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         headline:Initial genome sequencing and analysis of multiple myeloma
         description:Multiple myeloma is an incurable malignancy of plasma cells, and its pathogenesis is poorly understood. Here we report the massively parallel sequencing of 38 tumour genomes and their comparison to matched normal DNAs. Several new and unexpected oncogenic mechanisms were suggested by the pattern of somatic mutation across the data set. These include the mutation of genes involved in protein translation (seen in nearly half of the patients), genes involved in histone methylation, and genes involved in blood coagulation. In addition, a broader than anticipated role of NF-κB signalling was indicated by mutations in 11 members of the NF-κB pathway. Of potential immediate clinical relevance, activating mutations of the kinase BRAF were observed in 4% of patients, suggesting the evaluation of BRAF inhibitors in multiple myeloma clinical trials. These results indicate that cancer genome sequencing of large collections of samples will yield new insights into cancer not anticipated by existing knowledge. Multiple myeloma, a malignancy of plasma cells, remains incurable and is poorly understood. Chapman et al. have used next-generation sequencing to compare 38 multiple myeloma genomes with those of normal cells from the same patients. The disease involves mutations of genes with roles in protein translation, histone methylation and blood coagulation. In terms of clinically relevant findings, unexpected activating mutations were found in the kinase BRAF, inhibitors of which have recently shown dramatic clinical activity. This suggests that BRAF inhibitors should be evaluated in patients with BRAF-mutated multiple myeloma. Multiple myeloma, a malignancy of plasma cells, remains incurable and is poorly understood. Using next-generation sequencing of several multiple myeloma genomes reveals that this disease involves mutations of genes involved in protein translation, histone methylation and blood coagulation. The study suggests that BRAF inhibitors should be evaluated in multiple myeloma clinical trials.
         datePublished:2011-03-23T00:00:00Z
         dateModified:2011-03-23T00:00:00Z
         pageStart:467
         pageEnd:472
         license:http://creativecommons.org/licenses/by-nc-sa/3.0/
         sameAs:https://doi.org/10.1038/nature09837
         keywords:
            Cancer genetics
            Myeloma
            Sequencing
            Science
            Humanities and Social Sciences
            multidisciplinary
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               1476-4687
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                     name:Present address: Department of Haematology, Addenbrookes Hospital, Hills Road, Cambridge CB2 0QQ, UK.
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                     name:Dana-Farber Cancer Institute, 44 Binney Street
                     address:
                        name:Dana-Farber Cancer Institute, 44 Binney Street, Boston, USA
                        type:PostalAddress
                     type:Organization
                     name:Harvard Medical School
                     address:
                        name:Harvard Medical School, Boston, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Levi A. Garraway
               affiliation:
                     name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center
                     address:
                        name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center, Cambridge, USA
                        type:PostalAddress
                     type:Organization
                     name:Dana-Farber Cancer Institute, 44 Binney Street
                     address:
                        name:Dana-Farber Cancer Institute, 44 Binney Street, Boston, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Matthew Meyerson
               affiliation:
                     name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center
                     address:
                        name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center, Cambridge, USA
                        type:PostalAddress
                     type:Organization
                     name:Dana-Farber Cancer Institute, 44 Binney Street
                     address:
                        name:Dana-Farber Cancer Institute, 44 Binney Street, Boston, USA
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                     type:Organization
                     name:Harvard Medical School
                     address:
                        name:Harvard Medical School, Boston, USA
                        type:PostalAddress
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               type:Person
               name:Eric S. Lander
               affiliation:
                     name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center
                     address:
                        name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center, Cambridge, USA
                        type:PostalAddress
                     type:Organization
