      affiliation:
            name:University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
            address:
               name:Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada,
               type:PostalAddress
            type:Organization
            name: Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada
            address:
               name: Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada ,
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Oncology, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK,
      name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
      name:Present addresses: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA (Ch.C.); University College London, Genetics Institute, WC1E 6BT, UK (D.S.).,
      name:Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada,
      name: Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada ,
      name:Department of Oncology, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK,
      name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
      name:Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada,
      name: Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada ,
      name:Department of Oncology, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK,
      name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
      name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
      name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
      name:Department of Applied Mathematics and Theoretical Physics, University of Cambridge, Centre for Mathematical Sciences, Cambridge CB3 0WA, UK,
      name:Present addresses: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA (Ch.C.); University College London, Genetics Institute, WC1E 6BT, UK (D.S.).,
      name:Department of Oncology, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK,
      name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
      name:Department of Oncology, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK,
      name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
      name:Department of Oncology, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK,
      name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
      name:Department of Oncology, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK,
      name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
      name:Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada,
      name:Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada,
      name:Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada,
      name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
      name:Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada,
      name: Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada ,
      name:Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Montebello, 0310 Oslo, Norway,
      name:Department of Histopathology, School of Molecular Medical Sciences, University of Nottingham, Nottingham NG5 1PB, UK,
      name: Cambridge Breast Unit, Addenbrooke’s Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 2QQ, UK ,
      name: Cambridge Breast Unit, Addenbrooke’s Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 2QQ, UK ,
      name: King’s College London, Breakthrough Breast Cancer Research Unit, London WC2R 2LS, UK ,
      name:Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada,
      name: Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada ,
      name:Manitoba Institute of Cell Biology, University of Manitoba, Manitoba R3E 0V9, Canada
      name:Department of Oncology, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK,
      name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
      name:Manitoba Institute of Cell Biology, University of Manitoba, Manitoba R3E 0V9, Canada
      name:Department of Histopathology, School of Molecular Medical Sciences, University of Nottingham, Nottingham NG5 1PB, UK,
      name: King’s College London, Breakthrough Breast Cancer Research Unit, London WC2R 2LS, UK ,
      name: NIHR Comprehensive Biomedical Research Centre at Guy’s and St Thomas’ NHS Foundation Trust and King’s College London, London WC2R 2LS, UK ,
      name:Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Montebello, 0310 Oslo, Norway,
      name: Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, 0316 Oslo, Norway ,
      name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
      name: Cambridge Experimental Cancer Medicine Centre, Cambridge CB2 0RE, UK ,
      name:Department of Oncology, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK,
      name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
      name:Department of Applied Mathematics and Theoretical Physics, University of Cambridge, Centre for Mathematical Sciences, Cambridge CB3 0WA, UK,
      name:Molecular and Computational Biology Program, University of Southern California, Los Angeles, USA
      name:Department of Oncology, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK,
      name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
      name: Cambridge Breast Unit, Addenbrooke’s Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 2QQ, UK ,
      name: Cambridge Experimental Cancer Medicine Centre, Cambridge CB2 0RE, UK ,
      name:Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada,
      name: Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada ,
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

Social Networks {👍}(2)

• https://www.facebook.com/Nature
• https://twitter.com/nature

External Links {🔗}(155)

