NCBI . NLM . NIH . GOV {
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Title[redir]:
Noncompetitive allosteric inhibitors of the inflammatory chemokine receptors CXCR1 and CXCR2: Prevention of reperfusion injury - PMC
Description:
The chemokine CXC ligand 8 (CXCL8)/IL-8 and related agonists recruit and activate polymorphonuclear cells by binding the CXC chemokine receptor 1 (CXCR1) and CXCR2. Here we characterize the unique mode of action of a small-molecule inhibitor ...
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Keywords {🔍}
repertaxin, cxcr, cxcl, pmn, binding, fig, google, scholar, pubmed, doi, data, migration, receptors, open, animals, reperfusion, receptor, site, interaction, human, transfectants, model, squares, allosteric, supporting, clp, filled, noncompetitive, chemokine, activity, interactions, induced, group, ischaemia, experiment, radiolabeled, cell, cxcrl, hydrophobic, shown, pmc, inhibitors, cells, molecular, vehicle, results, inhibited, ccr, nlm, inhibitor,
Topics {✒️}
10 nm n-formyl-l-methionyl-l-leucyl-l-phenylalanine n-formyl-l-methionyl-l-leucyl-l-phenylalanine n-terminal modified chemokines high-density oligonucleotide arrays double-stranded dna sequencing pmc beta search cxcl8-dependent gene regulation support cxcl8-induced chemotaxis cxcl8-elicited pmn chemotaxis peptide-based inhibitors acting inhibit cxcl8-induced chemotaxis putative ketoprofen-binding site tm1/tm3 hydrophobic pocket molecular mechanics methods tyr-258 tm6–glu-291 tm7 cc chemokine receptor lys-99 tm2–asn-120 tm3 molecular dynamics calculations nonsteroidal antiinflammatory drugs pnas web site intracellular calcium increase l-lysine inhibited ccr1 responses structure activity relationship irreversible hepatic damage wild-type cxcr1 publisher site pdf hydrophobic interactions play gaetano d'anniballe conjugate gradient algorithms handheld uv illuminator alanin-aminotransferase levels reactive oxygen intermediates ile-43 additionally contributes flat blue ribbon receptor expression levels rodent animal models downstream signal transduction classical receptor antagonists extracellular domain acting disrupt receptor function delayed graft function cadaver-donor kidneys ligand/receptor interactions related chemokine receptors key lipophilic interactions mediating cxcl8 chemotaxis anti-pyk2 antibody license information pmcid gene expression analysis
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