LINK . SPRINGER . COM {}

Matching Content Categories {📚}

• Health & Fitness
• Science
• Education

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


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The income method remains a mystery to us.

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Keywords {🔍}

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Topics {✒️}

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Questions {❓}

• Muscle fiber types: how many and what kind?

Schema {🗺️}

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         headline:Neonatal vitamin A injection promotes cattle muscle growth and increases oxidative muscle fibers
         description:Vitamin A and its metabolite, retinoic acid (RA), are important regulators of cell differentiation and organ morphogenesis. Its impact on beef cattle muscle growth remains undefined. Angus steer calves were administrated with 0 (control) or 150,000 IU vitamin A (retinyl palmitate in glycerol, i.m.) per calf at birth and 1 month of age. At 2 months of age, a biopsy of the Biceps femoris muscle was obtained to analyze the immediate effects of vitamin A injection on myogenic capacity of muscle cells. The resulting steers were harvested at 14 months of age. Vitamin A administration increased cattle growth at 2 months. At 2 months of age, Vitamin A increased PAX7 positive satellite cells and the expression of myogenic marker genes including PAX7, MYF5, MYOD and MYOG. Muscle derived mononuclear cells were further isolated and induced myogenesis in vitro. More myotubes and a higher degree of myogenesis was observed in vitamin A groups. Consistently, vitamin A increased Latissimus dorsi (LD) muscle fiber size at harvest. In addition, vitamin A increased the ratio of oxidative type I and type IIA fibers and reduced the glycolic type IIX fibers. Furthermore, we found that RA, a key bioactive metabolite of vitamin A, activated PPARGC1A promoter, which explains the upregulated expression of PPARGC1A in skeletal muscle. Vitamin A administration to neonatal calves enhanced postnatal muscle growth by promoting myogenesis and increasing satellite cell density, accompanied with a shift to oxidative muscle fibers.
         datePublished:2018-11-15T00:00:00Z
         dateModified:2018-11-15T00:00:00Z
         pageStart:1
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            Muscle growth
            Myogenesis
            PAX7
            Satellite cells
            Vitamin A
            Agriculture
            Biotechnology
            Food Science
            Animal Genetics and Genomics
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      headline:Neonatal vitamin A injection promotes cattle muscle growth and increases oxidative muscle fibers
      description:Vitamin A and its metabolite, retinoic acid (RA), are important regulators of cell differentiation and organ morphogenesis. Its impact on beef cattle muscle growth remains undefined. Angus steer calves were administrated with 0 (control) or 150,000 IU vitamin A (retinyl palmitate in glycerol, i.m.) per calf at birth and 1 month of age. At 2 months of age, a biopsy of the Biceps femoris muscle was obtained to analyze the immediate effects of vitamin A injection on myogenic capacity of muscle cells. The resulting steers were harvested at 14 months of age. Vitamin A administration increased cattle growth at 2 months. At 2 months of age, Vitamin A increased PAX7 positive satellite cells and the expression of myogenic marker genes including PAX7, MYF5, MYOD and MYOG. Muscle derived mononuclear cells were further isolated and induced myogenesis in vitro. More myotubes and a higher degree of myogenesis was observed in vitamin A groups. Consistently, vitamin A increased Latissimus dorsi (LD) muscle fiber size at harvest. In addition, vitamin A increased the ratio of oxidative type I and type IIA fibers and reduced the glycolic type IIX fibers. Furthermore, we found that RA, a key bioactive metabolite of vitamin A, activated PPARGC1A promoter, which explains the upregulated expression of PPARGC1A in skeletal muscle. Vitamin A administration to neonatal calves enhanced postnatal muscle growth by promoting myogenesis and increasing satellite cell density, accompanied with a shift to oxidative muscle fibers.
      datePublished:2018-11-15T00:00:00Z
      dateModified:2018-11-15T00:00:00Z
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      pageEnd:10
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      keywords:
         Cattle
         Muscle Fiber type
         Muscle growth
         Myogenesis
         PAX7
         Satellite cells
         Vitamin A
         Agriculture
         Biotechnology
         Food Science
         Animal Genetics and Genomics
         Animal Physiology
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      name:Martin Maquivar
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               type:PostalAddress
            type:Organization
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            address:
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               type:PostalAddress
            type:Organization
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      affiliation:
            name:Washington State University
            address:
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               type:PostalAddress
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      name:Mark L Nelson
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            name:Washington State University
            address:
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               type:PostalAddress
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      name:Min Du
      url:http://orcid.org/0000-0002-7232-072X
      affiliation:
            name:Washington State University
            address:
               name:Department of Animal Sciences, Washington State University, Pullman, USA
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      name:State Key Lab of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, People’s Republic of China
      name:Department of Animal Sciences, Washington State University, Pullman, USA
      name:State Key Lab of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, People’s Republic of China
      name:Department of Animal Sciences, Washington State University, Pullman, USA
      name:Department of Animal Sciences, Washington State University, Pullman, USA
      name:Department of Animal Sciences, Louisiana State University, Baton Rouge, USA
      name:Department of Animal Sciences, Washington State University, Pullman, USA
      name:Department of Animal Sciences, Washington State University, Pullman, USA
      name:College of Animal Science and Technology, Gansu Agricultural University, Lanzhou, People’s Republic of China
      name:School of Food Science, Washington State University, Pullman, USA
      name:Department of Animal Sciences, Washington State University, Pullman, USA
      name:College of Veterinary Science, Washington State University, Pullman, USA
      name:Department of Animal Sciences, Washington State University, Pullman, USA
      name:Department of Animal Sciences, Washington State University, Pullman, USA
      name:Department of Animal Sciences, Washington State University, Pullman, USA

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