• What's the monthly income of https://link.springer.com/article/10.1038/nature10983?utm_source=nature&utm_medium=referral&utm_campaign=buyArticle?
• How much income does http://www.ebi.ac.uk/ega/ have?
• https://doi.org/10.1073%2Fpnas.0808041105's total income per month
• What are the earnings of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2008PNAS..10516224L?
• What is the monthly revenue of http://scholar.google.com/scholar_lookup?&title=Integrated%20analysis%20of%20homozygous%20deletions%2C%20focal%20amplifications%2C%20and%20sequence%20alterations%20in%20breast%20and%20colorectal%20cancers&journal=Proc.%20Natl%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.0808041105&volume=105&pages=16224-16229&publication_year=2008&author=Leary%2CRJ?
• Get to know what's the income of https://doi.org/10.1038%2Fnature08768
• Monthly income for http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2010Natur.463..893B
• Get to know http://scholar.google.com/scholar_lookup?&title=Signatures%20of%20mutation%20and%20selection%20in%20the%20cancer%20genome&journal=Nature&doi=10.1038%2Fnature08768&volume=463&pages=893-898&publication_year=2010&author=Bignell%2CGR's earnings
• How much profit is https://doi.org/10.1038%2F35021093 making per month?
• What is the monthly revenue of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2000Natur.406..747P?
• What's the revenue for http://scholar.google.com/scholar_lookup?&title=Molecular%20portraits%20of%20human%20breast%20tumours&journal=Nature&doi=10.1038%2F35021093&volume=406&pages=747-752&publication_year=2000&author=Perou%2CCM?
• How profitable is https://doi.org/10.1073%2Fpnas.191367098?
• How much profit does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2001PNAS...9810869S generate?
• See how much http://scholar.google.com/scholar_lookup?&title=Gene%20expression%20patterns%20of%20breast%20carcinomas%20distinguish%20tumor%20subclasses%20with%20clinical%20implications&journal=Proc.%20Natl%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.191367098&volume=98&pages=10869-10874&publication_year=2001&author=S%C3%B8rlie%2CT makes per month
• Get to know what's the income of https://doi.org/10.1016%2Fj.ccr.2006.10.009
• What is the earnings of http://scholar.google.com/scholar_lookup?&title=Genomic%20and%20transcriptional%20aberrations%20linked%20to%20breast%20cancer%20pathophysiologies&journal=Cancer%20Cell&doi=10.1016%2Fj.ccr.2006.10.009&volume=10&pages=529-541&publication_year=2006&author=Chin%2CK?
• How much cash flow does https://link.springer.com/doi/10.1186/gb-2007-8-10-r215 have monthly?
• Revenue of http://scholar.google.com/scholar_lookup?&title=High-resolution%20aCGH%20and%20expression%20profiling%20identifies%20a%20novel%20genomic%20subtype%20of%20ER%20negative%20breast%20cancer&journal=Genome%20Biol.&doi=10.1186%2Fgb-2007-8-10-r215&volume=8&publication_year=2007&author=Chin%2CSF
• What's the financial intake of https://doi.org/10.1200%2FJCO.2008.18.1370?
• How much does http://scholar.google.com/scholar_lookup?&title=Supervised%20risk%20predictor%20of%20breast%20cancer%20based%20on%20intrinsic%20subtypes&journal=J.%20Clin.%20Oncol.&doi=10.1200%2FJCO.2008.18.1370&volume=27&pages=1160-1167&publication_year=2009&author=Parker%2CJS net monthly?
• Get to know https://doi.org/10.1371%2Fjournal.pgen.0010078's earnings
• Get to know http://scholar.google.com/scholar_lookup?&title=Genome-wide%20associations%20of%20gene%20expression%20variation%20in%20humans&journal=PLoS%20Genet.&doi=10.1371%2Fjournal.pgen.0010078&volume=1&publication_year=2005&author=Stranger%2CBE's earnings
• How much revenue does https://doi.org/10.1016%2Fj.tig.2008.06.001 generate?
• What's the revenue for http://scholar.google.com/scholar_lookup?&title=Revealing%20the%20architecture%20of%20gene%20regulation%3A%20the%20promise%20of%20eQTL%20studies&journal=Trends%20Genet.&doi=10.1016%2Fj.tig.2008.06.001&volume=24&pages=408-415&publication_year=2008&author=Gilad%2CY&author=Rifkin%2CSA&author=Pritchard%2CJK?
• Monthly income for https://doi.org/10.1093%2Fbioinformatics%2Fbtl174
• Monthly income for http://scholar.google.com/scholar_lookup?&title=PACK%3A%20Profile%20analysis%20using%20clustering%20and%20kurtosis%20to%20find%20molecular%20classifiers%20in%20cancer&journal=Bioinformatics&doi=10.1093%2Fbioinformatics%2Fbtl174&volume=22&pages=2269-2275&publication_year=2006&author=Teschendorff%2CAE&author=Naderi%2CA&author=Barbosa-Morais%2CNL&author=Caldas%2CC
• Get to know https://doi.org/10.1002%2Femmm.201100122's earnings
• Income figures for http://scholar.google.com/scholar_lookup?&title=ZNF703%20is%20a%20common%20Luminal%20B%20breast%20cancer%20oncogene%20that%20differentially%20regulates%20luminal%20and%20basal%20progenitors%20in%20human%20mammary%20epithelium&journal=EMBO%20Mol.%20Med.&doi=10.1002%2Femmm.201100122&volume=3&pages=167-180&publication_year=2011&author=Holland%2CD
