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LINK . SPRINGER . COM {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Link.springer.com Make Money
  6. Keywords
  7. Topics
  8. Schema
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We are analyzing https://link.springer.com/article/10.1186/s13045-024-01545-6.

Title:
Epigenetic regulation of diverse cell death modalities in cancer: a focus on pyroptosis, ferroptosis, cuproptosis, and disulfidptosis | Journal of Hematology & Oncology
Description:
Tumor is a local tissue hyperplasia resulted from cancerous transformation of normal cells under the action of various physical, chemical and biological factors. The exploration of tumorigenesis mechanism is crucial for early prevention and treatment of tumors. Epigenetic modification is a common and important modification in cells, including DNA methylation, histone modification, non-coding RNA modification and m6A modification. The normal mode of cell death is programmed by cell death-related genes; however, recent researches have revealed some new modes of cell death, including pyroptosis, ferroptosis, cuproptosis and disulfidptosis. Epigenetic regulation of various cell deaths is mainly involved in the regulation of key cell death proteins and affects cell death by up-regulating or down-regulating the expression levels of key proteins. This study aims to investigate the mechanism of epigenetic modifications regulating pyroptosis, ferroptosis, cuproptosis and disulfidptosis of tumor cells, explore possible triggering factors in tumor development from a microscopic point of view, and provide potential targets for tumor therapy and new perspective for the development of antitumor drugs or combination therapies.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {πŸ“š}

  • Health & Fitness
  • Science
  • Education

Content Management System {πŸ“}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {πŸ“ˆ}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

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How Does Link.springer.com Make Money? {πŸ’Έ}

We can't see how the site brings in money.

Not every website is profit-driven; some are created to spread information or serve as an online presence. Websites can be made for many reasons. This could be one of them. Link.springer.com could have a money-making trick up its sleeve, but it's undetectable for now.

Keywords {πŸ”}

pubmed, cancer, article, google, scholar, cell, cas, wang, ferroptosis, central, liu, death, pyroptosis, zhang, tumor, modification, epigenetic, cells, methylation, chen, disulfidptosis, expression, modifications, yang, promotes, cuproptosis, dna, histone, slca, huang, zhou, inhibits, regulation, therapy, carcinoma, rna, apoptosis, prognosis, progression, copper, zhao, growth, mol, pathways, cellular, breast, nlrp, target, inhibitors, genes,

Topics {βœ’οΈ}

regulating mir-125b/foxp3/caspase-1/gsdmd signaling npd-l1/p-stat3 complex increases mettl1-m7g-egfr/efemp1 axis promotes g-egfr/efemp1 axis promotes mettl1/wdr4/arg-tct-4-1 axis [34] mir-146a-5p/traf6 axis m6a-hur-dependent epigenetic silencing enhance t-cell-mediated toxicity triggering tlr4/nlrp3/gsdmd-dependent pyroptosis simvastatin activates nlrp3-caspase-1-il-1Ξ² pri-mir-26a regulates ferroptosis glutathione-resistant copper-based nanomedicine esophageal squamous-cell carcinoma meg3/nlrp3/caspase-1/gsdmd pathway diabetes-induced myocardial injury mir-146a-5p/traf6 [72] promotes acquired chemo-resistance article download pdf cd8 + t-cell-mediated immunosuppression disulfidptosis-related lncrnas zscan16-as1 histone-lysine n-methyltransferase setd7 double-edged sword effect fda-approved anti-inflammatory agent inhibiting hypoxia-inducible factor triple-negative breast cancer restricts nf-kappab signaling accelerating pri-mir221/222 maturation masked nitrile-oxide electrophiles lymphocyte-specific deconjugation enzymes nk/t-cell lymphoma rptor/ulk1/autophagy axis [36] rptor/ulk1/autophagy axis xiaowei qi nsun2/ybx1/qsox1 axis [32] nsun2/ybx1/qsox1 axis block stress-related ferroptosis attenuate inflammation-induced pyroptosis enzyme-engineered nonporous copper copper-induced cell death heavily post-translationally modified m6a-pd-l1 manner suppress erastin-induced ferroptosis promotes pd-l1 expression immune profile inhibits sorafenib-induced ferroptosis pd-l1-mediated gasdermin cuproptosis-related lncrna signature induces anti-tumor immunity cell death-related genes m6a-ythdf2-dependent manner

