We are analyzing https://link.springer.com/article/10.1186/bcr559.

Title:
Is there a role for Notch signalling in human breast cancer? | Breast Cancer Research
Description:
Aberrant Notch signalling has been observed in several human cancers, including acute T-cell lymphoblastic leukaemia and cervical cancer, and is strongly implicated in tumourigenesis. Unregulated Notch signalling in the mouse mammary gland leads to tumour formation. These results raise the possibility that Notch signalling might play a role in human breast cancer. There are currently few reports that address this question directly and this appears to be an area worthy of further investigation.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Science
Technology & Computing

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 7,643,078 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We don’t know how the website earns money.

Earning money isn't the goal of every website; some are designed to offer support or promote social causes. People have different reasons for creating websites. This might be one such reason. Link.springer.com has a secret sauce for making money, but we can't detect it yet.

Keywords {🔍}

notch, signalling, pubmed, cell, google, scholar, cas, article, cells, cancer, development, expression, mammary, pathway, breast, human, proteins, fate, role, tumour, tcell, protein, domain, signaling, mice, activated, drosophila, central, biol, genes, intracellular, mouse, csl, epithelial, leads, formation, virus, cervical, activation, signal, dev, unregulated, play, factor, differentiation, gene, research, aberrant, dsl, growth,

Topics {✒️}

induces t-cell leukemia/lyphoma retrovirus-induced t-cell lymphomas cd4+cd8+double-positive stages high-molecular-weight notch complex induce t-cell leukaemia phosphatidylinositol-3-kinase/protein kinase t-cell leukemia/lymphoma t-cell lymphomas induced cd4-cd8- double-negative carboxy-terminal deletion mutant dsl/notch/csl signalling pathway membrane-bound transcription factor excessive csl-dependent signalling hpv-induced cervical tumours csl-dependent reporter gene developmental biology dominant-negative cbf1 protein e2a-pbx1 transgenic mice t-cell lymphoma development csl-dependent notch signalling retroviral-mediated gene transfer csl-independent notch signalling deltex-dependent pathway suppresses increased deltex-dependent signalling deltex-dependent notch signalling cd4-cd8- cell fate sustained hpv-e6/e7 expression t-cell leukemia epstein–barr virus [47] epstein–barr virus human breast cancer breast cancer campaign c-myc transgenic mice t-cell lymphoma cold spring harbor t-lymphoblastic neoplasms keith brennan growth-related genes virus-induced lymphomas cell-cycle machinery privacy choices/manage cookies human ras-transformed cells article brennan ap-1 transcription factor hepatocyte growth factor drosophila neurogenic gene-delta xenopus embryos regulated cell leukemia identifies t-cell lymphomas murine mammary gland

Questions {❓}

Is there a role for Notch signalling in human breast cancer?
Is there a role for Notch signalling in human breast cancer?
Martinez Arias A, Zecchini V, Brennan K: CSL-independent Notch signalling: a check point in cell fate decisions during development?
What is the mechanism by which Notch signalling contributes to tumour formation?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Is there a role for Notch signalling in human breast cancer?
         description:Aberrant Notch signalling has been observed in several human cancers, including acute T-cell lymphoblastic leukaemia and cervical cancer, and is strongly implicated in tumourigenesis. Unregulated Notch signalling in the mouse mammary gland leads to tumour formation. These results raise the possibility that Notch signalling might play a role in human breast cancer. There are currently few reports that address this question directly and this appears to be an area worthy of further investigation.
         datePublished:2003-04-01T00:00:00Z
         dateModified:2003-04-01T00:00:00Z
         pageStart:1
         pageEnd:7
         sameAs:https://doi.org/10.1186/bcr559
         keywords:
            breast cancer
            Notch signalling
            Cancer Research
            Oncology
            Surgical Oncology
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fbcr559/MediaObjects/13058_2003_Article_563_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fbcr559/MediaObjects/13058_2003_Article_563_HTML.jpg
         isPartOf:
            name:Breast Cancer Research
            issn:
               1465-542X
            volumeNumber:5
            type:
               Periodical
               PublicationVolume
         publisher:
            name:BioMed Central
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Keith Brennan
               affiliation:
                     name:University of Manchester
                     address:
                        name:School of Biological Sciences, University of Manchester, UK
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Anthony MC Brown
               affiliation:
                     name:Strang Cancer Research Laboratory at The Rockefeller University
                     address:
                        name:Strang Cancer Research Laboratory at The Rockefeller University, New York, USA
                        type:PostalAddress
                     type:Organization
                     name:Weill Medical College of Cornell University
                     address:
                        name:Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, USA
                        type:PostalAddress
                     type:Organization
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Is there a role for Notch signalling in human breast cancer?
      description:Aberrant Notch signalling has been observed in several human cancers, including acute T-cell lymphoblastic leukaemia and cervical cancer, and is strongly implicated in tumourigenesis. Unregulated Notch signalling in the mouse mammary gland leads to tumour formation. These results raise the possibility that Notch signalling might play a role in human breast cancer. There are currently few reports that address this question directly and this appears to be an area worthy of further investigation.
      datePublished:2003-04-01T00:00:00Z
      dateModified:2003-04-01T00:00:00Z
      pageStart:1
      pageEnd:7
      sameAs:https://doi.org/10.1186/bcr559
      keywords:
         breast cancer
         Notch signalling
         Cancer Research
         Oncology
         Surgical Oncology
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fbcr559/MediaObjects/13058_2003_Article_563_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fbcr559/MediaObjects/13058_2003_Article_563_HTML.jpg
      isPartOf:
         name:Breast Cancer Research
         issn:
            1465-542X
         volumeNumber:5
         type:
            Periodical
            PublicationVolume
      publisher:
         name:BioMed Central
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Keith Brennan
            affiliation:
                  name:University of Manchester
                  address:
                     name:School of Biological Sciences, University of Manchester, UK
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Anthony MC Brown
            affiliation:
                  name:Strang Cancer Research Laboratory at The Rockefeller University
                  address:
                     name:Strang Cancer Research Laboratory at The Rockefeller University, New York, USA
                     type:PostalAddress
                  type:Organization
                  name:Weill Medical College of Cornell University
                  address:
                     name:Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, USA
                     type:PostalAddress
                  type:Organization
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Breast Cancer Research
      issn:
         1465-542X
      volumeNumber:5
Organization:
      name:BioMed Central
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:University of Manchester
      address:
         name:School of Biological Sciences, University of Manchester, UK
         type:PostalAddress
      name:Strang Cancer Research Laboratory at The Rockefeller University
      address:
         name:Strang Cancer Research Laboratory at The Rockefeller University, New York, USA
         type:PostalAddress
      name:Weill Medical College of Cornell University
      address:
         name:Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Keith Brennan
      affiliation:
            name:University of Manchester
            address:
               name:School of Biological Sciences, University of Manchester, UK
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Anthony MC Brown
      affiliation:
            name:Strang Cancer Research Laboratory at The Rockefeller University
            address:
               name:Strang Cancer Research Laboratory at The Rockefeller University, New York, USA
               type:PostalAddress
            type:Organization
            name:Weill Medical College of Cornell University
            address:
               name:Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, USA
               type:PostalAddress
            type:Organization
PostalAddress:
      name:School of Biological Sciences, University of Manchester, UK
      name:Strang Cancer Research Laboratory at The Rockefeller University, New York, USA
      name:Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, USA

External Links {🔗}(212)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

5.45s.

LINK . SPRINGER . COM {}