• What's the revenue for https://doi.org/10.1126%2Fscience.275.5308.1943?
• Income figures for http://scholar.google.com/scholar_lookup?&title=PTEN%2C%20a%20putative%20protein%20tyrosine%20phosphatase%20gene%20mutated%20in%20human%20brain%2C%20breast%2C%20and%20prostate%20cancer&journal=Science&doi=10.1126%2Fscience.275.5308.1943&volume=275&pages=1943-1947&publication_year=1997&author=Li%2CJ
• How much does https://doi.org/10.1038%2Fnrc2771 net monthly?
• Get to know what's the income of http://scholar.google.com/scholar_lookup?&title=A%20census%20of%20amplified%20and%20overexpressed%20human%20cancer%20genes&journal=Nature%20Rev.%20Cancer&doi=10.1038%2Fnrc2771&volume=10&pages=59-64&publication_year=2010&author=Santarius%2CT&author=Shiply%2CJ&author=Brewer%2CD&author=Stratton%2CMR&author=Cooper%2CCS
• What's the income of https://doi.org/10.1126%2Fscience.1196333?
• What's the financial outcome of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2010Sci...330..228J?
• What's the financial gain of http://scholar.google.com/scholar_lookup?&title=Frequent%20mutations%20of%20chromatin%20remodeling%20gene%20ARID1A%20in%20ovarian%20clear%20cell%20carcinoma&journal=Science&doi=10.1126%2Fscience.1196333&volume=330&pages=228-231&publication_year=2010&author=Jones%2CS?
• What's https://doi.org/10.1002%2Fpath.2848's gross income?
• What's the profit of http://scholar.google.com/scholar_lookup?&title=Subtype-specific%20mutation%20of%20PPP2R1A%20in%20endometrial%20and%20ovarian%20carcinomas&journal=J.%20Pathol.&doi=10.1002%2Fpath.2848&volume=223&pages=567-573&publication_year=2011&author=McConechy%2CMK?
• Revenue of https://doi.org/10.1016%2Fj.ccr.2010.10.021
• Check the income stats for http://scholar.google.com/scholar_lookup?&title=B55%CE%B2-associated%20PP2A%20complex%20controls%20PDK1-directed%20MYC%20signaling%20and%20modulates%20rapamycin%20sensitivity%20in%20colorectal%20cancer&journal=Cancer%20Cell&doi=10.1016%2Fj.ccr.2010.10.021&volume=18&pages=459-471&publication_year=2010&author=Tan%2CJ
• What are the earnings of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12438261?
• Get to know what's the income of http://scholar.google.com/scholar_lookup?&title=Methylthioadenosine%20phosphorylase%2C%20a%20gene%20frequently%20codeleted%20with%20p16%20%28CDKN2A%2FARF%29%2C%20acts%20as%20a%20tumor%20suppressor%20in%20a%20breast%20cancer%20cell%20line&journal=Cancer%20Res.&volume=62&pages=6639-6644&publication_year=2002&author=Christopher%2CSA&author=Diegelman%2CP&author=Porter%2CCW&author=Kruger%2CWD
• How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=9331070 net monthly?
• What's http://scholar.google.com/scholar_lookup?&title=Human%20mitogen-activated%20protein%20kinase%20kinase%204%20as%20a%20candidate%20tumor%20suppressor&journal=Cancer%20Res.&volume=57&pages=4177-4182&publication_year=1997&author=Teng%2CDH's gross income?
• Income figures for https://link.springer.com/doi/10.1007/s10549-009-0460-8
• Income figures for http://scholar.google.com/scholar_lookup?&title=Distinct%20gene%20mutation%20profiles%20among%20luminal-type%20and%20basal-type%20breast%20cancer%20cell%20lines&journal=Breast%20Cancer%20Res.%20Treat.&doi=10.1007%2Fs10549-009-0460-8&volume=121&pages=53-64&publication_year=2010&author=Hollestelle%2CA
• What's the profit of https://doi.org/10.1093%2Fbioinformatics%2Fbtp543?
• What are the earnings of http://scholar.google.com/scholar_lookup?&title=Integrative%20clustering%20of%20multiple%20genomic%20data%20types%20using%20a%20joint%20latent%20variable%20model%20with%20application%20to%20breast%20and%20lung%20cancer%20subtype%20analysis&journal=Bioinformatics&doi=10.1093%2Fbioinformatics%2Fbtp543&volume=25&pages=2906-2912&publication_year=2009&author=Shen%2CR&author=Olshen%2CAB&author=Ladanyi%2CM?
• Get to know https://doi.org/10.1073%2Fpnas.082099299's earnings
• What's the monthly money flow for http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2002PNAS...99.6567T?
• Check the income stats for http://scholar.google.com/scholar_lookup?&title=Diagnosis%20of%20multiple%20cancer%20types%20by%20shrunken%20centroids%20of%20gene%20expression&journal=Proc.%20Natl%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.082099299&volume=99&pages=6567-6572&publication_year=2002&author=Tibshirani%2CR&author=Hastie%2CT&author=Narasimhan%2CB&author=Chu%2CG
• How much does https://doi.org/10.1093%2Fbiostatistics%2Fkxj029 rake in every month?
• Learn how profitable http://scholar.google.com/scholar_lookup?&title=Are%20clusters%20found%20in%20one%20dataset%20present%20in%20another%20dataset%3F&journal=Biostatistics&doi=10.1093%2Fbiostatistics%2Fkxj029&volume=8&pages=9-31&publication_year=2007&author=Kapp%2CAV&author=Tibshirani%2CR is on a monthly basis
• Explore the financials of https://doi.org/10.1016%2FS0092-8674%2803%2900930-9
