NATURE . COM {}

Matching Content Categories {📚}

• Education
• Science
• Health & Fitness

Content Management System {📝}

What CMS is nature.com built with?

Custom-built

No common CMS systems were detected on Nature.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of nature.com audience?

🚀🌠 Tremendous Traffic: 10M - 20M visitors per month


Based on our best estimate, this website will receive around 16,942,715 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Nature.com Make Money? {💸}

Display Ads {🎯}

Direct Advertisers (10)

Reseller Advertisers (38)

How Much Does Nature.com Make? {💰}

Display Ads {🎯}

$213,500 per month
Our estimates place Nature.com's monthly online earnings from display ads at $142,361 to $391,492.

Keywords {🔍}

article, cancer, google, scholar, breast, cas, nature, receptor, clinical, estrogen, expression, cambridge, data, binding, research, access, content, analysis, outcome, carroll, cell, gene, university, cookies, information, differential, carlos, caldas, primary, tumours, foxa, authors, centre, privacy, ali, jason, factor, cancers, genes, growth, erbinding, chromatin, chipseq, cells, powerpoint, oestrogen, rossinnes, stark, andrew, ondrej,

Topics {✒️}

nature portfolio permissions reprints privacy policy org/packages/release/bioc/html/diffbind enhancer-driven lineage-specific transcription author information authors accession number gse32222 advertising mod tools cambridge research institute nature genet social media cancer research uk translational research fellowship gene expression omnibus node-negative breast cancer nature 462 nature 481 nature oestrogen receptor-α gene expression data prevents aging-related euchromatinization discover protein–dna interactions chip-seq peak data cis-regulatory elements linked establishing transcription-factor mapping unique er-binding regions er-positive disease exclusively distant er-positive metastases foxa1 dna-binding protein drug-resistant cellular contexts tamoxifen-resistant mcf-7 cells estrogen receptor-positive springerlink instant access predict distant metastasis independent data sets expression profiles reveals estrogen receptor status primary breast cancers permissions breast cancer biology breast tumor subtype gene-expression profiles foxa1-mediated reprogramming estrogen receptor function gene-expression signature gene expression profiling solid primary cancers prognostic gene signatures primary tumour material

