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Keywords {🔍}

cancer, prostate, pubmed, google, scholar, article, cas, lncrna, cells, lncrnas, central, expression, cell, signaling, progression, wang, proliferation, metastasis, noncoding, role, tumor, promotes, zhang, rna, resistance, long, chen, liu, regulating, therapy, pathway, level, axis, yang, invasion, mol, targeting, apoptosis, immune, growth, migration, nfκb, inhibits, pathways, activation, targets, molecular, wnt, rnas, sun,

Topics {✒️}

tgf-β/pi3k/akt/mtor/nf-kb pathway mir-30a-5p/rab11a/wnt/β-catenin pathway 7a-5p/egfr-related pathway regulates regulating mir-29a-3p/dvl3 axis fak/akt/β-catenin signaling pathway fak/pi3k/akt/gsk3β/snail pathway regulating mir-543-3p/slc39a10/pten axis modulating mmp/timp/nf-κb system tgf-β/smad axis stimulation mir-520a-3p/limk1 axis erk-rhoa-nfκb activation loop mir-27a-5p/top2a axis mir-526b-3p/ccnd1 axis fak/pi3k/akt axis induction lncrna-xist/mir-101-3p/klf6/ activates wnt/β-catenin signaling wnt/β-catenin signaling pathway inducing pi3k/akt/mtor axis trigger hif-1α/notch1 signaling targeting mir-509-3p/pbx3 axis mediating pi3k/akt/mtor signaling regulating mir-211-5p/chi3l1 pathway inactivating wnt/β-catenin pathway pi3k/akt/mtor signaling pathways regulating mir-338-3p/fkbp1a axis regulating mir-195-5p/sept2 axis norad targets mirna-30a-5p modulating mir-9-5p/qki-5 axis exosome-mediated mir-95 transfer tug1/mir-139-5p/smc1a axis regulating mir-181a-5p expression alan prem kumar androgen-reduced prostate-specific lncrna lncrna afap1-as1 modulates microrna-146a promoter modulates akt phosphorylates gsk-3β silencing lncrna mnx1-as1 reducing mirna-15a-5p expression exosome-mediated lncrna delivery nf-κb signaling cascade mir-15a/ccne2 axis mir-125a regulates has1 exosomal lncrna sap30l-as1 lncrna hoxa-as2 promotes mir-593-3p promotes proliferation wnt β-catenin signaling lncrna/pi3k/akt axis lncrna loxl1-as1/mir wnt/β-catenin pathway mir-144-3p/met axis

Questions {❓}

• Extracellular vesicles, the cornerstone of next-generation cancer diagnosis?
• Liquid Biopsy for Cancer: Circulating Tumor Cells, Circulating Free DNA or Exosomes?
• PTEN: What we know of the function and regulation of this onco-suppressor factor in bladder cancer?
• Regulation of Nuclear Factor-KappaB (NF-κB) signaling pathway by non-coding RNAs in cancer: Inhibiting or promoting carcinogenesis?

