We are analyzing https://link.springer.com/article/10.1186/s12935-020-01450-1.

Title:
The biological function of m6A demethylase ALKBH5 and its role in human disease | Cancer Cell International
Description:
Human AlkB homolog H5 (ALKBH5) is a primary m6A demethylase, which is dysregulated and acts as a biological and pharmacological role in human cancers or non-cancers. ALKBH5 plays a dual role in various cancers through regulating kinds of biological processes, such as proliferation, migration, invasion, metastasis and tumor growth. In addition, it takes a great part in human non-cancer, including reproductive system diseases. The underlying regulatory mechanisms of ALKBH5 that relys on m6A-dependent modification are implicated with long non-coding RNA, cancer stem cell, autophagy and hypoxia. ALKBH5 is also an independent prognostic indicator in various cancers. In this review, we summarized the current evidence on ALKBH5 in diverse human cancers or non-cancers and its potential as a prognostic target.
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Keywords {🔍}

alkbh, cancer, pubmed, article, google, scholar, cas, cells, rna, human, cell, wang, expression, role, cancers, central, demethylase, mechanisms, invasion, breast, methylation, mrna, pancreatic, zhang, tumor, stem, metastasis, foxm, proliferation, lung, chen, biological, modification, autophagy, demethylation, yang, noncancers, diseases, long, hypoxia, signaling, glioblastoma, nanjing, data, research, jinyan, zhu, great, reproductive, system,

Topics {✒️}

preliminary x-ray diffraction dead-box rna helicases regulating mir-107/lats2 axis triple-negative breast cancer n6-methyladenosine-independent manner article download pdf hypoxia/reoxygenation treated cardiomyocytes hypoxia/reoxygenation-treated cardiomyocytes mettl3-mediated m6a methylation pancreatic ductal adenocarcinoma akt signaling pathway lysosomal-autophagic pathway alkbh5-deficient male mice mrna-enriched rna fractions understanding m6a modifications alkbh5-mediated m6a-demethylation privacy choices/manage cookies ythdfs-mediated yap primary m6a demethylase single-nucleotide polymorphisms cancer stem cell key residues related breast cancer cell hypoxia-inducible factor n6-methyladenosine detected disordered conformational state reproductive system diseases related subjects specific clinicopathological features cell proliferation program epithelial ovarian cancer cancer cell proliferation m6a rna methylation full access cancer cell int cancer-specific survival primary tumor formation cancer stem cells modulating m6a methylation mediating wnt signaling pancreatic cancer cells nucleic acids res famous m6a demethylase breast cancer cells famous signaling pathways nf-κb signaling creative commons licence including breast cancer lung adenocarcinoma cells mammalian rna demethylase

Schema {🗺️}

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         headline:The biological function of m6A demethylase ALKBH5 and its role in human disease
         description:Human AlkB homolog H5 (ALKBH5) is a primary m6A demethylase, which is dysregulated and acts as a biological and pharmacological role in human cancers or non-cancers. ALKBH5 plays a dual role in various cancers through regulating kinds of biological processes, such as proliferation, migration, invasion, metastasis and tumor growth. In addition, it takes a great part in human non-cancer, including reproductive system diseases. The underlying regulatory mechanisms of ALKBH5 that relys on m6A-dependent modification are implicated with long non-coding RNA, cancer stem cell, autophagy and hypoxia. ALKBH5 is also an independent prognostic indicator in various cancers. In this review, we summarized the current evidence on ALKBH5 in diverse human cancers or non-cancers and its potential as a prognostic target.
         datePublished:2020-07-28T00:00:00Z
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            Cancer Research
            Cell Biology
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      headline:The biological function of m6A demethylase ALKBH5 and its role in human disease
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      dateModified:2020-07-28T00:00:00Z
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         Non-cancer
         Mechanisms
         Prognosis
         Cancer Research
         Cell Biology
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