We are analyzing https://link.springer.com/article/10.1186/s12935-020-01412-7.

Title:
LncRNA & Wnt signaling in colorectal cancer | Cancer Cell International
Description:
The outlook for new therapeutic approaches is pivotal to ameliorate the deterioration caused by the abrogated Wnt signaling. Long non-coding RNAs (lncRNAs) are tiny molecules that have begun emerging as vital molecular manager for the regulation of various cellular processes at transcription and translation levels in the colorectal cancer (CRC). Targeting Wnt pathway with lncRNA seems a promising approach to eradicate CRC. However, little is known of their active role in commencing both apoptosis and proliferation in CRC. This article  reviews the importance of these molecules in the pathogenesis of CRC and also emphasizes on the development of new therapeutic strategies to cope with the Wnt mediated CRC.
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Keywords {🔍}

crc, pubmed, cancer, wnt, article, signaling, google, scholar, cas, lncrna, expression, cell, lncrnas, central, colorectal, growth, cells, noncoding, role, rna, βcatenin, metastasis, long, differentiation, transcription, pathway, proliferation, myc, zhang, stem, ccat, tumor, cascade, gene, development, promotes, interaction, reported, factor, chen, progression, therapeutic, wang, protein, complex, overexpression, mira, data, pvt, rnas,

Topics {✒️}

lncrna-apc1-silenced crc cells promoted angiogenesis mir-203a-3p significantly reduced beta-catenin-dependent wnt pathway mir-181a-5p negatively modulated wnt/β-catenin/sox2 pathway wnt/beta-catenin signaling pathway repressing wnt/beta-catenin signaling wnt/β-catenin signaling pathway regulating wnt/beta-catenin signaling promotes gsk-3β-dependent phosphorylation regulates essential rb-e2f context-specific afferent ligands article download pdf wnt/beta-catenin pathway wnt/beta-catenin signaling target hmga2-mediated emt large-scale database analysis somatic copy-number alteration beta-catenin-tcf signaling mir-203a-3p wnt/β-catenin pathway wnt/β-catenin signaling wnt/β-catenin pathways cdk8-beta-catenin signaling exert allele-specific effects beta-catenin-tcf complex proteasome-mediated destruction complex khushbukhat khan mir-34a directly targets micro-rna genes mir15 single-nucleotide polymorphism design oligonucleotide-based drugs β-catenin destruction complex allele-specific cpg methylation neat1/ddx5/wnt cascade β-catenin/tcf7l2 interaction vascular endothelial growth factor rbm5-as1 promptly increased slco4a1-as1 directly interacts anti-sense oligonucleotides anti-sense orientation anti-proliferative aspects asymmetric cell division inhibit crc cell growth javad sharifi-rad zeb-as1 knockdown resulted beta-catenin pathway sirna-based approaches applied rbm5-as1 directly interacts mir-181a-5p

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WebPage:
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         headline:LncRNA & Wnt signaling in colorectal cancer
         description:The outlook for new therapeutic approaches is pivotal to ameliorate the deterioration caused by the abrogated Wnt signaling. Long non-coding RNAs (lncRNAs) are tiny molecules that have begun emerging as vital molecular manager for the regulation of various cellular processes at transcription and translation levels in the colorectal cancer (CRC). Targeting Wnt pathway with lncRNA seems a promising approach to eradicate CRC. However, little is known of their active role in commencing both apoptosis and proliferation in CRC. This article reviews the importance of these molecules in the pathogenesis of CRC and also emphasizes on the development of new therapeutic strategies to cope with the Wnt mediated CRC.
         datePublished:2020-07-20T00:00:00Z
         dateModified:2021-09-19T00:00:00Z
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            Colorectal cancer
            lncRNA
            Therapeutics strategy
            Cancer Research
            Cell Biology
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      headline:LncRNA & Wnt signaling in colorectal cancer
      description:The outlook for new therapeutic approaches is pivotal to ameliorate the deterioration caused by the abrogated Wnt signaling. Long non-coding RNAs (lncRNAs) are tiny molecules that have begun emerging as vital molecular manager for the regulation of various cellular processes at transcription and translation levels in the colorectal cancer (CRC). Targeting Wnt pathway with lncRNA seems a promising approach to eradicate CRC. However, little is known of their active role in commencing both apoptosis and proliferation in CRC. This article reviews the importance of these molecules in the pathogenesis of CRC and also emphasizes on the development of new therapeutic strategies to cope with the Wnt mediated CRC.
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      dateModified:2021-09-19T00:00:00Z
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         Colorectal cancer
         lncRNA
         Therapeutics strategy
         Cancer Research
         Cell Biology
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         type:PostalAddress
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         type:PostalAddress
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         type:PostalAddress
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         name:Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
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            address:
               name:Department of Biotechnology, Balochistan University of Information Technology, Engineering and Management Sciences, Quetta, Pakistan
               type:PostalAddress
            type:Organization
      name:Shahid Raza
      affiliation:
            name:University of Central Punjab
            address:
               name:Department of Biotechnology, University of Central Punjab, Lahore, Pakistan
               type:PostalAddress
            type:Organization
      name:Bahare Salehi
      affiliation:
            name:Bam University of Medical Sciences
            address:
               name:Noncommunicable Diseases Research Center, Bam University of Medical Sciences, Bam, Iran
               type:PostalAddress
            type:Organization
            name:Bam University of Medical Sciences
            address:
               name:Student Research Committee, School of Medicine, Bam University of Medical Sciences, Bam, Iran
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Javad Sharifi-Rad
      url:http://orcid.org/0000-0002-7301-8151
      affiliation:
            name:Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences
            address:
               name:Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:William C. Cho
      affiliation:
            name:Queen Elizabeth Hospital
            address:
               name:Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong, China
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Office for Research Innovation and Commercialization, Lahore Garrison University, Lahore, Pakistan
      name:Atta-ur-Rahman School of Applied Biosciences (ASAB), National University of Sciences and Technology (NUST), Islamabad, Pakistan
      name:Department of Biotechnology, Balochistan University of Information Technology, Engineering and Management Sciences, Quetta, Pakistan
      name:Department of Biotechnology, University of Central Punjab, Lahore, Pakistan
      name:Noncommunicable Diseases Research Center, Bam University of Medical Sciences, Bam, Iran
      name:Student Research Committee, School of Medicine, Bam University of Medical Sciences, Bam, Iran
      name:Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
      name:Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong, China

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