                     name:Harvard Medical School
                     address:
                        name:Harvard Medical School, Boston, USA
                        type:PostalAddress
                     type:Organization
                     name:Massachusetts Institute of Technology
                     address:
                        name:Massachusetts Institute of Technology, Cambridge, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Gad Getz
               affiliation:
                     name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center
                     address:
                        name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center, Cambridge, USA
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Todd R. Golub
               affiliation:
                     name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center
                     address:
                        name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center, Cambridge, USA
                        type:PostalAddress
                     type:Organization
                     name:Dana-Farber Cancer Institute, 44 Binney Street
                     address:
                        name:Dana-Farber Cancer Institute, 44 Binney Street, Boston, USA
                        type:PostalAddress
                     type:Organization
                     name:Harvard Medical School
                     address:
                        name:Harvard Medical School, Boston, USA
                        type:PostalAddress
                     type:Organization
                     name:Howard Hughes Medical Institute
                     address:
                        name:Howard Hughes Medical Institute, Chevy Chase, USA
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Initial genome sequencing and analysis of multiple myeloma
      description:Multiple myeloma is an incurable malignancy of plasma cells, and its pathogenesis is poorly understood. Here we report the massively parallel sequencing of 38 tumour genomes and their comparison to matched normal DNAs. Several new and unexpected oncogenic mechanisms were suggested by the pattern of somatic mutation across the data set. These include the mutation of genes involved in protein translation (seen in nearly half of the patients), genes involved in histone methylation, and genes involved in blood coagulation. In addition, a broader than anticipated role of NF-κB signalling was indicated by mutations in 11 members of the NF-κB pathway. Of potential immediate clinical relevance, activating mutations of the kinase BRAF were observed in 4% of patients, suggesting the evaluation of BRAF inhibitors in multiple myeloma clinical trials. These results indicate that cancer genome sequencing of large collections of samples will yield new insights into cancer not anticipated by existing knowledge. Multiple myeloma, a malignancy of plasma cells, remains incurable and is poorly understood. Chapman et al. have used next-generation sequencing to compare 38 multiple myeloma genomes with those of normal cells from the same patients. The disease involves mutations of genes with roles in protein translation, histone methylation and blood coagulation. In terms of clinically relevant findings, unexpected activating mutations were found in the kinase BRAF, inhibitors of which have recently shown dramatic clinical activity. This suggests that BRAF inhibitors should be evaluated in patients with BRAF-mutated multiple myeloma. Multiple myeloma, a malignancy of plasma cells, remains incurable and is poorly understood. Using next-generation sequencing of several multiple myeloma genomes reveals that this disease involves mutations of genes involved in protein translation, histone methylation and blood coagulation. The study suggests that BRAF inhibitors should be evaluated in multiple myeloma clinical trials.
      datePublished:2011-03-23T00:00:00Z
      dateModified:2011-03-23T00:00:00Z
      pageStart:467
      pageEnd:472
      license:http://creativecommons.org/licenses/by-nc-sa/3.0/
      sameAs:https://doi.org/10.1038/nature09837
      keywords:
         Cancer genetics
         Myeloma
         Sequencing
         Science
         Humanities and Social Sciences
         multidisciplinary
      image:
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         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature09837/MediaObjects/41586_2011_Article_BFnature09837_Fig3_HTML.jpg
      isPartOf:
         name:Nature
         issn:
            1476-4687
            0028-0836
         volumeNumber:471
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Nature Publishing Group UK
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Michael A. Chapman
            affiliation:
                  name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center
                  address:
                     name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center, Cambridge, USA
                     type:PostalAddress
                  type:Organization
                  name:Present address: Department of Haematology, Addenbrookes Hospital, Hills Road, Cambridge CB2 0QQ, UK.