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Differential oestrogen receptor binding is associated with clinical outcome in breast cancer
         description:Genome-wide mapping of oestrogen receptor-α binding sites in primary breast cancer tissues shows that oestrogen receptor binding is dynamically regulated and that the expression of genes near differentially bound regulatory regions is associated with clinical outcome. Most breast tumours express the oestrogen receptor-α (ER), and this transcription factor is seen as an important drug target for the treatment of breast cancer. Jason Carroll and colleagues have mapped ER binding sites in solid primary cancers for the first time, and find distinct ER-binding profiles that are mediated in part by the FoxA1 DNA-binding protein and are associated with better or worse clinical outcome. As well as providing a potentially useful method of prognosis, this work may help to answer one of the major questions in breast cancer biology: how some ER+ tumours become drug resistant. Oestrogen receptor-α (ER) is the defining and driving transcription factor in the majority of breast cancers and its target genes dictate cell growth and endocrine response, yet genomic understanding of ER function has been restricted to model systems1,2,3. Here we map genome-wide ER-binding events, by chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq), in primary breast cancers from patients with different clinical outcomes and in distant ER-positive metastases. We find that drug-resistant cancers still recruit ER to the chromatin, but that ER binding is a dynamic process, with the acquisition of unique ER-binding regions in tumours from patients that are likely to relapse. The acquired ER regulatory regions associated with poor clinical outcome observed in primary tumours reveal gene signatures that predict clinical outcome in ER-positive disease exclusively. We find that the differential ER-binding programme observed in tumours from patients with poor outcome is not due to the selection of a rare subpopulation of cells, but is due to the FOXA1-mediated reprogramming of ER binding on a rapid timescale. The parallel redistribution of ER and FOXA1 binding events in drug-resistant cellular contexts is supported by histological co-expression of ER and FOXA1 in metastatic samples. By establishing transcription-factor mapping in primary tumour material, we show that there is plasticity in ER-binding capacity, with distinct combinations of cis-regulatory elements linked with the different clinical outcomes.
         datePublished:2012-01-04T00:00:00Z
         dateModified:2012-01-04T00:00:00Z
         pageStart:389
         pageEnd:393
         sameAs:https://doi.org/10.1038/nature10730
         keywords:
            Science
            Humanities and Social Sciences
            multidisciplinary
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature10730/MediaObjects/41586_2012_Article_BFnature10730_Fig1_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature10730/MediaObjects/41586_2012_Article_BFnature10730_Fig2_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature10730/MediaObjects/41586_2012_Article_BFnature10730_Fig3_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature10730/MediaObjects/41586_2012_Article_BFnature10730_Fig4_HTML.jpg
         isPartOf:
            name:Nature
            issn:
               1476-4687
               0028-0836
            volumeNumber:481
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Nature Publishing Group UK
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Caryn S. Ross-Innes
               affiliation:
                     name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
                     address:
                        name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Rory Stark
               affiliation:
                     name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
                     address:
                        name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Andrew E. Teschendorff
               affiliation:
                     name: UCL Cancer Institute, University College London, 72 Huntley Street, London WC1E 6BT, UK
                     address:
                        name: UCL Cancer Institute, University College London, 72 Huntley Street, London WC1E 6BT, UK ,
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Kelly A. Holmes
               affiliation:
                     name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
                     address:
                        name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
                        type:PostalAddress
                     type:Organization
               type:Person
               name:H. Raza Ali
               affiliation:
                     name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
                     address:
                        name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
                        type:PostalAddress
                     type:Organization
                     name: Cambridge Breast Unit, Addenbrooke's Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 2QQ, UK
                     address:
                        name: Cambridge Breast Unit, Addenbrooke's Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 2QQ, UK ,
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Mark J. Dunning
               affiliation:
                     name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
                     address:
                        name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Gordon D. Brown
               affiliation:
                     name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
                     address:
                        name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Ondrej Gojis
               affiliation:
                     name: Imperial College London, Hammersmith Campus, London W12 0NN, UK
                     address:
                        name: Imperial College London, Hammersmith Campus, London W12 0NN, UK ,
                        type:PostalAddress
                     type:Organization
                     name:Third Faculty of Medicine, Charles University, Ruska 87, Prague 10, 100 00, Czech Republic
                     address:
                        name:Department of Gynaecology and Obstetrics, Third Faculty of Medicine, Charles University, Ruska 87, Prague 10, 100 00, Czech Republic,
                        type:PostalAddress
                     type:Organization
                     name:Third Faculty of Medicine, Charles University, Ruska 87, Prague 10, 100 00, Czech Republic
                     address:
                        name:Department of Pathology, Third Faculty of Medicine, Charles University, Ruska 87, Prague 10, 100 00, Czech Republic,
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Ian O. Ellis
               affiliation:
                     name:Nottingham University Hospitals NHS Trust, Nottingham City Hospital, Nottingham NG5 1PB, UK
                     address:
                        name:Department of Histopathology, Nottingham University Hospitals NHS Trust, Nottingham City Hospital, Nottingham NG5 1PB, UK,
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Andrew R. Green
               affiliation:
                     name:Nottingham University Hospitals NHS Trust, Nottingham City Hospital, Nottingham NG5 1PB, UK
                     address:
                        name:Department of Histopathology, Nottingham University Hospitals NHS Trust, Nottingham City Hospital, Nottingham NG5 1PB, UK,
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Simak Ali
               affiliation:
                     name: Imperial College London, Hammersmith Campus, London W12 0NN, UK
                     address:
                        name: Imperial College London, Hammersmith Campus, London W12 0NN, UK ,
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Suet-Feung Chin
               affiliation:
                     name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
                     address:
                        name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Carlo Palmieri
               affiliation:
