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Title:
Natural Killer Cells in the Mouse: An Alternative Immune Surveillance Mechanism? | SpringerLink
Description:
During thelast 10 years thenumber of effector cell types active in growth inhibition or cytolysis of tumor cells has steadily increased. Although theimportance of immune T cells in tumor rejection, measured by cytolytic or cyto-static activity in vitro, is firmly...
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google, scholar, pubmed, cas, article, cancer, immunol, kiessling, exp, wigzell, med, chapter, haller, natl, int, klein, cudkowicz, cells, nature, inst, herberman, research, tumor, perlmann, proc, eur, petrányi, privacy, cookies, content, information, publish, natural, download, acad, sci, res, bennet, hellström, shearer, springer, search, immunobiology, killer, immune, preview, access, lavrin, hammarström, submitted,

Topics {✒️}

t-cell-dependent mechanisms antibody-dependent cellular cytotoxicity natural cell-mediated immunity month download article/chapter natural killer cells privacy choices/manage cookies chapter contemporary topics device instant download fundamental cancer research nonimmune effector cells european economic area cyto-static activity journal finder publish conditions privacy policy download preview pdf ciba foundation symposium accepting optional cookies experimental hematology today main content log contemporary topics check access ethics access cancer research natl cancer inst chapter usd 29 chapter kiessling journal publish tumor cells privacy policy chapter cite springer verlag article permissions reprints ma books a neoplastic cells chapter log optional cookies personal data manage preferences williams & wilkins affiliations department cancer inst data protection tumor rejection tumor resistance tumor res tumor biology essential cookies cookies skip

Questions {❓}

Natural Killer Cells in the Mouse: An Alternative Immune Surveillance Mechanism?
Natural Killer Cells in the Mouse: An Alternative Immune Surveillance Mechanism?
Natural Killer Cells: What Have We Learned?

Schema {🗺️}

ScholarlyArticle:
      headline:Natural Killer Cells in the Mouse: An Alternative Immune Surveillance Mechanism?
      pageEnd:201
      pageStart:171
      image:https://media.springernature.com/w153/springer-static/cover/book/978-1-4684-0922-2.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Contemporary Topics in Immunobiology
         isbn:
            978-1-4684-0922-2
            978-1-4684-0924-6
         type:Book
      publisher:
         name:Springer US
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Rolf Kiessling
            affiliation:
                  name:Karolinska Institute
                  address:
                     name:Department of Tumor Biology, Karolinska Institute, Stockholm 60, Sweden
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Otto Haller
            affiliation:
                  name:Uppsala University
                  address:
                     name:Department of Immunology, Uppsala University, Uppsala, Sweden
                     type:PostalAddress
                  type:Organization
            type:Person
      keywords:Natural Killer Cell, Spleen Cell, Natural Killer Activity, Helix Pomatia, Fetal Liver Cell
      description:During thelast 10 years thenumber of effector cell types active in growth inhibition or cytolysis of tumor cells has steadily increased. Although theimportance of immune T cells in tumor rejection, measured by cytolytic or cyto-static activity in vitro, is firmly established, there is an increasing amount of evidence showing that tumor resistance also could be mediated by non-T-cell-dependent mechanisms. Some of these alternatives to T-cell cytotoxicity involve tumor killing by activated macrophages (Keller, 1976) or by antibody-dependent cellular cytotoxicity (ADCC) (Perlmann et al, 1972) carried out by a variety of nonimmune effector cells. The phenomenon of natural cell-mediated immunity to be discussed in this article will add further to thecomplexity of this field. The purpose of this chapter is, however, to convince thereader that this phenomenon, although still poorly understood, is a factor which must be seriously considered when discussing immune surveillance mechanisms against tumors.
      datePublished:1978
      isAccessibleForFree:
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Book:
      name:Contemporary Topics in Immunobiology
      isbn:
         978-1-4684-0922-2
         978-1-4684-0924-6
Organization:
      name:Springer US
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Karolinska Institute
      address:
         name:Department of Tumor Biology, Karolinska Institute, Stockholm 60, Sweden
         type:PostalAddress
      name:Uppsala University
      address:
         name:Department of Immunology, Uppsala University, Uppsala, Sweden
         type:PostalAddress
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      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Rolf Kiessling
      affiliation:
            name:Karolinska Institute
            address:
               name:Department of Tumor Biology, Karolinska Institute, Stockholm 60, Sweden
               type:PostalAddress
            type:Organization
      name:Otto Haller
      affiliation:
            name:Uppsala University
            address:
               name:Department of Immunology, Uppsala University, Uppsala, Sweden
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Department of Tumor Biology, Karolinska Institute, Stockholm 60, Sweden
      name:Department of Immunology, Uppsala University, Uppsala, Sweden
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