
PUBMED . NCBI . NLM . NIH . GOV {
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Title:
The role of mitochondria in protection of the heart by preconditioning - PubMed
Description:
A prolonged period of ischaemia followed by reperfusion irreversibly damages the heart. Such reperfusion injury (RI) involves opening of the mitochondrial permeability transition pore (MPTP) under the conditions of calcium overload and oxidative stress that accompany reperfusion. Protection from MPT …
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Keywords {🔍}
mitochondrial, reperfusion, doi, pore, pmid, opening, pmc, permeability, ros, pubmed, halestrap, transition, preconditioning, free, article, myocardial, epub, mitochondria, injury, review, mptp, metabolism, protection, heart, clarke, potassium, channels, fig, ischemic, res, rat, articles, role, prolonged, ischaemia, oxidative, stress, kinase, inhibition, hearts, main, ncbi, similar, cited, references, mesh, resources, biochim, biophys, acta,
Topics {✒️}
reactive oxygen species mitochondrial potassium channels mitochondrial proteins permeability transition pore electron transport decreases myocardial injury reperfused rat myocardium ischemia/reperfusion injury revisited mitochondrial pore opening oxidation reperfusion injury reperfusion injury main page content myocardial reperfusion myocardial reperfusion similar articles cited acute myocardial infarction mitochondrial protein phosphorylation reduction sensitise pore opening myocardial mitochondria myocardial protection real-time fluorescence measurements mitochondrial reperfusion irreversibly damages articles references halestrap heart united states government mptp-induced ros production funding linkout accompany reperfusion respiratory chain inhibitors potent cardioprotective effect 008 abstract involve direct phosphorylation reducing infarct size protein kinase cascades protein kinase cepsilon aged rat hearts bona fide uncouplers biochim biophys acta castro-e-silva 4-anilinoquinazoline derivative pd153035 da silva cc ischemia protects mitochondria isolated rat hearts reperfusion critical thiol groups show cross-talk detectable increases occur
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