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nature portfolio privacy policy advertising nature 449 nature 392 nature 451 nature author information authors invasion kits 0/ reprints notch/hif/maml1 immuno-complex initiative event resulting icn3-induced notch signaling regulates notch signaling human ras-transformed cells warm serum-free media ligand-induced notch signaling inhibits hras1-induced oncogenesis hypoxia inducible factor-1α hrp-conjugated secondary antibodies author correspondence dana-farber cancer institute notch1-induced mammary tumorigenesis ligand-mediated notch activation rbp-jκ-binding sites rbp-jκ binding sites real-time pcr analysis published pathway figures zinc-finger proteins snail mouse mammary epithelium cell–cell adhesion molecule hypoxia-mediated notch signaling pre-existing notch signaling real-time pcr experiments induces mammary tumors notch-dependent mechanism hif-1α transcription complex hif-2α potentiated icn1 mouse mammary tumor scratch wound-healing assay low oxygen content antibodies pcdna3/hif-1α full size image notch intracellular domain breast cancer development hypoxia inducible factor permissions notch signaling induces notch1 intracellular domain human mammary tumourigenesis

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• Peinado H, Olmeda D, Cano A (2007) Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?

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      headline:Hypoxia potentiates Notch signaling in breast cancer leading to decreased E-cadherin expression and increased cell migration and invasion
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