We are analyzing https://link.springer.com/article/10.1186/bcr3658.

Title:
Breast cancer intra-tumor heterogeneity | Breast Cancer Research
Description:
In recent years it has become clear that cancer cells within a single tumor can display striking morphological, genetic and behavioral variability. Burgeoning genetic, epigenetic and phenomenological data support the existence of intra-tumor genetic heterogeneity in breast cancers; however, its basis is yet to be fully defined. Two of the most widely evoked concepts to explain the origin of heterogeneity within tumors are the cancer stem cell hypothesis and the clonal evolution model. Although the cancer stem cell model appeared to provide an explanation for the variability among the neoplastic cells within a given cancer, advances in massively parallel sequencing have provided several lines of evidence to suggest that intra-tumor genetic heterogeneity likely plays a fundamental role in the phenotypic heterogeneity observed in cancers. Many challenges remain, however, in the interpretation of the next generation sequencing results obtained so far. Here we review the models that explain tumor heterogeneity, the causes of intra-tumor genetic diversity and their impact on our understanding and management of breast cancer, methods to study intra-tumor heterogeneity and the assessment of intra-tumor genetic heterogeneity in the clinic.
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Keywords {🔍}

cancer, heterogeneity, tumor, cells, pubmed, genetic, sequencing, breast, article, google, scholar, mutations, clonal, cas, cell, intratumor, cancers, tumors, nature, aberrations, dna, central, single, primary, evolution, situ, detection, analysis, stem, progression, genomic, number, model, csc, mps, selective, genome, singlecell, reisfilho, phenotypic, methods, subclonal, ctcs, invasive, amplification, temporal, alterations, somatic, copy, bulk,

Topics {✒️}

routinely formalin-fixed paraffin-embedded triple-negative breast cancer early-stage breast cancer full size image article download pdf intra-tumor heterogeneity poses intra-tumor genetic heterogeneity intra-tumor genetic diversity single-molecule sequencing eliminates metaplastic breast carcinomas metaplastic breast cancers single-cell sequencing genomics assessing intra-tumor heterogeneity profiling intra-tumor heterogeneity translating single-cell methods cancer stem cell massively parallel sequencing study intra-tumor heterogeneity single-molecule sequencing platform single-molecule sequencing technologies detecting ultra-rare aberrations open reading frame intra-tumour heterogeneity full access cell stem cell single-cell genetic analysis cancer stem cells allele-specific expression directly advanced breast cancer molecular analysis reveals invasive breast cancer polygenomic breast cancers human breast cancer high-fidelity sequencing privacy choices/manage cookies intra-tumor heterogeneity breast cancer patients tumour cell plasticity cell-surface markers intra-genic deletions cancer cell plasticity genetic heterogeneity observed cancer genomics studies breast tumor heterogeneity cell population size detailed review breast cancer metastasis related subjects efficient tumour formation sequencing depth employed

Questions {❓}

Campbell LL, Polyak K: Breast tumor heterogeneity: cancer stem cells or clonal evolution?
Marusyk A, Almendro V, Polyak K: Intra-tumour heterogeneity: a looking glass for cancer?

Schema {🗺️}

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         headline:Breast cancer intra-tumor heterogeneity
         description:In recent years it has become clear that cancer cells within a single tumor can display striking morphological, genetic and behavioral variability. Burgeoning genetic, epigenetic and phenomenological data support the existence of intra-tumor genetic heterogeneity in breast cancers; however, its basis is yet to be fully defined. Two of the most widely evoked concepts to explain the origin of heterogeneity within tumors are the cancer stem cell hypothesis and the clonal evolution model. Although the cancer stem cell model appeared to provide an explanation for the variability among the neoplastic cells within a given cancer, advances in massively parallel sequencing have provided several lines of evidence to suggest that intra-tumor genetic heterogeneity likely plays a fundamental role in the phenotypic heterogeneity observed in cancers. Many challenges remain, however, in the interpretation of the next generation sequencing results obtained so far. Here we review the models that explain tumor heterogeneity, the causes of intra-tumor genetic diversity and their impact on our understanding and management of breast cancer, methods to study intra-tumor heterogeneity and the assessment of intra-tumor genetic heterogeneity in the clinic.
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      headline:Breast cancer intra-tumor heterogeneity
      description:In recent years it has become clear that cancer cells within a single tumor can display striking morphological, genetic and behavioral variability. Burgeoning genetic, epigenetic and phenomenological data support the existence of intra-tumor genetic heterogeneity in breast cancers; however, its basis is yet to be fully defined. Two of the most widely evoked concepts to explain the origin of heterogeneity within tumors are the cancer stem cell hypothesis and the clonal evolution model. Although the cancer stem cell model appeared to provide an explanation for the variability among the neoplastic cells within a given cancer, advances in massively parallel sequencing have provided several lines of evidence to suggest that intra-tumor genetic heterogeneity likely plays a fundamental role in the phenotypic heterogeneity observed in cancers. Many challenges remain, however, in the interpretation of the next generation sequencing results obtained so far. Here we review the models that explain tumor heterogeneity, the causes of intra-tumor genetic diversity and their impact on our understanding and management of breast cancer, methods to study intra-tumor heterogeneity and the assessment of intra-tumor genetic heterogeneity in the clinic.
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         Genetic Aberration
         Massively Parallel Sequencing
         Metaplastic Breast Cancer
         Cancer Stem Cell Hypothesis
         Cancer Research
         Oncology
         Surgical Oncology
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               type:PostalAddress
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      affiliation:
            name:Memorial Sloan Kettering Cancer Center
            address:
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               type:PostalAddress
            type:Organization
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            name:Memorial Sloan Kettering Cancer Center
            address:
               name:Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, USA
               type:PostalAddress
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      name:Jorge S Reis-Filho
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