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We are analyzing https://www.nature.com/articles/6800717.

Title:
Adjusting multiple testing in multilocus analyses using the eigenvalues of a correlation matrix | Heredity
Description:
Correlated multiple testing is widely performed in genetic research, particularly in multilocus analyses of complex diseases. Failure to control appropriately for the effect of multiple testing will either result in a flood of false-positive claims or in true hits being overlooked. Cheverud proposed the idea of adjusting correlated tests as if they were independent, according to an ‘effective number’ (Meff) of independent tests. However, our experience has indicated that Cheverud
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30 years and 10 months (reg. 1994-08-11).

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Education
Technology & Computing
Science

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Custom-built

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🌆 Monumental Traffic: 20M - 50M visitors per month

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$536,300 per month
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Keywords {🔍}

meff, tests, equation, article, analyses, data, google, scholar, pubmed, test, multilocus, fdr, correlated, independent, correlation, method, control, cas, multiple, number, testing, loci, procedure, nature, permutation, ewsl, cheverud, estimate, rate, snps, hypotheses, table, genetic, proposed, methods, rejected, singlelocus, benjamini, applied, genet, eigenvalues, discovery, equal, stepup, study, eigenvalue, central, analysis, false, step,

Topics {✒️}

nature portfolio permissions reprints privacy policy [18f]fe-pe2i dat correlates genetic research experiment-wise significant level nature point-wise significant level advertising social media author information authors fractionation/mass spectrometry platform published schizophrenia data author correspondence multifactor dimensionality reduction mathematical multi-locus approaches suggested resampling-based methods false discovery rate dual-task test verbal angiotensin-i-converting enzyme false discovery rates employed resampling-based methods data-driven algorithm based detecting gene-gene interactions permissions generous sharing china genome-wise type design meff-based procedures quantitative trait mapping simulated case–control data adjusting multiple testing data-driven meff method false-positive claims correlated multiple testing environmental risk factors privacy resampling-based methods single-locus analysis keavney data set explore content similar content k-locus analysis performance single-locus analyses journals search log low replication rate computing approximate thresholds composite interval mapping schizophrenia data set nonintegral part represents

Questions {❓}

Are Genetic and Environmental Risk Factors for Psychopathology Amplified in Children with Below-Average Intelligence?
‘Are we there yet’?

Schema {🗺️}

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