• How much revenue does http://scholar.google.com/scholar_lookup?&title=EMSY%20links%20the%20BRCA2%20pathway%20to%20sporadic%20breast%20and%20ovarian%20cancer&journal=Cell&doi=10.1016%2FS0092-8674%2803%2900930-9&volume=115&pages=523-535&publication_year=2003&author=Hughes-Davies%2CL generate?
• How much does https://doi.org/10.1002%2Fgcc.20549 bring in each month?
• How much revenue does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2008ocs..conf.....B produce monthly?
• How much money does http://scholar.google.com/scholar_lookup?&title=Amplification%20of%2011q13%20in%20ovarian%20carcinoma&journal=Genes%20Chromosom.%20Cancer&doi=10.1002%2Fgcc.20549&volume=47&pages=481-489&publication_year=2008&author=Brown%2CLA make?
• How much does https://doi.org/10.1126%2Fscitranslmed.3000611 generate monthly?
• Financial intake of http://scholar.google.com/scholar_lookup?&title=Genomic%20architecture%20characterizes%20tumor%20progression%20paths%20and%20fate%20in%20breast%20cancer%20patients&journal=Sci.%20Transl.%20Med.&doi=10.1126%2Fscitranslmed.3000611&volume=2&publication_year=2010&author=Russnes%2CHG
• How much does https://doi.org/10.1371%2Fjournal.pmed.1000279 bring in each month?
• How much does http://scholar.google.com/scholar_lookup?&title=Subtyping%20of%20breast%20cancer%20by%20immunohistochemistry%20to%20investigate%20a%20relationship%20between%20subtype%20and%20short%20and%20long%20term%20survival%3A%20a%20collaborative%20analysis%20of%20data%20for%2010%2C159%20cases%20from%2012%20studies&journal=PLoS%20Med.&doi=10.1371%2Fjournal.pmed.1000279&volume=7&publication_year=2010&author=Blows%2CFM gross monthly?
• What are the total earnings of https://doi.org/10.1200%2FJCO.2010.30.5037?
• http://scholar.google.com/scholar_lookup?&title=Tumor-infiltrating%20CD8%2B%20lymphocytes%20predict%20clinical%20outcome%20in%20breast%20cancer&journal=J.%20Clin.%20Oncol.&doi=10.1200%2FJCO.2010.30.5037&volume=29&pages=1949-1955&publication_year=2011&author=Mahmoud%2CSMA income
• How much does https://doi.org/10.1073%2Fpnas.1007645108 pull in?
• What are the earnings of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2011PNAS..108.5384D?
• What's the revenue for http://scholar.google.com/scholar_lookup?&title=High%20levels%20of%20the%20Mps1%20checkpoint%20protein%20are%20protective%20of%20aneuploidy%20in%20breast%20cancer%20cells&journal=Proc.%20Natl%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.1007645108&volume=108&pages=5384-5389&publication_year=2011&author=Daniel%2CJ&author=Coulter%2CJ&author=Woo%2CJ-H&author=Wilsbach%2CK&author=Gabrielson%2CE?
• What's the total monthly financial gain of https://doi.org/10.1038%2Fnature06757?
• How much does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2008Natur.452..429C pull in?
• Find out how much http://scholar.google.com/scholar_lookup?&title=Variations%20in%20DNA%20elucidate%20molecular%20networks%20that%20cause%20disease&journal=Nature&doi=10.1038%2Fnature06757&volume=452&pages=429-435&publication_year=2008&author=Chen%2CY earns monthly
• Earnings of https://citation-needed.springer.com/v2/references/10.1038/nature10983?format=refman&flavour=references
• How much cash flow does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Christina%20Curtis have monthly?
• How much money does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Christina%20Curtis%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en make?
• How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Sohrab%20P.%20Shah bring in each month?
• Find out how much https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Sohrab%20P.%20Shah%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en earns monthly
• What is the monthly revenue of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Suet-Feung%20Chin?
• See how much https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Suet-Feung%20Chin%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en makes per month
• How much profit is https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Gulisa%20Turashvili making per month?
• What's the profit of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Gulisa%20Turashvili%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• What's the income of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Oscar%20M.%20Rueda?
• Profit of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Oscar%20M.%20Rueda%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• What's the total monthly financial gain of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Mark%20J.%20Dunning?
• Learn how profitable https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Mark%20J.%20Dunning%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en is on a monthly basis
• Check the income stats for https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Doug%20Speed