                     name: Imperial College London, Hammersmith Campus, London W12 0NN, UK
                     address:
                        name: Imperial College London, Hammersmith Campus, London W12 0NN, UK ,
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Carlos Caldas
               affiliation:
                     name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
                     address:
                        name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
                        type:PostalAddress
                     type:Organization
                     name:University of Cambridge CB2 0XZ
                     address:
                        name:Department of Oncology, University of Cambridge CB2 0XZ, UK
                        type:PostalAddress
                     type:Organization
                     name: Cambridge Breast Unit, Addenbrooke's Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 2QQ, UK
                     address:
                        name: Cambridge Breast Unit, Addenbrooke's Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 2QQ, UK ,
                        type:PostalAddress
                     type:Organization
                     name: Cambridge Experimental Cancer Medicine Centre (ECMC), Cambridge CB2 0RE, UK
                     address:
                        name: Cambridge Experimental Cancer Medicine Centre (ECMC), Cambridge CB2 0RE, UK ,
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Jason S. Carroll
               affiliation:
                     name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
                     address:
                        name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
                        type:PostalAddress
                     type:Organization
                     name:University of Cambridge CB2 0XZ
                     address:
                        name:Department of Oncology, University of Cambridge CB2 0XZ, UK
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Differential oestrogen receptor binding is associated with clinical outcome in breast cancer
      description:Genome-wide mapping of oestrogen receptor-α binding sites in primary breast cancer tissues shows that oestrogen receptor binding is dynamically regulated and that the expression of genes near differentially bound regulatory regions is associated with clinical outcome. Most breast tumours express the oestrogen receptor-α (ER), and this transcription factor is seen as an important drug target for the treatment of breast cancer. Jason Carroll and colleagues have mapped ER binding sites in solid primary cancers for the first time, and find distinct ER-binding profiles that are mediated in part by the FoxA1 DNA-binding protein and are associated with better or worse clinical outcome. As well as providing a potentially useful method of prognosis, this work may help to answer one of the major questions in breast cancer biology: how some ER+ tumours become drug resistant. Oestrogen receptor-α (ER) is the defining and driving transcription factor in the majority of breast cancers and its target genes dictate cell growth and endocrine response, yet genomic understanding of ER function has been restricted to model systems1,2,3. Here we map genome-wide ER-binding events, by chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq), in primary breast cancers from patients with different clinical outcomes and in distant ER-positive metastases. We find that drug-resistant cancers still recruit ER to the chromatin, but that ER binding is a dynamic process, with the acquisition of unique ER-binding regions in tumours from patients that are likely to relapse. The acquired ER regulatory regions associated with poor clinical outcome observed in primary tumours reveal gene signatures that predict clinical outcome in ER-positive disease exclusively. We find that the differential ER-binding programme observed in tumours from patients with poor outcome is not due to the selection of a rare subpopulation of cells, but is due to the FOXA1-mediated reprogramming of ER binding on a rapid timescale. The parallel redistribution of ER and FOXA1 binding events in drug-resistant cellular contexts is supported by histological co-expression of ER and FOXA1 in metastatic samples. By establishing transcription-factor mapping in primary tumour material, we show that there is plasticity in ER-binding capacity, with distinct combinations of cis-regulatory elements linked with the different clinical outcomes.
      datePublished:2012-01-04T00:00:00Z
      dateModified:2012-01-04T00:00:00Z
      pageStart:389
      pageEnd:393
      sameAs:https://doi.org/10.1038/nature10730
      keywords:
         Science
         Humanities and Social Sciences
         multidisciplinary
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature10730/MediaObjects/41586_2012_Article_BFnature10730_Fig1_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature10730/MediaObjects/41586_2012_Article_BFnature10730_Fig2_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature10730/MediaObjects/41586_2012_Article_BFnature10730_Fig3_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature10730/MediaObjects/41586_2012_Article_BFnature10730_Fig4_HTML.jpg
      isPartOf:
         name:Nature
         issn:
            1476-4687
            0028-0836
         volumeNumber:481
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Nature Publishing Group UK
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Caryn S. Ross-Innes
            affiliation:
                  name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
                  address:
                     name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Rory Stark
            affiliation:
                  name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
                  address:
                     name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Andrew E. Teschendorff
            affiliation:
                  name: UCL Cancer Institute, University College London, 72 Huntley Street, London WC1E 6BT, UK
                  address:
                     name: UCL Cancer Institute, University College London, 72 Huntley Street, London WC1E 6BT, UK ,
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Kelly A. Holmes
            affiliation:
                  name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
                  address:
                     name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
                     type:PostalAddress
                  type:Organization
            type:Person
            name:H. Raza Ali
            affiliation:
                  name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
                  address:
                     name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
                     type:PostalAddress
                  type:Organization
                  name: Cambridge Breast Unit, Addenbrooke's Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 2QQ, UK
                  address:
                     name: Cambridge Breast Unit, Addenbrooke's Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 2QQ, UK ,
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Mark J. Dunning
            affiliation:
                  name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
                  address:
                     name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Gordon D. Brown
            affiliation:
                  name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
                  address:
                     name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ondrej Gojis
            affiliation:
                  name: Imperial College London, Hammersmith Campus, London W12 0NN, UK
                  address:
                     name: Imperial College London, Hammersmith Campus, London W12 0NN, UK ,
                     type:PostalAddress
                  type:Organization
                  name:Third Faculty of Medicine, Charles University, Ruska 87, Prague 10, 100 00, Czech Republic
                  address:
                     name:Department of Gynaecology and Obstetrics, Third Faculty of Medicine, Charles University, Ruska 87, Prague 10, 100 00, Czech Republic,
                     type:PostalAddress