Schema {🗺️}

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         headline:Molecular Landscape of LncRNAs in Prostate Cancer: A focus on pathways and therapeutic targets for intervention
         description:One of the most malignant tumors in men is prostate cancer that is still incurable due to its heterogenous and progressive natures. Genetic and epigenetic changes play significant roles in its development. The RNA molecules with more than 200 nucleotides in length are known as lncRNAs and these epigenetic factors do not encode protein. They regulate gene expression at transcriptional, post-transcriptional and epigenetic levels. LncRNAs play vital biological functions in cells and in pathological events, hence their expression undergoes dysregulation. The role of epigenetic alterations in prostate cancer development are emphasized here. Therefore, lncRNAs were chosen for this purpose and their expression level and interaction with other signaling networks in prostate cancer progression were examined. The aberrant expression of lncRNAs in prostate cancer has been well-documented and progression rate of tumor cells are regulated via affecting STAT3, NF-κB, Wnt, PI3K/Akt and PTEN, among other molecular pathways. Furthermore, lncRNAs regulate radio-resistance and chemo-resistance features of prostate tumor cells. Overexpression of tumor-promoting lncRNAs such as HOXD-AS1 and CCAT1 can result in drug resistance. Besides, lncRNAs can induce immune evasion of prostate cancer via upregulating PD-1. Pharmacological compounds such as quercetin and curcumin have been applied for targeting lncRNAs. Furthermore, siRNA tool can reduce expression of lncRNAs thereby suppressing prostate cancer progression. Prognosis and diagnosis of prostate tumor at clinical course can be evaluated by lncRNAs. The expression level of exosomal lncRNAs such as lncRNA-p21 can be investigated in serum of prostate cancer patients as a reliable biomarker.
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      headline:Molecular Landscape of LncRNAs in Prostate Cancer: A focus on pathways and therapeutic targets for intervention
      description:One of the most malignant tumors in men is prostate cancer that is still incurable due to its heterogenous and progressive natures. Genetic and epigenetic changes play significant roles in its development. The RNA molecules with more than 200 nucleotides in length are known as lncRNAs and these epigenetic factors do not encode protein. They regulate gene expression at transcriptional, post-transcriptional and epigenetic levels. LncRNAs play vital biological functions in cells and in pathological events, hence their expression undergoes dysregulation. The role of epigenetic alterations in prostate cancer development are emphasized here. Therefore, lncRNAs were chosen for this purpose and their expression level and interaction with other signaling networks in prostate cancer progression were examined. The aberrant expression of lncRNAs in prostate cancer has been well-documented and progression rate of tumor cells are regulated via affecting STAT3, NF-κB, Wnt, PI3K/Akt and PTEN, among other molecular pathways. Furthermore, lncRNAs regulate radio-resistance and chemo-resistance features of prostate tumor cells. Overexpression of tumor-promoting lncRNAs such as HOXD-AS1 and CCAT1 can result in drug resistance. Besides, lncRNAs can induce immune evasion of prostate cancer via upregulating PD-1. Pharmacological compounds such as quercetin and curcumin have been applied for targeting lncRNAs. Furthermore, siRNA tool can reduce expression of lncRNAs thereby suppressing prostate cancer progression. Prognosis and diagnosis of prostate tumor at clinical course can be evaluated by lncRNAs. The expression level of exosomal lncRNAs such as lncRNA-p21 can be investigated in serum of prostate cancer patients as a reliable biomarker.
      datePublished:2022-07-01T00:00:00Z
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         Prostate cancer
         Long non-coding RNA (lncRNA)
         MicroRNA
         Drug resistance
         Immune evasion
         Exosome
         Cancer Research
         Immunology
         Apoptosis
         Oncology
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            address:
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            name:Quchan University of Technology
            address:
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            name:University of Johannesburg
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               name:Department of Chemical Sciences, University of Johannesburg, Johannesburg, South Africa
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      affiliation:
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            address:
               name:Faculty of Engineering and Natural Sciences, Sabanci University, Istanbul, Turkey
               type:PostalAddress
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      name:Alan Prem Kumar
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      affiliation:
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            address:
               name:Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
               type:PostalAddress
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            name:National University of Singapore
            address:
               name:NUS Centre for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Yuzhuo Wang
      url:https://orcid.org/0000-0002-9749-8591
      affiliation:
            name:University of British Columbia
            address:
               name:Department of Urologic Sciences and Vancouver Prostate Centre, University of British Columbia, Vancouver, Canada
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Biology, Faculty of Science, Islamic Azad University, Science and Research Branch, Tehran, Iran
      name:Department of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
      name:Farhikhtegan Medical Convergence sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
      name:Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
      name:NUS Centre for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
      name:Faculty of Veterinary Medicine, Kazerun Branch, Islamic Azad University, Kazerun, Iran
      name:Department of Food Hygiene and Quality Control, Division of epidemiology & Zoonoses, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
      name:Department of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
      name:Farhikhtegan Medical Convergence sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
      name:School of Life, Health & Chemical Sciences, The Open University, Milton Keynes, United Kingdom
      name:Pathology, Sheffield Teaching Hospital, Sheffield, United Kingdom
      name:Department of Biomedical Engineering, Faculty of Engineering and Natural Sciences, Istinye University, Istanbul, Turkey
      name:Department of Urologic Sciences and Vancouver Prostate Centre, University of British Columbia, Vancouver, Canada
      name:Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), Pohang, Korea
      name:School of Engineering, Macquarie University, Sydney, Australia
      name:Department of Tissue Engineering and Biomaterials, School of Advanced Medical Sciences and Technologies, Hamadan University of Medical Sciences, Hamadan, Iran
      name:School of Resources and Environment, University of Electronic Science and Technology of China, Chengdu, PR China
      name:Department of Chemical Engineering, Quchan University of Technology, Quchan, Iran
      name:Department of Chemical Sciences, University of Johannesburg, Johannesburg, South Africa
      name:Faculty of Engineering and Natural Sciences, Sabanci University, Istanbul, Turkey
      name:Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
      name:NUS Centre for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
      name:Department of Urologic Sciences and Vancouver Prostate Centre, University of British Columbia, Vancouver, Canada

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