                  address:
                     name:Present address: Department of Haematology, Addenbrookes Hospital, Hills Road, Cambridge CB2 0QQ, UK.,
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Michael S. Lawrence
            affiliation:
                  name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center
                  address:
                     name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center, Cambridge, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jonathan J. Keats
            affiliation:
                  name:Mayo Clinic Arizona, 13400 East Shea Boulevard
                  address:
                     name:Mayo Clinic Arizona, 13400 East Shea Boulevard, Scottsdale, USA
                     type:PostalAddress
                  type:Organization
                  name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor
                  address:
                     name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor, Norwalk, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Kristian Cibulskis
            affiliation:
                  name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center
                  address:
                     name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center, Cambridge, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Carrie Sougnez
            affiliation:
                  name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center
                  address:
                     name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center, Cambridge, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Anna C. Schinzel
            affiliation:
                  name:Dana-Farber Cancer Institute, 44 Binney Street
                  address:
                     name:Dana-Farber Cancer Institute, 44 Binney Street, Boston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Christina L. Harview
            affiliation:
                  name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center
                  address:
                     name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center, Cambridge, USA
                     type:PostalAddress
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            type:Person
            name:Jean-Philippe Brunet
            affiliation:
                  name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center
                  address:
                     name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center, Cambridge, USA
                     type:PostalAddress
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            type:Person
            name:Gregory J. Ahmann
            affiliation:
                  name:Mayo Clinic Arizona, 13400 East Shea Boulevard
                  address:
                     name:Mayo Clinic Arizona, 13400 East Shea Boulevard, Scottsdale, USA
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                  name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor
                  address:
                     name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor, Norwalk, USA
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            type:Person
            name:Mazhar Adli
            affiliation:
                  name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center
                  address:
                     name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center, Cambridge, USA
                     type:PostalAddress
                  type:Organization
                  name:Massachusetts General Hospital, 55 Fruit Street
                  address:
                     name:Massachusetts General Hospital, 55 Fruit Street, Boston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Kenneth C. Anderson
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                     name:Dana-Farber Cancer Institute, 44 Binney Street, Boston, USA
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            type:Person
            name:Kristin G. Ardlie
            affiliation:
                  name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center
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                     name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center, Cambridge, USA
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            type:Person
            name:Daniel Auclair
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                  name:Multiple Myeloma Research Foundation, 383 Main Avenue, 5th Floor
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                     name:Multiple Myeloma Research Foundation, 383 Main Avenue, 5th Floor, Norwalk, USA
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            type:Person
            name:Angela Baker
            affiliation:
                  name:The Translational Genomics Research Institute, 445 North Fifth Street
                  address:
                     name:The Translational Genomics Research Institute, 445 North Fifth Street, Phoenix, USA
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            name:P. Leif Bergsagel
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                  name:Mayo Clinic Arizona, 13400 East Shea Boulevard
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                     name:Mayo Clinic Arizona, 13400 East Shea Boulevard, Scottsdale, USA
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                  name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor
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                     name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor, Norwalk, USA
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            type:Person
            name:Bradley E. Bernstein
            affiliation:
                  name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center
                  address:
                     name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center, Cambridge, USA
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                  name:Massachusetts General Hospital, 55 Fruit Street
                  address:
                     name:Massachusetts General Hospital, 55 Fruit Street, Boston, USA
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                  name:Harvard Medical School
                  address:
                     name:Harvard Medical School, Boston, USA
                     type:PostalAddress
                  type:Organization
                  name:Howard Hughes Medical Institute
                  address:
                     name:Howard Hughes Medical Institute, Chevy Chase, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yotam Drier
            affiliation:
                  name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center
                  address:
                     name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center, Cambridge, USA
                     type:PostalAddress
                  type:Organization
                  name:Weizmann Institute of Science
                  address:
                     name:Department of Physics of Complex Systems, Weizmann Institute of Science, Rehovot 76100, Israel
                     type:PostalAddress