                  type:Organization
                  name:Third Faculty of Medicine, Charles University, Ruska 87, Prague 10, 100 00, Czech Republic
                  address:
                     name:Department of Pathology, Third Faculty of Medicine, Charles University, Ruska 87, Prague 10, 100 00, Czech Republic,
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ian O. Ellis
            affiliation:
                  name:Nottingham University Hospitals NHS Trust, Nottingham City Hospital, Nottingham NG5 1PB, UK
                  address:
                     name:Department of Histopathology, Nottingham University Hospitals NHS Trust, Nottingham City Hospital, Nottingham NG5 1PB, UK,
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Andrew R. Green
            affiliation:
                  name:Nottingham University Hospitals NHS Trust, Nottingham City Hospital, Nottingham NG5 1PB, UK
                  address:
                     name:Department of Histopathology, Nottingham University Hospitals NHS Trust, Nottingham City Hospital, Nottingham NG5 1PB, UK,
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Simak Ali
            affiliation:
                  name: Imperial College London, Hammersmith Campus, London W12 0NN, UK
                  address:
                     name: Imperial College London, Hammersmith Campus, London W12 0NN, UK ,
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Suet-Feung Chin
            affiliation:
                  name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
                  address:
                     name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Carlo Palmieri
            affiliation:
                  name: Imperial College London, Hammersmith Campus, London W12 0NN, UK
                  address:
                     name: Imperial College London, Hammersmith Campus, London W12 0NN, UK ,
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Carlos Caldas
            affiliation:
                  name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
                  address:
                     name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
                     type:PostalAddress
                  type:Organization
                  name:University of Cambridge CB2 0XZ
                  address:
                     name:Department of Oncology, University of Cambridge CB2 0XZ, UK
                     type:PostalAddress
                  type:Organization
                  name: Cambridge Breast Unit, Addenbrooke's Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 2QQ, UK
                  address:
                     name: Cambridge Breast Unit, Addenbrooke's Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 2QQ, UK ,
                     type:PostalAddress
                  type:Organization
                  name: Cambridge Experimental Cancer Medicine Centre (ECMC), Cambridge CB2 0RE, UK
                  address:
                     name: Cambridge Experimental Cancer Medicine Centre (ECMC), Cambridge CB2 0RE, UK ,
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Jason S. Carroll
            affiliation:
                  name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
                  address:
                     name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
                     type:PostalAddress
                  type:Organization
                  name:University of Cambridge CB2 0XZ
                  address:
                     name:Department of Oncology, University of Cambridge CB2 0XZ, UK
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Nature
      issn:
         1476-4687
         0028-0836
      volumeNumber:481
Organization:
      name:Nature Publishing Group UK
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
      address:
         name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
         type:PostalAddress
      name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
      address:
         name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
         type:PostalAddress
      name: UCL Cancer Institute, University College London, 72 Huntley Street, London WC1E 6BT, UK
      address:
         name: UCL Cancer Institute, University College London, 72 Huntley Street, London WC1E 6BT, UK ,
         type:PostalAddress
      name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
      address:
         name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
         type:PostalAddress
      name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
      address:
         name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
         type:PostalAddress
      name: Cambridge Breast Unit, Addenbrooke's Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 2QQ, UK
      address:
         name: Cambridge Breast Unit, Addenbrooke's Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 2QQ, UK ,
         type:PostalAddress
      name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
      address:
         name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
         type:PostalAddress
      name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
      address:
         name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
         type:PostalAddress
      name: Imperial College London, Hammersmith Campus, London W12 0NN, UK
      address:
         name: Imperial College London, Hammersmith Campus, London W12 0NN, UK ,
         type:PostalAddress
      name:Third Faculty of Medicine, Charles University, Ruska 87, Prague 10, 100 00, Czech Republic
      address:
         name:Department of Gynaecology and Obstetrics, Third Faculty of Medicine, Charles University, Ruska 87, Prague 10, 100 00, Czech Republic,
         type:PostalAddress
      name:Third Faculty of Medicine, Charles University, Ruska 87, Prague 10, 100 00, Czech Republic
      address:
         name:Department of Pathology, Third Faculty of Medicine, Charles University, Ruska 87, Prague 10, 100 00, Czech Republic,
         type:PostalAddress
      name:Nottingham University Hospitals NHS Trust, Nottingham City Hospital, Nottingham NG5 1PB, UK
      address:
         name:Department of Histopathology, Nottingham University Hospitals NHS Trust, Nottingham City Hospital, Nottingham NG5 1PB, UK,
         type:PostalAddress
      name:Nottingham University Hospitals NHS Trust, Nottingham City Hospital, Nottingham NG5 1PB, UK
      address:
         name:Department of Histopathology, Nottingham University Hospitals NHS Trust, Nottingham City Hospital, Nottingham NG5 1PB, UK,
         type:PostalAddress
      name: Imperial College London, Hammersmith Campus, London W12 0NN, UK
      address:
         name: Imperial College London, Hammersmith Campus, London W12 0NN, UK ,
         type:PostalAddress
      name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
      address:
         name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
         type:PostalAddress
      name: Imperial College London, Hammersmith Campus, London W12 0NN, UK
      address:
         name: Imperial College London, Hammersmith Campus, London W12 0NN, UK ,
         type:PostalAddress
      name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
      address:
         name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
         type:PostalAddress
      name:University of Cambridge CB2 0XZ
      address:
         name:Department of Oncology, University of Cambridge CB2 0XZ, UK
         type:PostalAddress
      name: Cambridge Breast Unit, Addenbrooke's Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 2QQ, UK
      address:
         name: Cambridge Breast Unit, Addenbrooke's Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 2QQ, UK ,
         type:PostalAddress
      name: Cambridge Experimental Cancer Medicine Centre (ECMC), Cambridge CB2 0RE, UK
      address:
         name: Cambridge Experimental Cancer Medicine Centre (ECMC), Cambridge CB2 0RE, UK ,
         type:PostalAddress
      name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
      address:
         name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
         type:PostalAddress
      name:University of Cambridge CB2 0XZ
      address:
         name:Department of Oncology, University of Cambridge CB2 0XZ, UK
