We are analyzing https://link.springer.com/article/10.1186/s12935-015-0221-1.

Title:
Resistance to cancer chemotherapy: failure in drug response from ADME to P-gp | Cancer Cell International
Description:
Cancer chemotherapy resistance (MDR) is the innate and/or acquired ability of cancer cells to evade the effects of chemotherapeutics and is one of the most pressing major dilemmas in cancer therapy. Chemotherapy resistance can arise due to several host or tumor-related factors. However, most current research is focused on tumor-specific factors and specifically genes that handle expression of pumps that efflux accumulated drugs inside malignantly transformed types of cells. In this work, we suggest a wider and alternative perspective that sets the stage for a future platform in modifying drug resistance with respect to the treatment of cancer.
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Keywords {🔍}

pubmed, google, scholar, cas, cancer, drug, resistance, drugs, tumor, central, anticancer, clin, cells, pharmacol, agents, chemotherapy, cell, metabolism, res, protein, human, pgp, expression, pglycoprotein, role, activity, plasma, rev, blood, hypoxia, circadian, excretion, glutathione, biol, multidrug, pharmacokinetics, patients, oral, proteins, cytochrome, ther, factors, overexpression, acid, mrp, chem, mdr, treatment, tumors, sci,

Topics {✒️}

integral molecular/biochemical/metabolic/clinical approach glutathione s-transferase-activated prodrug multidrug-resistance-linked p-glycoprotein xenobiotic-transporting mrp-related proteins γ-secretase inhibitor ro4929097 glutathione s-transferase theta hmg-coa reductase inhibitor hypoxia-inducible factor-1-alpha glutathione-s-transferase pi glutathione s-transferase gstm1 glutathione s-transferase variants central pacemaker located long-awaited magic bullet human small-cell carcinoma doxorubicin-resistant k562 cells lung resistance-related protein capacity-limited renal glucuronidation small-cell lung cancer small-cell lung cancer extracellular signal-regulated kinase famous key-lock model oxa β-lactamase genes carrier-mediated hepatic uptake article download pdf anti-cancer drug resistance hydrogen ion-dependent oncogenesis glutathione s-transferase ii high-fat breakfast shows ph-based etiopathogenic perspective multidrug resistance p-glycoprotein p-glycoprotein-mediated resistance full size image resistance [host–related factors] vascular-targeted therapies hypoxia-induced drug resistance multidrug-resistant cells increased brain p-glycoprotein iii drug metabolism/transport van zomeren dm transfectant cell lines transporter-mediated efflux mrp2-mediated drug resistance powerful nhe1 inhibitors privacy choices/manage cookies glutathione-s-transferase induces p-gp expression otto warburg discovered mediated unifying approach capillary endothelial cells drug-binding plasma proteins

Questions {❓}

Gatenby RA, Gillies RJ (2004) Why do cancers have high aerobic glycolysis?
Kerbel RS (2006) Antiangiogenic therapy: a universal chemosensitization strategy for cancer?
Lis CG, Grutsch JF, Vashi PG, Lammersfeld CA (2003) Is serum albumin an independent predictor of survival in patients with breast cancer?

Schema {🗺️}

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         description:Cancer chemotherapy resistance (MDR) is the innate and/or acquired ability of cancer cells to evade the effects of chemotherapeutics and is one of the most pressing major dilemmas in cancer therapy. Chemotherapy resistance can arise due to several host or tumor-related factors. However, most current research is focused on tumor-specific factors and specifically genes that handle expression of pumps that efflux accumulated drugs inside malignantly transformed types of cells. In this work, we suggest a wider and alternative perspective that sets the stage for a future platform in modifying drug resistance with respect to the treatment of cancer.
         datePublished:2015-07-15T00:00:00Z
         dateModified:2015-07-15T00:00:00Z
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            Resistance
            Pharmacokinetics
            ADME
            pH
            MDR
            Cancer Research
            Cell Biology
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ScholarlyArticle:
      headline:Resistance to cancer chemotherapy: failure in drug response from ADME to P-gp
      description:Cancer chemotherapy resistance (MDR) is the innate and/or acquired ability of cancer cells to evade the effects of chemotherapeutics and is one of the most pressing major dilemmas in cancer therapy. Chemotherapy resistance can arise due to several host or tumor-related factors. However, most current research is focused on tumor-specific factors and specifically genes that handle expression of pumps that efflux accumulated drugs inside malignantly transformed types of cells. In this work, we suggest a wider and alternative perspective that sets the stage for a future platform in modifying drug resistance with respect to the treatment of cancer.
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         Drug
         Resistance
         Pharmacokinetics
         ADME
         pH
         MDR
         Cancer Research
         Cell Biology
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            type:Person
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            affiliation:
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                     name:University of Münster, Münster, Germany
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               type:PostalAddress
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      affiliation:
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            address:
               name:H. Lee Moffitt Cancer Center, Tampa, USA
               type:PostalAddress
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      name:Adil H H Bashir
      affiliation:
            name:University of Khartoum
            address:
               name:Institute of Endemic Diseases, University of Khartoum, Khartoum, Sudan
               type:PostalAddress
            type:Organization
      name:Osama Y Mohammed
      affiliation:
            name:King Saud University
            address:
               name:King Saud University, Riyadh, Kingdom of Saudi Arabia
               type:PostalAddress
            type:Organization
      name:Gamal O Elhassan
      affiliation:
            name:Qassim University
            address:
               name:Uneizah Pharmacy College, Qassim University, AL-Qassim, Kingdom of Saudi Arabia
               type:PostalAddress
            type:Organization
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            address:
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               type:PostalAddress
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      affiliation:
            name:Institute of Clinical Biology and Metabolism
            address:
               name:Institute of Clinical Biology and Metabolism, Vitoria, Spain
               type:PostalAddress
            type:Organization
      name:Stephan J Reshkin
      affiliation:
            name:University of Bari
            address:
               name:Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Bari, Italy
               type:PostalAddress
            type:Organization
      name:Muntaser E Ibrahim
      affiliation:
            name:University of Khartoum
            address:
               name:Institute of Endemic Diseases, University of Khartoum, Khartoum, Sudan
               type:PostalAddress
            type:Organization
      name:Cyril Rauch
      affiliation:
            name:University of Nottingham
            address:
               name:School of Veterinary Medicine and Science, University of Nottingham, Nottingham, UK
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Institute of Endemic Diseases, University of Khartoum, Khartoum, Sudan
      name:University of Münster, Münster, Germany
      name:School of Veterinary Medicine and Science, University of Nottingham, Nottingham, UK
      name:School of Veterinary Medicine and Science, University of Nottingham, Nottingham, UK
      name:Faculty of Pharmacy, University of Khartoum, Khartoum, Sudan
      name:H. Lee Moffitt Cancer Center, Tampa, USA
      name:Institute of Endemic Diseases, University of Khartoum, Khartoum, Sudan
      name:King Saud University, Riyadh, Kingdom of Saudi Arabia
      name:Uneizah Pharmacy College, Qassim University, AL-Qassim, Kingdom of Saudi Arabia
      name:Faculty of Pharmacy, Omdurman Islamic University, Khartoum, Sudan
      name:Institute of Clinical Biology and Metabolism, Vitoria, Spain
      name:Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Bari, Italy
      name:Institute of Endemic Diseases, University of Khartoum, Khartoum, Sudan
      name:School of Veterinary Medicine and Science, University of Nottingham, Nottingham, UK

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