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Keywords {🔍}

google, scholar, pubmed, doi, complex, causation, traits, association, pmc, disease, genet, genetic, article, studies, diseases, free, data, population, study, biological, genes, linkage, identification, results, hum, quantitative, causative, bias, gene, biases, information, guidelines, human, errors, admixture, sufficient, evidence, statistical, genetics, true, populations, polymorphisms, associations, polymorphism, disequilibrium, analysis, mendelian, science, hill, control,

Topics {✒️}

de la chapelle pmc beta search gov/ references ahmad-annuar early–onset breast cancer pmc copyright notice electronic-database information rigorous quality-control checks publisher site pdf induce false-positive results induce false-negative results appropriately small frequentist generate false-positive results main article stoeckert cj jr pmc disclaimer substance-abuse loci human lipoprotein lipase nickerson da doyle ac parra ej suggested false-discovery-rate united states government homozygous mutants strains uric acid nephrolithiasis internationalen medichinischen congresses large-scale typing tightly linked loci case-control studies license information pmcid hirschhorn jn sardinian genetic isolate false-positive associations marker-assisted selection requires extensive sequencing publicly funded investigations mary claire king stat soc ser epidemiologic research ii combining p-values contopoulos-ioannidis dg false-positive results false-negative results computing sample sizes dose-response relationships snp consortium website philosopher karl popper modest geographic distance african-american populations cystic fibrosis gene unlinked genetic markers

Questions {❓}

• Hill A (1965) The environment and disease: association or causation?
• If causation cannot be proven, however, what does constitute sufficient evidence for causation?
• Ioannidis JP (2003) Genetic associations: false or true?
• Thomas DC, Witte JS (2002) Point: population stratification: a problem for case-control studies of candidate-gene associations?
• Why has the identification of causative genes for complex diseases been so elusive?
• Why should I let others reap the benefits?
• “Are We There Yet?

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