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Title:
Apoptotic signals delivered through the T-cell receptor of a T-cell hybrid require the immediate–early gene nur77 | Nature
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ENGAGEMENT of the T-cell antigen receptor (TCR) on immature thymic T cells induces death by apoptosis1–3. Although several lines of evidence indicate that apoptosis requires de novo gene expression, little is known about the molecular pathways that mediate this response. Here we show that nur77 (refs 4–7), a zinc-finger transcription factor, is expressed in response to TCR engagement in immature T cells and T-cell hybrids. Antisense inhibition of nur77 expression prevents apoptosis in TCR-stimulated cells. nur77 is also expressed in response to mitogens, but in this case transcription is regulated by 5
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nature portfolio permissions reprints privacy policy advertising social media subscribe nature nature 343 nature 351 nature 337 nature 284 nature 336 nature 367 nature t-cell hybrid require metastasis-specific regulation network t-cell antigen receptor zinc-finger transcription factor springerlink instant access data support permissions early gene nur77 personal data data protection apoptotic signals delivered privacy t-cell receptor cell receptor repertoires t-cell hybrids explore content subscription content article liu european economic area institutional subscriptions read rapid parallel reconstruction ovarian cancer based tcr-stimulated cells accepting optional cookies nfat transcription factors nur77 transcripts found rat thymic involution thymic oxidative status tcr engagement journals search log issue learn cells induces death manage preferences animal sciences macdonald-bravo content article purchase
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- mxa-002c5801.gslb.pphosted.com
- mxb-002c5801.gslb.pphosted.com
Name Servers:
- pdns1.ultradns.net
- pdns2.ultradns.net
- pdns3.ultradns.org
- pdns4.ultradns.org
- pdns5.ultradns.info
- pdns6.ultradns.co.uk
CDN Services {📦}
- Crossref