• How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Doug%20Speed%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en pull in?
• Discover the revenue of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Andy%20G.%20Lynch
• What's the financial intake of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Andy%20G.%20Lynch%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• What is the earnings of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Shamith%20Samarajiwa?
• Income figures for https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Shamith%20Samarajiwa%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• What's the total monthly financial gain of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Yinyin%20Yuan?
• How much profit does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Yinyin%20Yuan%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en generate?
• How much cash flow does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Stefan%20Gr%C3%A4f have monthly?
• Get to know https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Stefan%20Gr%C3%A4f%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en's earnings
• How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Gavin%20Ha bring in each month?
• https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Gavin%20Ha%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en's total income per month
• What is the earnings of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Gholamreza%20Haffari?
• What's the revenue for https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Gholamreza%20Haffari%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• Learn about the earnings of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Ali%20Bashashati
• How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Ali%20Bashashati%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en generate monthly?
• How much profit does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Roslin%20Russell generate?
• How much money does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Roslin%20Russell%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en generate?
• Discover the revenue of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Steven%20McKinney
• Profit of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Steven%20McKinney%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Anita%20Langer%C3%B8d's revenue stream
• How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Anita%20Langer%C3%B8d%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en generate monthly?
• Financial intake of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Andrew%20Green
• How much revenue does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Andrew%20Green%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en produce monthly?
• Earnings of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Elena%20Provenzano
• How much profit does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Elena%20Provenzano%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en generate?
• What are the total earnings of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Gordon%20Wishart?
• Explore the financials of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Gordon%20Wishart%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• How much profit is https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Sarah%20Pinder making per month?
• See how much https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Sarah%20Pinder%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en makes per month
• What's the monthly income of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Peter%20Watson?
• How much cash flow does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Peter%20Watson%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en have monthly?
• What's the financial intake of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Florian%20Markowetz?
• Get to know what's the income of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Florian%20Markowetz%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• What's the total monthly financial gain of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Leigh%20Murphy?
• https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Leigh%20Murphy%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en's financial summary
• How much profit is https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Ian%20Ellis making per month?
• https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Ian%20Ellis%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en's revenue stream
• https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Arnie%20Purushotham's financial summary
• How much money does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Arnie%20Purushotham%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en make?