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Caryn S. Ross-Innes
      affiliation:
            name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
            address:
               name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
               type:PostalAddress
            type:Organization
      name:Rory Stark
      affiliation:
            name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
            address:
               name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
               type:PostalAddress
            type:Organization
      name:Andrew E. Teschendorff
      affiliation:
            name: UCL Cancer Institute, University College London, 72 Huntley Street, London WC1E 6BT, UK
            address:
               name: UCL Cancer Institute, University College London, 72 Huntley Street, London WC1E 6BT, UK ,
               type:PostalAddress
            type:Organization
      name:Kelly A. Holmes
      affiliation:
            name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
            address:
               name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
               type:PostalAddress
            type:Organization
      name:H. Raza Ali
      affiliation:
            name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
            address:
               name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
               type:PostalAddress
            type:Organization
            name: Cambridge Breast Unit, Addenbrooke's Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 2QQ, UK
            address:
               name: Cambridge Breast Unit, Addenbrooke's Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 2QQ, UK ,
               type:PostalAddress
            type:Organization
      name:Mark J. Dunning
      affiliation:
            name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
            address:
               name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
               type:PostalAddress
            type:Organization
      name:Gordon D. Brown
      affiliation:
            name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
            address:
               name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
               type:PostalAddress
            type:Organization
      name:Ondrej Gojis
      affiliation:
            name: Imperial College London, Hammersmith Campus, London W12 0NN, UK
            address:
               name: Imperial College London, Hammersmith Campus, London W12 0NN, UK ,
               type:PostalAddress
            type:Organization
            name:Third Faculty of Medicine, Charles University, Ruska 87, Prague 10, 100 00, Czech Republic
            address:
               name:Department of Gynaecology and Obstetrics, Third Faculty of Medicine, Charles University, Ruska 87, Prague 10, 100 00, Czech Republic,
               type:PostalAddress
            type:Organization
            name:Third Faculty of Medicine, Charles University, Ruska 87, Prague 10, 100 00, Czech Republic
            address:
               name:Department of Pathology, Third Faculty of Medicine, Charles University, Ruska 87, Prague 10, 100 00, Czech Republic,
               type:PostalAddress
            type:Organization
      name:Ian O. Ellis
      affiliation:
            name:Nottingham University Hospitals NHS Trust, Nottingham City Hospital, Nottingham NG5 1PB, UK
            address:
               name:Department of Histopathology, Nottingham University Hospitals NHS Trust, Nottingham City Hospital, Nottingham NG5 1PB, UK,
               type:PostalAddress
            type:Organization
      name:Andrew R. Green
      affiliation:
            name:Nottingham University Hospitals NHS Trust, Nottingham City Hospital, Nottingham NG5 1PB, UK
            address:
               name:Department of Histopathology, Nottingham University Hospitals NHS Trust, Nottingham City Hospital, Nottingham NG5 1PB, UK,
               type:PostalAddress
            type:Organization
      name:Simak Ali
      affiliation:
            name: Imperial College London, Hammersmith Campus, London W12 0NN, UK
            address:
               name: Imperial College London, Hammersmith Campus, London W12 0NN, UK ,
               type:PostalAddress
            type:Organization
      name:Suet-Feung Chin
      affiliation:
            name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
            address:
               name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
               type:PostalAddress
            type:Organization
      name:Carlo Palmieri
      affiliation:
            name: Imperial College London, Hammersmith Campus, London W12 0NN, UK
            address:
               name: Imperial College London, Hammersmith Campus, London W12 0NN, UK ,
               type:PostalAddress
            type:Organization
      name:Carlos Caldas
      affiliation:
            name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
            address:
               name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
               type:PostalAddress
            type:Organization
            name:University of Cambridge CB2 0XZ
            address:
               name:Department of Oncology, University of Cambridge CB2 0XZ, UK
               type:PostalAddress
            type:Organization
            name: Cambridge Breast Unit, Addenbrooke's Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 2QQ, UK
            address:
               name: Cambridge Breast Unit, Addenbrooke's Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 2QQ, UK ,
               type:PostalAddress
            type:Organization
            name: Cambridge Experimental Cancer Medicine Centre (ECMC), Cambridge CB2 0RE, UK
            address:
               name: Cambridge Experimental Cancer Medicine Centre (ECMC), Cambridge CB2 0RE, UK ,
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Jason S. Carroll
      affiliation:
            name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
            address:
               name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
               type:PostalAddress
            type:Organization
            name:University of Cambridge CB2 0XZ
            address:
               name:Department of Oncology, University of Cambridge CB2 0XZ, UK
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
      name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
      name: UCL Cancer Institute, University College London, 72 Huntley Street, London WC1E 6BT, UK ,
      name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
      name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
      name: Cambridge Breast Unit, Addenbrooke's Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 2QQ, UK ,
      name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
      name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
      name: Imperial College London, Hammersmith Campus, London W12 0NN, UK ,
      name:Department of Gynaecology and Obstetrics, Third Faculty of Medicine, Charles University, Ruska 87, Prague 10, 100 00, Czech Republic,
      name:Department of Pathology, Third Faculty of Medicine, Charles University, Ruska 87, Prague 10, 100 00, Czech Republic,
      name:Department of Histopathology, Nottingham University Hospitals NHS Trust, Nottingham City Hospital, Nottingham NG5 1PB, UK,
      name:Department of Histopathology, Nottingham University Hospitals NHS Trust, Nottingham City Hospital, Nottingham NG5 1PB, UK,
      name: Imperial College London, Hammersmith Campus, London W12 0NN, UK ,
      name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
      name: Imperial College London, Hammersmith Campus, London W12 0NN, UK ,
      name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
      name:Department of Oncology, University of Cambridge CB2 0XZ, UK
      name: Cambridge Breast Unit, Addenbrooke's Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 2QQ, UK ,
      name: Cambridge Experimental Cancer Medicine Centre (ECMC), Cambridge CB2 0RE, UK ,
      name: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK ,
      name:Department of Oncology, University of Cambridge CB2 0XZ, UK
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

