NCBI . NLM . NIH . GOV {
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We began analyzing https://pmc.ncbi.nlm.nih.gov/articles/PMC3985658/, but it redirected us to https://pmc.ncbi.nlm.nih.gov/articles/PMC3985658/. The analysis below is for the second page.
Title[redir]:
Structure of human RNA N6-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation - PMC
Description:
ALKBH5 is a 2-oxoglutarate (2OG) and ferrous iron-dependent nucleic acid oxygenase (NAOX) that catalyzes the demethylation of N6-methyladenine in RNA. ALKBH5 is upregulated under hypoxia and plays a role in spermatogenesis. We describe a crystal ...
Title[redir]:
Structure of human RNA N6-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation - PMC
Description:
ALKBH5 is a 2-oxoglutarate (2OG) and ferrous iron-dependent nucleic acid oxygenase (NAOX) that catalyzes the demethylation of N6-methyladenine in RNA. ALKBH5 is upregulated under hypoxia and plays a role in spermatogenesis. We describe a crystal ...
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Keywords {🔍}
doi, alkbh, google, scholar, pubmed, fto, figure, pmc, residues, article, binding, free, site, structure, alkb, substrate, rna, active, observed, oxygenases, activity, loop, pdb, nrl, supplementary, dsbh, dna, iox, chem, conserved, protein, structural, sequence, acid, data, nucleic, human, demethylation, schofield, oxygenase, crystal, βivv, nature, biol, naoxs, inhibitors, domain, cell, complex, arg,
Topics {✒️}
core double-stranded β-helix-fold meta-generalized-gradient-approximation density functional anti-parallel β-strands βi–viii colle-salvetti correlation-energy formula dft-m06-2x/6-31g level s-adenosyl methionine-dependent methyltransferase anti-parallel strand β5 pmc beta search 0σ mfo-dfc omit 0σ mfo–dfc omit n-terminal acetyltransferase natb arg–ser-rich regions c1-chlorinated isoquinoline derivatives tet-mediated 5mc oxidation c18 sep-pak cartridge refined scx-based approach reverse dna/rna damage tyr108 π-stacks directly mrna n6-adenosine methyltransferase c-terminal methyltransferase domain comprehensive python-based system n-terminal acetylome analyses iron-dependent oxygenase enzymes thiol/disulfide ‘redox shuffle primary oxidative demethylase high-throughput sequencing methods direct base-stacking mode ten-eleven translocation enzymes small molecule-based therapeutics preferentially catalyzes n-demethylation enzyme-derived histidine ligands n-terminal helix α1 multiple post-translational modifications hexahistidine-tagged alkbh566–292 construct double-stranded dna 2og c5-carboxylate binding 2og c1-carboxylate binding position-specific scoring matrices context-dependent physiological roles hypoxia-inducible factor 1alpha alkb-tri-nucleotide structure maldi-tof mass spectrometry substrate recognition/selection elements small-molecule-based inhibition single-stranded dna single-stranded rna mammalian rna demethylase naox–2og/nog complexes 2og oxygenase–substrate structures lyase activity independent
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- https://www.nlm.nih.gov/'s financial summary
- https://www.nih.gov/ income
- How much does https://www.hhs.gov/ rake in every month?
- Learn about the earnings of https://www.usa.gov/
Analytics and Tracking {📊}
- Google Analytics
- Google Analytics 4
- Google Tag Manager
Libraries {📚}
- Backbone.js
- jQuery
- jQuery module (jquery-3.6.0)
- Zoom.js
Emails and Hosting {✉️}
Mail Servers:
- nihcesxway.hub.nih.gov
- nihcesxway2.hub.nih.gov
- nihcesxway3.hub.nih.gov
- nihcesxway4.hub.nih.gov
- nihcesxway5.hub.nih.gov
Name Servers:
- dns1-ncbi.ncbi.nlm.nih.gov
- dns2-ncbi.ncbi.nlm.nih.gov
- lhcns1.nlm.nih.gov
- lhcns2.nlm.nih.gov
CDN Services {📦}
- Ncbi