We are analyzing https://link.springer.com/article/10.1186/s13045-015-0224-3.

Title:
ABT-199 (venetoclax) and BCL-2 inhibitors in clinical development | Journal of Hematology & Oncology
Description:
With the advent of new agents targeting CD20, Bruton’s tyrosine kinase, and phosphoinositol-3 kinase for chronic lymphoid leukemia (CLL), more treatment options exist than ever before. B-cell lymphoma-2 (BCL-2) plays a major role in cellular apoptosis and is a druggable target. Small molecule inhibitors of BCL-2 are in active clinical studies. ABT-199 (venetoclax, RG7601, GDC-0199) has been granted breakthrough designation by FDA for relapsed or refractory CLL with 17p deletion. In this review, we summarized the latest clinical development of ABT-199/venetoclax and other novel agents targeting the BCL-2 proteins.
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Keywords {🔍}

pubmed, abt, google, scholar, article, bcl, patients, cas, central, leukemia, cell, lymphoma, cll, proteins, cancer, phase, study, cells, oncol, chronic, combination, hematol, inhibitors, inhibitor, blood, lymphocytic, family, mcl, clinical, activity, nct, liu, apoptosis, gdc, bclxl, dose, malignancies, acute, vivo, dosing, relapsedrefractory, pts, death, thrombocytopenia, response, med, treatment, role, studies, relapsed,

Topics {✒️}

chronic lymphocytic leukaemia chimeric t-cell receptors diffuse large b-cell adult t-cell leukemia/lymphoma preventing pi3k/akt/mtor activation chimeric antigen receptor-engineered apoptosis-inducing factor article download pdf t-cell immune suppression cd19-negative relapses occurring relapsed cd30-positive lymphomas aggressive myc-driven lymphomas nk cell-mediated immunotherapy anti-cd19 monoclonal antibody small-cell lung cancer chimeric antigen receptor nk cell-specific antibodies anti-apoptotic bcl-2 proteins anti-apoptotic proteins bcl-2 b-cell lymphoma-2 xpo1/crm1-selective inhibitors cml stem/progenitor cells acute myeloid leukemia tyrosine kinase inhibitors chronic lymphocytic leukemia targeted high-affinity inhibitor bcl-xl-dependent resistance bcl-xl levels culminating bcl-2-related protein a1 inhibitory manner tetravalent bispecific tandab nucleo-cytoplasmic transport acute lymphoblastic leukemia b-cell malignancies bcl-2-specific bh3 mimetic dose-limiting severe thrombocytopenia chronic lymphoid leukemia mantle cell lymphoma median progression-free survival privacy choices/manage cookies cd30+ tumor cells anti-apoptotic proteins anti-apoptotic protein furman rr van oers mh high-risk relapsed/refractory small lymphocytic lymphoma henan cancer hospital cell death differ cell death dis

Questions {❓}

BTKi, venetoclax, obinutuzumab: what is the ideal combination?
Role of Bcl-2 family proteins in apoptosis: apoptosomes or mitochondria?

Schema {🗺️}

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         headline:ABT-199 (venetoclax) and BCL-2 inhibitors in clinical development
         description:With the advent of new agents targeting CD20, Bruton’s tyrosine kinase, and phosphoinositol-3 kinase for chronic lymphoid leukemia (CLL), more treatment options exist than ever before. B-cell lymphoma-2 (BCL-2) plays a major role in cellular apoptosis and is a druggable target. Small molecule inhibitors of BCL-2 are in active clinical studies. ABT-199 (venetoclax, RG7601, GDC-0199) has been granted breakthrough designation by FDA for relapsed or refractory CLL with 17p deletion. In this review, we summarized the latest clinical development of ABT-199/venetoclax and other novel agents targeting the BCL-2 proteins.
         datePublished:2015-11-20T00:00:00Z
         dateModified:2015-11-20T00:00:00Z
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            Mantle Cell Lymphoma
            Overall Response Rate
            Nilotinib
            Bendamustine
            Oncology
            Hematology
            Cancer Research
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      headline:ABT-199 (venetoclax) and BCL-2 inhibitors in clinical development
      description:With the advent of new agents targeting CD20, Bruton’s tyrosine kinase, and phosphoinositol-3 kinase for chronic lymphoid leukemia (CLL), more treatment options exist than ever before. B-cell lymphoma-2 (BCL-2) plays a major role in cellular apoptosis and is a druggable target. Small molecule inhibitors of BCL-2 are in active clinical studies. ABT-199 (venetoclax, RG7601, GDC-0199) has been granted breakthrough designation by FDA for relapsed or refractory CLL with 17p deletion. In this review, we summarized the latest clinical development of ABT-199/venetoclax and other novel agents targeting the BCL-2 proteins.
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         Follicular Lymphoma
         Mantle Cell Lymphoma
         Overall Response Rate
         Nilotinib
         Bendamustine
         Oncology
         Hematology
         Cancer Research
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               type:PostalAddress
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      affiliation:
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            address:
               name:Henan Cancer Hospital and the Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China
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