Social Networks {👍}(2)

• https://www.facebook.com/Nature
• https://twitter.com/nature

External Links {🔗}(107)

• How much does https://link.springer.com/article/10.1038/nature10730?utm_source=nature&utm_medium=referral&utm_campaign=buyArticle gross monthly?
• What are the earnings of http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE32222?
• How much profit is https://doi.org/10.1038%2Fng1901 making per month?
• http://scholar.google.com/scholar_lookup?&title=Genome-wide%20analysis%20of%20estrogen%20receptor%20binding%20sites&journal=Nature%20Genet.&doi=10.1038%2Fng1901&volume=38&pages=1289-1297&publication_year=2006&author=Carroll%2CJS income
• https://doi.org/10.1371%2Fjournal.pgen.0030087's financial summary
• What's the financial gain of http://scholar.google.com/scholar_lookup?&title=Whole-genome%20cartography%20of%20estrogen%20receptor%20%CE%B1%20binding%20sites&journal=PLoS%20Genet.&doi=10.1371%2Fjournal.pgen.0030087&volume=3&publication_year=2007&author=Lin%2CCY?
• How much revenue does https://doi.org/10.1038%2Femboj.2009.88 bring in?
• Get to know http://scholar.google.com/scholar_lookup?&title=ChIP-Seq%20of%20ER%CE%B1%20and%20RNA%20polymerase%20II%20defines%20genes%20differentially%20responding%20to%20ligands&journal=EMBO%20J.&doi=10.1038%2Femboj.2009.88&volume=28&pages=1418-1428&publication_year=2009&author=Welboren%2CWJ's earnings
• Profit of https://doi.org/10.1016%2Fj.cell.2005.05.008
• How much revenue does http://scholar.google.com/scholar_lookup?&title=Chromosome-wide%20mapping%20of%20estrogen%20receptor%20binding%20reveals%20long-range%20regulation%20requiring%20the%20forkhead%20protein%20FoxA1&journal=Cell&doi=10.1016%2Fj.cell.2005.05.008&volume=122&pages=33-43&publication_year=2005&author=Carroll%2CJS generate?
• How much does https://doi.org/10.1016%2Fj.cell.2008.01.018 net monthly?
• How much does http://scholar.google.com/scholar_lookup?&title=FoxA1%20translates%20epigenetic%20signatures%20into%20enhancer-driven%20lineage-specific%20transcription&journal=Cell&doi=10.1016%2Fj.cell.2008.01.018&volume=132&pages=958-970&publication_year=2008&author=Lupien%2CM generate monthly?
• What are the earnings of https://doi.org/10.1038%2Fng.730?
• http://scholar.google.com/scholar_lookup?&title=FOXA1%20is%20a%20key%20determinant%20of%20estrogen%20receptor%20function%20and%20endocrine%20response&journal=Nature%20Genet.&doi=10.1038%2Fng.730&volume=43&pages=27-33&publication_year=2011&author=Hurtado%2CA&author=Holmes%2CKA&author=Ross-Innes%2CCS&author=Schmidt%2CD&author=Carroll%2CJS's revenue stream
• How much does https://doi.org/10.1093%2Fhmg%2Fddg347 rake in every month?
• How much income is http://scholar.google.com/scholar_lookup?&title=Classifying%20the%20estrogen%20receptor%20status%20of%20breast%20cancers%20by%20expression%20profiles%20reveals%20a%20poor%20prognosis%20subpopulation%20exhibiting%20high%20expression%20of%20the%20ERBB2%20receptor&journal=Hum.%20Mol.%20Genet.&doi=10.1093%2Fhmg%2Fddg347&volume=12&pages=3245-3258&publication_year=2003&author=Kun%2CY earning monthly?
• How much cash flow does https://doi.org/10.1093%2Fjnci%2Fdji249 have monthly?
• How much revenue does http://scholar.google.com/scholar_lookup?&title=Estrogen%20receptor-positive%2C%20progesterone%20receptor-negative%20breast%20cancer%3A%20association%20with%20growth%20factor%20receptor%20expression%20and%20tamoxifen%20resistance&journal=J.%20Natl%20Cancer%20Inst.&doi=10.1093%2Fjnci%2Fdji249&volume=97&pages=1254-1261&publication_year=2005&author=Arpino%2CG produce monthly?
• What's the total monthly financial gain of https://link.springer.com/doi/10.1186/gb-2008-9-9-r137?
• How much does http://scholar.google.com/scholar_lookup?&title=Model-based%20Analysis%20of%20ChIP-Seq%20%28MACS%29&journal=Genome%20Biol.&doi=10.1186%2Fgb-2008-9-9-r137&volume=9&publication_year=2008&author=Zhang%2CY net monthly?
• Find out how much https://doi.org/10.1038%2Fnature08497 earns monthly
• How much does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2009Natur.462...58F pull in?
• How much cash flow does http://scholar.google.com/scholar_lookup?&title=An%20oestrogen-receptor-%CE%B1-bound%20human%20chromatin%20interactome&journal=Nature&doi=10.1038%2Fnature08497&volume=462&pages=58-64&publication_year=2009&author=Fullwood%2CMJ have monthly?
• Revenue of https://doi.org/10.1200%2FJCO.2006.07.1522
• How much income does http://scholar.google.com/scholar_lookup?&title=Definition%20of%20clinically%20distinct%20molecular%20subtypes%20in%20estrogen%20receptor-positive%20breast%20carcinomas%20through%20genomic%20grade&journal=J.%20Clin.%20Oncol.&doi=10.1200%2FJCO.2006.07.1522&volume=25&pages=1239-1246&publication_year=2007&author=Loi%2CS have?
• Profit of https://doi.org/10.1210%2Fen.2002-220620
• How much does http://scholar.google.com/scholar_lookup?&title=Elevated%20levels%20of%20epidermal%20growth%20factor%20receptor%2Fc-erbB2%20heterodimers%20mediate%20an%20autocrine%20growth%20regulatory%20pathway%20in%20tamoxifen-resistant%20MCF-7%20cells&journal=Endocrinology&doi=10.1210%2Fen.2002-220620&volume=144&pages=1032-1044&publication_year=2003&author=Knowlden%2CJM pull in?
• How much does https://doi.org/10.1101%2Fgad.1944810 generate monthly?
• Income figures for http://scholar.google.com/scholar_lookup?&title=Growth%20factor%20stimulation%20induces%20a%20distinct%20ER%CE%B1%20cistrome%20underlying%20breast%20cancer%20endocrine%20resistance&journal=Genes%20Dev.&doi=10.1101%2Fgad.1944810&volume=24&pages=2219-2227&publication_year=2010&author=Lupien%2CM
• What are the total earnings of https://doi.org/10.1074%2Fjbc.M608653200?
• How much does http://scholar.google.com/scholar_lookup?&title=Quantitative%20transcriptional%20control%20of%20ErbB%20receptor%20signaling%20undergoes%20graded%20to%20biphasic%20response%20for%20cell%20differentiation&journal=J.%20Biol.%20Chem.&doi=10.1074%2Fjbc.M608653200&volume=282&pages=4045-4056&publication_year=2007&author=Nagashima%2CT rake in every month?
