We are analyzing https://link.springer.com/article/10.1186/s12951-022-01635-y.

Title:
Enhanced natural killer cell anti-tumor activity with nanoparticles mediated ferroptosis and potential therapeutic application in prostate cancer | Journal of Nanobiotechnology
Description:
Ferroptosis provides an opportunity to overcome the cancer cell therapeutic resistance and modulate the immune system. Here an interaction between ferroptosis of cancer cells and natural killer (NK) cells was investigated with a clinical grade iron oxide nanoparticle (ferumoxytol) for potential synergistic anti-cancer effect of ferroptosis and NK cell therapy in prostate cancer. When ferumoxytol mediated ferroptosis of cancer cells was combined with NK cells, the NK cells’ cytotoxic function was increased. Observed ferroptosis mediated NK cell activation was also confirmed with IFN-γ secretion and lytic degranulation. Upregulation of ULBPs, which is one of the ligands for NK cell activating receptor NKG2D, was observed in the co-treatment of ferumoxytol mediated ferroptosis and NK cells. Additionally, HMGB1 and PD-L1 expression of cancer cells were observed in the treatment of ferroptosis + NK cells. Finally, in vivo therapeutic efficacy of ferumoxytol mediated ferroptosis and NK cell therapy was observed with significant tumor volume regression in a prostate cancer mice model. These results suggest that the NK cells’ function can be enhanced with ferumoxytol mediated ferroptosis.
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28 years and 1 months (reg. 1997-05-29).

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Keywords {🔍}

cells, cell, ferroptosis, cancer, ferumoxytol, pubmed, article, google, scholar, mediated, treatment, therapy, fig, tumor, cas, immune, prostate, nkmi, apdl, mice, group, treated, enhanced, effect, expression, central, activation, tumors, therapeutic, kim, natural, killer, iron, flow, potential, cytotoxic, additional, data, nanoparticles, cytometry, analysis, anticancer, ifnγ, combination, groups, killing, showed, death, images, significantly,

Topics {✒️}

metal–organic framework nanoparticles nk cell + ferumoxytol + apd-l1 compared designing ferroptosis-based immuno-therapies nk cell + ferumoxytol + apd-l1 ferumoxytol + nk cells + apd-l1 nk cells + ferumoxytol + apd-l1 synergistic anti-cancer effect enhanced anti-cancer effect dong-hyun kim full size image dong-hwan kim enzyme-linked immunosorbent assay nk-92mi + fer-apdl1 group nk cell-based therapy cationic nanoparticle-mediated activation goat anti-rabbit igg inhibiting nrf2/ho-1 pathway ferroptosis-induced cancer therapy article download pdf anti-human cd107a-apc intra-tumoral nk cells activation receptor/ligand interaction nutrient-deprived cancer cells cancer cell therapeutic-resistance nk cell + ferroptosis enhanced nk-92mi cell injection nk cell + ferumoxytol compared iron based nanoparticles microenvironment-driven sequential ferroptosis nk-92mi + ferumoxytol group vivo expansion/activation technology ferroptotic cell death ferroptosis mediated enhancement additional apd-l1 treatment 4 mm l-glutamine adjusted 005 mg/ml bovine insulin ferumoxytol + nk cell treatment min jun ko her2-amplified brain tumors ferroptotic cancer cells image guided delivery induces specific killing cd19-positive lymphoid tumors immune suppressive tme anti-cancer immunity nk-92mi treated group cancer specific therapy chain-related protein cell immuno-therapy treatment ferumoxytol + nk-92mi

Schema {🗺️}

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         headline:Enhanced natural killer cell anti-tumor activity with nanoparticles mediated ferroptosis and potential therapeutic application in prostate cancer
         description:Ferroptosis provides an opportunity to overcome the cancer cell therapeutic resistance and modulate the immune system. Here an interaction between ferroptosis of cancer cells and natural killer (NK) cells was investigated with a clinical grade iron oxide nanoparticle (ferumoxytol) for potential synergistic anti-cancer effect of ferroptosis and NK cell therapy in prostate cancer. When ferumoxytol mediated ferroptosis of cancer cells was combined with NK cells, the NK cells’ cytotoxic function was increased. Observed ferroptosis mediated NK cell activation was also confirmed with IFN-γ secretion and lytic degranulation. Upregulation of ULBPs, which is one of the ligands for NK cell activating receptor NKG2D, was observed in the co-treatment of ferumoxytol mediated ferroptosis and NK cells. Additionally, HMGB1 and PD-L1 expression of cancer cells were observed in the treatment of ferroptosis + NK cells. Finally, in vivo therapeutic efficacy of ferumoxytol mediated ferroptosis and NK cell therapy was observed with significant tumor volume regression in a prostate cancer mice model. These results suggest that the NK cells’ function can be enhanced with ferumoxytol mediated ferroptosis.
         datePublished:2022-09-29T00:00:00Z
         dateModified:2022-09-29T00:00:00Z
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            Nanomedicine
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            Biotechnology
            Nanotechnology
            Molecular Medicine
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      headline:Enhanced natural killer cell anti-tumor activity with nanoparticles mediated ferroptosis and potential therapeutic application in prostate cancer
      description:Ferroptosis provides an opportunity to overcome the cancer cell therapeutic resistance and modulate the immune system. Here an interaction between ferroptosis of cancer cells and natural killer (NK) cells was investigated with a clinical grade iron oxide nanoparticle (ferumoxytol) for potential synergistic anti-cancer effect of ferroptosis and NK cell therapy in prostate cancer. When ferumoxytol mediated ferroptosis of cancer cells was combined with NK cells, the NK cells’ cytotoxic function was increased. Observed ferroptosis mediated NK cell activation was also confirmed with IFN-γ secretion and lytic degranulation. Upregulation of ULBPs, which is one of the ligands for NK cell activating receptor NKG2D, was observed in the co-treatment of ferumoxytol mediated ferroptosis and NK cells. Additionally, HMGB1 and PD-L1 expression of cancer cells were observed in the treatment of ferroptosis + NK cells. Finally, in vivo therapeutic efficacy of ferumoxytol mediated ferroptosis and NK cell therapy was observed with significant tumor volume regression in a prostate cancer mice model. These results suggest that the NK cells’ function can be enhanced with ferumoxytol mediated ferroptosis.
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         Ferroptosis
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         Nanotechnology
         Molecular Medicine
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               name:Department of Biomedical Engineering, University of Illinois, Chicago, USA
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               type:PostalAddress
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      name:Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, USA
      name:Department of Biomedical Engineering, University of Illinois, Chicago, USA
      name:Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, USA
      name:School of Chemical Engineering, Sungkyunkwan University (SKKU), Suwon, Korea
      name:Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, USA
      name:Department of Biomedical Engineering, University of Illinois, Chicago, USA
      name:Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, USA
      name:Department of Biomedical Engineering, McCormick School of Engineering, Northwestern University, Evanston, USA

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