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We began analyzing https://www.nature.com/articles/nature05372, but it redirected us to https://www.nature.com/articles/nature05372. The analysis below is for the second page.

Title[redir]:
A human colon cancer cell capable of initiating tumour growth in immunodeficient mice | Nature
Description:
Two papers in this issue report the identification of a specific type of colon cancer cell that initiates tumour growth in mice. This lends support to the theory that only a few cells within a tumour, the cancer stem cells, are responsible for tumour formation and maintenance. The finding highlights the importance of finding therapeutics to target cancer stem cells. Colon cancer is one of the best-understood neoplasms from a genetic perspective1,2,3, yet it remains the second most common cause of cancer-related death, indicating that some of its cancer cells are not eradicated by current therapies4,5. What has yet to be established is whether every colon cancer cell possesses the potential to initiate and sustain tumour growth, or whether the tumour is hierarchically organized so that only a subset of cells—cancer stem cells—possess such potential6,7. Here we use renal capsule transplantation in immunodeficient NOD/SCID mice to identify a human colon cancer-initiating cell (CC-IC). Purification experiments established that all CC-ICs were CD133+; the CD133- cells that comprised the majority of the tumour were unable to initiate tumour growth. We calculated by limiting dilution analysis that there was one CC-IC in 5.7 × 104 unfractionated tumour cells, whereas there was one CC-IC in 262 CD133+ cells, representing >200-fold enrichment. CC-ICs within the CD133+ population were able to maintain themselves as well as differentiate and re-establish tumour heterogeneity upon serial transplantation. The identification of colon cancer stem cells that are distinct from the bulk tumour cells provides strong support for the hierarchical organization of human colon cancer, and their existence suggests that for therapeutic strategies to be effective, they must target the cancer stem cells.

Matching Content Categories {📚}

  • Science
  • Education
  • Health & Fitness

Content Management System {📝}

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Custom-built

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Traffic Estimate {📈}

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🌠 Phenomenal Traffic: 5M - 10M visitors per month


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Keywords {🔍}

cancer, article, cells, google, scholar, nature, cas, stem, cell, colon, tumour, human, access, dick, research, supplementary, content, cookies, data, information, mice, ads, canada, ontario, privacy, analysis, growth, colorectal, initiating, john, identification, open, molecular, natl, leukemia, clarke, membrane, manuscript, health, jed, institute, author, toronto, permissions, figure, advertising, journal, subscribe, immunodeficient, obrien,

Topics {✒️}

nature portfolio privacy policy colorectal cancer development advertising permissions reprints cells—cancer stem cells—possess canada research chair social media nature immunol nature med health research integrated multi-omics unveils nature 432 nature 414 nature 367 nature nature 445 author information authors p53-independent cross-talk human colon cancer springerlink instant access colon cancer cell immunodeficient nod/scid mice author contributions author correspondence colon cancer cells permissions information colorectal cancer tumorigenesis human colon cancers cancer stem cells competing financial interests personal data /reprints university health network national cancer institute privacy cancer-related death rectal cancer surgery initiating tumour growth permissions cell signaling pathways data protection analysed data natl cancer inst orthotopic xenograft models nod/scid mice explore content subscription content colorectal cancer bulk tumour cells

Schema {🗺️}

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         headline:A human colon cancer cell capable of initiating tumour growth in immunodeficient mice
         description:Two papers in this issue report the identification of a specific type of colon cancer cell that initiates tumour growth in mice. This lends support to the theory that only a few cells within a tumour, the cancer stem cells, are responsible for tumour formation and maintenance. The finding highlights the importance of finding therapeutics to target cancer stem cells. Colon cancer is one of the best-understood neoplasms from a genetic perspective1,2,3, yet it remains the second most common cause of cancer-related death, indicating that some of its cancer cells are not eradicated by current therapies4,5. What has yet to be established is whether every colon cancer cell possesses the potential to initiate and sustain tumour growth, or whether the tumour is hierarchically organized so that only a subset of cells—cancer stem cells—possess such potential6,7. Here we use renal capsule transplantation in immunodeficient NOD/SCID mice to identify a human colon cancer-initiating cell (CC-IC). Purification experiments established that all CC-ICs were CD133+; the CD133- cells that comprised the majority of the tumour were unable to initiate tumour growth. We calculated by limiting dilution analysis that there was one CC-IC in 5.7 × 104 unfractionated tumour cells, whereas there was one CC-IC in 262 CD133+ cells, representing >200-fold enrichment. CC-ICs within the CD133+ population were able to maintain themselves as well as differentiate and re-establish tumour heterogeneity upon serial transplantation. The identification of colon cancer stem cells that are distinct from the bulk tumour cells provides strong support for the hierarchical organization of human colon cancer, and their existence suggests that for therapeutic strategies to be effective, they must target the cancer stem cells.
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      headline:A human colon cancer cell capable of initiating tumour growth in immunodeficient mice
      description:Two papers in this issue report the identification of a specific type of colon cancer cell that initiates tumour growth in mice. This lends support to the theory that only a few cells within a tumour, the cancer stem cells, are responsible for tumour formation and maintenance. The finding highlights the importance of finding therapeutics to target cancer stem cells. Colon cancer is one of the best-understood neoplasms from a genetic perspective1,2,3, yet it remains the second most common cause of cancer-related death, indicating that some of its cancer cells are not eradicated by current therapies4,5. What has yet to be established is whether every colon cancer cell possesses the potential to initiate and sustain tumour growth, or whether the tumour is hierarchically organized so that only a subset of cells—cancer stem cells—possess such potential6,7. Here we use renal capsule transplantation in immunodeficient NOD/SCID mice to identify a human colon cancer-initiating cell (CC-IC). Purification experiments established that all CC-ICs were CD133+; the CD133- cells that comprised the majority of the tumour were unable to initiate tumour growth. We calculated by limiting dilution analysis that there was one CC-IC in 5.7 × 104 unfractionated tumour cells, whereas there was one CC-IC in 262 CD133+ cells, representing >200-fold enrichment. CC-ICs within the CD133+ population were able to maintain themselves as well as differentiate and re-establish tumour heterogeneity upon serial transplantation. The identification of colon cancer stem cells that are distinct from the bulk tumour cells provides strong support for the hierarchical organization of human colon cancer, and their existence suggests that for therapeutic strategies to be effective, they must target the cancer stem cells.
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Social Networks {👍}(2)

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