Schema {πŸ—ΊοΈ}

WebPage:
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         headline:Epigenetic regulation of diverse cell death modalities in cancer: a focus on pyroptosis, ferroptosis, cuproptosis, and disulfidptosis
         description:Tumor is a local tissue hyperplasia resulted from cancerous transformation of normal cells under the action of various physical, chemical and biological factors. The exploration of tumorigenesis mechanism is crucial for early prevention and treatment of tumors. Epigenetic modification is a common and important modification in cells, including DNA methylation, histone modification, non-coding RNA modification and m6A modification. The normal mode of cell death is programmed by cell death-related genes; however, recent researches have revealed some new modes of cell death, including pyroptosis, ferroptosis, cuproptosis and disulfidptosis. Epigenetic regulation of various cell deaths is mainly involved in the regulation of key cell death proteins and affects cell death by up-regulating or down-regulating the expression levels of key proteins. This study aims to investigate the mechanism of epigenetic modifications regulating pyroptosis, ferroptosis, cuproptosis and disulfidptosis of tumor cells, explore possible triggering factors in tumor development from a microscopic point of view, and provide potential targets for tumor therapy and new perspective for the development of antitumor drugs or combination therapies.
         datePublished:2024-04-23T00:00:00Z
         dateModified:2024-04-23T00:00:00Z
         pageStart:1
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         license:http://creativecommons.org/publicdomain/zero/1.0/
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         keywords:
            Epigenetic modification
            Pyroptosis
            Ferroptosis
            Cuproptosis
            Disulfidptosis
            Oncology
            Hematology
            Cancer Research
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                     address:
                        name:Department of Breast and Thyroid Surgery, Southwest Hospital, Army Medical University, Chongqing, China
                        type:PostalAddress
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                     name:Key Laboratory of Chongqing Health Commission for Minimally Invasive and Precise Diagnosis
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      headline:Epigenetic regulation of diverse cell death modalities in cancer: a focus on pyroptosis, ferroptosis, cuproptosis, and disulfidptosis
      description:Tumor is a local tissue hyperplasia resulted from cancerous transformation of normal cells under the action of various physical, chemical and biological factors. The exploration of tumorigenesis mechanism is crucial for early prevention and treatment of tumors. Epigenetic modification is a common and important modification in cells, including DNA methylation, histone modification, non-coding RNA modification and m6A modification. The normal mode of cell death is programmed by cell death-related genes; however, recent researches have revealed some new modes of cell death, including pyroptosis, ferroptosis, cuproptosis and disulfidptosis. Epigenetic regulation of various cell deaths is mainly involved in the regulation of key cell death proteins and affects cell death by up-regulating or down-regulating the expression levels of key proteins. This study aims to investigate the mechanism of epigenetic modifications regulating pyroptosis, ferroptosis, cuproptosis and disulfidptosis of tumor cells, explore possible triggering factors in tumor development from a microscopic point of view, and provide potential targets for tumor therapy and new perspective for the development of antitumor drugs or combination therapies.
      datePublished:2024-04-23T00:00:00Z
      dateModified:2024-04-23T00:00:00Z
      pageStart:1
      pageEnd:20
      license:http://creativecommons.org/publicdomain/zero/1.0/
      sameAs:https://doi.org/10.1186/s13045-024-01545-6
      keywords:
         Epigenetic modification
         Pyroptosis
         Ferroptosis
         Cuproptosis
         Disulfidptosis
         Oncology
         Hematology
         Cancer Research
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      author:
            name:Shimeng Zhou
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                     type:PostalAddress
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                  name:Key Laboratory of Chongqing Health Commission for Minimally Invasive and Precise Diagnosis
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                     name:Key Laboratory of Chongqing Health Commission for Minimally Invasive and Precise Diagnosis, Chongqing, China