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            type:Person
            name:Rafael Fonseca
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                  name:Mayo Clinic Arizona, 13400 East Shea Boulevard
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                     name:Mayo Clinic Arizona, 13400 East Shea Boulevard, Scottsdale, USA
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                     name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor, Norwalk, USA
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            name:Stacey B. Gabriel
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                  name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center
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                     name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center, Cambridge, USA
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            name:Craig C. Hofmeister
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                     name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor, Norwalk, USA
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                  name:The Ohio State University Medical Center, 320 West 10th Avenue
                  address:
                     name:The Ohio State University Medical Center, 320 West 10th Avenue, Columbus, USA
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            type:Person
            name:Sundar Jagannath
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                  name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor
                  address:
                     name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor, Norwalk, USA
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                  name:St Vincent’s Comprehensive Cancer Center, 325 West 15th Street
                  address:
                     name:St Vincent’s Comprehensive Cancer Center, 325 West 15th Street, New York, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Andrzej J. Jakubowiak
            affiliation:
                  name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor
                  address:
                     name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor, Norwalk, USA
                     type:PostalAddress
                  type:Organization
                  name:University of Michigan Comprehensive Cancer Center, 1500 East Medical Center Drive
                  address:
                     name:University of Michigan Comprehensive Cancer Center, 1500 East Medical Center Drive, Ann Arbor, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Amrita Krishnan
            affiliation:
                  name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor
                  address:
                     name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor, Norwalk, USA
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                  name:City of Hope Comprehensive Cancer Center, 1500 East Duarte Road
                  address:
                     name:City of Hope Comprehensive Cancer Center, 1500 East Duarte Road, Duarte, USA
                     type:PostalAddress
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            type:Person
            name:Joan Levy
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                  name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor
                  address:
                     name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor, Norwalk, USA
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                  name:Multiple Myeloma Research Foundation, 383 Main Avenue, 5th Floor
                  address:
                     name:Multiple Myeloma Research Foundation, 383 Main Avenue, 5th Floor, Norwalk, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ted Liefeld
            affiliation:
                  name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center
                  address:
                     name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center, Cambridge, USA
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                  type:Organization
            type:Person
            name:Sagar Lonial
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                  address:
                     name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor, Norwalk, USA
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                  type:Organization
                  name:Winship Cancer Institute, Emory University, 1365-C Clifton Road
                  address:
                     name:Winship Cancer Institute, Emory University, 1365-C Clifton Road, NE Atlanta, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Scott Mahan
            affiliation:
                  name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center
                  address:
                     name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center, Cambridge, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Bunmi Mfuko
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                  address:
                     name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor, Norwalk, USA
                     type:PostalAddress
                  type:Organization
                  name:Multiple Myeloma Research Foundation, 383 Main Avenue, 5th Floor
                  address:
                     name:Multiple Myeloma Research Foundation, 383 Main Avenue, 5th Floor, Norwalk, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Stefano Monti
            affiliation:
                  name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center
                  address:
                     name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center, Cambridge, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Louise M. Perkins
            affiliation:
                  name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor
                  address:
                     name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor, Norwalk, USA
                     type:PostalAddress
                  type:Organization
                  name:Multiple Myeloma Research Foundation, 383 Main Avenue, 5th Floor
                  address:
                     name:Multiple Myeloma Research Foundation, 383 Main Avenue, 5th Floor, Norwalk, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Robb Onofrio
            affiliation:
                  name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center
                  address:
                     name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center, Cambridge, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Trevor J. Pugh
            affiliation:
                  name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center
                  address:
                     name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center, Cambridge, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:S. Vincent Rajkumar
            affiliation:
                  name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor
                  address:
                     name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor, Norwalk, USA
                     type:PostalAddress
                  type:Organization