• https://doi.org/10.1016%2Fj.ymeth.2009.03.001's revenue stream
• How much does http://scholar.google.com/scholar_lookup?&title=ChIP-seq%3A%20using%20high-throughput%20sequencing%20to%20discover%20protein%E2%80%93DNA%20interactions&journal=Methods&doi=10.1016%2Fj.ymeth.2009.03.001&volume=48&pages=240-248&publication_year=2009&author=Schmidt%2CD gross monthly?
• How profitable is https://doi.org/10.1006%2Fabio.1995.1196?
• What's the monthly money flow for http://scholar.google.com/scholar_lookup?&title=Isolation%20of%20pure%20populations%20of%20epithelial%20and%20myoepithelial%20cells%20from%20the%20normal%20human%20mammary%20gland%20using%20immunomagnetic%20separation%20with%20Dynabeads&journal=Anal.%20Biochem.&doi=10.1006%2Fabio.1995.1196&volume=226&pages=91-99&publication_year=1995&author=Gomm%2CJJ?
• How much does https://doi.org/10.1093%2Fbioinformatics%2Fbtp324 pull in monthly?
• Earnings of http://scholar.google.com/scholar_lookup?&title=Fast%20and%20accurate%20short%20read%20alignment%20with%20Burrows%E2%80%93Wheeler%20transform&journal=Bioinformatics&doi=10.1093%2Fbioinformatics%2Fbtp324&volume=25&pages=1754-1760&publication_year=2009&author=Li%2CH&author=Durbin%2CR
• Discover the revenue of http://bioconductor.org/packages/release/bioc/html/DiffBind.html
• Check the income stats for https://doi.org/10.1093%2Fbioinformatics%2Fbtp616
• How profitable is http://scholar.google.com/scholar_lookup?&title=edgeR%3A%20a%20Bioconductor%20package%20for%20differential%20expression%20analysis%20of%20digital%20gene%20expression%20data&journal=Bioinformatics&doi=10.1093%2Fbioinformatics%2Fbtp616&volume=26&pages=139-140&publication_year=2010&author=Robinson%2CMD&author=McCarthy%2CDJ&author=Smyth%2CGK?
• Get to know https://doi.org/10.1093%2Fnar%2Fgkl285's earnings
• How much money does http://scholar.google.com/scholar_lookup?&title=MoD%20Tools%3A%20regulatory%20motif%20discovery%20in%20nucleotide%20sequences%20from%20co-regulated%20or%20homologous%20genes&journal=Nucleic%20Acids%20Res.&doi=10.1093%2Fnar%2Fgkl285&volume=34&pages=W566-W570&publication_year=2006&author=Pavesi%2CG make?
• What's the income of https://doi.org/10.1016%2FS0140-6736%2805%2970933-8?
• Explore the financials of http://scholar.google.com/scholar_lookup?&title=Gene-expression%20profiles%20to%20predict%20distant%20metastasis%20of%20lymph-node-negative%20primary%20breast%20cancer&journal=Lancet&doi=10.1016%2FS0140-6736%2805%2970933-8&volume=365&pages=671-679&publication_year=2005&author=Wang%2CY
• How much does https://doi.org/10.1056%2FNEJMoa021967 make?
• Get to know http://scholar.google.com/scholar_lookup?&title=A%20gene-expression%20signature%20as%20a%20predictor%20of%20survival%20in%20breast%20cancer&journal=N.%20Engl.%20J.%20Med.&doi=10.1056%2FNEJMoa021967&volume=347&pages=1999-2009&publication_year=2002&author=van%20de%20Vijver%2CMJ's earnings
• https://doi.org/10.1093%2Fjnci%2Fdjj052 income
• Discover the revenue of http://scholar.google.com/scholar_lookup?&title=Gene%20expression%20profiling%20in%20breast%20cancer%3A%20understanding%20the%20molecular%20basis%20of%20histologic%20grade%20to%20improve%20prognosis&journal=J.%20Natl.%20Cancer%20Inst.&doi=10.1093%2Fjnci%2Fdjj052&volume=98&pages=262-272&publication_year=2006&author=Sotiriou%2CC
• What's the monthly money flow for https://doi.org/10.1016%2Fj.ccr.2006.10.009?
• http://scholar.google.com/scholar_lookup?&title=Genomic%20and%20transcriptional%20aberrations%20linked%20to%20breast%20cancer%20pathophysiologies&journal=Cancer%20Cell&doi=10.1016%2Fj.ccr.2006.10.009&volume=10&pages=529-541&publication_year=2006&author=Chin%2CK's revenue stream
• What's the revenue for https://doi.org/10.1158%2F0008-5472.CAN-07-5206?
• How much money does http://scholar.google.com/scholar_lookup?&title=The%20humoral%20immune%20system%20has%20a%20key%20prognostic%20impact%20in%20node-negative%20breast%20cancer&journal=Cancer%20Res.&doi=10.1158%2F0008-5472.CAN-07-5206&volume=68&pages=5405-5413&publication_year=2008&author=Schmidt%2CM generate?
• What's the income generated by https://doi.org/10.1158%2F0008-5472.CAN-11-0489 each month?
• Profit of http://scholar.google.com/scholar_lookup?&title=microRNA%20associated%20progression%20pathways%20and%20potential%20therapeutic%20targets%20identified%20by%20integrated%20mRNA%20and%20microRNA%20expression%20profiling%20in%20breast%20cancer&journal=Cancer%20Res.&doi=10.1158%2F0008-5472.CAN-11-0489&volume=71&publication_year=2011&author=Buffa%2CFM
• What's the financial outcome of https://doi.org/10.1038%2Fsj.onc.1209920?
• What is the monthly revenue of http://scholar.google.com/scholar_lookup?&title=A%20gene-expression%20signature%20to%20predict%20survival%20in%20breast%20cancer%20across%20independent%20data%20sets&journal=Oncogene&doi=10.1038%2Fsj.onc.1209920&volume=26&pages=1507-1516&publication_year=2007&author=Naderi%2CA?
• Profit of https://link.springer.com/doi/10.1186/1471-2164-8-258
• How much does http://scholar.google.com/scholar_lookup?&title=EGFR%20associated%20expression%20profiles%20vary%20with%20breast%20tumor%20subtype&journal=BMC%20Genomics&doi=10.1186%2F1471-2164-8-258&volume=8&publication_year=2007&author=Hoadley%2CKA gross monthly?
• Find out how much https://doi.org/10.1371%2Fjournal.pbio.0020108 earns monthly
• How much profit does http://scholar.google.com/scholar_lookup?&title=Semi-supervised%20methods%20to%20predict%20patient%20survival%20from%20gene%20expression%20data&journal=PLoS%20Biol.&doi=10.1371%2Fjournal.pbio.0020108&volume=2&publication_year=2004&author=Bair%2CE&author=Tibshirani%2CR generate?
• What's the monthly income of https://citation-needed.springer.com/v2/references/10.1038/nature10730?format=refman&flavour=references?