                     type:PostalAddress
                  type:Organization
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            name:Junlan Liu
            affiliation:
                  name:Southwest Hospital, Army Medical University
                  address:
                     name:Department of Breast and Thyroid Surgery, Southwest Hospital, Army Medical University, Chongqing, China
                     type:PostalAddress
                  type:Organization
                  name:Key Laboratory of Chongqing Health Commission for Minimally Invasive and Precise Diagnosis
                  address:
                     name:Key Laboratory of Chongqing Health Commission for Minimally Invasive and Precise Diagnosis, Chongqing, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Andi Wan
            affiliation:
                  name:Southwest Hospital, Army Medical University
                  address:
                     name:Department of Breast and Thyroid Surgery, Southwest Hospital, Army Medical University, Chongqing, China
                     type:PostalAddress
                  type:Organization
                  name:Key Laboratory of Chongqing Health Commission for Minimally Invasive and Precise Diagnosis
                  address:
                     name:Key Laboratory of Chongqing Health Commission for Minimally Invasive and Precise Diagnosis, Chongqing, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yi Zhang
            affiliation:
                  name:Southwest Hospital, Army Medical University
                  address:
                     name:Department of Breast and Thyroid Surgery, Southwest Hospital, Army Medical University, Chongqing, China
                     type:PostalAddress
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                  name:Key Laboratory of Chongqing Health Commission for Minimally Invasive and Precise Diagnosis
                  address:
                     name:Key Laboratory of Chongqing Health Commission for Minimally Invasive and Precise Diagnosis, Chongqing, China
                     type:PostalAddress
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            type:Person
            name:Xiaowei Qi
            affiliation:
                  name:Southwest Hospital, Army Medical University
                  address:
                     name:Department of Breast and Thyroid Surgery, Southwest Hospital, Army Medical University, Chongqing, China
                     type:PostalAddress
                  type:Organization
                  name:Key Laboratory of Chongqing Health Commission for Minimally Invasive and Precise Diagnosis
                  address:
                     name:Key Laboratory of Chongqing Health Commission for Minimally Invasive and Precise Diagnosis, Chongqing, China
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      name:Journal of Hematology & Oncology
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      volumeNumber:17
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      name:BioMed Central
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      name:Southwest Hospital, Army Medical University
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         name:Department of Breast and Thyroid Surgery, Southwest Hospital, Army Medical University, Chongqing, China
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         name:Key Laboratory of Chongqing Health Commission for Minimally Invasive and Precise Diagnosis, Chongqing, China
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      name:Southwest Hospital, Army Medical University
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         name:Department of Breast and Thyroid Surgery, Southwest Hospital, Army Medical University, Chongqing, China
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         name:Key Laboratory of Chongqing Health Commission for Minimally Invasive and Precise Diagnosis, Chongqing, China
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      name:Key Laboratory of Chongqing Health Commission for Minimally Invasive and Precise Diagnosis
      address:
         name:Key Laboratory of Chongqing Health Commission for Minimally Invasive and Precise Diagnosis, Chongqing, China
         type:PostalAddress
      name:Southwest Hospital, Army Medical University
      address:
         name:Department of Breast and Thyroid Surgery, Southwest Hospital, Army Medical University, Chongqing, China
         type:PostalAddress
      name:Key Laboratory of Chongqing Health Commission for Minimally Invasive and Precise Diagnosis
      address:
         name:Key Laboratory of Chongqing Health Commission for Minimally Invasive and Precise Diagnosis, Chongqing, China
         type:PostalAddress