                  name:Mayo Clinic Rochester
                  address:
                     name:Mayo Clinic Rochester, 200 1st Street SW Rochester, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Alex H. Ramos
            affiliation:
                  name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center
                  address:
                     name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center, Cambridge, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:David S. Siegel
            affiliation:
                  name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor
                  address:
                     name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor, Norwalk, USA
                     type:PostalAddress
                  type:Organization
                  name:John Theurer Cancer Center at Hackensack University Medical Center, 92 Second Street
                  address:
                     name:John Theurer Cancer Center at Hackensack University Medical Center, 92 Second Street, Hackensack, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Andrey Sivachenko
            affiliation:
                  name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center
                  address:
                     name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center, Cambridge, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:A. Keith Stewart
            affiliation:
                  name:Mayo Clinic Arizona, 13400 East Shea Boulevard
                  address:
                     name:Mayo Clinic Arizona, 13400 East Shea Boulevard, Scottsdale, USA
                     type:PostalAddress
                  type:Organization
                  name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor
                  address:
                     name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor, Norwalk, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Suzanne Trudel
            affiliation:
                  name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor
                  address:
                     name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor, Norwalk, USA
                     type:PostalAddress
                  type:Organization
                  name:Princess Margaret Hospital, 610 University Avenue
                  address:
                     name:Princess Margaret Hospital, 610 University Avenue, Toronto, Canada
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ravi Vij
            affiliation:
                  name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor
                  address:
                     name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor, Norwalk, USA
                     type:PostalAddress
                  type:Organization
                  name:Washington University School of Medicine, Washington University in St Louis
                  address:
                     name:Washington University School of Medicine, Washington University in St Louis, St Louis, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Douglas Voet
            affiliation:
                  name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center
                  address:
                     name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center, Cambridge, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Wendy Winckler
            affiliation:
                  name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center
                  address:
                     name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center, Cambridge, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Todd Zimmerman
            affiliation:
                  name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor
                  address:
                     name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor, Norwalk, USA
                     type:PostalAddress
                  type:Organization
                  name:University of Chicago Medical Center, 5841 South Maryland Avenue
                  address:
                     name:University of Chicago Medical Center, 5841 South Maryland Avenue, Chicago, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:John Carpten
            affiliation:
                  name:The Translational Genomics Research Institute, 445 North Fifth Street
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               name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor, Norwalk, USA
               type:PostalAddress
            type:Organization
            name:Multiple Myeloma Research Foundation, 383 Main Avenue, 5th Floor
            address:
               name:Multiple Myeloma Research Foundation, 383 Main Avenue, 5th Floor, Norwalk, USA
               type:PostalAddress
            type:Organization
      name:Angela Baker
      affiliation:
            name:The Translational Genomics Research Institute, 445 North Fifth Street
            address:
               name:The Translational Genomics Research Institute, 445 North Fifth Street, Phoenix, USA
               type:PostalAddress
            type:Organization
      name:P. Leif Bergsagel
      affiliation:
            name:Mayo Clinic Arizona, 13400 East Shea Boulevard
            address:
               name:Mayo Clinic Arizona, 13400 East Shea Boulevard, Scottsdale, USA
               type:PostalAddress
            type:Organization
            name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor
            address:
               name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor, Norwalk, USA
               type:PostalAddress
            type:Organization
      name:Bradley E. Bernstein
      affiliation:
            name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center
            address:
               name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center, Cambridge, USA
               type:PostalAddress
            type:Organization
            name:Massachusetts General Hospital, 55 Fruit Street
            address:
               name:Massachusetts General Hospital, 55 Fruit Street, Boston, USA
               type:PostalAddress
            type:Organization
            name:Harvard Medical School
            address:
               name:Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
            name:Howard Hughes Medical Institute
            address:
               name:Howard Hughes Medical Institute, Chevy Chase, USA
               type:PostalAddress
            type:Organization
      name:Yotam Drier
      affiliation:
            name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center
            address:
               name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center, Cambridge, USA
               type:PostalAddress
            type:Organization
            name:Weizmann Institute of Science
            address:
               name:Department of Physics of Complex Systems, Weizmann Institute of Science, Rehovot 76100, Israel
               type:PostalAddress
            type:Organization
      name:Rafael Fonseca
      affiliation:
            name:Mayo Clinic Arizona, 13400 East Shea Boulevard
            address:
               name:Mayo Clinic Arizona, 13400 East Shea Boulevard, Scottsdale, USA
               type:PostalAddress