• What's the revenue for https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Caryn%20S.%20Ross-Innes?
• How much profit does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Caryn%20S.%20Ross-Innes%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en make?
• How profitable is https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Rory%20Stark?
• How much revenue does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Rory%20Stark%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en bring in?
• How much revenue does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Andrew%20E.%20Teschendorff bring in?
• What's the total monthly financial gain of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Andrew%20E.%20Teschendorff%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• Explore the financials of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Kelly%20A.%20Holmes
• How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Kelly%20A.%20Holmes%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en pull in monthly?
• Explore the financials of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=H.%20Raza%20Ali
• https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22H.%20Raza%20Ali%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en's financial summary
• How much revenue does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Mark%20J.%20Dunning generate?
• What is the earnings of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Mark%20J.%20Dunning%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• How much revenue does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Gordon%20D.%20Brown produce monthly?
• What's the revenue for https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Gordon%20D.%20Brown%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• What's the financial outcome of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Ondrej%20Gojis?
• How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Ondrej%20Gojis%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en pull in monthly?
• How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Ian%20O.%20Ellis bring in each month?
• Revenue of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Ian%20O.%20Ellis%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Andrew%20R.%20Green pull in monthly?
• How much profit is https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Andrew%20R.%20Green%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en making per month?
• How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Simak%20Ali net monthly?
• How much revenue does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Simak%20Ali%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en generate?
• What's the profit of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Suet-Feung%20Chin?
• https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Suet-Feung%20Chin%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en's revenue stream
• Earnings of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Carlo%20Palmieri
• How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Carlo%20Palmieri%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en pull in monthly?
• Learn about the earnings of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Carlos%20Caldas
• Financial intake of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Carlos%20Caldas%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Jason%20S.%20Carroll bring in each month?
• How much profit does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Jason%20S.%20Carroll%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en generate?
• How much does https://static-content.springer.com/esm/art%3A10.1038%2Fnature10730/MediaObjects/41586_2012_BFnature10730_MOESM316_ESM.pdf rake in every month?
• https://static-content.springer.com/esm/art%3A10.1038%2Fnature10730/MediaObjects/41586_2012_BFnature10730_MOESM312_ESM.ppt income
• How much does https://static-content.springer.com/esm/art%3A10.1038%2Fnature10730/MediaObjects/41586_2012_BFnature10730_MOESM313_ESM.ppt rake in every month?
• What's the financial outcome of https://static-content.springer.com/esm/art%3A10.1038%2Fnature10730/MediaObjects/41586_2012_BFnature10730_MOESM314_ESM.ppt?
• What's the income generated by https://static-content.springer.com/esm/art%3A10.1038%2Fnature10730/MediaObjects/41586_2012_BFnature10730_MOESM315_ESM.ppt each month?
• Get to know https://s100.copyright.com/AppDispatchServlet?title=Differential%20oestrogen%20receptor%20binding%20is%20associated%20with%20clinical%20outcome%20in%20breast%20cancer&author=Caryn%20S.%20Ross-Innes%20et%20al&contentID=10.1038%2Fnature10730©right=Springer%20Nature%20Limited&publication=0028-0836&publicationDate=2012-01-04&publisherName=SpringerNature&orderBeanReset=true's earnings
• How much does https://citation-needed.springer.com/v2/references/10.1038/nature10730?format=refman&flavour=citation make?
• How much does https://doi.org/10.1186/s13059-023-03161-y generate monthly?
• How much does https://doi.org/10.1186/s13072-024-00526-w rake in every month?
• Revenue of https://doi.org/10.1038/s42003-024-05898-z
• https://doi.org/10.1038/s41467-024-45773-3 income
• Revenue of https://doi.org/10.1038/s41389-023-00504-z
• Discover the revenue of https://www.protocols.io/
• What's the monthly income of https://www.natureindex.com/?
• http://www.naturechina.com's financial summary
• Get to know what's the income of https://www.natureasia.com/ja-jp

Analytics and Tracking {📊}

• Google Tag Manager

Libraries {📚}

• Prism.js
• Zoom.js

Emails and Hosting {✉️}

Mail Servers:

• mxa-002c5801.gslb.pphosted.com
• mxb-002c5801.gslb.pphosted.com

Name Servers:

• pdns1.ultradns.net
• pdns2.ultradns.net
• pdns3.ultradns.org
• pdns4.ultradns.org
• pdns5.ultradns.info
• pdns6.ultradns.co.uk

CDN Services {📦}

• Crossref