      name:Southwest Hospital, Army Medical University
      address:
         name:Department of Breast and Thyroid Surgery, Southwest Hospital, Army Medical University, Chongqing, China
         type:PostalAddress
      name:Key Laboratory of Chongqing Health Commission for Minimally Invasive and Precise Diagnosis
      address:
         name:Key Laboratory of Chongqing Health Commission for Minimally Invasive and Precise Diagnosis, Chongqing, China
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Shimeng Zhou
      affiliation:
            name:Southwest Hospital, Army Medical University
            address:
               name:Department of Breast and Thyroid Surgery, Southwest Hospital, Army Medical University, Chongqing, China
               type:PostalAddress
            type:Organization
            name:Key Laboratory of Chongqing Health Commission for Minimally Invasive and Precise Diagnosis
            address:
               name:Key Laboratory of Chongqing Health Commission for Minimally Invasive and Precise Diagnosis, Chongqing, China
               type:PostalAddress
            type:Organization
      name:Junlan Liu
      affiliation:
            name:Southwest Hospital, Army Medical University
            address:
               name:Department of Breast and Thyroid Surgery, Southwest Hospital, Army Medical University, Chongqing, China
               type:PostalAddress
            type:Organization
            name:Key Laboratory of Chongqing Health Commission for Minimally Invasive and Precise Diagnosis
            address:
               name:Key Laboratory of Chongqing Health Commission for Minimally Invasive and Precise Diagnosis, Chongqing, China
               type:PostalAddress
            type:Organization
      name:Andi Wan
      affiliation:
            name:Southwest Hospital, Army Medical University
            address:
               name:Department of Breast and Thyroid Surgery, Southwest Hospital, Army Medical University, Chongqing, China
               type:PostalAddress
            type:Organization
            name:Key Laboratory of Chongqing Health Commission for Minimally Invasive and Precise Diagnosis
            address:
               name:Key Laboratory of Chongqing Health Commission for Minimally Invasive and Precise Diagnosis, Chongqing, China
               type:PostalAddress
            type:Organization
      name:Yi Zhang
      affiliation:
            name:Southwest Hospital, Army Medical University
            address:
               name:Department of Breast and Thyroid Surgery, Southwest Hospital, Army Medical University, Chongqing, China
               type:PostalAddress
            type:Organization
            name:Key Laboratory of Chongqing Health Commission for Minimally Invasive and Precise Diagnosis
            address:
               name:Key Laboratory of Chongqing Health Commission for Minimally Invasive and Precise Diagnosis, Chongqing, China
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Xiaowei Qi
      affiliation:
            name:Southwest Hospital, Army Medical University
            address:
               name:Department of Breast and Thyroid Surgery, Southwest Hospital, Army Medical University, Chongqing, China
               type:PostalAddress
            type:Organization
            name:Key Laboratory of Chongqing Health Commission for Minimally Invasive and Precise Diagnosis
            address:
               name:Key Laboratory of Chongqing Health Commission for Minimally Invasive and Precise Diagnosis, Chongqing, China
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Breast and Thyroid Surgery, Southwest Hospital, Army Medical University, Chongqing, China
      name:Key Laboratory of Chongqing Health Commission for Minimally Invasive and Precise Diagnosis, Chongqing, China
      name:Department of Breast and Thyroid Surgery, Southwest Hospital, Army Medical University, Chongqing, China
      name:Key Laboratory of Chongqing Health Commission for Minimally Invasive and Precise Diagnosis, Chongqing, China
      name:Department of Breast and Thyroid Surgery, Southwest Hospital, Army Medical University, Chongqing, China
      name:Key Laboratory of Chongqing Health Commission for Minimally Invasive and Precise Diagnosis, Chongqing, China
      name:Department of Breast and Thyroid Surgery, Southwest Hospital, Army Medical University, Chongqing, China
      name:Key Laboratory of Chongqing Health Commission for Minimally Invasive and Precise Diagnosis, Chongqing, China
      name:Department of Breast and Thyroid Surgery, Southwest Hospital, Army Medical University, Chongqing, China
      name:Key Laboratory of Chongqing Health Commission for Minimally Invasive and Precise Diagnosis, Chongqing, China

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