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nature, article, google, scholar, cas, cells, access, cell, content, killer, roder, pubmed, immun, cookies, natural, privacy, mouse, function, data, duwe, tumour, open, press, kiessling, advertising, information, subscribe, beige, john, axel, contact, institution, buy, author, department, permissions, cancer, research, optional, media, personal, including, parties, policy, journals, log, journal, march, mutation, selectively,

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nature portfolio permissions reprints privacy policy advertising subscribe nature valuable tools social media nature 273 nature 278 nature development patient-derived xenograft models including natural killer tumour cell contact natural killer cells personal data cell-mediated lysis springerlink instant access data protection permissions article roder mouse called beige privacy cell types explore content subscription content european economic area complex biological systems lytic pathway subsequent t-lymphoid system institutional subscriptions read contemporary topics immunobiol accepting optional cookies journals search log defective gene product issue learn manage preferences colorado medical center tumour immunology nude mouse article purchase line content access duwe article cite university college london 29 march 1979 https 1038/278451a0

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         headline:The beige mutation in the mouse selectively impairs natural killer cell function
         description:GERM LINE mutations affecting defined cell populations are often valuable tools in elucidating the function of these cells in complex biological systems such as tumour rejection. We report here that a mutant gene in the mouse called beige (bgJ), leads to a complete and selective impairment of naturally occurring killer lymphocytes, whereas all other forms of cell-mediated lysis are apparently normal. The defective gene product may lie within the lytic pathway subsequent to tumour cell contact. Because many cell types, including natural killer (NK) cells, T cells and macrophages, may be involved in tumour resistance in vivo1, these mice will provide a critical test of the hypothesis that it is NK cells which provide a first line of defence against neoplasia2. It is likely that this mutant will be invaluable for further investigations in tumour immunology just as the nude mouse has been indispensable in evaluating the role of thethymus in the development of the T-lymphoid system and the role of T cells in the rejection of tumours.
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      headline:The beige mutation in the mouse selectively impairs natural killer cell function
      description:GERM LINE mutations affecting defined cell populations are often valuable tools in elucidating the function of these cells in complex biological systems such as tumour rejection. We report here that a mutant gene in the mouse called beige (bgJ), leads to a complete and selective impairment of naturally occurring killer lymphocytes, whereas all other forms of cell-mediated lysis are apparently normal. The defective gene product may lie within the lytic pathway subsequent to tumour cell contact. Because many cell types, including natural killer (NK) cells, T cells and macrophages, may be involved in tumour resistance in vivo1, these mice will provide a critical test of the hypothesis that it is NK cells which provide a first line of defence against neoplasia2. It is likely that this mutant will be invaluable for further investigations in tumour immunology just as the nude mouse has been indispensable in evaluating the role of thethymus in the development of the T-lymphoid system and the role of T cells in the rejection of tumours.
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