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Title:
Epigenetic regulation of diverse cell death modalities in cancer: a focus on pyroptosis, ferroptosis, cuproptosis, and disulfidptosis | Journal of Hematology & Oncology
Description:
Tumor is a local tissue hyperplasia resulted from cancerous transformation of normal cells under the action of various physical, chemical and biological factors. The exploration of tumorigenesis mechanism is crucial for early prevention and treatment of tumors. Epigenetic modification is a common and important modification in cells, including DNA methylation, histone modification, non-coding RNA modification and m6A modification. The normal mode of cell death is programmed by cell death-related genes; however, recent researches have revealed some new modes of cell death, including pyroptosis, ferroptosis, cuproptosis and disulfidptosis. Epigenetic regulation of various cell deaths is mainly involved in the regulation of key cell death proteins and affects cell death by up-regulating or down-regulating the expression levels of key proteins. This study aims to investigate the mechanism of epigenetic modifications regulating pyroptosis, ferroptosis, cuproptosis and disulfidptosis of tumor cells, explore possible triggering factors in tumor development from a microscopic point of view, and provide potential targets for tumor therapy and new perspective for the development of antitumor drugs or combination therapies.
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Keywords {π}
pubmed, cancer, article, google, scholar, cell, cas, wang, ferroptosis, central, liu, death, pyroptosis, zhang, tumor, modification, epigenetic, cells, methylation, chen, disulfidptosis, expression, modifications, yang, promotes, cuproptosis, dna, histone, slca, huang, zhou, inhibits, regulation, therapy, carcinoma, rna, apoptosis, prognosis, progression, copper, zhao, growth, mol, pathways, cellular, breast, nlrp, target, inhibitors, genes,
Topics {βοΈ}
regulating mir-125b/foxp3/caspase-1/gsdmd signaling npd-l1/p-stat3 complex increases mettl1-m7g-egfr/efemp1 axis promotes g-egfr/efemp1 axis promotes mettl1/wdr4/arg-tct-4-1 axis [34] mir-146a-5p/traf6 axis m6a-hur-dependent epigenetic silencing enhance t-cell-mediated toxicity triggering tlr4/nlrp3/gsdmd-dependent pyroptosis simvastatin activates nlrp3-caspase-1-il-1Ξ² pri-mir-26a regulates ferroptosis glutathione-resistant copper-based nanomedicine esophageal squamous-cell carcinoma meg3/nlrp3/caspase-1/gsdmd pathway diabetes-induced myocardial injury mir-146a-5p/traf6 [72] promotes acquired chemo-resistance article download pdf cd8β+βt-cell-mediated immunosuppression disulfidptosis-related lncrnas zscan16-as1 histone-lysine n-methyltransferase setd7 double-edged sword effect fda-approved anti-inflammatory agent inhibiting hypoxia-inducible factor triple-negative breast cancer restricts nf-kappab signaling accelerating pri-mir221/222 maturation masked nitrile-oxide electrophiles lymphocyte-specific deconjugation enzymes nk/t-cell lymphoma rptor/ulk1/autophagy axis [36] rptor/ulk1/autophagy axis xiaowei qi nsun2/ybx1/qsox1 axis [32] nsun2/ybx1/qsox1 axis block stress-related ferroptosis attenuate inflammation-induced pyroptosis enzyme-engineered nonporous copper copper-induced cell death heavily post-translationally modified m6a-pd-l1 manner suppress erastin-induced ferroptosis promotes pd-l1 expression immune profile inhibits sorafenib-induced ferroptosis pd-l1-mediated gasdermin cuproptosis-related lncrna signature induces anti-tumor immunity cell death-related genes m6a-ythdf2-dependent manner
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headline:Epigenetic regulation of diverse cell death modalities in cancer: a focus on pyroptosis, ferroptosis, cuproptosis, and disulfidptosis
description:Tumor is a local tissue hyperplasia resulted from cancerous transformation of normal cells under the action of various physical, chemical and biological factors. The exploration of tumorigenesis mechanism is crucial for early prevention and treatment of tumors. Epigenetic modification is a common and important modification in cells, including DNA methylation, histone modification, non-coding RNA modification and m6A modification. The normal mode of cell death is programmed by cell death-related genes; however, recent researches have revealed some new modes of cell death, including pyroptosis, ferroptosis, cuproptosis and disulfidptosis. Epigenetic regulation of various cell deaths is mainly involved in the regulation of key cell death proteins and affects cell death by up-regulating or down-regulating the expression levels of key proteins. This study aims to investigate the mechanism of epigenetic modifications regulating pyroptosis, ferroptosis, cuproptosis and disulfidptosis of tumor cells, explore possible triggering factors in tumor development from a microscopic point of view, and provide potential targets for tumor therapy and new perspective for the development of antitumor drugs or combination therapies.
datePublished:2024-04-23T00:00:00Z
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Pyroptosis
Ferroptosis
Cuproptosis
Disulfidptosis
Oncology
Hematology
Cancer Research
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headline:Epigenetic regulation of diverse cell death modalities in cancer: a focus on pyroptosis, ferroptosis, cuproptosis, and disulfidptosis
description:Tumor is a local tissue hyperplasia resulted from cancerous transformation of normal cells under the action of various physical, chemical and biological factors. The exploration of tumorigenesis mechanism is crucial for early prevention and treatment of tumors. Epigenetic modification is a common and important modification in cells, including DNA methylation, histone modification, non-coding RNA modification and m6A modification. The normal mode of cell death is programmed by cell death-related genes; however, recent researches have revealed some new modes of cell death, including pyroptosis, ferroptosis, cuproptosis and disulfidptosis. Epigenetic regulation of various cell deaths is mainly involved in the regulation of key cell death proteins and affects cell death by up-regulating or down-regulating the expression levels of key proteins. This study aims to investigate the mechanism of epigenetic modifications regulating pyroptosis, ferroptosis, cuproptosis and disulfidptosis of tumor cells, explore possible triggering factors in tumor development from a microscopic point of view, and provide potential targets for tumor therapy and new perspective for the development of antitumor drugs or combination therapies.
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Pyroptosis
Ferroptosis
Cuproptosis
Disulfidptosis
Oncology
Hematology
Cancer Research
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