            type:Organization
            name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor
            address:
               name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor, Norwalk, USA
               type:PostalAddress
            type:Organization
      name:Stacey B. Gabriel
      affiliation:
            name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center
            address:
               name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center, Cambridge, USA
               type:PostalAddress
            type:Organization
      name:Craig C. Hofmeister
      affiliation:
            name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor
            address:
               name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor, Norwalk, USA
               type:PostalAddress
            type:Organization
            name:The Ohio State University Medical Center, 320 West 10th Avenue
            address:
               name:The Ohio State University Medical Center, 320 West 10th Avenue, Columbus, USA
               type:PostalAddress
            type:Organization
      name:Sundar Jagannath
      affiliation:
            name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor
            address:
               name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor, Norwalk, USA
               type:PostalAddress
            type:Organization
            name:St Vincent’s Comprehensive Cancer Center, 325 West 15th Street
            address:
               name:St Vincent’s Comprehensive Cancer Center, 325 West 15th Street, New York, USA
               type:PostalAddress
            type:Organization
      name:Andrzej J. Jakubowiak
      affiliation:
            name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor
            address:
               name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor, Norwalk, USA
               type:PostalAddress
            type:Organization
            name:University of Michigan Comprehensive Cancer Center, 1500 East Medical Center Drive
            address:
               name:University of Michigan Comprehensive Cancer Center, 1500 East Medical Center Drive, Ann Arbor, USA
               type:PostalAddress
            type:Organization
      name:Amrita Krishnan
      affiliation:
            name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor
            address:
               name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor, Norwalk, USA
               type:PostalAddress
            type:Organization
            name:City of Hope Comprehensive Cancer Center, 1500 East Duarte Road
            address:
               name:City of Hope Comprehensive Cancer Center, 1500 East Duarte Road, Duarte, USA
               type:PostalAddress
            type:Organization
      name:Joan Levy
      affiliation:
            name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor
            address:
               name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor, Norwalk, USA
               type:PostalAddress
            type:Organization
            name:Multiple Myeloma Research Foundation, 383 Main Avenue, 5th Floor
            address:
               name:Multiple Myeloma Research Foundation, 383 Main Avenue, 5th Floor, Norwalk, USA
               type:PostalAddress
            type:Organization
      name:Ted Liefeld
      affiliation:
            name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center
            address:
               name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center, Cambridge, USA
               type:PostalAddress
            type:Organization
      name:Sagar Lonial
      affiliation:
            name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor
            address:
               name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor, Norwalk, USA
               type:PostalAddress
            type:Organization
            name:Winship Cancer Institute, Emory University, 1365-C Clifton Road
            address:
               name:Winship Cancer Institute, Emory University, 1365-C Clifton Road, NE Atlanta, USA
               type:PostalAddress
            type:Organization
      name:Scott Mahan
      affiliation:
            name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center
            address:
               name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center, Cambridge, USA
               type:PostalAddress
            type:Organization
      name:Bunmi Mfuko
      affiliation:
            name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor
            address:
               name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor, Norwalk, USA
               type:PostalAddress
            type:Organization
            name:Multiple Myeloma Research Foundation, 383 Main Avenue, 5th Floor
            address:
               name:Multiple Myeloma Research Foundation, 383 Main Avenue, 5th Floor, Norwalk, USA
               type:PostalAddress
            type:Organization
      name:Stefano Monti
      affiliation:
            name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center
            address:
               name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center, Cambridge, USA
               type:PostalAddress
            type:Organization
      name:Louise M. Perkins
      affiliation:
            name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor
            address:
               name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor, Norwalk, USA
               type:PostalAddress
            type:Organization
            name:Multiple Myeloma Research Foundation, 383 Main Avenue, 5th Floor
            address:
               name:Multiple Myeloma Research Foundation, 383 Main Avenue, 5th Floor, Norwalk, USA
               type:PostalAddress
            type:Organization
      name:Robb Onofrio
      affiliation:
            name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center
            address:
               name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center, Cambridge, USA
               type:PostalAddress
            type:Organization
      name:Trevor J. Pugh
      affiliation:
            name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center
            address:
               name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center, Cambridge, USA
               type:PostalAddress
            type:Organization
      name:S. Vincent Rajkumar
      affiliation:
            name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor
            address:
               name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor, Norwalk, USA
               type:PostalAddress
            type:Organization
            name:Mayo Clinic Rochester
            address:
               name:Mayo Clinic Rochester, 200 1st Street SW Rochester, USA
               type:PostalAddress
            type:Organization
      name:Alex H. Ramos
      affiliation:
            name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center
            address:
               name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center, Cambridge, USA
               type:PostalAddress
            type:Organization
      name:David S. Siegel
      affiliation:
            name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor
            address:
               name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor, Norwalk, USA
               type:PostalAddress
            type:Organization
            name:John Theurer Cancer Center at Hackensack University Medical Center, 92 Second Street
            address:
               name:John Theurer Cancer Center at Hackensack University Medical Center, 92 Second Street, Hackensack, USA
               type:PostalAddress
            type:Organization
      name:Andrey Sivachenko
      affiliation:
            name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center
            address:
               name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center, Cambridge, USA
               type:PostalAddress
            type:Organization
      name:A. Keith Stewart
      affiliation:
            name:Mayo Clinic Arizona, 13400 East Shea Boulevard
            address:
               name:Mayo Clinic Arizona, 13400 East Shea Boulevard, Scottsdale, USA
               type:PostalAddress
            type:Organization
            name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor
            address:
               name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor, Norwalk, USA
               type:PostalAddress
            type:Organization
      name:Suzanne Trudel
      affiliation:
            name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor
            address:
               name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor, Norwalk, USA
               type:PostalAddress
            type:Organization
            name:Princess Margaret Hospital, 610 University Avenue
            address:
               name:Princess Margaret Hospital, 610 University Avenue, Toronto, Canada
               type:PostalAddress
            type:Organization
      name:Ravi Vij
      affiliation:
            name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor
            address:
               name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor, Norwalk, USA
               type:PostalAddress
            type:Organization
            name:Washington University School of Medicine, Washington University in St Louis
            address:
               name:Washington University School of Medicine, Washington University in St Louis, St Louis, USA
               type:PostalAddress
            type:Organization
      name:Douglas Voet
      affiliation:
            name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center
            address:
               name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center, Cambridge, USA
               type:PostalAddress
            type:Organization
      name:Wendy Winckler
      affiliation:
            name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center
            address:
               name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center, Cambridge, USA
               type:PostalAddress
            type:Organization
      name:Todd Zimmerman
      affiliation:
            name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor
            address:
               name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor, Norwalk, USA
               type:PostalAddress
            type:Organization
            name:University of Chicago Medical Center, 5841 South Maryland Avenue
            address:
               name:University of Chicago Medical Center, 5841 South Maryland Avenue, Chicago, USA
               type:PostalAddress
            type:Organization
      name:John Carpten
      affiliation:
            name:The Translational Genomics Research Institute, 445 North Fifth Street
            address:
               name:The Translational Genomics Research Institute, 445 North Fifth Street, Phoenix, USA
               type:PostalAddress
            type:Organization
      name:Jeff Trent
      affiliation:
            name:The Translational Genomics Research Institute, 445 North Fifth Street
            address:
               name:The Translational Genomics Research Institute, 445 North Fifth Street, Phoenix, USA
               type:PostalAddress
            type:Organization
      name:William C. Hahn
      affiliation:
            name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center
            address:
               name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center, Cambridge, USA
               type:PostalAddress
            type:Organization
            name:Dana-Farber Cancer Institute, 44 Binney Street
            address:
               name:Dana-Farber Cancer Institute, 44 Binney Street, Boston, USA
               type:PostalAddress
            type:Organization
            name:Harvard Medical School
            address:
               name:Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
      name:Levi A. Garraway
      affiliation:
            name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center
            address:
               name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center, Cambridge, USA
               type:PostalAddress
            type:Organization
            name:Dana-Farber Cancer Institute, 44 Binney Street
            address:
               name:Dana-Farber Cancer Institute, 44 Binney Street, Boston, USA
               type:PostalAddress
            type:Organization
      name:Matthew Meyerson
      affiliation:
            name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center
            address:
               name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center, Cambridge, USA
               type:PostalAddress
            type:Organization
            name:Dana-Farber Cancer Institute, 44 Binney Street
            address:
               name:Dana-Farber Cancer Institute, 44 Binney Street, Boston, USA
               type:PostalAddress
            type:Organization
            name:Harvard Medical School
            address:
               name:Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
      name:Eric S. Lander
      affiliation:
            name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center
            address:
               name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center, Cambridge, USA
               type:PostalAddress
            type:Organization
            name:Harvard Medical School
            address:
               name:Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
            name:Massachusetts Institute of Technology
            address:
               name:Massachusetts Institute of Technology, Cambridge, USA
               type:PostalAddress
            type:Organization
      name:Gad Getz
      affiliation:
            name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center
            address:
               name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center, Cambridge, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Todd R. Golub
      affiliation:
            name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center
            address:
               name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center, Cambridge, USA
               type:PostalAddress
            type:Organization
            name:Dana-Farber Cancer Institute, 44 Binney Street
            address:
               name:Dana-Farber Cancer Institute, 44 Binney Street, Boston, USA
               type:PostalAddress
            type:Organization
            name:Harvard Medical School
            address:
               name:Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
            name:Howard Hughes Medical Institute
            address:
               name:Howard Hughes Medical Institute, Chevy Chase, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center, Cambridge, USA
      name:Present address: Department of Haematology, Addenbrookes Hospital, Hills Road, Cambridge CB2 0QQ, UK.,
      name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center, Cambridge, USA
      name:Mayo Clinic Arizona, 13400 East Shea Boulevard, Scottsdale, USA
      name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor, Norwalk, USA
      name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center, Cambridge, USA
      name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center, Cambridge, USA
      name:Dana-Farber Cancer Institute, 44 Binney Street, Boston, USA
      name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center, Cambridge, USA
      name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center, Cambridge, USA
      name:Mayo Clinic Arizona, 13400 East Shea Boulevard, Scottsdale, USA
      name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor, Norwalk, USA
      name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center, Cambridge, USA
      name:Massachusetts General Hospital, 55 Fruit Street, Boston, USA
      name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor, Norwalk, USA
      name:Dana-Farber Cancer Institute, 44 Binney Street, Boston, USA
      name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center, Cambridge, USA
      name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor, Norwalk, USA
      name:Multiple Myeloma Research Foundation, 383 Main Avenue, 5th Floor, Norwalk, USA
      name:The Translational Genomics Research Institute, 445 North Fifth Street, Phoenix, USA
      name:Mayo Clinic Arizona, 13400 East Shea Boulevard, Scottsdale, USA
      name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor, Norwalk, USA
      name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center, Cambridge, USA
      name:Massachusetts General Hospital, 55 Fruit Street, Boston, USA
      name:Harvard Medical School, Boston, USA
      name:Howard Hughes Medical Institute, Chevy Chase, USA
      name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center, Cambridge, USA
      name:Department of Physics of Complex Systems, Weizmann Institute of Science, Rehovot 76100, Israel
      name:Mayo Clinic Arizona, 13400 East Shea Boulevard, Scottsdale, USA
      name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor, Norwalk, USA
      name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center, Cambridge, USA
      name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor, Norwalk, USA
      name:The Ohio State University Medical Center, 320 West 10th Avenue, Columbus, USA
      name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor, Norwalk, USA
      name:St Vincent’s Comprehensive Cancer Center, 325 West 15th Street, New York, USA
      name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor, Norwalk, USA
      name:University of Michigan Comprehensive Cancer Center, 1500 East Medical Center Drive, Ann Arbor, USA
      name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor, Norwalk, USA
      name:City of Hope Comprehensive Cancer Center, 1500 East Duarte Road, Duarte, USA
      name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor, Norwalk, USA
      name:Multiple Myeloma Research Foundation, 383 Main Avenue, 5th Floor, Norwalk, USA
      name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center, Cambridge, USA
      name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor, Norwalk, USA
      name:Winship Cancer Institute, Emory University, 1365-C Clifton Road, NE Atlanta, USA
      name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center, Cambridge, USA
      name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor, Norwalk, USA
      name:Multiple Myeloma Research Foundation, 383 Main Avenue, 5th Floor, Norwalk, USA
      name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center, Cambridge, USA
      name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor, Norwalk, USA
      name:Multiple Myeloma Research Foundation, 383 Main Avenue, 5th Floor, Norwalk, USA
      name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center, Cambridge, USA
      name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center, Cambridge, USA
      name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor, Norwalk, USA
      name:Mayo Clinic Rochester, 200 1st Street SW Rochester, USA
      name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center, Cambridge, USA
      name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor, Norwalk, USA
      name:John Theurer Cancer Center at Hackensack University Medical Center, 92 Second Street, Hackensack, USA
      name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center, Cambridge, USA
      name:Mayo Clinic Arizona, 13400 East Shea Boulevard, Scottsdale, USA
      name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor, Norwalk, USA
      name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor, Norwalk, USA
      name:Princess Margaret Hospital, 610 University Avenue, Toronto, Canada
      name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor, Norwalk, USA
      name:Washington University School of Medicine, Washington University in St Louis, St Louis, USA
      name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center, Cambridge, USA
      name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center, Cambridge, USA
      name:The Multiple Myeloma Research Consortium, 383 Main Avenue, 5th Floor, Norwalk, USA
      name:University of Chicago Medical Center, 5841 South Maryland Avenue, Chicago, USA
      name:The Translational Genomics Research Institute, 445 North Fifth Street, Phoenix, USA
      name:The Translational Genomics Research Institute, 445 North Fifth Street, Phoenix, USA
      name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center, Cambridge, USA
      name:Dana-Farber Cancer Institute, 44 Binney Street, Boston, USA
      name:Harvard Medical School, Boston, USA
      name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center, Cambridge, USA
      name:Dana-Farber Cancer Institute, 44 Binney Street, Boston, USA
      name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center, Cambridge, USA
      name:Dana-Farber Cancer Institute, 44 Binney Street, Boston, USA
      name:Harvard Medical School, Boston, USA
      name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center, Cambridge, USA
      name:Harvard Medical School, Boston, USA
      name:Massachusetts Institute of Technology, Cambridge, USA
      name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center, Cambridge, USA
      name:The Eli and Edythe L. Broad Institute, 7 Cambridge Center, Cambridge, USA
      name:Dana-Farber Cancer Institute, 44 Binney Street, Boston, USA
      name:Harvard Medical School, Boston, USA
      name:Howard Hughes Medical Institute, Chevy Chase, USA

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