• How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Anne-Lise%20B%C3%B8rresen-Dale pull in?
• What's the total monthly financial gain of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Anne-Lise%20B%C3%B8rresen-Dale%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• Income figures for https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=James%20D.%20Brenton
• Revenue of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22James%20D.%20Brenton%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Simon%20Tavar%C3%A9's financial summary
• What's the financial outcome of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Simon%20Tavar%C3%A9%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• Learn how profitable https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Carlos%20Caldas is on a monthly basis
• Explore the financials of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Carlos%20Caldas%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• What's the total monthly financial gain of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Samuel%20Aparicio?
• How much money does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Samuel%20Aparicio%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en generate?
• How much revenue does https://static-content.springer.com/esm/art%3A10.1038%2Fnature10983/MediaObjects/41586_2012_BFnature10983_MOESM265_ESM.pdf produce monthly?
• https://static-content.springer.com/esm/art%3A10.1038%2Fnature10983/MediaObjects/41586_2012_BFnature10983_MOESM266_ESM.zip's financial summary
• What's the income of https://static-content.springer.com/esm/art%3A10.1038%2Fnature10983/MediaObjects/41586_2012_BFnature10983_MOESM267_ESM.zip?
• https://static-content.springer.com/esm/art%3A10.1038%2Fnature10983/MediaObjects/41586_2012_BFnature10983_MOESM268_ESM.zip's total income per month
• How profitable is https://static-content.springer.com/esm/art%3A10.1038%2Fnature10983/MediaObjects/41586_2012_BFnature10983_MOESM269_ESM.zip?
• Check the income stats for https://static-content.springer.com/esm/art%3A10.1038%2Fnature10983/MediaObjects/41586_2012_BFnature10983_MOESM270_ESM.zip
• Check the income stats for https://static-content.springer.com/esm/art%3A10.1038%2Fnature10983/MediaObjects/41586_2012_BFnature10983_MOESM271_ESM.zip
• How much cash flow does https://static-content.springer.com/esm/art%3A10.1038%2Fnature10983/MediaObjects/41586_2012_BFnature10983_MOESM260_ESM.ppt have monthly?
• Monthly income for https://static-content.springer.com/esm/art%3A10.1038%2Fnature10983/MediaObjects/41586_2012_BFnature10983_MOESM261_ESM.ppt
• What's the profit of https://static-content.springer.com/esm/art%3A10.1038%2Fnature10983/MediaObjects/41586_2012_BFnature10983_MOESM262_ESM.ppt?
• How much income does https://static-content.springer.com/esm/art%3A10.1038%2Fnature10983/MediaObjects/41586_2012_BFnature10983_MOESM263_ESM.ppt have?
• https://static-content.springer.com/esm/art%3A10.1038%2Fnature10983/MediaObjects/41586_2012_BFnature10983_MOESM264_ESM.ppt income
• Discover the revenue of https://s100.copyright.com/AppDispatchServlet?title=The%20genomic%20and%20transcriptomic%20architecture%20of%202%2C000%20breast%20tumours%20reveals%20novel%20subgroups&author=Christina%20Curtis%20Carlos%20Caldas%20Christina%20Curtis%E2%80%A0%20James%20D.%20Brenton%20Carlos%20Caldas%20Samuel%20Aparicio%20Ian%20Ellis%20Arnie%20Purushotham%20Leigh%20Murphy%20Carlos%20Caldas%20Samuel%20Aparicio%20Carlos%20Caldas%20Samuel%20Aparicio%20et%20al&contentID=10.1038%2Fnature10983©right=Springer%20Nature%20Limited&publication=0028-0836&publicationDate=2012-04-18&publisherName=SpringerNature&orderBeanReset=true
• Explore the financials of https://citation-needed.springer.com/v2/references/10.1038/nature10983?format=refman&flavour=citation
• What are the total earnings of https://doi.org/10.1186/s13058-024-01826-5?
• What's the financial intake of https://doi.org/10.1038/s41388-024-03007-2?
• How much income is https://doi.org/10.1038/s41380-024-02423-w earning monthly?
• Find out how much https://doi.org/10.1038/s41523-023-00609-z earns monthly
• What's the income generated by https://doi.org/10.1038/s41586-023-06889-6 each month?
• How much does https://www.protocols.io/ net monthly?
• Get to know https://www.natureindex.com/'s earnings
• What's the monthly money flow for http://www.naturechina.com?
• What's the financial gain of https://www.natureasia.com/ja-jp?

Analytics and Tracking {📊}

• Google Tag Manager

Libraries {📚}

• Prism.js
• Zoom.js

Emails and Hosting {✉️}

Mail Servers:

• mxa-002c5801.gslb.pphosted.com
• mxb-002c5801.gslb.pphosted.com

Name Servers:

• pdns1.ultradns.net
• pdns2.ultradns.net
• pdns3.ultradns.org
• pdns4.ultradns.org
• pdns5.ultradns.info
• pdns6.ultradns.co.uk

CDN Services {📦}

• Crossref